Previous issue | Next issue | Archive   

Volume 12 (14); 2022

Research Papers

Graphic abstract

Integrin β3-PKM2 pathway-mediated aerobic glycolysis contributes to mechanical ventilation-induced pulmonary fibrosis
Shuya Mei, Qiaoyi Xu, Yue Hu, Ri Tang, Jinhua Feng, Yang Zhou, Shunpeng Xing, Yuan Gao, Zhengyu He
Theranostics 2022; 12(14): 6057-6068. doi:10.7150/thno.72328
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

DDX56 transcriptionally activates MIST1 to facilitate tumorigenesis of HCC through PTEN-AKT signaling
Hongzhong Zhou, Yiqun Du, Xiafei Wei, Chunli Song, Jianning Song, Nanson Xu, Weihong Huang, Lichan Chen, Fuwen Yao, Duanming Du, Chuanghua Qiu, Lihong Zhong, Yuchen Liu, Dayong Gu, Jin Wang, Yong Xu
Theranostics 2022; 12(14): 6069-6087. doi:10.7150/thno.72471
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

Self-assembled traditional Chinese nanomedicine modulating tumor immunosuppressive microenvironment for colorectal cancer immunotherapy
Qianqian Mao, Juan Min, Rui Zeng, Haiqin Liu, Hao Li, Cao Zhang, Aixian Zheng, Jiumao Lin, Xiaolong Liu, Ming Wu
Theranostics 2022; 12(14): 6088-6105. doi:10.7150/thno.72509
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

Lgr5+ cell fate regulation by coordination of metabolic nuclear receptors during liver repair
Dan Qin, Shenghui Liu, Yuanyuan Lu, Yi Yan, Jing Zhang, Shiyao Cao, Mi Chen, Ning Chen, Wendong Huang, Liqiang Wang, Xiangmei Chen, Lisheng Zhang
Theranostics 2022; 12(14): 6130-6142. doi:10.7150/thno.74194
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

Redox dyshomeostasis modulation of the tumor intracellular environment through a metabolic intervention strategy for enhanced photodynamic therapy
Zuo Yang, Chaoqiang Qiao, Qian Jia, Zhuang Chen, Xiaofei Wang, Xuelan liu, Ruili Zhang, Kanyi Pu, Zhongliang Wang
Theranostics 2022; 12(14): 6143-6154. doi:10.7150/thno.75837
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

The metabolic genomic atlas reveals potential drivers and clinically relevant insights into the etiology of esophageal squamous cell carcinoma
Xuesong Liu, Ruoxi Hong, Peina Du, Di Yang, Meibo He, Qingnan Wu, Lin Li, Yan Wang, Jie Chen, Qingjie Min, Jinting Li, Weimin Zhang, Qimin Zhan
Theranostics 2022; 12(14): 6160-6178. doi:10.7150/thno.70814
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

What a difference a methylene makes: replacing Glu with Asp or Aad in the Lys-urea-Glu pharmacophore of PSMA-targeting radioligands to reduce kidney and salivary gland uptake
Hsiou-Ting Kuo, Kuo-Shyan Lin, Zhengxing Zhang, Chengcheng Zhang, Helen Merkens, Ruiyan Tan, Aron Roxin, Carlos F. Uribe, François Bénard
Theranostics 2022; 12(14): 6179-6188. doi:10.7150/thno.76571
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold
Wenjing Yang, Beili Wang, Qian Yu, Te Liu, Tong Li, Tongtong Tian, Anli Jin, Lin Ding, Wei Chen, Hao Wang, Jingrong Xian, Baishen Pan, Jian Zhou, Jia Fan, Xinrong Yang, Wei Guo
Theranostics 2022; 12(14): 6189-6206. doi:10.7150/thno.72134
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

Metal-fluorouracil networks with disruption of mitochondrion enhanced ferroptosis for synergistic immune activation
Lingling Lei, Zhe Dong, Li Xu, Fengrui Yang, Baoli Yin, Youjuan Wang, Renye Yue, Guoqiang Guan, Juntao Xu, Guosheng Song, Xiao-bing Zhang
Theranostics 2022; 12(14): 6207-6222. doi:10.7150/thno.75323
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

Single-Cell RNA sequencing reveals immune cell dynamics and local intercellular communication in acute murine cardiac allograft rejection
Zhang Chen, Heng Xu, Yuan Li, Xi Zhang, Jikai Cui, Yanqiang Zou, Jizhang Yu, Jie Wu, Jiahong Xia
Theranostics 2022; 12(14): 6242-6257. doi:10.7150/thno.75543
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

Intratumoral synthesis of transformable metal-phenolic nanoaggregates with enhanced tumor penetration and retention for photothermal immunotherapy
Xianglian He, Hongfu Zhu, Jiaojiao Shang, Meifeng Li, Yaoyao Zhang, Shicheng Zhou, Guidong Gong, Yunxiang He, Anna Blocki, Junling Guo
Theranostics 2022; 12(14): 6258-6272. doi:10.7150/thno.74808
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

m6A-induced lncDBET promotes the malignant progression of bladder cancer through FABP5-mediated lipid metabolism
Peihua Liu, Benyi Fan, Belaydi Othmane, Jiao Hu, Huihuang Li, Yu Cui, Zhenyu Ou, Jinbo Chen, Xiongbing Zu
Theranostics 2022; 12(14): 6291-6307. doi:10.7150/thno.71456
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

Polyglutamate-based nanoconjugates for image-guided surgery and post-operative melanoma metastases prevention
Yana Epshtein, Rachel Blau, Evgeni Pisarevsky, Shani Koshrovski-Michael, Dikla Ben-Shushan, Sabina Pozzi, Gal Shenbach-Koltin, Lidar Fridrich, Marina Buzhor, Adva Krivitsky, Pradip Dey, Ronit Satchi-Fainaro
Theranostics 2022; 12(14): 6339-6362. doi:10.7150/thno.72941
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2
Boyan Li, Rongrong Zhao, Wei Qiu, Ziwen Pan, Shulin Zhao, Yanhua Qi, Jiawei Qiu, Shouji Zhang, Qindong Guo, Yang Fan, Hao Xu, Ming Li, Gang Li, Hao Xue
Theranostics 2022; 12(14): 6363-6379. doi:10.7150/thno.74600
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

Cerenkov luminescence imaging of interscapular brown adipose tissue using a TSPO-targeting PET probe in the UCP1 ThermoMouse
Seok-Yong Lee, Ho Rim Oh, Young-Hwa Kim, Sung-Hwan Bae, Yongseok Lee, Yun-Sang Lee, Byung Chul Lee, Gi Jeong Cheon, Keon Wook Kang, Hyewon Youn
Theranostics 2022; 12(14): 6380-6394. doi:10.7150/thno.74828
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

18F-FDG PET as an imaging biomarker for the response to FGFR-targeted therapy of cancer cells via FGFR-initiated mTOR/HK2 axis
Yuchen Jiang, Qinghe Zeng, Qinghui Jiang, Xia Peng, Jing Gao, Haiyan Wan, Luting Wang, Yinglei Gao, Xiaoyu Zhou, Dongze Lin, Hanyi Feng, Sheng Liang, Hu Zhou, Jian Ding, Jing Ai, Ruimin Huang
Theranostics 2022; 12(14): 6395-6408. doi:10.7150/thno.74848
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

Strategies for accelerating osteogenesis through nanoparticle-based DNA/mitochondrial damage repair
Hye Jin Kim, Hui Bang Cho, Sujin Lee, Jiyon Lyu, Hye-Ryoung Kim, Sujeong Lee, Ji-In Park, Keun-Hong Park
Theranostics 2022; 12(14): 6409-6421. doi:10.7150/thno.77089
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies
Hongjian Li, Kun Peng, Kai Yang, Wenbo Ma, Shaolong Qi, Xinyang Yu, Jia He, Xin Lin, Guocan Yu
Theranostics 2022; 12(14): 6422-6436. doi:10.7150/thno.77350
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

Graphic abstract

Immunotherapy in soft tissue and bone sarcoma: unraveling the barriers to effectiveness
Myrofora Panagi, Pampina Pilavaki, Anastasia Constantinidou, Triantafyllos Stylianopoulos
Theranostics 2022; 12(14): 6106-6129. doi:10.7150/thno.72800
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

Targeted delivery of nanomedicines for promoting vascular regeneration in ischemic diseases
Jie Zhuang, Xiangyun Zhang, Qiqi Liu, Mingsheng Zhu, Xinglu Huang
Theranostics 2022; 12(14): 6223-6241. doi:10.7150/thno.73421
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

Immunosuppression in tumor immune microenvironment and its optimization from CAR-T cell therapy
Zaoqu Liu, Zhaokai Zhou, Qin Dang, Hui Xu, Jinxiang Lv, Huanyun Li, Xinwei Han
Theranostics 2022; 12(14): 6273-6290. doi:10.7150/thno.76854
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

Nanozyme-based colorimetric biosensor with a systemic quantification algorithm for noninvasive glucose monitoring
Hee-Jae Jeon, Hyung Shik Kim, Euiheon Chung, Dong Yun Lee
Theranostics 2022; 12(14): 6308-6338. doi:10.7150/thno.72152
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Errata

Preventing tumor progression to the bone by induced tumor-suppressing MSCs: Erratum
Xun Sun, Kexin Li, Rongrong Zha, Shengzhi Liu, Yao Fan, Di Wu, Misato Hase, Uma K. Aryal, Chien-Chi Lin, Bai-Yan Li, Hiroki Yokota
Theranostics 2022; 12(14): 6155-6156. doi:10.7150/thno.77186
[Abstract] [Full text] [PDF] [PubMed] [PMC]


FOSL2 promotes VEGF-independent angiogenesis by transcriptionnally activating Wnt5a in breast cancer-associated fibroblasts: Erratum
Xueying Wan, Shengdong Guan, Yixuan Hou, Yilu Qin, Huan Zeng, Liping Yang, Yina Qiao, Shuiqing Liu, Qiao Li, Ting Jin, Yuxiang Qiu, Manran Liu
Theranostics 2022; 12(14): 6157-6158. doi:10.7150/thno.77019
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Co-delivery of 5-fluorouracil and miRNA-34a mimics by host-guest self-assembly nanocarriers for efficacious targeted therapy in colorectal cancer patient-derived tumor xenografts: Erratum
Jianbin Xu, Guolin Zhang, Xin Luo, Di Wang, Wei Zhou, Yan Zhang, Wei Zhang, Jiaxin Chen, Qing Meng, Engeng Chen, Heng Chen, Zhangfa Song
Theranostics 2022; 12(14): 6159. doi:10.7150/thno.76869
[Abstract] [Full text] [PDF]