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Volume 16 (14); 2026
Research Papers
YOD1 drives acute kidney injury by deubiquitinating Bax and promoting apoptosis in tubular epithelial cells Ying Zhao, Shijie Fan, Yu Fang, Qingqing Zhao, Qian Zhou, Zheng Xu, Hong Zhu, Guang Liang
Theranostics 2026; 16(14): 7765-7779. doi:10.7150/thno.132208
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The role of an ultrasound-responsive injectable piezoelectric hydrogel in promoting nerve regeneration and alleviating neuropathic pain Zhaoyang Guo, Weiqian Jiang, Wentao Zhang, Zhongju Liu, Hang Zhou, Hang Liu, Lin Wang, Jiahao Zhang, Xinliang Peng, Xingyu Yang, Maohui Li, Hanchao Liang, Zhongyuan He, Rui Deng, Yongjun Dang, Wei Fu, Keyu Wei, Chao Xie, Zhong-Liang Deng, Youliang Ren, Lei Chu
Theranostics 2026; 16(14): 7780-7805. doi:10.7150/thno.131276
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PSMA-targeting hybrid molecule PSMA-914 for preoperative imaging and intraoperative fluorescence-guidance: A first-in-human experience Ann-Christin Eder, Mohamed A. Omrane, Jessica Matthias, Sven Stadlbauer, Mareike Roscher, Kerstin Michalski, Martin A. Schick, Christoph-Ferdinand Wielenberg, Peter Bronsert, Christian Gratzke, Martin Freitag, Klaus Kopka, Matthias Eder, Philipp T. Meyer, Cordula A. Jilg, Juri Ruf
Theranostics 2026; 16(14): 7926-7936. doi:10.7150/thno.129889
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Quantitative MRI Pharmacokinetic Modeling and MALDI Mass Spectrometry Imaging Biodistribution of a pH Mapping MRI Contrast Agent Zinia Mohanta, Caitlin M. Tressler, Sadakatali Gori, Aruna Singh, Julia Stabinska, Shaowei Bo, Sana Karbalaei, Sophie Sall, Assaf Gilad, Hernando Lopez Bertoni, Eric Gale, Kristine Glunde, Michael T. McMahon
Theranostics 2026; 16(14): 7937-7957. doi:10.7150/thno.128499
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Targeting microglial MyD88 reprograms injury-activated microglia and promotes spinal cord repair via TGF-β signaling and biomimetic nanodelivery Jintao Liu, Beibei Yu, Wanjun Cao, Jilu Liu, Yundi Gao, Honghui Mao, Xiaochuan Gao, Lingli Guo, Shengyou Li, Qiao Huang, Mingze Qin, Fang Kuang, Jinghui Huang
Theranostics 2026; 16(14): 8017-8035. doi:10.7150/thno.136733
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Endothelial epigenetic senescence driven microglial activation mediates cardio-retinal neuroinflammation in heart failure Mengdan Wang, Shuo Zhang, Tursunjan Aziz, Shiyao Zhang, Xiao Wu, Gang Li, Yan Wang
Theranostics 2026; 16(14): 8055-8076. doi:10.7150/thno.136220
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An engineered ferritin nanocage co-delivery system for targeted hair cells protection and hearing loss attenuation Junying Zhang, Zhiwei Zheng, Jiaru Zhang, Xinyuan Ma, Zihao Li, Hongyan Lin, Guohui Nie, Minmin Liang, Hui Ding, Yingzi He
Theranostics 2026; 16(14): 8104-8116. doi:10.7150/thno.131600
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Trop2-targeted PET/CT imaging with 68Ga-MY6349 improves diagnostic accuracy and influences clinical management in breast cancer Lingyu Yu, Liang Zhao, Ru Zeng, Yonghui Su, Zhenyu Wu, Shan Yu, Yin Li, Hao Fu, Wei Guo, Yining Sun, Hannan Gao, Long Sun, Hua Wu, Feng Ye, Fan Wang, Haojun Chen
Theranostics 2026; 16(14): 8117-8128. doi:10.7150/thno.136704
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A miniaturized-tumor culture platform for developing anti-tumor immunotherapies Yangyang Feng, Ling Li, Josh Haipeng Lei, Yuzhong Peng, Lijian Wang, Heng Sun, Dongyang Tang, Xinyu Guo, Xiangpeng Chu, Yunfeng Qiao, Kai Miao, Wen-Li Zhu, Chon-Wa Lam, Kin-Iong Chan, Wai-Kuok Chu, Shi-Xian Yao, Wei-Jian Hou, Xiaoling Xu, Zheng Chen, Chu-Xia Deng
Theranostics 2026; 16(14): 8129-8150. doi:10.7150/thno.132113
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Surface-cleaned black phosphorus nanosheets chelate iron and rebalance the ferroptosis-immune axis in acute kidney injury Wan-Lin Tan, Jin-Ming Zhu, Xiao-Xiao Xu, Jing Jia, Rong-Yu Chen, Xiong Yu, Lu-Qun Liang, Yuan-Yuan Ruan, Fang-Fang Wang, Yu-Ting Chen, Yu-Lin Peng, Jin Peng, Dan Wang, Ling-Ling Liu, Yao Ran, Bing Guo, Jian Feng, Yuan-Yuan Wang
Theranostics 2026; 16(14): 8151-8179. doi:10.7150/thno.129807
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MENTSH: A novel mitochondrial microprotein linked to a SNP associated with type 2 diabetes Kelvin Yen, Ricardo Ramirez, Brendan Miller, Hiroshi Kumagai, Jie Yao, Morgan Levine, Xiuqing Guo, Jihui Sha, Ana Silverstein, Roberto Vicinanza, Kent D. Taylor, Melanie Flores, Zeferino Reyna, Su-Jeong Kim, Noel Guerrero, Hemal H. Mehta, Junxiang Wan, Zhongzheng Niu, Carrie V. Breton, Maria C. Kenney, Thalida Em Arpawong, James Wohlschlegel, Jerome I. Rotter, Eileen Crimmins, Pinchas Cohen
Theranostics 2026; 16(14): 8180-8194. doi:10.7150/thno.134637
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CTPS1 is an unexplored vulnerability in breast and ovarian cancer Xiyin Wang, Michael J. Emch, Lauren A. Voll, Rebecca Epp, Esther P. B. Rodman, Noa J. Odell, Hannah M. Smith, Nicole A. Pearson, Xiaonan Hou, Ya Li, Melissa C. Larson, Ann L. Oberg, Taro Hitosugi, Matthew P. Goetz, Scott H. Kaufmann, S. John Weroha, Philip A. Beer, John R. Hawse
Theranostics 2026; 16(14): 8195-8214. doi:10.7150/thno.134720
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Programmable transcriptional condensates for enhanced CRISPR-based gene regulation Aolin Li, Congcong Cao, Chunyan Yang, Yuchen Liu
Theranostics 2026; 16(14): 8215-8229. doi:10.7150/thno.139164
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A reproducible ultrasound localization microscopy framework for the quantitative imaging of hepatocellular carcinoma on a clinical ultrasound system Jiajia Tang, Huazhen Liu, Baoluhe Zhang, Shunda Du, Long Zou, Jinghui Liang, Meng Yang
Theranostics 2026; 16(14): 8230-8246. doi:10.7150/thno.133561
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Structure-based redesign enables clinical translation of CAIX-targeted theranostics in clear cell renal cell carcinoma Zexin Xu, Hui Zhou, Ye Dong, Dan Feng, Baocheng Chen, Hongxin Li, Ruitao Yang, Ningjie Li, Yuting Cao, Hankuan He, Han Wu, Yuhua Zhong, Hubing Wu, Liang Zhao, Haojun Chen, Kongzhen Hu
Theranostics 2026; 16(14): 8247-8262. doi:10.7150/thno.134970
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Metabolic-Immune Reprogramming via CuZnS@BSA Nanoregulators to Overcome Resistance in Triple-Negative Breast Cancer Jingyi Yang, Qi Li, Pi Zhao, Zixin Luo, Zhaokai Wang, Rui Yang, Min Zhou, Jie Zhou, Daozhen Chen, Yu Chen
Theranostics 2026; 16(14): 8263-8283. doi:10.7150/thno.134131
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Clinically accessible drug-based nano-assemblies with self-targeting ability for NIR-II fluorescence imaging-guided surgery in triple-negative breast cancer Ruiqin Yang, Kangliang Lou, Shuangyan Bao, Chen Yang, Yating Gai, Shuanglong Chen, Qingmo Yang, Siqi Qiu, Yilong Lin, Hairong Zhao, Yang Li
Theranostics 2026; 16(14): 8284-8301. doi:10.7150/thno.133735
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Magnetofection-mediated siRNA delivery ameliorates cartilage damage in Kashin-Beck disease via targeting SIRT3 and protecting primary cilia Yangmengfan Chen, Duan Wang, Yao Zhang, Xiaoyang Liu, Ze Du, Xuming Chen, Xufeng Wan, Yongrui Cai, Anjing Chen, Jiehao Chen, Hao Du, Zongke Zhou
Theranostics 2026; 16(14): 8302-8325. doi:10.7150/thno.134335
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CCR2 deficiency protects against doxorubicin-induced cardiac dysfunction through enhanced IL12B-dependent autophagy Lizhi Hu, Li Lin, Long Chen, Yuhang Wang, Lulu Ning, Wanheng Tu, Cheng Wang, Shan Deng, Kai Huang
Theranostics 2026; 16(14): 8326-8346. doi:10.7150/thno.131005
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Reshaping immune cell distribution with mRNA noncationic lipid nanoparticles for overcoming neoadjuvant chemo-immunotherapy resistance Yiwen Liu, Rui Chang, Kenan Chen, Lin Li, Xiaogang An, Shegan Gao, Dingjun Zha, Hongzhang Deng
Theranostics 2026; 16(14): 8347-8360. doi:10.7150/thno.136879
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A mechanobiology-driven cell-derived ECM bioink for engineering 3D glioblastoma tumor microenvironment models Seohyeon An, Seoyul Jo, GeunHyung Kim
Theranostics 2026; 16(14): 8361-8384. doi:10.7150/thno.137729
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miR-15a-5p outperforms anti-VEGF drug in ocular neovascularization by providing dual anti-angiogenic and neuroprotective effects Hui Zhang, Xinyue Yu, Fuhua Yang, Rongguo Yu, Liangzhang Tan, Jinying An, Huan Wang, Yiran Cui, Wenrui Linghu, Yue Wang, Jiahui Wu, Xiaomin Zhang, Xiaorong Li
Theranostics 2026; 16(14): 8427-8446. doi:10.7150/thno.134644
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Reviews
Illumination of Targeting Nanotherapeutics with Precision Eyes: From Optical to Radio-nanotheranostics Maharajan Sivasubramanian, Yao-Chen Chuang, Chia-Hui Chu, Yu Hsia, Li-Jie Lin, Leu-Wei Lo
Theranostics 2026; 16(14): 7806-7868. doi:10.7150/thno.130824
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Recent advances in targeting cyanine dyes: hierarchical targeting mechanisms and theranostic integration for multi-disease precision therapy Shuai Zhang, Yang Xu, Yu Wang, Zelin Chen, Yang Wang, Quanying Liu, Tantan Wang, Yali Dai, Chunmeng Shi
Theranostics 2026; 16(14): 7869-7896. doi:10.7150/thno.132719
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Magnetic hyperthermia as an intracellular immunomodulatory technology: From heat transduction to tumor immune reprogramming Bin Yan, Lijun Dai, Hugang Li, Kexin Yuan, Huimin Yao, Lidan Chang, Haibin Peng, Xing-Jie Liang, Xiaoli Liu
Theranostics 2026; 16(14): 7897-7925. doi:10.7150/thno.130650
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Ligand-modified multifunctional liposome-based targeted delivery platform: a multimodal cancer combination therapy strategy Xuehong Zhang, Yingjie Jiang, Xing Duan, Fuchun Li, Xiaozhuo Chen, Aikepaer Aikedai, Wanting Pan, Liangjie Ren, Yufei Su, Chengqi Li, Zhaoshuo Gao, Shengcai Liao, Qiang Zhang, Zhenyu Zhu, Kaipei Luo, Yingji Wang
Theranostics 2026; 16(14): 7958-7984. doi:10.7150/thno.136152
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The challenges and strategies for navigating in vivo barriers to therapeutic bacterial delivery Haoda Yu, Jieyu Liu, Shuxin Zhang, Bing Wang, Kui Luo, Xian Jiang
Theranostics 2026; 16(14): 7985-8016. doi:10.7150/thno.137940
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Emerging trends in bone marrow organoid research: From hematopoietic microenvironment reconstruction to translational and regenerative theranostic applications Heebin Park, Jaemin Jeong
Theranostics 2026; 16(14): 8036-8054. doi:10.7150/thno.137874
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Decoding autophagy in neuro-tumor crosstalk: from underlying mechanisms to translational opportunities Huifang Cheng, Hongyao Li, Peiyan Liu, Xin Jin, Yi Qu, Bo Liu, Aizhuo Li
Theranostics 2026; 16(14): 8077-8103. doi:10.7150/thno.134896
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Multifunctional nanozyme platforms in central nervous system therapies: from rational design to translational medicine Shufang Niu, Xiaoyin Liu, Ran Xu, An Zhu, Shihong Zhu, Fuheng Hu, Kunlun Ding, Siyi Li, Bingcan Zhu, Peize Liang, Siqi Zhang, Anqi Xiao, Kelong Fan, Zhiyong Zhang
Theranostics 2026; 16(14): 8385-8426. doi:10.7150/thno.136080
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