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Volume 12 (13); 2022

Editorial

Multiple functions of MLKL in liver fibrosis, from necroptosis to hepatic stellate cell activation
Valeria Pistorio, Chantal Housset, Jérémie Gautheron
Theranostics 2022; 12(13): 5820-5823. doi:10.7150/thno.76902
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Research Papers

Translational immunoPET imaging using a radiolabeled GD2-specific antibody in neuroblastoma
Julia Schmitt, Johannes Schwenck, Andreas Maurer, Mirko Przybille, Dominik Sonanini, Gerald Reischl, Jöri E. Wehrmüller, Leticia Quintanilla-Martinez, Stephen D. Gillies, Marcel A. Krueger, Juergen F. Schaefer, Christian la Fougère, Rupert Handgretinger, Bernd J. Pichler
Theranostics 2022; 12(13): 5615-5630. doi:10.7150/thno.56736
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Lgr5⁺ cells are required and dynamically participate in olfactory epithelium regeneration: a revisiting shows Lgr5 expression in multiple cell lineages
Wenwen Ren, Zhenjie Ma, Li Wang, Xiaoyu Feng, Hongmeng Yu, Yiqun Yu
Theranostics 2022; 12(13): 5631-5644. doi:10.7150/thno.60636
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Therapeutic aptamer targeting sclerostin loop3 for promoting bone formation without increasing cardiovascular risk in osteogenesis imperfecta mice
Luyao Wang, Yuanyuan Yu, Shuaijian Ni, Dijie Li, Jin Liu, Duoli Xie, Hang Yin Chu, Qing Ren, Chuanxin Zhong, Ning Zhang, Nanxi Li, Meiheng Sun, Zong-Kang Zhang, Zhenjian Zhuo, Huarui Zhang, Shu Zhang, Mei Li, Weibo Xia, Zhenlin Zhang, Lin Chen, Peng Shang, Xiaohua Pan, Aiping Lu, Bao-Ting Zhang, Ge Zhang
Theranostics 2022; 12(13): 5645-5674. doi:10.7150/thno.63177
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Lipid phosphate phosphatase-2 promotes tumor growth through increased c-Myc expression
Xiaoyun Tang, Christopher R. Cromwell, Rongzong Liu, Roseline Godbout, Basil P. Hubbard, Todd P.W. McMullen, David N. Brindley
Theranostics 2022; 12(13): 5675-5690. doi:10.7150/thno.66230
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Continuous theta-burst stimulation enhances and sustains neurogenesis following ischemic stroke
Xuemei Zong, Jie Gu, Siqi Zhou, Ding Ding, Yuting Hu, Lorelei Tucker, Zhihai Huang, Deqin Geng, Dianshuai Gao
Theranostics 2022; 12(13): 5710-5726. doi:10.7150/thno.71832
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RNA N⁶-methyladenosine reader YTHDC1 is essential for TGF-beta-mediated metastasis of triple negative breast cancer
Brandon Tan, Keren Zhou, Wei Liu, Emily Prince, Ying Qing, Yangchan Li, Li Han, Xi Qin, Rui Su, Sheela Pangeni Pokharel, Lu Yang, Zhicong Zhao, Chao Shen, Wei Li, Zhenhua Chen, Zheng Zhang, Xiaolan Deng, Andrew Small, Kitty Wang, Keith Leung, Chun-Wei Chen, Binghui Shen, Jianjun Chen
Theranostics 2022; 12(13): 5727-5743. doi:10.7150/thno.71872
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MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation
Jyun-Ni Chi, Jhih-Yu Yang, Chia-Hsin Hsueh, Ching-Yi Tsai, Huai-Chia Chuang, Tse-Hua Tan
Theranostics 2022; 12(13): 5744-5760. doi:10.7150/thno.72148
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SETD1A-SOX2 axis is involved in tamoxifen resistance in estrogen receptor α-positive breast cancer cells
Ming Li Jin, Liu Yang, Kwang Won Jeong
Theranostics 2022; 12(13): 5761-5775. doi:10.7150/thno.72599
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Postnatal Dexamethasone Therapy Impairs Brown Adipose Tissue Thermogenesis and Autophagy Flux in Neonatal Rat Pups
Yu-Shan Chang, Shun-Yun Hou, Shang-Shiuan Yu, Shin-Yu Tsai, Ying-Yi Chen, Li-Jin Hsu, Pei-Jane Tsai, Hui-Kuan Lin, Chyi-Her Lin, Yau-Sheng Tsai
Theranostics 2022; 12(13): 5803-5819. doi:10.7150/thno.70752
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LRRC8A critically regulates myofibroblast phenotypes and fibrotic remodeling following myocardial infarction
Xiyao Chen, Fuyang Zhang, Guangyu Hu, Xing Li, Lin Wang, Congye Li, Cong Huo, Rong Xu, Liming Hou, Ning Wang, Xiaoming Wang
Theranostics 2022; 12(13): 5824-5835. doi:10.7150/thno.75200
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Nanogel-mediated delivery of oncomodulin secreted from regeneration-associated macrophages promotes sensory axon regeneration in the spinal cord
Min Jung Kwon, Yeojin Seo, Hana Cho, Hyung Soon Kim, Young Joo Oh, Simay Genişcan, Minjae Kim, Hee Hwan Park, Eun-Hye Joe, Myung-Hee Kwon, Han Chang Kang, Byung Gon Kim
Theranostics 2022; 12(13): 5856-5876. doi:10.7150/thno.73386
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Single-cell transcriptomics reveals the regulative roles of cancer associated fibroblasts in tumor immune microenvironment of recurrent osteosarcoma
Xin Huang, Lutong Wang, Haoyu Guo, Weiyue Zhang, Zengwu Shao
Theranostics 2022; 12(13): 5877-5887. doi:10.7150/thno.73714
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A CRISPR-Cas12a integrated SERS nanoplatform with chimeric DNA/RNA hairpin guide for ultrasensitive nucleic acid detection
Bohan Yin, Qin Zhang, Xinyue Xia, Chuanqi Li, Willis Kwun Hei Ho, Jiaxiang Yan, Yingying Huang, Honglian Wu, Pui Wang, Changqing Yi, Jianhua Hao, Jianfang Wang, Honglin Chen, Siu Hong Dexter Wong, Mo Yang
Theranostics 2022; 12(13): 5914-5930. doi:10.7150/thno.75816
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Machine learning-based identification of tumor-infiltrating immune cell-associated lncRNAs for improving outcomes and immunotherapy responses in patients with low-grade glioma
Nan Zhang, Hao Zhang, Wantao Wu, Ran Zhou, Shuyu Li, Zeyu Wang, Ziyu Dai, Liyang Zhang, Fangkun Liu, Zaoqu Liu, Jian Zhang, Peng Luo, Zhixiong Liu, Quan Cheng
Theranostics 2022; 12(13): 5931-5948. doi:10.7150/thno.74281
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CRISPR/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells
Apoorvi Tyagi, Kamini Kaushal, Arun Pandian Chandrasekaran, Neha Sarodaya, Soumyadip Das, Chang-Hwan Park, Seok-Ho Hong, Kye-Seong Kim, Suresh Ramakrishna
Theranostics 2022; 12(13): 5949-5970. doi:10.7150/thno.72826
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3p-C-NETA: A versatile and effective chelator for development of Al¹⁸F-labeled and therapeutic radiopharmaceuticals
Stephen Ahenkorah, Erika Murce, Christopher Cawthorne, Jessica Pougoue Ketchemen, Christophe M. Deroose, Thomas Cardinaels, Yann Seimbille, Humphrey Fonge, Willy Gsell, Guy Bormans, Maarten Ooms, Frederik Cleeren
Theranostics 2022; 12(13): 5971-5985. doi:10.7150/thno.75336
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Reduced splenic uptake on ⁶⁸Ga-Pentixafor-PET/CT imaging in multiple myeloma - a potential imaging biomarker for disease prognosis
Sabrina Kraus, Philipp Klassen, Malte Kircher, Alexander Dierks, Stefan Habringer, Alexander Gäble, Klaus Martin Kortüm, Niels Weinhold, Valëza Ademaj-Kospiri, Rudolf A Werner, Andreas Schirbel, Andreas K Buck, Peter Herhaus, Hans-Jürgen Wester, Andreas Rosenwald, Wolfgang A Weber, Hermann Einsele, Ulrich Keller, Leo Rasche, Constantin Lapa
Theranostics 2022; 12(13): 5986-5994. doi:10.7150/thno.75847
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Engineered extracellular vesicles with high collagen-binding affinity present superior in situ retention and therapeutic efficacy in tissue repair
Dake Hao, Lu Lu, Hengyue Song, Yixin Duan, Jianing Chen, Randy Carney, Jian Jian Li, Ping Zhou, Jan Nolta, Kit S. Lam, J. Kent Leach, Diana L Farmer, Alyssa Panitch, Aijun Wang
Theranostics 2022; 12(13): 6021-6037. doi:10.7150/thno.70448
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Glutamine is essential for overcoming the immunosuppressive microenvironment in malignant salivary gland tumors
Shuting Cao, Yu-Wen Hung, Yi-Chang Wang, Yiyin Chung, Yue Qi, Ching Ouyang, Xiancai Zhong, Weidong Hu, Alaysia Coblentz, Ellie Maghami, Zuoming Sun, H. Helen Lin, David K. Ann
Theranostics 2022; 12(13): 6038-6056. doi:10.7150/thno.73896
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Reviews

Conquering oncogenic KRAS and its bypass mechanisms
Pingping Hou, Y. Alan Wang
Theranostics 2022; 12(13): 5691-5709. doi:10.7150/thno.71260
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Emerging roles of extracellular vesicle-associated non-coding RNAs in hypoxia: Insights from cancer, myocardial infarction and ischemic stroke
Dirk M. Hermann, Wenqiang Xin, Mathias Bähr, Bernd Giebel, Thorsten R. Doeppner
Theranostics 2022; 12(13): 5776-5802. doi:10.7150/thno.73931
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Extracellular Vesicles and Circulating Tumour Cells - complementary liquid biopsies or standalone concepts?
Artur Słomka, Bingduo Wang, Tudor Mocan, Adelina Horhat, Arnulf G. Willms, Ingo G.H. Schmidt-Wolf, Christian P. Strassburg, Maria A. Gonzalez-Carmona, Veronika Lukacs-Kornek, Miroslaw T. Kornek
Theranostics 2022; 12(13): 5836-5855. doi:10.7150/thno.73400
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Antigen transfer and its effect on vaccine-induced immune amplification and tolerance
Yingying Shi, Yichao Lu, Jian You
Theranostics 2022; 12(13): 5888-5913. doi:10.7150/thno.75904
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Emerging nanozyme-based multimodal synergistic therapies in combating bacterial infections
Yanmei Zhang, Xin Hu, Jing Shang, Wenhui Shao, Liming Jin, Chunshan Quan, Jun Li
Theranostics 2022; 12(13): 5995-6020. doi:10.7150/thno.73681
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