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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Research Paper
Cerebellar Purkinje cell firing promotes conscious recovery from anesthesia state through coordinating neuronal communications with motor cortex
Jinpiao Zhu, Chang Chen, Xiaodong Liu, Mengying He, Yuanyuan Fang, Li Wang, Junke Jia, Juan Guo, Ziyue Zhao, Chenyi Gao, Jingang He, Chengshi Xu, Fuqiang Xu, Daqing Ma, Jie Wang, Zongze Zhang
Theranostics 2024; 14(2): 480-495. doi:10.7150/thno.89592
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Research Paper
Differential effect of cancer-associated fibroblast-derived extracellular vesicles on cisplatin resistance in oral squamous cell carcinoma via miR-876-3p
Soo Hyun Kang, Su Young Oh, Kah-Young Lee, Heon-Jin Lee, Mee-Seon Kim, Tae-Geon Kwon, Jin-Wook Kim, Sung-Tak Lee, So-Young Choi, Su-Hyung Hong
Theranostics 2024; 14(2): 460-479. doi:10.7150/thno.87329
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Research Paper
Long-term Nephrotoxicity after PRRT: Myth or Reality
Richard P. Baum, Xin Fan, Vivianne Jakobsson, Fei Yu, Christiane Schuchardt, Xiaoyuan Chen, Jingjing Zhang
Theranostics 2024; 14(2): 451-459. doi:10.7150/thno.92487
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Research Paper
Vitamin D binding protein (VDBP) hijacks twist1 to inhibit vasculogenic mimicry in hepatocellular carcinoma
Lu-ning Qin, Heng Zhang, Qing-qing Li, Ting Wu, Shan-bin Cheng, Kai-wen Wang, Yue Shi, Hao-ran Ren, Xue-wu Xing, Cheng Yang, Tao Sun
Theranostics 2024; 14(1): 436-450. doi:10.7150/thno.90322
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Research Paper
Klotho-derived peptide 1 inhibits cellular senescence in the fibrotic kidney by restoring Klotho expression via posttranscriptional regulation
Xiaoyao Zhang, Li Li, Huishi Tan, Xue Hong, Qian Yuan, Fan Fan Hou, Lili Zhou, Youhua Liu
Theranostics 2024; 14(1): 420-435. doi:10.7150/thno.89105
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Research Paper
Efficient 3D imaging and pathological analysis of the human lymphoma tumor microenvironment using light-sheet immunofluorescence microscopy
Liting Chen, Jiao Meng, Yao Zhou, Fang Zhao, Yifan Ma, Wenyang Feng, Xingyu Chen, Jin jin, Shimeng Gao, Jianchao Liu, Man Zhang, Aichun Liu, Zhenya Hong, Jiang Tang, Dong Kuang, Liang Huang, Yicheng Zhang, Peng Fei
Theranostics 2024; 14(1): 406-419. doi:10.7150/thno.86221
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Research Paper
Imaging diagnosis and efficacy monitoring by [89Zr]Zr-DFO-KN035 immunoPET in patients with PD-L1-positive solid malignancies
Huihui He, Xiaowei Qi, Haitian Fu, Jianfeng Xu, Qihuang Zheng, Liping Chen, Yu Zhang, Haiying Hua, Wenhuan Xu, Zhenyu Xu, Xiaoping Chen, Qingjun You, Jianguo Lin, Gang Huang, Yong Mao, Chunjing Yu
Theranostics 2024; 14(1): 392-405. doi:10.7150/thno.87243
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Review
Endosialin in Cancer: Expression Patterns, Mechanistic Insights, and Therapeutic Approaches
Shiqi Lu, Lunbiao Gan, Tong Lu, Keying Zhang, Jiayu Zhang, Xinjie Wu, Donghui Han, Chao Xu, Shaojie Liu, Fa Yang, Weijun Qin, Weihong Wen
Theranostics 2024; 14(1): 379-391. doi:10.7150/thno.89495
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile



Special Issue: Osteoarthritis Theranostics. Guest Editors: Dr. WEN, CHUNYI, Dr. Magali Cucchiarini.


CFP: Special issue on mRNA-based vaccine and therapy. Guest Editors: Guocan Yu (Tsinghua University, China), Qiaobing Xu (Tufts University, USA), Wei Tao (Harvard Medical School, USA)


Background: Klotho deficiency is a common feature of premature aging and chronic kidney disease (CKD). As such, restoring Klotho expression could be a logic strategy for protecting against various nephropathies. In this study, we demonstrate that KP1, a Klotho-derived peptide, inhibits cellular senescence by restoring endogenous Klotho expression. Methods: The effects of KP1 on cellular senescence and Klotho expression were assessed in mouse models of CKD. RNA-sequencing was employed to identify the microRNA involved in regulating Klotho by KP1. Gain- or loss-of-function approaches were used to....
Rationale: The kidneys are commonly considered as the potential dose-limiting organ for peptide receptor radionuclide therapy (PRRT), making the risk of nephrotoxicity a primary concern. This retrospective analysis with prospective documentation and long-term follow-up aims to assess the risk of nephrotoxicity after PRRT in a large cohort of patients with neuroendocrine neoplasms (NENs) treated at our institution over the past 18 years. Methods: A total of 1361 NEN patients treated with 1-10 cycles of 177Lu-DOTA-TOC/-NOC/-TATE, 90Y-DOTA-TOC/-NOC/-TATE, DUO-PRRT (sequential administration of 90Y-....

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Theranostic Phthalocyanine and Naphthalocyanine Nanoparticles for Photoacoustic Imaging and Photothermal Therapy of Tumors
Yiran Tian, Nicole Carrillo-Malani, Kailin Feng, Joann Miller, Theresa M. Busch, Karthik M. Sundaram, Zhiliang Cheng, Ahmad Amirshaghaghi, Andrew Tsourkas
Nanotheranostics 2024; 8(1): 100-111. doi:10.7150/ntno.88892
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