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Review Harnessing ultrasound-responsive technologies for precision periodontitis therapy: a perspective Chao Xing, Sibtain Muhammad, Bing Guo Theranostics 2026; 16(16): 9434-9483. doi:10.7150/thno.138283 Full text PDF


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Research Paper A dual CEST-fluorescent reporter enables cross-validated tracking of hematopoietic engraftment in deep bone marrow Tehila Alter, Narmeen Haj, Doaa Ali-Naffaa, Maya Rom, Ramez Daniel, Galit Saar, Assaf A. Gilad, Katrien Vandoorne Theranostics 2026; 16(16): 9416-9433. doi:10.7150/thno.140697 Full text PDF


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Review Recent advances in CRISPR technologies for biomedical applications and disease treatment Xue Wu, Xiaorong Kou, Liping Bai, Chao Liu, Qinjie Wu, Ming Zhang, Ning Wang, Changyang Gong Theranostics 2026; 16(16): 9384-9415. doi:10.7150/thno.136062 Full text PDF


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Review Organelle-targeted precision cancer theranostics: From molecular design to NIR-II imaging Dandan Chen, Beiling Zheng, Zhixiang Lu, Yaohui He, Pengfei Lyu Theranostics 2026; 16(16): 9346-9383. doi:10.7150/thno.137525 Full text PDF


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Research Paper Early micro- and nanoscale microglial responses to blood–brain barrier modulation by transcranial focused ultrasound Elisa Gonçalves de Andrade, Jared VanderZwaag, Rikke Hahn Kofoed, Katherine Picard, Keelin Henderson Pekarik, Micaël Carrier, Fernando González Ibáñez, Mohammadparsa Khakpour, Kullervo Hynynen, Isabelle Aubert, Marie-Ève Tremblay Theranostics 2026; 16(16): 9322-9345. doi:10.7150/thno.131051 Full text PDF


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Research Paper ARG2 drives osteoblast senescence by repressing mitophagy via the IκB–NF-κB–TXN2 signaling axis: implications for age-associated osteoporosis Jinli Li, Liyao Zhang, Yuanyuan Ren, Junxuan Wang, Pan Zhang, Qianran Shen, Yaqi Wang, Yi Yu, Zi Cheng, Qiang Wang, Haiying Wang, Yuyan Xiong Theranostics 2026; 16(16): 9295-9321. doi:10.7150/thno.129818 Full text PDF

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Issue 13; 2026

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Founding Editor-in-Chief:
Prof. Xiaoyuan (Shawn) Chen, PhD
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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.



Special Issue - Advanced Cell and Gene Therapy Strategies for Precision Treatment of Autoimmune Diseases. Theme issue editors: Weisheng Guo (Guangzhou Medical University), Xiaoyuan Chen (Shandong Cancer Hospital and Institute).


Early micro- and nanoscale microglial responses to blood–brain barrier modulation by transcranial focused ultrasound

Modulation of the blood-brain barrier (BBB) using transcranial focused ultrasound with intravenous microbubbles (FUS) has progressed to clinical trials. Guided by magnetic resonance imaging (MRI), FUS significantly increases local BBB permeability for approximately 6-24 h in mice, with an ensuing mild inflammation. Microglia, as the immune cells of the brain, are stimulated by FUS-BBB modulation, although the timing and nature of their responses remain ...

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