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Volume 15 (3); 2025

Research Papers

Vascularized tumor on a microfluidic chip to study mechanisms promoting tumor neovascularization and vascular targeted therapies
Magdalena Skubal, Benedict Mc Larney, Ngan Bao Phung, Juan Carlos Desmaras, Abdul Vehab Dozic, Alessia Volpe, Anuja Ogirala, Camila Longo Machado, Jakob Djibankov, Vladimir Ponomarev, Jan Grimm
Theranostics 2025; 15(3): 766-783. doi:10.7150/thno.95334
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Advancing the clinical assessment of glomerular podocyte pathology in kidney biopsies via super-resolution microscopy and angiopoietin-like 4 staining
Xiaojing Liu, Suxia Wang, Gang Liu, Yan Wang, Shunlai Shang, Guming Zou, Shimin Jiang, Xuliang Wang, Li Yang, Wenge Li
Theranostics 2025; 15(3): 784-803. doi:10.7150/thno.101498
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C-X-C motif chemokine receptor 4-directed PET signal in the arterial tree is not consistently linked to calcified plaque burden and cardiovascular risk
Aleksander Kosmala, Natalie Hasenauer, Sebastian E. Serfling, Kerstin Michalski, Matthias Fröhlich, Niklas Dreher, Philipp E. Hartrampf, Takahiro Higuchi, Andreas K. Buck, Alexander Weich, Theresa Reiter, Rudolf A. Werner
Theranostics 2025; 15(3): 804-814. doi:10.7150/thno.102910
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Millisecond-level transient heating and temperature monitoring technique for ultrasound-induced thermal strain imaging
Mengyue Chen, Zhiyu Sheng, Ran Wei, Bohua Zhang, Howuk Kim, Huaiyu Wu, Yu Chu, Qiyang Chen, Andrew Breon, Sibo Li, Matthew B. Wielgat, Dhanansayan Shanmuganayagam, Edith Tzeng, Xuecang Geng, Kang Kim, Xiaoning Jiang
Theranostics 2025; 15(3): 815-827. doi:10.7150/thno.95997
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Monitoring of cancer ferroptosis with [¹⁸F]hGTS13, a system xc- specific radiotracer
Abraham Moses, Rim Malek, Mustafa Tansel Kendirli, Pierre Cheung, Madeleine Landry, Marco Herrera-Barrera, Abbas Khojasteh, Monica Granucci, Syed. A. Bukhari, Jody E. Hooper, Melanie Hayden-Gephart, Scott J. Dixon, Lawrence D. Recht, Corinne Beinat
Theranostics 2025; 15(3): 836-849. doi:10.7150/thno.101882
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Ex vivo enhancement of CD8+ T cell activity using functionalized hydrogel encapsulating tonsil-derived lymphatic endothelial cells
Heesun Hong, Chan Hum Park, Ji Seung Lee, Kyunghee Kim, Sudarshini Nath, Moon Sik Oh, Sol Kim, Chul Hee Lee, Ki Hyun Kim, Woo Hee Choi, Kyu Young Choi, Hae Sang Park, Ok Joo Lee, In-Sun Hong, Soon Hee Kim
Theranostics 2025; 15(3): 850-874. doi:10.7150/thno.100079
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Prevention of radiotherapy-induced pro-tumorigenic microenvironment by SFK inhibitors
Yong June Choi, Myung Jun Kim, Young Joo Lee, Munkyung Choi, Wan Seob Shim, Miso Park, Yong-Chul Kim, Keon Wook Kang
Theranostics 2025; 15(3): 875-893. doi:10.7150/thno.100970
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Clinical-grade human dental pulp stem cells improve adult hippocampal neural regeneration and cognitive deficits in Alzheimer's disease
Wei Xiong, Wenting She, Ye Liu, Heng Zhou, Xinxin Wang, Fang Li, Ruohan Li, Junnan Wang, Dongdong Qin, Shuili Jing, Xingxiang Duan, Cailei Jiang, Chun Xu, Yan He, Zhihao Wang, Qingsong Ye
Theranostics 2025; 15(3): 894-914. doi:10.7150/thno.102315
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A general strategy towards activatable nanophotosensitizer for phototoxicity-free photodynamic therapy
Guozhu Tan, Qinjie Zhong, Jibin Zhang, Peiyi He, Xiaoxi Zhao, Guifeng Miao, Yafei Xu, Xiaorui Wang
Theranostics 2025; 15(3): 943-964. doi:10.7150/thno.100597
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Ultra-small quercetin-based nanotherapeutics ameliorate acute liver failure by combatting inflammation/cellular senescence cycle
Yali Feng, Xiaoli Zhang, Juan Li, Shan Fu, Weicheng Xu, Jinfeng Liu, Yuan Yang, Tianyan Chen, Yingren Zhao, Dongmin Li, Mingzhen Zhang, Yingli He
Theranostics 2025; 15(3): 1035-1056. doi:10.7150/thno.103746
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Bisphosphonate-mineralized nano-IFNγ suppresses residual tumor growth caused by incomplete radiofrequency ablation through metabolically remodeling tumor-associated macrophages
Zhicheng Yan, Bing Wang, Yuhan Shen, Junji Ren, Meifang Chen, Yunhui Jiang, Hao Wu, Wenbing Dai, Hua Zhang, Xueqing Wang, Qiang Zhang, Wei Yang, Bing He
Theranostics 2025; 15(3): 1057-1076. doi:10.7150/thno.100998
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Perfluorocarbon-polyepinephrine core-shell nanoparticles as a near-infrared light activatable theranostic platform for bimodal imaging-guided photothermal/chemodynamic synergistic cancer therapy
Kyung Kwan Lee, Kyung-Woo Park, Sang Cheon Lee, Chang-Soo Lee
Theranostics 2025; 15(3): 1077-1093. doi:10.7150/thno.102743
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A specific and adaptable approach to track CD206⁺ macrophages by molecular MRI and fluorescence imaging
Cuihua Wang, Negin Jalali Motlagh, Gregory R. Wojtkiewicz, Hongzhi Yang, Hyung-Hwan Kim, John W. Chen
Theranostics 2025; 15(3): 1094-1109. doi:10.7150/thno.96488
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Non-invasive volumetric ultrasound localization microscopy detects vascular changes in mice with Alzheimer's disease
Rebecca M. Jones, Ryan M. DeRuiter, Mohanish Deshmukh, Paul A. Dayton, Gianmarco F. Pinton
Theranostics 2025; 15(3): 1110-1121. doi:10.7150/thno.99097
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Drug repositioning of mesalamine via supramolecular nanoassembly for the treatment of drug-induced acute liver failure
Byeongmin Park, Eun Hye Kim, Hochung Jang, Yelee Kim, Youngri Ryu, Jiwoong Choi, Dongwon Shin, Myung Chul Lee, Yoosoo Yang, Kwangmeyung Kim, Sangmin Lee, Sun Hwa Kim, Man Kyu Shim
Theranostics 2025; 15(3): 1122-1134. doi:10.7150/thno.101358
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OTUB2 contributes to vascular calcification in chronic kidney disease via the YAP-mediated transcription of PFKFB3
Yalan Li, Xiaoyue Chen, Xueqiang Xu, Cheng Chen, Min Min, Dongmei Liang, Jiafa Ren, Huijuan Mao
Theranostics 2025; 15(3): 1185-1204. doi:10.7150/thno.98660
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Reviews

Advances in adhesive hydrogels applied for ophthalmology: An overview focused on the treatment
Ke Yan, Qinghe Zhang, Qiuping Liu, Yi Han, Zuguo Liu
Theranostics 2025; 15(3): 915-942. doi:10.7150/thno.103266
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RNA nanotherapeutics for hepatocellular carcinoma treatment
Yihang Yuan, Weijie Sun, Jiaqi Xie, Ziheng Zhang, Jing Luo, Xiangfei Han, Yongfu Xiong, Yang Yang, Yang Zhang
Theranostics 2025; 15(3): 965-992. doi:10.7150/thno.102964
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Metformin-based nanomedicines for reprogramming tumor immune microenvironment
Jieyu Liu, Xiaoling Li, Yinggang Li, Qiyong Gong, Kui Luo
Theranostics 2025; 15(3): 993-1016. doi:10.7150/thno.104872
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Optical molecular imaging technology and its application in precise surgical navigation of liver cancer
Pan He, Haitian Tang, Yating Zheng, Xiao Xu, Xuqi Peng, Tao Jiang, Yongfu Xiong, Yang Zhang, Yu Zhang, Gang Liu
Theranostics 2025; 15(3): 1017-1034. doi:10.7150/thno.102671
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Advances in subpopulation separation and detection of extracellular vesicles: for liquid biopsy and downstream research
Zi-Xiu Liu, Gang Chen, Zi-Li Yu
Theranostics 2025; 15(3): 1135-1155. doi:10.7150/thno.106459
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Protein serine/threonine phosphatases in tumor microenvironment: a vital player and a promising therapeutic target
Yiyang Liu, Feng Xia, Chang Zhu, Jia Song, Bufu Tang, Bixiang Zhang, Zhao Huang
Theranostics 2025; 15(3): 1164-1184. doi:10.7150/thno.104529
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Errata

Piezo1 specific deletion in macrophage protects the progression of liver fibrosis in mice: Erratum
Shangfei Luo, Xiaoduo Zhao, Jintao Jiang, Bo Deng, Silin Liu, Honglin Xu, Qiaorui Tan, Yu'an Chen, Ziyan Zhang, Xianmei Pan, Rentao Wan, Xiaoting Chen, Youfen Yao, Jing Li
Theranostics 2025; 15(3): 1156-1157. doi:10.7150/thno.107640
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Regulation of ezrin tension by S-nitrosylation mediates non-small cell lung cancer invasion and metastasis: Erratum
Xiaolong Zhang, Guangming Li, Yichen Guo, Ying Song, Linlin Chen, Qinli Ruan, Yifan Wang, Lixia Sun, Yunfeng Hu, Jingwen Zhou, Bin Ren, Jun Guo
Theranostics 2025; 15(3): 1158-1159. doi:10.7150/thno.107681
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Octopod PtCu Nanoframe for Dual-Modal Imaging-Guided Synergistic Photothermal Radiotherapy: Erratum
Jinghua Li, Xiangyang Zu, Gaofeng Liang, KeKe Zhang, Yuliang Liu, Ke Li, Zhong Luo, Kaiyong Cai
Theranostics 2025; 15(3): 1160-1163. doi:10.7150/thno.107893
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