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Volume 12 (12); 2022

Research Papers

Graphic abstract

DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis
Jee-Heun Kim, So-Yeon Park, So-El Jeon, Jang-Hyun Choi, Choong-Jae Lee, Tae-Young Jang, Hyeon-Ji Yun, Yuno Lee, Pilho Kim, Sang Hee Cho, Ji Shin Lee, Jeong-Seok Nam
Theranostics 2022; 12(12): 5258-5271. doi:10.7150/thno.72037
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Accurate programmed multifunctional nano-missiles for self-promoted deep delivery and synergistic cascade tumor therapy: Tactfully collaborating chemosynthesis with tumor microenvironment remodeling
Runxin Lu, Siqi Wang, Zhongzhen Yang, Lin Zhou, Chunyan Yang, Yong Wu
Theranostics 2022; 12(12): 5299-5316. doi:10.7150/thno.74550
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Recapitulating influenza virus infection and facilitating antiviral and neuroprotective screening in tractable brain organoids
Xiaodong Zhang, Haishuang Lin, Liangzhen Dong, Qing Xia
Theranostics 2022; 12(12): 5317-5329. doi:10.7150/thno.75123
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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XBP1 is required in Th2 polarization induction in airway allergy
Xianhai Zeng, Xiaojun Xiao, Suqin Hu, Weiyi He, Gaohui Wu, Xiaorui Geng, Jialiang Fan, Longpeng Ma, Jiangqi Liu, Zhiqiang Liu, Pingchang Yang
Theranostics 2022; 12(12): 5337-5349. doi:10.7150/thno.75100
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Raman spectroscopy reveals phenotype switches in breast cancer metastasis
Santosh Kumar Paidi, Joel Rodriguez Troncoso, Mason G. Harper, Zhenhui Liu, Khue G. Nguyen, Sruthi Ravindranathan, Lisa Rebello, David E. Lee, Jesse D. Ivers, David A. Zaharoff, Narasimhan Rajaram, Ishan Barman
Theranostics 2022; 12(12): 5351-5363. doi:10.7150/thno.74002
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Impairment of autophagy after spinal cord injury potentiates neuroinflammation and motor function deficit in mice
Yun Li, Zhuofan Lei, Rodney M. Ritzel, Junyun He, Hui Li, Harry M. C. Choi, Marta M. Lipinski, Junfang Wu
Theranostics 2022; 12(12): 5364-5388. doi:10.7150/thno.72713
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Subpial delivery of adeno-associated virus 9-synapsin-caveolin-1 (AAV9-SynCav1) preserves motor neuron and neuromuscular junction morphology, motor function, delays disease onset, and extends survival in hSOD1G93A mice
Shanshan Wang, Taiga Ichinomiya, Paul Savchenko, Dongsheng Wang, Atsushi Sawada, Xiaojing Li, Tiffany Duong, Wenxi Li, Jacqueline A. Bonds, Eun Jung Kim, Atsushi Miyanohara, David M. Roth, Hemal H. Patel, Piyush M. Patel, Takahiro Tadokoro, Martin Marsala, Brian P. Head
Theranostics 2022; 12(12): 5389-5403. doi:10.7150/thno.72614
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Bone tissue engineering supported by bioprinted cell constructs with endothelial cell spheroids
WonJin Kim, Chul Ho Jang, GeunHyung Kim
Theranostics 2022; 12(12): 5404-5417. doi:10.7150/thno.74852
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Mesoscale visualization of three-dimensional microvascular architecture and immunocyte distribution in intact mouse liver lobes
Zheng Liu, Mengli Xu, Songlin Huang, Qi Pan, Chong Liu, Fanxin Zeng, Zhan Fan, Yafang Lu, Jialu Wang, Jinxin Liu, Xinlin Li, Qingming Luo, Zhihong Zhang
Theranostics 2022; 12(12): 5418-5433. doi:10.7150/thno.71718
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Transient upregulation of EGR1 signaling enhances kidney repair by activating SOX9+ renal tubular cells
Jian-Wen Chen, Meng-Jie Huang, Xiao-Niao Chen, Ling-Ling Wu, Qing-Gang Li, Quan Hong, Jie Wu, Fei Li, Liang-Mei Chen, Yu Dong, Guang-Yan Cai, Xue-Yuan Bai, Zongjin Li, Xiang-Mei Chen
Theranostics 2022; 12(12): 5434-5450. doi:10.7150/thno.73426
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Targeting the splicing factor NONO inhibits GBM progression through GPX1 intron retention
Xu Wang, Mingzhi Han, Shuai Wang, Yanfei Sun, Wenbo Zhao, Zhiyi Xue, Xiangjun Liang, Bin Huang, Gang Li, Anjing Chen, Xingang Li, Jian Wang
Theranostics 2022; 12(12): 5451-5469. doi:10.7150/thno.72248
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Dedifferentiated Schwann cell-derived TGF-β3 is essential for the neural system to promote wound healing
Min-Yi Ou, Poh-Ching Tan, Yun Xie, Kai Liu, Yi-Ming Gao, Xiao-Sheng Yang, Shuang-Bai Zhou, Qing-Feng Li
Theranostics 2022; 12(12): 5470-5487. doi:10.7150/thno.72317
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Co-delivery of phagocytosis checkpoint and STING agonist by a Trojan horse nanocapsule for orthotopic glioma immunotherapy
Ying Zhou, Yuxin Guo, Lufei Chen, Xiaoli Zhang, Wei Wu, Zhimin Yang, Xuejie Li, Yuanzhuo Wang, Zhiyuan Hu, Zihua Wang
Theranostics 2022; 12(12): 5488-5503. doi:10.7150/thno.73104
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A surrogate marker for very early-stage tau pathology is detectable by molecular magnetic resonance imaging
Parag Parekh, Qingshan Mu, Andrew Badachhape, Rohan Bhavane, Mayank Srivastava, Laxman Devkota, Xianwei Sun, Prajwal Bhandari, Jason L. Eriksen, Eric Tanifum, Ketan Ghaghada, Ananth Annapragada
Theranostics 2022; 12(12): 5504-5521. doi:10.7150/thno.72258
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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DNA aptamers inhibit SARS-CoV-2 spike-protein binding to hACE2 by an RBD- independent or dependent approach
Achut Prasad Silwal, Siddhartha Kalpa Samadhi Thennakoon, Satya Prakash Arya, Rick Mason Postema, Raunak Jahan, Chien Minh Tran Phuoc, Xiaohong Tan
Theranostics 2022; 12(12): 5522-5536. doi:10.7150/thno.74428
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Inhibition of acylglycerol kinase sensitizes DLBCL to venetoclax via upregulation of FOXO1-mediated BCL-2 expression
Na Ning, Si Zhang, Qi Wu, Xun Li, Dong Kuang, Yaqi Duan, Minghui Xia, Huicheng Liu, Junmei Weng, Hongping Ba, Zhaohui Tang, Xiang Cheng, Heng Mei, Liu Huang, Qilin Ao, Guoping Wang, Yu Hu, Arian Laurence, Jing Wang, Guihua Wang, Xiang-Ping Yang
Theranostics 2022; 12(12): 5537-5550. doi:10.7150/thno.72786
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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HER2-targeted dual radiotracer approach with clinical potential for noninvasive imaging of trastuzumab-resistance caused by epitope masking
Liqiang Li, Tianyu Liu, Linqing Shi, Xin Zhang, Xiaoyi Guo, Biao Hu, Meinan Yao, Hua Zhu, Zhi Yang, Bing Jia, Fan Wang
Theranostics 2022; 12(12): 5551-5563. doi:10.7150/thno.74154
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Identification of early invisible acute ischemic stroke in non-contrast computed tomography using two-stage deep-learning model
Jun Lu, Yiran Zhou, Wenzhi Lv, Hongquan Zhu, Tian Tian, Su Yan, Yan Xie, Di Wu, Yuanhao Li, Yufei Liu, Luyue Gao, Wei Fan, Yan Nan, Shun Zhang, Xiaolong Peng, Guiling Zhang, Wenzhen Zhu
Theranostics 2022; 12(12): 5564-5573. doi:10.7150/thno.74125
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Microbial metabolite restricts 5-fluorouracil-resistant colonic tumor progression by sensitizing drug transporters via regulation of FOXO3-FOXM1 axis
Sweta Ghosh, Rajbir Singh, Zachary Matthew Vanwinkle, Haixun Guo, Praveen Kumar Vemula, Ajay Goel, Bodduluri Haribabu, Venkatakrishna Rao Jala
Theranostics 2022; 12(12): 5574-5595. doi:10.7150/thno.70754
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Turmeric-derived nanovesicles as novel nanobiologics for targeted therapy of ulcerative colitis
Caifang Gao, Yangyang Zhou, Zhejie Chen, Hongyi Li, Yaqin Xiao, Wei Hao, Ying Zhu, Chi Teng Vong, Mohamed A. Farag, Yitao Wang, Shengpeng Wang
Theranostics 2022; 12(12): 5596-5614. doi:10.7150/thno.73650
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review

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Progress in advanced nanotherapeutics for enhanced photodynamic immunotherapy of tumor
Xiao Wei, Mingzhu Song, Guirong Jiang, Min Liang, Chunlan Chen, Zhiyong Yang, Liang Zou
Theranostics 2022; 12(12): 5272-5298. doi:10.7150/thno.73566
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Errata

Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition: Erratum
Qi Wang, Juan Liu, Yinan Hu, Ting Pan, Yongjian Xu, Jun Yu, Weining Xiong, Qing Zhou, Yi Wang
Theranostics 2022; 12(12): 5330-5331. doi:10.7150/thno.74512
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Human Umbilical Cord MSCs as New Cell Sources for Promoting Periodontal Regeneration in Inflammatory Periodontal Defect: Errautm
Fengqing Shang, Shiyu Liu, Leiguo Ming, Rong Tian, Fang Jin, Yin Ding, Yongjie Zhang, Hongmei Zhang, Zhihong Deng, Yan Jin
Theranostics 2022; 12(12): 5332-5333. doi:10.7150/thno.74942
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Resveratrol counteracts bone loss via mitofilin-mediated osteogenic improvement of mesenchymal stem cells in senescence-accelerated mice: Erratum
Ya-Jie Lv, Yi Yang, Bing-Dong Sui, Cheng-Hu Hu, Pan Zhao, Li Liao, Ji Chen, Li-Qiang Zhang, Tong-Tao Yang, Shao-Feng Zhang, Yan Jin
Theranostics 2022; 12(12): 5334. doi:10.7150/thno.74941
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Evaluation of 18F-IAM6067 as a sigma-1 receptor PET tracer for neurodegeneration in vivo in rodents and in human tissue: Erratum
François-Xavier Lepelletier, Matthias Vandesquille, Marie-Claude Asselin, Christian Prenant, Andrew C Robinson, David M A Mann, Michael Green, Elizabeth Barnett, Samuel D Banister, Marco Mottinelli, Christophe Mesangeau, Christopher R McCurdy, Inga B Fricke, Andreas H. Jacobs, Michael Kassiou, Hervé Boutin
Theranostics 2022; 12(12): 5335-5336. doi:10.7150/thno.76351
[Abstract] [Full text] [PDF] [PubMed] [PMC]