Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.

Research Paper
Comprehensive characterization of the epigenetic landscape in Multiple Myeloma
Elina Alaterre, Sara Ovejero, Laurie Herviou, Hugues de Boussac, Giorgio Papadopoulos, Marta Kulis, Stéphanie Boireau, Nicolas Robert, Guilhem Requirand, Angélique Bruyer, Guillaume Cartron, Laure Vincent, Anne Marie Martinez, José Ignacio Martin-Subero, Giacomo Cavalli, Jerome Moreaux
Theranostics 2022; 12(4): 1715-1729. doi:10.7150/thno.54453
[Abstract] [Full text] [PDF]

Review
Tumor-derived extracellular vesicles as messengers of natural products in cancer treatment
Yuanxin Xu, Kuanhan Feng, Huacong Zhao, Liuqing Di, Lei Wang, Ruoning Wang
Theranostics 2022; 12(4): 1683-1714. doi:10.7150/thno.67775
[Abstract] [Full text] [PDF]

Research Paper
Overexpression of S100A9 in obesity impairs macrophage differentiation via TLR4-NFkB-signaling worsening inflammation and wound healing
Sandra Franz, Anastasia Ertel, Kathrin M Engel, Jan C. Simon, Anja Saalbach
Theranostics 2022; 12(4): 1659-1682. doi:10.7150/thno.67174
[Abstract] [Full text] [PDF]

Review
Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment
Vismitha Rajeev, David Y. Fann, Quynh Nhu Dinh, Hyun Ah Kim, T. Michael De Silva, Mitchell K.P. Lai, Christopher Li-Hsian Chen, Grant R. Drummond, Christopher G. Sobey, Thiruma V. Arumugam
Theranostics 2022; 12(4): 1639-1658. doi:10.7150/thno.68304
[Abstract] [Full text] [PDF]

Research Paper
Piezo1-mediated mechanosensation in bone marrow macrophages promotes vascular niche regeneration after irradiation injury
Xiaomei Zhang, Lijia Hou, Fengjie Li, Weiwei Zhang, Chun Wu, Lixin Xiang, Jiuxuan Li, Luping Zhou, Xiaojie Wang, Yang Xiang, Yanni Xiao, Shengwen Calvin Li, Li Chen, Qian Ran, Zhongjun Li
Theranostics 2022; 12(4): 1621-1638. doi:10.7150/thno.64963
[Abstract] [Full text] [PDF]

Research Paper
A multi-omics approach to identify molecular alterations in a mouse model of heart failure
Xiang Zhou, Shuchen Zhang, Yiheng Zhao, Wenjing Wang, Hao Zhang
Theranostics 2022; 12(4): 1607-1620. doi:10.7150/thno.68232
[Abstract] [Full text] [PDF]

Research Paper
PPAR-γ integrates obesity and adipocyte clock through epigenetic regulation of Bmal1
Shuai Wang, Yanke Lin, Lu Gao, Zemin Yang, Jingpan Lin, Shujing Ren, Feng Li, Jing Chen, Zhigang Wang, Zhiyong Dong, Pinghua Sun, Baojian Wu
Theranostics 2022; 12(4): 1589-1606. doi:10.7150/thno.69054
[Abstract] [Full text] [PDF]

Research Paper
Gα₁₂ overexpression in hepatocytes by ER stress exacerbates acute liver injury via ROCK1-mediated miR-15a and ALOX12 dysregulation
Jihoon Tak, Yun Seok Kim, Tae Hyun Kim, Gil-Chun Park, Shin Hwang, Sang Geon Kim
Theranostics 2022; 12(4): 1570-1588. doi:10.7150/thno.67722
[Abstract] [Full text] [PDF]

Review
Fibroblast activation protein-based theranostics in cancer research: A state-of-the-art review
Liang Zhao, Jianhao Chen, Yizhen Pang, Kaili Fu, Qihang Shang, Hua Wu, Long Sun, Qin Lin, Haojun Chen
Theranostics 2022; 12(4): 1557-1569. doi:10.7150/thno.69475
[Abstract] [Full text] [PDF]

Review
Making human pancreatic islet organoids: Progresses on the cell origins, biomaterials and three-dimensional technologies
Lai Jiang, Yiru Shen, Yajing Liu, Lei Zhang, Wei Jiang
Theranostics 2022; 12(4): 1537-1556. doi:10.7150/thno.66670
[Abstract] [Full text] [PDF]

Research Paper
GKRP-dependent modulation of feeding behavior by tanycyte-released monocarboxylates
Magdiel Salgado, Roberto Elizondo-Vega, Pablo S Villar, Macarena Konar, Scarlet Gallegos, Estefanía Tarifeño-Saldivia, Patricia Luz-Crawford, Luis G. Aguayo, Ricardo C. Araneda, Elena Uribe, María Ángeles García-Robles
Theranostics 2022; 12(4): 1518-1536. doi:10.7150/thno.66634
[Abstract] [Full text] [PDF]

Research Paper
KDM1A promotes thyroid cancer progression and maintains stemness through the Wnt/β-catenin signaling pathway
Wei Zhang, Xianhui Ruan, Yaoshuang Li, Jingtai Zhi, Linfei Hu, Xiukun Hou, Xianle Shi, Xin Wang, Jinpeng Wang, Weike Ma, Pengfei Gu, Xiangqian Zheng, Ming Gao
Theranostics 2022; 12(4): 1500-1517. doi:10.7150/thno.66142
[Abstract] [Full text] [PDF]

Research Paper
CD40- and 41BB-specific antibody fusion proteins with PDL1 blockade-restricted agonism
Juliane Medler, Kirstin Kucka, Vinicio Melo, Tengyu Zhang, Stefan von Rotenhan, Jakob Ulrich, Edwin Bremer, Michael Hudecek, Andreas Beilhack, Harald Wajant
Theranostics 2022; 12(4): 1486-1499. doi:10.7150/thno.66119
[Abstract] [Full text] [PDF]

Review
Activated molecular probes for enzyme recognition and detection
Meng Yuan, Ying Wu, Caiyan Zhao, Zhongxiang Chen, Lichao Su, Huanghao Yang, Jibin Song
Theranostics 2022; 12(3): 1459-1485. doi:10.7150/thno.66676
[Abstract] [Full text] [PDF]

Research Paper
Downregulation of low-density lipoprotein receptor mRNA in lymphatic endothelial cells impairs lymphatic function through changes in intracellular lipids
Laurent Vachon, Ali Smaani, Nolwenn Tessier, Gabriel Jean, Annie Demers, Andreea Milasan, Nadine Ardo, Stéphanie Jarry, Louis Villeneuve, Azadeh Alikashani, Vincent Finherty, Matthieu Ruiz, Mary G. Sorci-Thomas, Gaétan Mayer, Catherine Martel
Theranostics 2022; 12(3): 1440-1458. doi:10.7150/thno.58780
[Abstract] [Full text] [PDF]

Review
Oral delivery of protein and peptide drugs: from non-specific formulation approaches to intestinal cell targeting strategies
Guanyu Chen, Weirong Kang, Wanqiong Li, Shaomeng Chen, Yanfeng Gao
Theranostics 2022; 12(3): 1419-1439. doi:10.7150/thno.61747
[Abstract] [Full text] [PDF]

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