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Volume 16 (15); 2026
Research Papers
Novel nastorazepide-based radioligands demonstrate effective cholecystokinin-2 receptor targeting with potential for theranostic applications Lennart Bohrmann, Doroteja Novak, Marko Kroselj, Raghuvir H. Gaonkar, Francesca Porto, Melpomeni Fani, Petra Kolenc, Marko Anderluh, Rosalba Mansi
Theranostics 2026; 16(15): 8447-8460. doi:10.7150/thno.129327
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Radiocopper in BCMA-targeted immunotheranostics of myeloma Martin Ullrich, Kristof Zarschler, Manja Kubeil, Markus Laube, Jens Pietzsch, Birgit Belter
Theranostics 2026; 16(15): 8461-8477. doi:10.7150/thno.134397
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An αvβ6/αvβ8-targeting peptibody inhibits integrin-dependent TGFβ activation, enables tumor-selective cytotoxic delivery, and synergizes with PD-L1 immune checkpoint blockade Angelo Corti, Anna Maria Gasparri, Barbara Colombo, Giulia Taiè, Elisa Sangiovanni, Leopoldo Sitia, Valeria Barreca, Alice Schirru, Alessandro Gori, Luc Garrigues, Sophie Chabot, Annapaola Andolfo, Maurilio Ponzoni, Anna Mondino, Arianna Pocaterra, Claudio Doglioni, Flavio Curnis
Theranostics 2026; 16(15): 8478-8500. doi:10.7150/thno.131237
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A multimodal pipeline for the identification and diagnostic immunoPET validation of hepatocellular carcinoma targets for radiotheranostic development Philip Homan, Joon-Yong Chung, Woonghee Lee, Divya Nambiar, Julia Sheehan-Klenk, Hima Makala, Stanley Fayn, Orit Jacobson, Arthur Paden King, Kyungeun Kim, Jeong Won Kim, Sung Ryol Lee, Maggie Cam, Stephen M. Hewitt, Xin Wei Wang, Mitchell Ho, Freddy E. Escorcia
Theranostics 2026; 16(15): 8501-8520. doi:10.7150/thno.136906
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Dual-metallic porphyrinic MOFs with pH/ROS-responsive release for antibacterial and antioxidant therapy of diabetic infected wounds Yipeng Pang, Fructueux Modeste Amona, Hanyuan Liu, Shuming Tang, Jianlong Lao, Xi Chen, Xiaoye Wang
Theranostics 2026; 16(15): 8521-8545. doi:10.7150/thno.135365
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Focused ultrasound-mediated blood–brain barrier modulation is associated with adult hippocampal neurogenic responses linked to zinc-dependent signaling Bo Young Choi, Jaewoo Shin, Chanho Kong, Min Kyu Park, Dae Ki Hong, Young-soo Chung, Sang Won Suh, Won Seok Chang
Theranostics 2026; 16(15): 8561-8579. doi:10.7150/thno.133902
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An integrated SOX4-driven transcriptional and metabolic program governs tumor-infiltrating regulatory T cells in ovarian cancer Lei Wu, Ziqi Tao, Yuelu Zhang, Yepeng Mao, Lei Zhang, Lina Yan, Rong Li, Lingfei Zhou, Zhijie Liu, Wenwen Shang, Shuna Liu, Jianfang Lou, Xi Huang, Ting Wang, Fang Wang
Theranostics 2026; 16(15): 8611-8632. doi:10.7150/thno.131793
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Unravelling the in vivo traits of vasculogenic mimicry Mariam-Eleni Oraiopoulou, Thierry L. Lefebvre, Eleftheria Tzamali, Thomas R. Else, Ian G. Cannell, Lorna C. Wright, Ellie V. Bunce, Cara Brodie, Paul W. Sweeney, Luca Porcu, Dominique-Laurent Couturier, Vangelis Sakkalis, Gregory J. Hannon, Sarah E. Bohndiek
Theranostics 2026; 16(15): 8633-8649. doi:10.7150/thno.140146
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Lactylation at H3K18 drives pathological angiogenesis via metabolic-epigenetic crosstalk in ischemic retinopathy Xin Chen, Yuhan Jiang, Weiqi Qian, Yi Lei, Siyue Chen, Yutian Zhang, Minghui Liang, Yuming Liu, Xiaohong Wang, Ding Ai, Xuyang Yao, Hua Yan
Theranostics 2026; 16(15): 8650-8668. doi:10.7150/thno.136054
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Mapping endometrial vascular functional gradients using depth-derived ultrasound localization microscopy (D-ULM) for early stratification of postinjury fibrotic remodeling and therapeutic guidance Xiaowen Liang, Le Gao, Zhili Guo, Meng Du, Yue Pan, Yixiang Lian, Yu Qiang, Haijun Luo, Ying Zhang, Xiaoyan Kui, Hairong Zheng, Weibao Qiu, Zhiyi Chen
Theranostics 2026; 16(15): 8669-8688. doi:10.7150/thno.138622
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Cardiomyocyte-Specific RNF128 Attenuates Pathological Cardiac Hypertrophy Progression by Stabilizing SERCA2a through Lys63-Linked Polyubiquitination Yujie Zhang, Xuehan Liu, Liwen Yu, Changhao Liu, Jingwei Li, Qingmei Han, Xiaohong Wang, Lei Cao, Liangyu Cai, Linqi Jiao, Guohai Su, Meng Zhang, Cheng Zhang
Theranostics 2026; 16(15): 8689-8707. doi:10.7150/thno.133221
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Targeting USP22 reprograms the tumor microenvironment and sensitizes KRAS/p53-driven lung cancer to anti-PD-1 immunotherapy Keqiang Zhang, Ching Ouyang, Jonathan Castillo, Jinhui Wang, Walter Tsark, Yuanyuan Gao, Wendong Li, Minxiao Yang, Aimin Li, Britney Oeung, Colt Egelston, Jun Wu, Mahima Raul, Leonidas Arvanitis, Crystal Marconett, Dan J Raz
Theranostics 2026; 16(15): 8708-8732. doi:10.7150/thno.125898
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PEGylated IL2 and tumor-targeted radiotherapy augment CD8+ T cell-mediated anti-tumor response to anti-PD-1 in head and neck squamous cell carcinoma Won Jong Jin, Hari Menon, Amber Bates, Lauren Zebertavage, Yujuan Wang, Paul A. Clark, Alexander A. Pieper, Caroline P. Kerr, Tracy J. Berg, Jens C Eickhoff, Sarah Seiter, A Mario Q. Marcondes, Mary A. Tagliaferri, Willem W. Overwijk, Tabassum A. Kennedy, Paul M. Sondel, Paul M. Harari, Justine Y. Bruce, Adam R. Burr, Reinier Hernandez, Irene M Ong, Jamey Weichert, Zachary S. Morris
Theranostics 2026; 16(15): 8733-8756. doi:10.7150/thno.135255
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Spatiotemporally programmed hybrid nano-prodrugs orchestrate multidimensionally synergistic cascade lethality in NSCLC Yan Wang, Chaozheng Zhang, Chen Sun, Yao Chen, Jielu Zhang, Yongsen He, Xue Sun, Jingping Wu, Xiaosong Xu, Xingtong Li, Li Deng, Fang Yan, Lang He, Tianbao Wang, Xin Zhou, Tingting Zhang, Maolin Wang, Jin Liu, Zhizhong Wang, Shilin Chen, Bo Ren, Jun Lu
Theranostics 2026; 16(15): 8808-8826. doi:10.7150/thno.135204
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Feedback-regulated 3D-printed hydrogel micropatch for integrated therapy of fungal keratitis Yujie Liu, Li Ma, Guodong Fang, Tan Li, Hongran Zhao, Ting Wu, Jiajia Zhang, Xia Qi, Xiangyue Hu, Hongwei Wang, Chao Yang, Depeng Shi
Theranostics 2026; 16(15): 8827-8843. doi:10.7150/thno.134232
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3D vascular mapping reveals multi-organ injury following severe acute pancreatitis Xiaomei Liu, Jingtan Zhu, Qiao Shi, Jianyi Xu, Zhang Liu, Yujia Kang, Kunxing Liu, Yuening He, Qihang Yang, Tingting Yu, Dan Zhu
Theranostics 2026; 16(15): 8844-8859. doi:10.7150/thno.141299
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Colon-targeted oral delivery of melatonin for regulating macrophage activity and intestinal barrier in ulcerative colitis Nhu-Nam Nguyen, Yoojin Seo, Tiep Tien Nguyen, Kim-Phuong Phan, Rabyya Kausar, Hu-Lin Jiang, Jae Young Lee, Seho Kweon, Nguyen-Thach Tung, Hyung-Sik Kim, Jee-Heon Jeong
Theranostics 2026; 16(15): 8860-8879. doi:10.7150/thno.133456
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Preclinical efficacy and dosimetry of CD44v6-directed terbium-161 radionuclide therapy Amanda Gustafsson, Anja Charlotte Lundgren Mortensen, Veronica Rondahl, Tianqi Xu, Klas Bratteby, Peter Bernhardt, Marika Nestor
Theranostics 2026; 16(15): 8880-8891. doi:10.7150/thno.135243
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Microbial enzyme-responsive inulin nanoparticles for colon-targeted oral delivery of 5-ASA toward improved therapy of inflammatory bowel disease Haena Park, Panmo Son, Chiwoo Oh, Hyeryeon Oh, Jee-Eun Hwang, Seo Young Kim, Jeongcheol Lee, Jae Kyoo Lee, Won Il Choi, Hyung-Jun Im
Theranostics 2026; 16(15): 8892-8913. doi:10.7150/thno.127560
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Nano-flow intracalvariosseous infusion enables skull-to-brain delivery of BBB-impermeable molecular and nanoscale agents in mice and rabbits Ji Hee Kang, O Hyun Lee, Min Suk Shim, Sehoon Kim, Dongyun Shin, Young Tag Ko
Theranostics 2026; 16(15): 8947-8967. doi:10.7150/thno.138110
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Membrane and soluble VTCN1 (B7H4) converge on Src signaling to mediate gemcitabine resistance in intrahepatic cholangiocarcinoma Yi-Ru Pan, Sheng-Hsuan Lin, Yu-Chan Chang, Shih-Ming Jung, Chiao-En Wu, Wen-Kuan Huang, Chun-Nan Yeh
Theranostics 2026; 16(15): 8968-8986. doi:10.7150/thno.130394
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EBDE clearing: A strategy for simultaneous 3D visualization and quantitative analysis of both renal arteries and glomeruli Yaping Wu, Qian Shen, Yan Liang, Lin Bai, Jinsai Wu, Qiuxiao Shi, Lei Wu, Menqi Wang, Yin Liu, Kui Huang
Theranostics 2026; 16(15): 8987-9006. doi:10.7150/thno.138951
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Targeted phagocytosis of TNF-α by CAR macrophages restores immune homeostasis in arthritis Mei-Qi Wang, Jie Zhu, Chun-Yu Liu, Xiao-Lin Yu, Ya-Ru Huang, Lei Zhang, Shi-Yu Liang, Lixia Zhang, Hao-Tian Wang, Hongbo Cheng, Jia-Qian Chai, Xi-Xiu Xie, Rui-Tian Liu
Theranostics 2026; 16(15): 9007-9029. doi:10.7150/thno.132172
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hNET-targeted [18F]MFBG PET as baseline functional imaging in newly diagnosed neuroblastoma Lifeng Zhang, Xinhui Su, Xinyue Zheng, En Ren, Li Hou, Junqing Mao, Tingting Zhang, Jinhu Wang, Jingjing Zhang, Peipei Wang
Theranostics 2026; 16(15): 9030-9040. doi:10.7150/thno.139324
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Reviews
Frailty and [177Lu]Lu-PSMA-617 therapy: tools and strategies for older men with metastatic castration-resistant prostate cancer Matteo Bauckneht, Nicolò Borsellino, Giuseppe Ferdinando Colloca, Lucia Fratino, Daniele Santini
Theranostics 2026; 16(15): 8546-8558. doi:10.7150/thno.131438
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The evolution of surrogate microspheres in transarterial radioembolization: from SPECT prediction to multimodal AI-guided precision dosimetry Arun Gupta, Andrew C. Gordon, Samdeep K. Mouli, Robert J. Lewandowski, Dong-Hyun Kim
Theranostics 2026; 16(15): 8580-8610. doi:10.7150/thno.134985
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Micro/nanorobotics for sepsis diagnosis and therapy: a frontier in precision medicine Yukun Liu, Kang Wang, Guoyun Wan, Fangli Gao, Huiming Tang, Xiangjun Bai, Zhanfei Li, Yuchang Wang
Theranostics 2026; 16(15): 8757-8774. doi:10.7150/thno.139332
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Towards practical radiopharmaceutical treatment planning: a review of dosimetry simplification techniques Elmira Yazdani, Zahra Mansouri, Yazdan Salimi, Habib Zaidi
Theranostics 2026; 16(15): 8775-8807. doi:10.7150/thno.132538
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Engineered nanomedicine remodels the postoperative cavity microenvironment to suppress glioblastoma recurrence Zhiqun Bai, Zhiguang Chen
Theranostics 2026; 16(15): 8914-8946. doi:10.7150/thno.141774
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Erratum
Co-delivery of siPTPN13 and siNOX4 via (myo)fibroblast-targeting polymeric micelles for idiopathic pulmonary fibrosis therapy: Erratum Jiwei Hou, Qijian Ji, Jie Ji, Shenghong Ju, Chun Xu, Xueqing Yong, Xiaoxuan Xu, Mohd. Muddassir, Xiang Chen, Jinbing Xie, Xiaodong Han
Theranostics 2026; 16(15): 8559-8560. doi:10.7150/thno.137233
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