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Volume 16 (13); 2026

Research Papers

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Ultrasound targeted fatty acid nitroalkene-containing lipid nanoparticles attenuate inflammation and reverse myocardial fibrosis Muhammad W. Amjad, Soheb A. Mohammed, Marco Fazzari, Xucai Chen, Bruce A. Freeman, Terry O. Matsunaga, Yijen L. Wu, Sean Hartwick, Thomas Becker-Szurszewski, Devin R. E. Cortes, John J. Pacella Theranostics 2026; 16(13): 7088-7107. doi:10.7150/thno.126503 Full text PDF

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Porphyrin-lipid nanotheranostics for multimodal imaging of nodal disease in preclinical oral cancers Michael S. Valic, Esmat Najjar, Mark Zheng, Jason L. Townson, Harley H. L. Chan, Sharon Tzelnick, Alessandra Ruaro, Abdullah El-Sayes, Michael Halim, Pamela Schimmer, Chris J. Zhang, Tina Ye, Wenlei Jiang, Juan Chen, Jonathan C. Irish, Gang Zheng Theranostics 2026; 16(13): 7108-7123. doi:10.7150/thno.129853 Full text PDF

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DKK3–CKAP4 signaling drives fibroimmune remodeling and hair follicle miniaturization in androgenetic alopecia Seungchan An, Hyunju Kim, Mei Zheng, In Guk Park, Leegu Song, Jino Kim, Minsoo Noh, Jong-Hyuk Sung Theranostics 2026; 16(13): 7124-7138. doi:10.7150/thno.135412 Full text PDF

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A clinically translatable, irreversibly attenuated Salmonella strain as a next-generation adjuvant for checkpoint immunotherapy Dinh-Huy Nguyen, Sung-Hwan You, Khuynh Van Nguyen, Phuong Thi-Minh Nguyen, Hien Thi-Thu Ngo, Khang Vuong Tran, Thanh Quang Tran, Miryoung Song, Yeongjin Hong, Jung-Joon Min Theranostics 2026; 16(13): 7139-7159. doi:10.7150/thno.129698 Full text PDF

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Intermittent hypoxia ameliorates behavioral deficits and exerts neurorestoration in a mouse photothrombotic stroke model Tao Wu, Shu Feng, Mengjie Chen, Xin Wang, Emily Parker, Li Gong, Luodan Yang, Rui Duan Theranostics 2026; 16(13): 7160-7177. doi:10.7150/thno.126126 Full text PDF

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c-Met-targeted NIR-II imaging for precision management of oral squamous cell carcinoma and premalignant lesions Zhipeng Xia, Aiyan Ji, Qifan Ma, Yonghao Li, Hongyue Lou, Kun Qian, Jie Tian, Ying Yuan, Zhen Cheng, Xiaofeng Tao Theranostics 2026; 16(13): 7178-7195. doi:10.7150/thno.132350 Full text PDF

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NOD1 is a key mediator of atrial myopathy in heart failure Marta Gil-Fernández, Almudena Val-Blasco, Andrea Bueno-Sen, Paula Cantolla-Pablo, Carlos Galán-Arriola, Ali Ayaon, Teresa López-Fernández, Yuriana Aguilar-Sanchez, Satadru K Lahiri, José Alberto Navarro-García, Rafael Peinado, Angel Aroca, Miguel Ángel Rubio, José Antonio Blázquez, María Tamayo, Eduardo López-Collazo, Gema Ruiz-Hurtado, Inmaculada Jorge, Jesús Vázquez, Patricia Prieto, Tarik Smani, Antonio Ordoñez, David Filgueiras-Dama, Raúl Moreno, Borja Rivero-Santana, Jorge Nuche, José Jalife, Borja Ibáñez, Carmen Delgado, Lisardo Boscá, Xander H.T. Wehrens, María Fernández-Velasco Theranostics 2026; 16(13): 7244-7258. doi:10.7150/thno.134756 Full text PDF

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P-glycoprotein 1 as a shared target for resensitizing drug-resistant tumor cells and preventing fibronectin-driven metastasis Li-Tzu Huang, Li-Hsin Cheng, Chin-Ho Kuo, Chin-Yun Cheng, Shane-Rong Sheu, Cheng-Han Yang, Pei-Chu Shih, Yi-Syuan Li, Lin Tseng, Wei-Ting Hsueh, Lyh-Jyh Hao, Hung-Chi Cheng Theranostics 2026; 16(13): 7288-7307. doi:10.7150/thno.131375 Full text PDF

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Targeted RNA Therapy Reprograms Fibrotic Macrophages to Reverse Pulmonary Fibrosis Zhimin Song, Jingjing Chen, Jiaying Fan, Tinghong Zhang, Xing Peng, Yao Pan, Yun Zhang, Yaofeng Wang, Jinling Qin, Shu Meng Theranostics 2026; 16(13): 7308-7323. doi:10.7150/thno.132296 Full text PDF

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Ion-Responsive Microneedles Delivering Subtype-Specific Mitochondrial Extracellular Vesicles from HEY1⁺ Cardiomyocytes for Cardiac Repair in Bama Minipigs with Myocardial Ischemia–Reperfusion Injury Peng Qu, Jiao Shi, Xue Li, Yao Gu, Jun Liu, Hongyan Zhang, MingZhi Zhou, Cui Ma, Xinghui Li, Wenjie Tian, Qi Liang, Gang Li, Panke Cheng Theranostics 2026; 16(13): 7367-7387. doi:10.7150/thno.123209 Full text PDF

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Engineered CCR2 positive macrophages coordinate immunoregulation with neural regeneration and matrix remodeling after spinal cord injury Yuqi Zhao, Tao Xie, Yanming Ma, Yuhao Wang, Shenghang Liu, Hui Li, Youjun Liu, Renfeng Liu, Hailiang Xu, Cheng Ju, Weidong Wu, Yifan Wang, Siyuan He, Rongjin Luo, Dageng Huang, Shuaijun Jia, Chunping Hu, Liang Yan, Zhiyuan Wang, Lei Zhu Theranostics 2026; 16(13): 7388-7418. doi:10.7150/thno.134560 Full text PDF

Reviews

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GRP78 in human diseases: From molecular chaperone to therapeutic target Yang Li, Dan Mu, Jiajie Feng, Zhijia Li, Lan Zhang, Lei Wang Theranostics 2026; 16(13): 7196-7243. doi:10.7150/thno.136060 Full text PDF

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Molecular design of MRI probes for targeting amyloid-β species: from in vitro binding to in vivo imaging Yupeng Shi, Ruiyang Zhang, Miaoqing Li, Yaning Xia, Mengyang Zhou, Rui Cao, Qing Zhou, Yong Zhang Theranostics 2026; 16(13): 7259-7287. doi:10.7150/thno.131311 Full text PDF

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Biomechanical signaling of cytoskeleton and membrane reorganization in tumor immune chemotactic migration Qijie Zhao, Keliang Chen, Minglu Zhou, Jing Jin Theranostics 2026; 16(13): 7324-7344. doi:10.7150/thno.134995 Full text PDF

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Sonogenetics for precision medicine: from molecular toolkit to clinical translation Xinrui Yu, Min Pu, Ruoli Wang, Haitao Ran Theranostics 2026; 16(13): 7345-7366. doi:10.7150/thno.134803 Full text PDF

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