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Volume 15 (4); 2025

Research Papers

Cancer-targeted pro-theranostic bi-metallic organo-coordination nanoparticles
Hengbo Huang, Lei Fang, Janaka Wansapura, Julie L. Prior, Brad Manion, Baogang Xu, Cody Hongsermeier, Nisha Gamadia, Nicole Blasi, Rui Tang, Christopher Egbulefu, Monica Shokeen, James D. Quirk, Samuel Achilefu
Theranostics 2025; 15(4): 1205-1220. doi:10.7150/thno.99863
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Transferrin-binding domain inserted-adenovirus hexon engineering enables systemic immune evasion and intratumoral T-cell activation
Dae Hoon Lee, Youngtae Kwon, Ki Hwan Um, Jung Ki Yoo, Wootae Ha, Ki-Su Kim, Jintak Cha, Ha-Eun Cho, Kyung Sun Park, Min Jeong Kye, Jin Woo Choi
Theranostics 2025; 15(4): 1221-1237. doi:10.7150/thno.105163
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A novel ROR1-targeting antibody-PROTAC conjugate promotes BRD4 degradation for solid tumor treatment
Lei Wang, Yong Ke, Qunye He, Pameila Paerhati, Weiliang Zhuang, Yali Yue, Junjun Liu, Jiawei Zhang, Lulu Huang, Qiang Yin, Huifang Zong, Jianwei Zhu, Baohong Zhang
Theranostics 2025; 15(4): 1238-1254. doi:10.7150/thno.102531
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PCBP2-dependent secretion of miRNAs via extracellular vesicles contributes to the EGFR-driven angiogenesis
Hou-Fu Xia, Xiao-Le Wang, He-Jing Zhang, Kui-Ming Wang, Lin-Zhou Zhang, Yang Yang, Xin Shi, Gang Chen
Theranostics 2025; 15(4): 1255-1271. doi:10.7150/thno.102391
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Unveiling urinary extracellular vesicle mRNA signature for early diagnosis and prognosis of bladder cancer
Ning Sun, Zhaowei Zhang, Xiaoqing Yang, Jingqi Li, Qiang Li, Jingjing Kang, Yongchun Wei, Xiaoxuan Yu, Rui Du, Xiaoqin Hong, Guangming Liu, Hongmei Gao, Dingbin Liu
Theranostics 2025; 15(4): 1272-1284. doi:10.7150/thno.107213
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Discovery of indole analogue Tc3 as a potent pyroptosis inducer and identification of its combination strategy against hepatic carcinoma
Xiao Hu, Xiaomei Tang, Xiaoman Tian, Xing Lv, Yuanyuan Zhang, Yingyue Pang, Weilong Deng, Yali Wang, Changliang Shan, Luqing Shang
Theranostics 2025; 15(4): 1285-1303. doi:10.7150/thno.102228
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Acylglycerol kinase inhibits macrophage anti-tumor activity via limiting mtDNA release and cGAS-STING-type I IFN response
Qiuyang Du, Na Ning, Xiujuan Zhao, Feifan Liu, Si Zhang, Yuting Xia, Fei Li, Shijie Yuan, Xiaorong Xie, Mengdi Zhu, Zehan Huang, Zhaohui Tang, Jing Wang, Ran He, Xiang-Ping Yang
Theranostics 2025; 15(4): 1304-1319. doi:10.7150/thno.101298
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JARID1D-dependent androgen receptor and JunD signaling activation of osteoclast differentiation inhibits prostate cancer bone metastasis through demethylating H3K4
Yaohua Hu, Zhite Zhao, Qinghua Xie, Hui Li, Chenyang Zhang, Xinglin He, Yifan Ma, Caiqin Zhang, Qinlong Li, Changhong Shi
Theranostics 2025; 15(4): 1320-1337. doi:10.7150/thno.104135
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RPS23RG1 inhibits SORT1-mediated lysosomal degradation of MDGA2 to protect against autism
Yuanhui Huo, Dongdong Zhao, Xiang Zhu, Naizhen Zheng, Dingting Yang, Jian Meng, Yiqing Chen, Yun-wu Zhang
Theranostics 2025; 15(4): 1338-1352. doi:10.7150/thno.100451
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Heat acclimation defense against exertional heat stroke by improving the function of preoptic TRPV1 neurons
Jing Li, Ziqing Zhou, You Wu, Jianshuai Zhao, Haokai Duan, Yuliang Peng, Xiaoke Wang, Zhongmin Fan, Lu Yin, Mengyun Li, Fuhong Liu, Yongheng Yang, Lixia Du, Jin Li, Haixing Zhong, Wugang Hou, Fanglin Zhang, Hongwei Ma, Xijing Zhang
Theranostics 2025; 15(4): 1376-1398. doi:10.7150/thno.101422
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Optimized circular RNA vaccines for superior cancer immunotherapy
Hongwu Yu, Yifan Wen, Wenqian Yu, Liang Lu, Yu Yang, Chengye Liu, Zhixiang Hu, Zhuting Fang, Shenglin Huang
Theranostics 2025; 15(4): 1420-1438. doi:10.7150/thno.104698
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Multiple crosslinked, self-healing, and shape-adaptable hydrogel laden with pain-relieving chitosan@borneol nanoparticles for infected burn wound healing
Zexing Deng, Yi Guo, Xuefeng Wang, Jiajie Song, Guan Yang, Litong Shen, Yuheng Wang, Xin Zhao, Baolin Guo, Wen Wang
Theranostics 2025; 15(4): 1439-1455. doi:10.7150/thno.102569
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Ultrasound-activated erythrocyte membrane-camouflaged Pt (II) layered double hydroxide enhances PD-1 inhibitor efficacy in triple-negative breast cancer through cGAS-STING pathway-mediated immunogenic cell death
Yanjie Wu, Zhiyu Zhao, Mengli Ma, Weijin Zhang, Wei Liu, Xiaochen Liang, Ting Zhao, Yi Luo, Yunjie Wang, Mengqi Li, Tingting Li, Cong Liu, Xian Luo, Shengyu Wang, Wanyun Li, Wei Zeng, Hong Wang, Wengang Li, Ting Wu, Zhihai Ke, Fanghong Luo
Theranostics 2025; 15(4): 1456-1477. doi:10.7150/thno.102284
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Targeting KAT7 inhibits the progression of colorectal cancer
Hao Wang, Tianwang Guan, Rong Hu, Zhongjie Huang, Zhao Liang, Xiaonan Lin, Yingqi Qiu, Peiyun Liao, Xiongbo Guo, Yushen Ke, Honghao Zhang, Caiwen Ou, Yuhua Li
Theranostics 2025; 15(4): 1478-1495. doi:10.7150/thno.106085
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Cardiomyocyte S1PR1 promotes cardiac regeneration via AKT/mTORC1 signaling pathway
Xiuxiang Liu, Jinnan Yue, Caixia Zhou, Yunhao Duan, Xiaoli Chen, Jie Liu, Shougang Zhuang, Yu Luo, Jinjin Wu, Yuzhen Zhang, Lin Zhang
Theranostics 2025; 15(4): 1524-1551. doi:10.7150/thno.103797
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Revisiting the unobtrusive role of exogenous stem cells beyond neural circuits replacement in spinal cord injury repair
Runlin Wen, Ge Long, Xinghui He, Kai Zhang, Wanrong Ma, Yeyu Shen, Zhifeng Xiao, Yannan Zhao, Dingyang Liu, Jianwu Dai, Xing Li
Theranostics 2025; 15(4): 1552-1569. doi:10.7150/thno.103033
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Reviews

Hypoxia-responsive nanoparticles for fluorescence diagnosis and therapy of cancer
Yubing Zhang, Jiaqi Xing, Juan Jiang, Maoliang Liao, Guojun Pan, Yanfeng Wang
Theranostics 2025; 15(4): 1353-1375. doi:10.7150/thno.104190
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Light-eye-body axis: exploring the network from retinal illumination to systemic regulation
Yi Zeng, Rong Rong, Mengling You, Peng Zhu, Jinglin Zhang, Xiaobo Xia
Theranostics 2025; 15(4): 1496-1523. doi:10.7150/thno.106589
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Macrophage-based pathogenesis and theranostics of vulnerable plaques
Fei Fang, Erxiang Wang, Mengjia Fang, Hongyan Yue, Hanqiao Yang, Xiaoheng Liu
Theranostics 2025; 15(4): 1570-1588. doi:10.7150/thno.105256
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