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Volume 15 (5); 2025
Research Papers
Shear stress unveils patient-specific transcriptional signatures in PAH: Towards personalized molecular diagnostics Corey Wittig, Jakob M König, Xiaoke Pan, Jurjan Aman, Harm-Jan Bogaard, Paul B Yu, Wolfgang M Kuebler, Katharina Baum, Robert Szulcek
Theranostics 2025; 15(5): 1589-1605. doi:10.7150/thno.105729
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Deubiquitinase MYSM1 drives myocardial ischemia/reperfusion injury by stabilizing STAT1 in cardiomyocytes Xiaowen Shi, Jianjiang Xu, Lei Liu, Shenggang Zhao, Yuanyuan Qian, Zimin Fang, Liming Lin, Xia Zhao, Shangcai Xie, Fengjie Shi, Jibo Han
Theranostics 2025; 15(5): 1606-1621. doi:10.7150/thno.100097
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Exosomes of human adipose stem cells mitigate irradiation injury to salivary glands by inhibiting epithelial-mesenchymal transition through miR-199a-3p targeting Twist1 and regulating TGFβ1/Smad3 pathway Xiaotong Guo, Zhu Huang, Fan Wu, Wentao Jiang, Yiyang Li, Tao Wang, Simon D Tran, Zhengmei Lin, Xinyun Su
Theranostics 2025; 15(5): 1622-1641. doi:10.7150/thno.102346
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A metagenome-wide study of the gut virome in chronic kidney disease Pan Zhang, Ruochun Guo, Shiyang Ma, Hongli Jiang, Qiulong Yan, Shenghui Li, Kairuo Wang, Jiang Deng, Yanli Zhang, Yue Zhang, Guangyang Wang, Lei Chen, Lu Li, Xiaoyan Guo, Gang Zhao, Longbao Yang, Yan Wang, Jian Kang, Shanshan Sha, Shao Fan, Lin Cheng, Jinxin Meng, Hailong Yu, Fenrong Chen, Danni He, Jinhai Wang, Shuxin Liu, Haitao Shi
Theranostics 2025; 15(5): 1642-1661. doi:10.7150/thno.101601
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Exercise ameliorates osteopenia in mice via intestinal microbial-mediated bile acid metabolism pathway Congcong Yu, Rongtai Sun, Wentao Yang, Tianyuan Gu, Xiaozhang Ying, Lin Ye, Yang Zheng, Shunwu Fan, Xiangjun Zeng, Shasha Yao
Theranostics 2025; 15(5): 1741-1759. doi:10.7150/thno.104186
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Glutamatergic pathways from medial prefrontal cortex to paraventricular nucleus of thalamus contribute to the methamphetamine-induced conditioned place preference without affecting wakefulness Xiang Li, Xing Xu, Quying Feng, Ning Zhou, Yuhong He, Ying Liu, Haoqing Tai, Hee Young Kim, Yu Fan, Xiaowei Guan
Theranostics 2025; 15(5): 1822-1841. doi:10.7150/thno.100688
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Chronic stress induces depression through MDGA1-Neuroligin2 mediated suppression of inhibitory synapses in the lateral habenula Xuehui Wang, Hao Wei, Zhe Hu, Jie Jiang, Xinyan Dong, Jinpiao Zhu, Haiyan Chen, Nils Brose, Noa Lipstein, Tonghui Xu, Steven A. Connor, Daqing Ma, Yicheng Xie
Theranostics 2025; 15(5): 1842-1863. doi:10.7150/thno.104282
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Loss of DDX24 inhibits lung cancer progression by stimulating IKBKG splicing-mediated autophagy Siwen Sun, Xiaomeng Jing, Guangquan Tong, Chaoqun Chen, Shuaijun Xie, Chong Wang, Dan Chen, Jinyao Zhao, Yangfan Qi, Wenjing Zhang, Congcong Liu, Ge Zhang, Jinrui Zhang, Bing Sun, Yang Wang, Yuesheng Lv
Theranostics 2025; 15(5): 1879-1895. doi:10.7150/thno.102425
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MgSO4 as a novel hypothermia infusion solution promotes ischemic stroke recovery through Ca2+ regulation of neurovascular units Yang Zhang, Miaowen Jiang, Ming Wei, Chuanjie Wu, Yiming Huang, Baoying Song, Yi Xu, Hongkang Zhang, Yunong Shen, Di Wu, Yufeng Zheng, Ming Li, Xunming Ji
Theranostics 2025; 15(5): 1896-1913. doi:10.7150/thno.104879
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LETM-domain containing 1 (LETMD1) protects against obesity via enhancing UCP1-independent energy expenditure in human beige adipocytes Jiaxing Liu, Ying Cheng, Qing Liu, Qiaoyun Long, Shiqing Liang, Wei Sun, Kerry M. Loomes, Xuefei Gao, Bin Lin, Xingguo Liu, Donghai Wu, Hannah Xiaoyan Hui
Theranostics 2025; 15(5): 1914-1929. doi:10.7150/thno.104568
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YAP1 mediates the dimensional and chemical coordination of immunoregulation and therapy in extensively passaged mesenchymal stem cells Fang-Ying Du, Feng Zhou, Na Zhao, Lei Bao, Cheng-Biao Hu, Jing Lei, An-Qi Liu, Ying-Feng Gao, Li-Hui Bao, Hua Ni, Xiao-Rui Yu, Ji Chen, Bing-Dong Sui
Theranostics 2025; 15(5): 1930-1948. doi:10.7150/thno.103314
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Betaine inhibits the stem cell-like properties of hepatocellular carcinoma by activating autophagy via SAM/m6A/YTHDF1-mediated enhancement on ATG3 stability Chen Wang, Meng-chu Li, Wen-ge Huang, Si-yu Huang, Maierhaba Wusiman, Zhao-yan Liu, Hui-lian Zhu
Theranostics 2025; 15(5): 1949-1965. doi:10.7150/thno.102682
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TBX3 shapes an immunosuppressive microenvironment and induces immunotherapy resistance Zhi Liu, Chunyu Zhang, Jiatong Xiao, Yunbo He, Haisu Liang, Jinliang Huang, Zhiyong Cai, Zhenglin Yi, Mingfeng Chen, Yixiao Li, Jun Zhang, Fenglian liu, Peng Ren, Huihuang Li, Jinbo Chen, Benyi Fan, Jiao Hu, Xiongbing Zu, Dingshan Deng
Theranostics 2025; 15(5): 1966-1986. doi:10.7150/thno.103175
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Stress granule formation is regulated by signaling machinery involving Sch9/Ypk1, sphingolipids, and Ubi4 Lihua Chen, Yuan Gao, Xinxin Hao, Xiaoxue Yang, Michelle Lindström, Shan Jiang, Xiuling Cao, Huisheng Liu, Thomas Nyström, Per Sunnerhagen, Beidong Liu
Theranostics 2025; 15(5): 1987-2005. doi:10.7150/thno.98199
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Silybin A from Silybum marianum reprograms lipid metabolism to induce a cell fate-dependent class switch from triglycerides to phospholipids Solveigh C. Koeberle, Maria Thürmer, Fengting Su, Markus Werner, Julia Grander, Laura Hofer, André Gollowitzer, Loc Le Xuan, Felix J. Benscheid, Ehsan Bonyadi Rad, Armando Zarrelli, Giovanni Di Fabio, Oliver Werz, Valeria Romanucci, Amelie Lupp, Andreas Koeberle
Theranostics 2025; 15(5): 2006-2034. doi:10.7150/thno.99562
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Oncogenic non-V600 mutations evade the regulatory machinery of RAF including the Cdc37/Hsp90 chaperone and the 14-3-3 scaffold Xiaoyu Wan, Jiajun Yap, Junjun Chen, Yifan Li, Regina Faruk, Nazereth Tan Chor Boon, Yiying Ma, Yiting Lim, Karlina Bte Jubri, Jingyi Hu, Jimin Yuan, Ge Zhang, Quan Li, Yoon Sim Yap, Paula Lam, Mei Wang, Naiyang Fu, Jiancheng Hu
Theranostics 2025; 15(5): 2035-2051. doi:10.7150/thno.103958
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Tumor-selective dye-based histological electrophoresis enables intraoperative tumor diagnosis via tumor-specific enhancement Feiran Zhang, Jianing Cheng, Xu Peng, Chengbin Zhang, Limei Qu, Songling Zhang, Junhu Zhang, Shoujun Zhu
Theranostics 2025; 15(5): 2052-2068. doi:10.7150/thno.105500
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Single-cell nanocapsules of gut microbiota facilitate fecal microbiota transplantation Weiliang Hou, Yuan Cao, Jifeng Wang, Fang Yin, Jiahui Wang, Ning Guo, Ziyi Wang, Xiaoqiong Lv, Chunlian Ma, Qiyi Chen, Rong Yang, Hong Wei, Juanjuan Li, Ruibing Wang, Huanlong Qin
Theranostics 2025; 15(5): 2069-2084. doi:10.7150/thno.104852
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Reviews
Current status, challenges, and prospects of artificial intelligence applications in wound repair theranostics Huazhen Liu, Wenbin Sun, Weihuang Cai, Kaidi Luo, Chunxiang Lu, Aoxiang Jin, Jiantao Zhang, Yuanyuan Liu
Theranostics 2025; 15(5): 1662-1688. doi:10.7150/thno.105109
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Tumor microenvironment targeted nano-drug delivery systems for multidrug resistant tumor therapy Xinyue Shao, Xiaoling Zhao, Binghao Wang, Jiahui Fan, Jinping Wang, Hailong An
Theranostics 2025; 15(5): 1689-1714. doi:10.7150/thno.103636
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Metabolism of hepatic stellate cells in chronic liver diseases: emerging molecular and therapeutic interventions Mengyao Yan, Yimin Cui, Qian Xiang
Theranostics 2025; 15(5): 1715-1740. doi:10.7150/thno.106597
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Stimulus-responsive smart bioactive glass composites for repair of complex tissue defects Yulian Yang, Yonghao Qiu, Cai Lin, Xiaofeng Chen, Fujian Zhao
Theranostics 2025; 15(5): 1760-1786. doi:10.7150/thno.104944
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Lactylation in health and disease: physiological or pathological? Lijun Zhao, Haonan Qi, Huiying Lv, Wenyue Liu, Rui Zhang, Angang Yang
Theranostics 2025; 15(5): 1787-1821. doi:10.7150/thno.105353
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LAT1-specific PET radiotracers: Development and clinical experiences of a new class of cancer-specific radiopharmaceuticals Arifudin Achmad, Hirofumi Hanaoka, Holis Abdul Holik, Keigo Endo, Yoshito Tsushima, Achmad Hussein S. Kartamihardja
Theranostics 2025; 15(5): 1864-1878. doi:10.7150/thno.99490
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Errata
Investigation of the role and mechanism of ARHGAP5-mediated colorectal cancer metastasis: Erratum Tian Tian, Zhan-Hong Chen, Zongheng Zheng, Yubo Liu, Qi Zhao, Yuying Liu, Huijun Qiu, Qian Long, Miao Chen, Liren Li, Fangyun Xie, Guangyu Luo, Xiaojun Wu, Wuguo Deng
Theranostics 2025; 15(5): 2085. doi:10.7150/thno.108943
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Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB2 expression: Erratum Dong-liang Chen, Yun-xin Lu, Jia-xing Zhang, Xiao-li Wei, Feng Wang, Zhao-lei Zeng, Zhi-zhong Pan, Yun-fei Yuan, Feng-hua Wang, Helene Pelicano, Paul J. Chiao, Peng Huang, Dan Xie, Yu-hong Li, Huai-qiang Ju, Rui-hua Xu
Theranostics 2025; 15(5): 2086-2087. doi:10.7150/thno.108968
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Edaravone-Encapsulated Agonistic Micelles Rescue Ischemic Brain Tissue by Tuning Blood-Brain Barrier Permeability: Erratum Qu Jin, Yu Cai, Sihan Li, Haoran Liu, Xingyu Zhou, Chunqiang Lu, Xihui Gao, Jun Qian, Jun Zhang, Shenghong Ju, Cong Li
Theranostics 2025; 15(5): 2088-2089. doi:10.7150/thno.108498
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Redox Regulation of Stem-like Cells Though the CD44v-xCT Axis in Colorectal Cancer: Mechanisms and Therapeutic Implications: Erratum Huai-Qiang Ju, Yun-Xin Lu, Dong-Liang Chen, Tian Tian, Hai-Yu Mo, Xiao-Li Wei, Jian-Wei Liao, Feng Wang, Zhao-Lei Zeng, Helene Pelicano, Mitzi Aguilar, Wei-Hua Jia, Rui-Hua Xu
Theranostics 2025; 15(5): 2090-2091. doi:10.7150/thno.109534
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