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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.

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Research Paper
Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral neuropathy
Minjee Kim, Hyeyoung Kim, Bu-Gyeong Kang, Jooyoung Lee, Taegun Kim, Hwanho Lee, Jane Jung, Myung Joon Oh, Seungyoon Seo, Myung-Jeom Ryu, Yeojin Sung, Yunji Lee, Jeonghun Yeom, Gyoonhee Han, Sun-Shin Cha, Hosung Jung, Hyun Seok Kim
Theranostics 2023; 13(14): 5075-5098. doi:10.7150/thno.85356
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Research Paper
Exosomal transfer leads to chemoresistance through oxidative phosphorylation-mediated stemness phenotype in colorectal cancer
Jinhai Deng, Teng Pan, Chunxin Lv, Lulu Cao, Lifeng Li, Xingang Zhou, Gang Li, Huanxin Li, Jose M Vicencio, Yihan Xu, Fengxiang Wei, Yazhou Wang, Zaoqu Liu, Guanglin Zhou, Mingzhu Yin
Theranostics 2023; 13(14): 5057-5074. doi:10.7150/thno.84937
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Review
Targeting cullin neddylation for cancer and fibrotic diseases
Zhang-Xu He, Wei-guang Yang, Dan Zengyangzong, Ge Gao, Qian Zhang, Hong-Min Liu, Wen Zhao, Li-Ying Ma
Theranostics 2023; 13(14): 5017-5056. doi:10.7150/thno.78876
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Research Paper
Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular endothelial ferroptosis and aggravates atherosclerosis progression in ApoE-/-mice
Peng Xiang, Qingqiu Chen, Le Chen, Jin Lei, Zhiyi Yuan, Hui Hu, Yining Lu, Xianmin Wang, Tingting Wang, Ruihong Yu, Wanping Zhang, Jun Zhang, Chao Yu, Limei Ma
Theranostics 2023; 13(14): 4993-5016. doi:10.7150/thno.87968
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Research Paper
Application of Lung-Targeted Lipid Nanoparticle-delivered mRNA of soluble PD-L1 via SORT Technology in Acute Respiratory Distress Syndrome
Han Sun, Yu Zhang, Jiahui Wang, Juncheng Su, Dejian Zhou, Xiang Yu, Yingjie Xu, Wen Yang
Theranostics 2023; 13(14): 4974-4992. doi:10.7150/thno.86466
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Research Paper
Polymer theranostics with multiple stimuli-based activation of photodynamic therapy and tumor imaging
Marina Rodrigues Tavares, Rayhanul Islam, Vladimír Šubr, Steffen Hackbarth, Shanghui Gao, Kai Yang, Volodymyr Lobaz, Jun Fang, Tomáš Etrych
Theranostics 2023; 13(14): 4952-4973. doi:10.7150/thno.86211
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Research Paper
Oral [60]fullerene reduces neuroinflammation to alleviate Parkinson's disease via regulating gut microbiome
Xue Li, Ruijun Deng, Jie Li, Hui Li, Zhe Xu, Lei Zhang, Linyin Feng, Chunying Shu, Mingming Zhen, Chunru Wang
Theranostics 2023; 13(14): 4936-4951. doi:10.7150/thno.85711
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Research Paper
E3 ubiquitin ligase TRIM21 targets TIF1γ to regulate β-catenin signaling in glioblastoma
YanLan Li, Lingbo Bao, Hong Zheng, Mingying Geng, TianYi Chen, Xiaoyan Dai, He Xiao, Lujie Yang, Chengyi Mao, Yuan Qiu, Yu Xu, Dong Wang, Meng Xia Li, Qian Chen
Theranostics 2023; 13(14): 4919-4935. doi:10.7150/thno.85662
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

Special Issue: Osteoarthritis Theranostics. Guest Editors: Dr. WEN, CHUNYI, Dr. Magali Cucchiarini.

CFP: Special issue on mRNA-based vaccine and therapy. Guest Editors: Guocan Yu (Tsinghua University, China), Qiaobing Xu (Tufts University, USA), Wei Tao (Harvard Medical School, USA)

Background: Recently years have seen the increasing evidence identifying that OXPHOS is involved in different processes of tumor progression and metastasis and has been proposed to be a potential therapeutical target for cancer treatment. However, the exploration in oxidative phosphorylation-mediated chemoresistance is still scarce. In our study, we identify exosomal transfer leads to chemoresistance by reprogramming metabolic phenotype in recipient cells. Methods: RNA sequencing analysis was used to screen altered targets mediating exosome transfer-induced chemoresistance. Seahorse assay allowed....
Neuroinflammation is considered to drive the pathogenic process of neuronal degeneration in Parkinson's disease (PD). However, effective anti-neuroinflammation therapeutics for PD still remain dissatisfactory. Here we explore a robust therapeutic strategy for PD using anti-neuroinflammatory fullerenes. Methods: Oral fullerene was prepared by a ball-milling method. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model was used to investigate the therapeutic effects and mechanisms of it. The gut microenvironment was evaluated by 16S rRNA gene sequencing, gas chromatography-mass....

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Review
Magnetic Resonance Imaging and Iron-oxide Nanoparticles in the era of Personalized Medicine
Mahbuba Rahman
Nanotheranostics 2023; 7(4): 424-449. doi:10.7150/ntno.86467
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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