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Volume 15 (2); 2025

Research Papers

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Targeting macrophage circadian rhythms with microcurrent stimulation to activate cancer immunity through phagocytic defense
Yuya Yoshida, Tomohito Tanihara, Keika Hamasaki, Fumiaki Tsurusaki, Taiki Fukuda, Satoka Adachi, Yuma Terada, Kaita Otsuki, Naoki Nishikawa, Kohei Fukuoka, Ryotaro Tsukamoto, Kengo Hamamura, Kosuke Oyama, Akito Tsuruta, Kouta Mayanagi, Satoru Koyanagi, Shigehiro Ohdo, Naoya Matsunaga
Theranostics 2025; 15(2): 340-361. doi:10.7150/thno.100748
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Platelet membrane decorated exosomes enhance targeting efficacy and therapeutic index to alleviate arterial restenosis
Shan Lu, Ruihan Wang, Minghao Cai, Chen Yuan, Bin Gao, Daqiao Guo, Yisheng Xu, Weiguo Fu, Xiaohua Yu, Yi Si
Theranostics 2025; 15(2): 408-427. doi:10.7150/thno.103747
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Targeted demethylation of cathepsin D via epigenome editing rescues pathology in Alzheimer's disease mouse model
Moonsu Park, Hongji Ryu, Suyeon Heo, Boyoung Kim, Junhang Park, Key-Hwan Lim, Sang-Bae Han, Hanseul Park
Theranostics 2025; 15(2): 428-438. doi:10.7150/thno.103455
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Inhibition of Bruton's tyrosine kinase restricts neuroinflammation following intracerebral hemorrhage
Hongying Hao, Tingyu Yin, Tuo Li, Xu Zhou, Honglei Ren, Mingming Liu, Huachen Huang, Caiyun Qi, Yuwen Xiu, Wenjin Qiu, Danni Wang, Mengxuan Shi, Xiaoying Wang, Aaron S. Dumont, Qiang Liu
Theranostics 2025; 15(2): 494-508. doi:10.7150/thno.101024
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Detecting metastatic potential of cancer through longitudinal vasculature imaging of biomaterial scaffold using non-invasive in vivo photoacoustic microscopy and optical coherence tomography
Zhanpeng Xu, Guillermo Escalona, Ian Schrack, Wei Zhang, Tianqu Zhai, Lonnie D. Shea, Xueding Wang
Theranostics 2025; 15(2): 509-520. doi:10.7150/thno.101685
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MRI guided copper deprivator activated immune responses and suppressed angiogenesis for enhanced antitumor immunotherapy
Yinfeng Wang, Peng Wang, Huimin Li, Miao Yan, Feixue Ni, Li Zhang, Zhen Zhao, Wenjuan Gao, Guilong Zhang
Theranostics 2025; 15(2): 546-559. doi:10.7150/thno.102556
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Inhibition of nitric oxide synthase transforms carotid occlusion-mediated benign oligemia into de novo large cerebral infarction
Ha Kim, Jinyong Chung, Jeong Wook Kang, Dawid Schellingerhout, Soo Ji Lee, Hee Jeong Jang, Inyeong Park, Taesu Kim, Dong-Seok Gwak, Ji Sung Lee, Sung-Ha Hong, Kang-Hoon Je, Hee-Joon Bae, Joohon Sung, Eng H. Lo, James Faber, Cenk Ayata, Dong-Eog Kim
Theranostics 2025; 15(2): 585-604. doi:10.7150/thno.104132
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Orchestrating the frontline: HDAC3-miKO recruits macrophage reinforcements for accelerated myelin debris clearance after stroke
Jiaying Li, Chenran Wang, Yue Zhang, Yichen Huang, Ziyu Shi, Yuwen Zhang, Yana Wang, Shuning Chen, Yiwen Yuan, He Wang, Leilei Mao, Yanqin Gao
Theranostics 2025; 15(2): 632-655. doi:10.7150/thno.103449
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A molecularly distinct cell type in the midbrain regulates intermale aggression behaviors in mice
Chunyang Li, Cheng Miao, Yao Ge, Jiaxing Wu, Panpan Gao, Songlin Yin, Pei Zhang, Hongbin Yang, Bo Tian, Wenqiang Chen, Xiao Qian Chen
Theranostics 2025; 15(2): 707-725. doi:10.7150/thno.101658
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S100A proteins show a spatial distribution of inflammation associated with the glioblastoma microenvironment architecture
Blanca Cómitre-Mariano, Berta Segura-Collar, Gabriel Vellila-Alonso, Rubén Contreras, Aurelio Henandez-Lain, Manuel Valiente, Juan M. Sepulveda, Stephen Garrett Marcus, Guillermo García-Posadas, Luis Jiménez-Roldán, Ángel Perez-Nuñez, Ricardo Gargini
Theranostics 2025; 15(2): 726-744. doi:10.7150/thno.100638
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PIM1 instigates endothelial-to-mesenchymal transition to aggravate atherosclerosis
Zhiwei Xue, Mengtao Han, Tao Sun, Yanzhao Wu, Wenchen Xing, Feiyu Mu, Zhihan Zhang, Junzhi Liu, Xiangjun Liang, Lu Ling, Jian Wang, Jiwei Wang, Xingang Li, Bin Huang, Donghai Wang
Theranostics 2025; 15(2): 745-765. doi:10.7150/thno.102597
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Reviews

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Photobiomodulation: shining a light on depression
Lian Wang, Liwei Mao, Zhihai Huang, Jeffrey A. Switzer, David C. Hess, Quanguang Zhang
Theranostics 2025; 15(2): 362-383. doi:10.7150/thno.104502
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Recent advances in ferrocene-based nanomedicines for enhanced chemodynamic therapy
Gui-long Wu, Senyou Tan, Xiaofeng Tan, Guodong Chen, Qinglai Yang
Theranostics 2025; 15(2): 384-407. doi:10.7150/thno.101697
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Engineering nanosystems for regulating reproductive health in women
Qinrui Fu, Lejun Fu
Theranostics 2025; 15(2): 439-459. doi:10.7150/thno.102626
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Advancements in GelMA bioactive hydrogels: Strategies for infection control and bone tissue regeneration
Lei Huang, Ziyao Guo, Xiaoxia Yang, Yinchun Zhang, Yiyun Liang, Xiaxue Chen, Xiaoling Qiu, Xuan Chen
Theranostics 2025; 15(2): 460-493. doi:10.7150/thno.103725
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Targeting ion channels: innovative approaches to combat cancer drug resistance
Qian Shi, Zijing Yang, Huan Yang, Lihui Xu, Jing Xia, Jie Gu, Mengting Chen, Yan Wang, Xiaohong Zhao, Zehua Liao, Yiping Mou, Xidong Gu, Tian Xie, Xinbing Sui
Theranostics 2025; 15(2): 521-545. doi:10.7150/thno.103384
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Silk fibroin-based hydrogels for cartilage organoids in osteoarthritis treatment
Congyi Shen, Ziyang Zhou, Ruiyang Li, Shike Yang, Dongyang Zhou, Fengjin Zhou, Zhen Geng, Jiacan Su
Theranostics 2025; 15(2): 560-584. doi:10.7150/thno.103491
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B cells and tertiary lymphoid structures in tumors: immunity cycle, clinical impact, and therapeutic applications
Xing Wu, Qibo Huang, Xiaoping Chen, Binhao Zhang, Junnan Liang, Bixiang Zhang
Theranostics 2025; 15(2): 605-631. doi:10.7150/thno.105423
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The evolving understanding of systemic mechanisms in organ-specific IgA nephropathy: a focus on gut-kidney crosstalk
Xin Wang, Xu-Jie Zhou, Xue Qiao, Mario Falchi, Jing Liu, Hong Zhang
Theranostics 2025; 15(2): 656-681. doi:10.7150/thno.104631
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Standardization and consensus in the development and application of bone organoids
Jian Wang, Xiao Chen, Ruiyang Li, Sicheng Wang, Zhen Geng, Zhongmin Shi, Yingying Jing, Ke Xu, Yan Wei, Guangchao Wang, Chongru He, Shiwu Dong, Guohui Liu, Zhiyong Hou, Zhidao Xia, Xinglong Wang, Zhou Ye, Fengjin Zhou, Long Bai, Hongbo Tan, Jiacan Su
Theranostics 2025; 15(2): 682-706. doi:10.7150/thno.105840
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