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Volume 15 (6); 2025

Research Papers

Collagen-targeted PET imaging for progressive experimental lung fibrosis quantification and monitoring of efficacy of anti-fibrotic therapies
Alexandre Magno Maneschy Dias, Olivier Burgy, Mathieu Moreau, Victor Goncalves, Lenny Pommerolle, Romain Douhard, Alan Courteau, Alex Helbling, Mélanie Guillemin, John Simonet, Alexandra Oudot, Carmen Garrido, Philippe Bonniaud, Françoise Goirand, Bertrand Collin, Pierre-Simon Bellaye
Theranostics 2025; 15(6): 2092-2103. doi:10.7150/thno.106367
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OASL promotes immune evasion in pancreatic ductal adenocarcinoma by enhancing autolysosome-mediated degradation of MHC-I
Xin Xing, Xia-Qing Li, Shi-Qi Yin, Hong-Tai Ma, Shu-Yu Xiao, Aziguli Tulamaiti, Yan Yang, Shu-Heng Jiang, Li-Peng Hu, Zhi-Gang Zhang, Yan-Miao Huo, Dong-Xue Li, Xiao-Mei Yang, Xue-Li Zhang
Theranostics 2025; 15(6): 2104-2120. doi:10.7150/thno.103494
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OTUD7B is a new deubiquitinase targeting p53
Caoyuan Ding, Leixi Cao, Ruijie Wang, Qichen Wu, Mengfan Li, Jinjing Zhang, Rick F. Thorne, Jinming Li, Jianli Ma, Mian Wu, Shundong Cang
Theranostics 2025; 15(6): 2121-2138. doi:10.7150/thno.103012
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Microalgae-based bacteria for oral treatment of ASD through enhanced intestinal colonization and homeostasis
Rongrong Yang, Li Ma, Huan Peng, Yifang Zhai, Gengyao Zhou, Linjuan Zhang, Lixia Zhuo, Wei Wu, Yuxi Guo, Jiao Han, Linlin Jing, Xinyu Zhou, Xiancang Ma, Yan Li
Theranostics 2025; 15(6): 2139-2158. doi:10.7150/thno.103737
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3D bioprintable Mg²⁺-incorporated hydrogels tailored for regeneration of volumetric muscle loss
Moon Sung Kang, Jeong Min Kim, Hyo Jung Jo, Hye Jin Heo, Yun Hak Kim, Kyung Min Park, Dong-Wook Han
Theranostics 2025; 15(6): 2185-2200. doi:10.7150/thno.103677
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Autophagy-enhanced nanosonosensitizer mediated sonodynamic therapy for post-myocardial infarction neuromodulation and arrhythmia prevention
Haoyuan Hu, Songyun Wang, Qian Li, Jiahui Zhao, Yida Pang, Jiale Wang, Huijun Wu, Xinqi Wang, Ye Cheng, Mengran Yu, Xinyue Yin, Yan Zhang, Lilei Yu, Yao Sun, Hong Jiang
Theranostics 2025; 15(6): 2201-2214. doi:10.7150/thno.103780
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Targeted delivery of Grem1 and IL-10 separately by mesenchymal stem cells effectively mitigates SETD2-deficient inflammatory bowel disease
Rebiguli Aji, Yue Xu, Ziyi Wang, Wenxin Feng, Liming Gui, Hanyu Rao, Wei Zhang, Ningyuan Liu, Wei-Qiang Gao, Li Li
Theranostics 2025; 15(6): 2215-2228. doi:10.7150/thno.105876
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Extracellular matrix proteins refine microenvironments for pancreatic organogenesis from induced pluripotent stem cell differentiation
Ming Hu, Tianzheng Liu, Hui Huang, Derek Ogi, Yinfei Tan, Kaiming Ye, Sha Jin
Theranostics 2025; 15(6): 2229-2249. doi:10.7150/thno.104883
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Neurotrophic factor-α1/carboxypeptidase E controls progression and reversal of Alzheimer's disease pathogenesis in mice
Fang-Cheng Fan, Li-Ming Liu, Mei Guo, Yang Du, Yue-Wen Chen, Y. Peng Loh, Yong Cheng
Theranostics 2025; 15(6): 2279-2292. doi:10.7150/thno.99908
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USP14 modulates stem-like properties, tumorigenicity, and radiotherapy resistance in glioblastoma stem cells through stabilization of MST4-phosphorylated ALKBH5
Xiao Zhou, Qiaoxi Xia, Botao Wang, Junjun Li, Bing Liu, Sisi Wang, Min Huang, Ronghui Zhong, Shi-Yuan Cheng, Xuan Wang, Xiaobing Jiang, Tianzhi Huang
Theranostics 2025; 15(6): 2293-2314. doi:10.7150/thno.103629
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Neural mechanism of trigeminal nerve stimulation recovering defensive arousal responses in traumatic brain injury
Qian Zhang, Haiyun Ma, Lifang Huo, Shaoling Wang, Qian Yang, Zhimin Ye, Jie Cao, Shaoling Wu, Chao Ma, Congping Shang
Theranostics 2025; 15(6): 2315-2337. doi:10.7150/thno.106323
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Histone lactylation-driven B7-H3 expression promotes tumor immune evasion
Zhibo Ma, Jincui Yang, Wenlong Jia, Le Li, Yixin Li, Junjie Hu, Wei Luo, Ronghui Li, Dawei Ye, Peixiang Lan
Theranostics 2025; 15(6): 2338-2359. doi:10.7150/thno.105947
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Inhibition of macrophage inflammasome assembly and pyroptosis with GC-1 ameliorates acute lung injury
Bin Li, Jingyi Liu, Wanyu He, Yanlin Zhou, Man Zhao, Cong Xia, Xiaoyue Pan, Zhihua Ji, Ruoyu Duan, Hui Lian, Kai Xu, Guoying Yu, Lan Wang
Theranostics 2025; 15(6): 2360-2374. doi:10.7150/thno.101866
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DLGAP5 enhances bladder cancer chemoresistance by regulating glycolysis through MYC stabilization
Zhao Deng, Fenfang Zhou, Mingxing Li, Wan Jin, Jingtian Yu, Gang Wang, Kaiyu Qian, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang
Theranostics 2025; 15(6): 2375-2392. doi:10.7150/thno.102730
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Nsun2 controls cardiac homeostasis and hypertrophic response by regulating PRKACA expression
Dongdong Jian, Xiaolei Cheng, Datun Qi, Shixing Wang, Chenqiu Wang, Yingchao Shi, Zhen Li, Shouyi Jin, Zhen Jia, Peng Teng, Zhen Pei, Xiaoping Gu, Liguo Jian, Wengong Wang, Xia Yi, Junyue Xing, Hao Tang
Theranostics 2025; 15(6): 2393-2412. doi:10.7150/thno.104441
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Renal tubular epithelial-derived follistatin-like 1 protects against UUO-induced renal fibrosis in mice via inhibiting NF-κB-mediated epithelial inflammation
Zhuan Niu, Jiasen Guo, Xingzu Liu, Mo Chen, Yueyue Jin, Maolin Yao, Xiaoxu Li, Qianqian Che, Shuzi Li, Chenjie Zhang, Kunyue Shangguan, Dekun Wang, Chuan'ai Chen, Wenli Yu, Xiaoyue Tan, Wen Ning, Lian Li
Theranostics 2025; 15(6): 2413-2427. doi:10.7150/thno.100969
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Glucose homeostasis controls N-acetyltransferase 10-mediated ac4C modification of HK2 to drive gastric tumorigenesis
Qiang Wang, Mengmeng Li, Chen Chen, Lei Xu, Yao Fu, Jiawen Xu, Chuanjun Shu, Bo Wang, Zhangding Wang, Changyu Chen, Tao Song, Shouyu Wang
Theranostics 2025; 15(6): 2428-2450. doi:10.7150/thno.104310
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Molecular simulation-aided self-adjuvanting nanoamplifier for cancer photoimmunotherapy
Junmou Gu, Rongtao Zhu, Ruopeng Liang, Weijie Wang, Jian Li, Senfeng Zhao, Yahui Wu, Jiahui Cao, Shihua Yang, Yuling Sun
Theranostics 2025; 15(6): 2451-2469. doi:10.7150/thno.102653
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Poly (I:C)-induced inflammation requires the activation of toll-like receptor 3/Ca²⁺/CaMKII/pannexin 1-dependent signaling
Magdiel Salgado, Vania Sepúlveda-Arriagada, Macarena Konar-Nié, María A. García-Robles, Juan C. Sáez
Theranostics 2025; 15(6): 2470-2486. doi:10.7150/thno.100687
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The sentinel against brain injury post-subarachnoid hemorrhage: efferocytosis of erythrocytes by leptomeningeal lymphatic endothelial cells
Hong-Ji Deng, Yun-Huo Xu, Kun Wu, Yun-Cong Li, Yong-Jin Zhang, Han-Fu Yu, Chong Li, Dan Xu, Fei Wang
Theranostics 2025; 15(6): 2487-2509. doi:10.7150/thno.103701
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First-in-human study of an optimized, potential kit-type, SSTR antagonist ⁶⁸Ga-DATA^5m-LM4 in patients with metastatic neuroendocrine tumors
Jingjing Zhang, Lukas Greifenstein, Vivianne Jakobsson, Elcin Zan, Andre Klega, Frank Rösch, Christian Landvogt, Corinna Mueller, Richard P. Baum
Theranostics 2025; 15(6): 2510-2522. doi:10.7150/thno.94521
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CD34⁺ PI16⁺ fibroblast progenitors aggravate neointimal lesions of allograft arteries via CCL11/CCR3-PI3K/AKT pathway
Xiaodong Xu, Pengwei Zhu, Han Wang, Kai Chen, Liang Liu, Luping Du, Liujun Jiang, Yanhua Hu, Xuhao Zhou, Bohuan Zhang, Xiangyuan Pu, Xiaosheng Hu, Qingbo Xu, Li Zhang, Weidong Li
Theranostics 2025; 15(6): 2523-2543. doi:10.7150/thno.104650
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Trehalose activates autophagy to alleviate cisplatin-induced chronic kidney injury by targeting the mTOR-dependent TFEB signaling pathway
Jingchao Yang, Longhui Yuan, Lan Li, Fei Liu, Jingping Liu, Younan Chen, Ping Fu, Yanrong Lu, Yujia Yuan
Theranostics 2025; 15(6): 2544-2563. doi:10.7150/thno.102559
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Ultrasmall radical metal organic cage as cascade antioxidant nanozyme for renal injury
Cheng Huang, Ziyu Liu, Yucen Deng, Xiaoyan Wang, Qing Miao, Demei Sun, Xinyuan Zhu, Jinghui Yang, Youfu Wang
Theranostics 2025; 15(6): 2564-2578. doi:10.7150/thno.105807
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Nano-fiber/net artificial bionic dura mater promotes neural stem cell differentiating by time sequence external-oral administration to repair spinal cord injury
Dapeng Zhang, Wenzhao Wang, Shuwei Han, Huiquan Duan, Mengfan Hou, Xiaolong Zhou, Xianzheng Guo, Haosheng Chen, Xiaohong Kong, Xingshuang Zhang, Hengxing Zhou, Shiqing Feng
Theranostics 2025; 15(6): 2579-2596. doi:10.7150/thno.102584
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Construction of human pluripotent stem cell-derived testicular organoids and their use as humanized testis models for evaluating the effects of semaglutide
Rufei Huang, Huan Xia, Tao Meng, Yufei Fan, Xun Tang, Yifang Li, Tiantian Zhang, Jingxian Deng, Bing Yao, Yadong Huang, Yan Yang
Theranostics 2025; 15(6): 2597-2623. doi:10.7150/thno.104523
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Calnexin promotes glioblastoma progression by inducing protective mitophagy through the MEK/ERK/BNIP3 pathway
Xuchen Liu, Jiangli Zhao, Qingyuan Sun, Zhiwei Xue, Ziyi Tang, Wenyu Liu, Junzhi Liu, Baojian Miao, Nan Su, Yanya He, Yuehua Zhu, Bin Huang, Ning Yang, Chao Li, Jiwei Wang, Xinyu Wang
Theranostics 2025; 15(6): 2624-2648. doi:10.7150/thno.105591
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Vascular regional analysis unveils differential responses to anti-angiogenic therapy in pancreatic xenografts through macroscopic photoacoustic imaging
Allison Sweeney, Andrew Langley, Marvin Xavierselvan, Ronak T. Shethia, Patrick Solomon, Aayush Arora, Srivalleesha Mallidi
Theranostics 2025; 15(6): 2649-2671. doi:10.7150/thno.99361
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Reviews

Metabolic regulation of myeloid-derived suppressor cells in tumor immune microenvironment: targets and therapeutic strategies
Hong Wang, Fei Zhou, Wenqing Qin, Yun Yang, Xiaojiaoyang Li, Runping Liu
Theranostics 2025; 15(6): 2159-2184. doi:10.7150/thno.105276
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Epigenetic regulation-mediated disorders in dopamine transporter endocytosis: A novel mechanism for the pathogenesis of Parkinson's disease
Ziqi Liang, Wanqing Liu, Mian Cao, Jiajun Cui, Jinshuai Lan, Yue Ding, Tong Zhang, Zizhao Yang
Theranostics 2025; 15(6): 2250-2278. doi:10.7150/thno.107436
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