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Volume 16 (15); 2026

Research Papers

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Novel nastorazepide-based radioligands demonstrate effective cholecystokinin-2 receptor targeting with potential for theranostic applications Lennart Bohrmann, Doroteja Novak, Marko Kroselj, Raghuvir H. Gaonkar, Francesca Porto, Melpomeni Fani, Petra Kolenc, Marko Anderluh, Rosalba Mansi Theranostics 2026; 16(15): 8447-8460. doi:10.7150/thno.129327 Full text PDF

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Radiocopper in BCMA-targeted immunotheranostics of myeloma Martin Ullrich, Kristof Zarschler, Manja Kubeil, Markus Laube, Jens Pietzsch, Birgit Belter Theranostics 2026; 16(15): 8461-8477. doi:10.7150/thno.134397 Full text PDF

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An αvβ6/αvβ8-targeting peptibody inhibits integrin-dependent TGFβ activation, enables tumor-selective cytotoxic delivery, and synergizes with PD-L1 immune checkpoint blockade Angelo Corti, Anna Maria Gasparri, Barbara Colombo, Giulia Taiè, Elisa Sangiovanni, Leopoldo Sitia, Valeria Barreca, Alice Schirru, Alessandro Gori, Luc Garrigues, Sophie Chabot, Annapaola Andolfo, Maurilio Ponzoni, Anna Mondino, Arianna Pocaterra, Claudio Doglioni, Flavio Curnis Theranostics 2026; 16(15): 8478-8500. doi:10.7150/thno.131237 Full text PDF

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A multimodal pipeline for the identification and diagnostic immunoPET validation of hepatocellular carcinoma targets for radiotheranostic development Philip Homan, Joon-Yong Chung, Woonghee Lee, Divya Nambiar, Julia Sheehan-Klenk, Hima Makala, Stanley Fayn, Orit Jacobson, Arthur Paden King, Kyungeun Kim, Jeong Won Kim, Sung Ryol Lee, Maggie Cam, Stephen M. Hewitt, Xin Wei Wang, Mitchell Ho, Freddy E. Escorcia Theranostics 2026; 16(15): 8501-8520. doi:10.7150/thno.136906 Full text PDF

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Dual-metallic porphyrinic MOFs with pH/ROS-responsive release for antibacterial and antioxidant therapy of diabetic infected wounds Yipeng Pang, Fructueux Modeste Amona, Hanyuan Liu, Shuming Tang, Jianlong Lao, Xi Chen, Xiaoye Wang Theranostics 2026; 16(15): 8521-8545. doi:10.7150/thno.135365 Full text PDF

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Focused ultrasound-mediated blood–brain barrier modulation is associated with adult hippocampal neurogenic responses linked to zinc-dependent signaling Bo Young Choi, Jaewoo Shin, Chanho Kong, Min Kyu Park, Dae Ki Hong, Young-soo Chung, Sang Won Suh, Won Seok Chang Theranostics 2026; 16(15): 8561-8579. doi:10.7150/thno.133902 Full text PDF

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An integrated SOX4-driven transcriptional and metabolic program governs tumor-infiltrating regulatory T cells in ovarian cancer Lei Wu, Ziqi Tao, Yuelu Zhang, Yepeng Mao, Lei Zhang, Lina Yan, Rong Li, Lingfei Zhou, Zhijie Liu, Wenwen Shang, Shuna Liu, Jianfang Lou, Xi Huang, Ting Wang, Fang Wang Theranostics 2026; 16(15): 8611-8632. doi:10.7150/thno.131793 Full text PDF

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Unravelling the in vivo traits of vasculogenic mimicry Mariam-Eleni Oraiopoulou, Thierry L. Lefebvre, Eleftheria Tzamali, Thomas R. Else, Ian G. Cannell, Lorna C. Wright, Ellie V. Bunce, Cara Brodie, Paul W. Sweeney, Luca Porcu, Dominique-Laurent Couturier, Vangelis Sakkalis, Gregory J. Hannon, Sarah E. Bohndiek Theranostics 2026; 16(15): 8633-8649. doi:10.7150/thno.140146 Full text PDF

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Lactylation at H3K18 drives pathological angiogenesis via metabolic-epigenetic crosstalk in ischemic retinopathy Xin Chen, Yuhan Jiang, Weiqi Qian, Yi Lei, Siyue Chen, Yutian Zhang, Minghui Liang, Yuming Liu, Xiaohong Wang, Ding Ai, Xuyang Yao, Hua Yan Theranostics 2026; 16(15): 8650-8668. doi:10.7150/thno.136054 Full text PDF

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Mapping endometrial vascular functional gradients using depth-derived ultrasound localization microscopy (D-ULM) for early stratification of postinjury fibrotic remodeling and therapeutic guidance Xiaowen Liang, Le Gao, Zhili Guo, Meng Du, Yue Pan, Yixiang Lian, Yu Qiang, Haijun Luo, Ying Zhang, Xiaoyan Kui, Hairong Zheng, Weibao Qiu, Zhiyi Chen Theranostics 2026; 16(15): 8669-8688. doi:10.7150/thno.138622 Full text PDF

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Cardiomyocyte-Specific RNF128 Attenuates Pathological Cardiac Hypertrophy Progression by Stabilizing SERCA2a through Lys63-Linked Polyubiquitination Yujie Zhang, Xuehan Liu, Liwen Yu, Changhao Liu, Jingwei Li, Qingmei Han, Xiaohong Wang, Lei Cao, Liangyu Cai, Linqi Jiao, Guohai Su, Meng Zhang, Cheng Zhang Theranostics 2026; 16(15): 8689-8707. doi:10.7150/thno.133221 Full text PDF

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Targeting USP22 reprograms the tumor microenvironment and sensitizes KRAS/p53-driven lung cancer to anti-PD-1 immunotherapy Keqiang Zhang, Ching Ouyang, Jonathan Castillo, Jinhui Wang, Walter Tsark, Yuanyuan Gao, Wendong Li, Minxiao Yang, Aimin Li, Britney Oeung, Colt Egelston, Jun Wu, Mahima Raul, Leonidas Arvanitis, Crystal Marconett, Dan J Raz Theranostics 2026; 16(15): 8708-8732. doi:10.7150/thno.125898 Full text PDF

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PEGylated IL2 and tumor-targeted radiotherapy augment CD8+ T cell-mediated anti-tumor response to anti-PD-1 in head and neck squamous cell carcinoma Won Jong Jin, Hari Menon, Amber Bates, Lauren Zebertavage, Yujuan Wang, Paul A. Clark, Alexander A. Pieper, Caroline P. Kerr, Tracy J. Berg, Jens C Eickhoff, Sarah Seiter, A Mario Q. Marcondes, Mary A. Tagliaferri, Willem W. Overwijk, Tabassum A. Kennedy, Paul M. Sondel, Paul M. Harari, Justine Y. Bruce, Adam R. Burr, Reinier Hernandez, Irene M Ong, Jamey Weichert, Zachary S. Morris Theranostics 2026; 16(15): 8733-8756. doi:10.7150/thno.135255 Full text PDF

Reviews

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Frailty and [177Lu]Lu-PSMA-617 therapy: tools and strategies for older men with metastatic castration-resistant prostate cancer Matteo Bauckneht, Nicolò Borsellino, Giuseppe Ferdinando Colloca, Lucia Fratino, Daniele Santini Theranostics 2026; 16(15): 8546-8558. doi:10.7150/thno.131438 Full text PDF

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The evolution of surrogate microspheres in transarterial radioembolization: from SPECT prediction to multimodal AI-guided precision dosimetry Arun Gupta, Andrew C. Gordon, Samdeep K. Mouli, Robert J. Lewandowski, Dong-Hyun Kim Theranostics 2026; 16(15): 8580-8610. doi:10.7150/thno.134985 Full text PDF

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Micro/nanorobotics for sepsis diagnosis and therapy: a frontier in precision medicine Yukun Liu, Kang Wang, Guoyun Wan, Fangli Gao, Huiming Tang, Xiangjun Bai, Zhanfei Li, Yuchang Wang Theranostics 2026; 16(15): 8757-8774. doi:10.7150/thno.139332 Full text PDF

Erratum

Co-delivery of siPTPN13 and siNOX4 via (myo)fibroblast-targeting polymeric micelles for idiopathic pulmonary fibrosis therapy: Erratum Jiwei Hou, Qijian Ji, Jie Ji, Shenghong Ju, Chun Xu, Xueqing Yong, Xiaoxuan Xu, Mohd. Muddassir, Xiang Chen, Jinbing Xie, Xiaodong Han Theranostics 2026; 16(15): 8559-8560. doi:10.7150/thno.137233 Full text PDF

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