Volume 15, Issue 11

open access Global reach, higher impact

Volume 15 (11); 2025

Research Papers

Pharmacological targeting of mitophagy via ALT001 improves herpes simplex virus 1 (HSV1)-mediated microglial inflammation and promotes amyloid β phagocytosis by restricting HSV1 infection
Soo-Jin Oh, Young Yeon Kim, Ruiying Ma, Seok Tae Choi, Se Myeong Choi, Jong Hyun Cho, Ji-Yeun Hur, Yongjin Yoo, Kihoon Han, Hosun Park, Jeanho Yun, Ok Sarah Shin
Theranostics 2025; 15(11): 4890-4908. doi:10.7150/thno.105953
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Mitochondria-targeting natural product rhein conjugated with dichloroacetate as the dual inhibitor of glycolysis and oxidative phosphorylation to off energize cancer cells and induce ROS storm
Zhili Zhang, Shiming Tang, Minghui Qi, Hongyang Zhao, Meng Wu, Shi-Wen Huang
Theranostics 2025; 15(11): 4909-4929. doi:10.7150/thno.107812
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AIG1 protects against doxorubicin-induced cardiomyocyte ferroptosis and cardiotoxicity by promoting ubiquitination-mediated p53 degradation
Yuekai Shi, Jieru Cai, Lu Chen, Hao Cheng, Xiaoyue Song, Junqiang Xue, Rende Xu, Jianying Ma, Junbo Ge
Theranostics 2025; 15(11): 4931-4954. doi:10.7150/thno.108410
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Biomimetic piezoelectric hydrogel system for energy metabolism reprogramming in spinal cord injury repair
Guoliang Shi, Tianqi Su, Junyang Li, Aoao Wang, Gan Gao, Benzhang Tao, Nantian Chen, Lu Tian, Jun Yan, Lingzhou Zhao, Jianning Zhang, Yantao Zhao
Theranostics 2025; 15(11): 4955-4969. doi:10.7150/thno.108329
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KMV-mediated cardiomyocyte-to-endothelial cell signaling drives capillary rarefaction to promote heart failure following pressure overload
Chenxi Gao, Yudong Xia, Chaofang Li, Tao Zhou, Wenyu Zhang, Hao Cheng, Xiaojin Zhang, Yunhao Yu, Chuanfu Li, Zhengnian Ding, Jun Wu, Li Liu
Theranostics 2025; 15(11): 4970-4988. doi:10.7150/thno.104899
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Inhibition of CAV1 attenuates diabetic cardiomyopathy through reducing ferroptosis via activating NRF2/GCLC signaling pathway
Guangru Li, Ruiqing Liu, Zeyan Peng, Shengzheng Zhang, Runjia Sun, Ziwei Wang, Jing Li, Yang Gao, Yang Xu, Jianlin Cui, Jie Liu, Jie Yan, Lei Cao, Shan Ren, Yushun Chu, Lifeng Feng, Liang Yang, Yanna Shen, Zhi Qi
Theranostics 2025; 15(11): 4989-5006. doi:10.7150/thno.107367
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PD-1 activation mitigates lupus nephritis by suppressing hyperactive and heterogeneous PD-1⁺CD8⁺ T cells
Jun Deng, Junling Zhu, Xiaoyue Jiang, Chao Yao, Haifeng Chen, Yanjie Ding, Peng Niu, Qian Chen, Huihua Ding, Nan Shen
Theranostics 2025; 15(11): 5029-5044. doi:10.7150/thno.107418
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Vine-inspired zinc-ion modified black phosphorus coating accelerates bone tissue infiltration of 3D printed scaffolds
Dan Li, Danni Dai, Jianrong Wang, Yan Wang, Yujia Tian, Chao Zhang
Theranostics 2025; 15(11): 5073-5086. doi:10.7150/thno.113623
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Serine supplementation suppresses hypoxia-induced pathological retinal angiogenesis
Hitomi Yagi, Chenxi Qiu, Yan Zeng, Myriam Boeck, Shen Nian, Chuck T. Chen, Jarrod C Harman, Taku Kasai, Jeff Lee, Victoria Hirst, Katherine Neilsen, Chaomei Wang, Kiran Bora, Meenakshi Maurya, Tori Rodrick, Matthew Grumbine, Yuelin Yang, Zhanqing Hua, Ian R. Sweet, Sasha A. Singh, Masanori Aikawa, Jing Chen, Zhongjie Fu
Theranostics 2025; 15(11): 5087-5105. doi:10.7150/thno.105299
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Noninvasive DWI tracking of hiPSCs differentiation into RTECs in AKI recovery via the KSP promoter-mediated AQP1 strategy
Yue Zhao, Mingfu Gong, Xu Liu, Qian Xie, Tao Sun, Chunyu Zhou, Tongsheng Shu, Shuang Wang, Liang Zhang, Dong Zhang
Theranostics 2025; 15(11): 5106-5120. doi:10.7150/thno.109826
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Extracellular vesicles play a central role in linking podocyte injury to mesangial activation in glomerular disease
Zhao Liu, Xi Liu, Yi Zhou, Xin Wen, Jie Xu, Meizhi He, Jiongcheng Chen, Nan Jia, Youhua Liu
Theranostics 2025; 15(11): 5121-5137. doi:10.7150/thno.110034
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Modulation of brain immune microenvironment and cellular dynamics in systemic inflammation
Junhao Wang, Zhaoqian Zhong, Haihua Luo, Qizheng Han, Kan Wu, Aolin Jiang, Li Chen, Yanxia Gao, Yong Jiang
Theranostics 2025; 15(11): 5153-5171. doi:10.7150/thno.107061
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ATP released by ultrasound targeted microbubble cavitation induces vascular inflammation and improves immune checkpoint blockade efficacy
Sepideh Jahangiri, Samuel Bourdages, Emma Skora, John Stagg, François Yu
Theranostics 2025; 15(11): 5220-5237. doi:10.7150/thno.105857
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Mechanism of valproic acid-induced hepatic steatosis via enhancing NRF2-FATP2-mediated fatty acid uptake
Xiaoliang He, Rui Yuan, Ying Chen, Wenni Huang, Zihao Xu, Bixia Wang, Changhui Liu, Tianqin Xiong
Theranostics 2025; 15(11): 5258-5276. doi:10.7150/thno.108593
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Spatially segregated APOE⁺ macrophages restrict immunotherapy efficacy in clear cell renal cell carcinoma
Qintao Ge, Jialin Meng, Zhongyuan Wang, Aihetaimujiang Anwaier, Jiahe Lu, Xi Tian, Yue Wang, Jianfeng Yang, Hailiang Zhang, Dingwei Ye, Wenhao Xu
Theranostics 2025; 15(11): 5312-5336. doi:10.7150/thno.109097
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Single-nucleus RNA sequencing and spatial transcriptomics reveal an immunosuppressive tumor microenvironment related to metastatic dissemination during pancreatic cancer liver metastasis
Hongsen Liu, Mengting Chen, Bo Hong, Yufei Xiao, Qianming Chen, Yun Qian
Theranostics 2025; 15(11): 5337-5357. doi:10.7150/thno.108925
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Magnetic sculpture-like tumor cell vaccines enable targeted in situ immune activation and potent antitumor effects
Heng Zhang, Qing-qing Li, Yue Shi, Lei Zhang, Kai-wen Wang, Ting Wu, Shan-bin Cheng, Zi-ren Zhang, Lu-ning Qin, Yun-long Zhao, Xue-ting Zhen, Hao-ran Ren, Lin-yong Du, Hui-juan Liu, Tao Sun
Theranostics 2025; 15(11): 5358-5380. doi:10.7150/thno.107162
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Targeting endothelial MYC using siRNA or miR-218 nanoparticles sensitizes chemo- and immuno-therapies by recapitulating the Notch activation-induced tumor vessel normalization
Xianchun Yan, Ziyan Yang, Xiuli Cao, Liang Liang, Yanyan Duan, Peiran Zhang, Yixuan Feng, Ting Wen, Shanqiang Luo, Lintao Jia, Jiaxing Sun, Hua Han
Theranostics 2025; 15(11): 5381-5401. doi:10.7150/thno.112023
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Topoisomerase IIα-mediated stemness response in reactive astrocytes to traumatic brain injury
Shangyao Qin, Xiao Huang, Yimin Yuan, Hong Liu, Jiali Li, Ziwei Dai, Zhida Lan, Yingyan Pu, Cheng He, Zhida Su
Theranostics 2025; 15(11): 5402-5419. doi:10.7150/thno.111923
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TMTP1-modified nanocarrier boosts cervical cancer immunotherapy by eliciting pyroptosis
Hanjie Xu, Danya Zhang, Yu Zhang, Yuxin Chen, Yue Sun, Jie Li, Songwei Tan, Ying Zhou, Rui Wei, Fei Li, Ling Xi
Theranostics 2025; 15(11): 5420-5439. doi:10.7150/thno.108357
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BARD1-mediated stabilization of METTL14 promotes retinal neovascularization by m6A-modifying MXD1 mRNA on a YTHDF2-dependent manner
Xianyang Liu, Shuhao Zeng, Jiayu Meng, Qian Zhou, Fan Cao, Baorui Chu, Chao Wu, Yakun Wang, Hui Feng, Xiaorui Bi, Xinyuan Chen, Wenxian Yang, Meng Tian, Hui Yang, Ke Hu, Shengping Hou
Theranostics 2025; 15(11): 5481-5498. doi:10.7150/thno.110122
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Nitric oxide-primed engineered extracellular vesicles restore bioenergetics in acute kidney injury via mitochondrial transfer
Fei Peng, Xiaoniao Chen, Lingling Wu, Jiayi He, Zongjin Li, Quan Hong, Qiang Zhao, Meng Qian, Xu Wang, Wanjun Shen, Tingting Qi, Yiyu Huang, Guangyan Cai, Chuyue Zhang, Xiangmei Chen
Theranostics 2025; 15(11): 5499-5517. doi:10.7150/thno.113741
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Reviews

Current landscape and future directions of targeted-alpha-therapy for glioblastoma treatment
Loris Roncali, François Hindré, Edouard Samarut, Franck Lacoeuille, Audrey Rousseau, Jean-Michel Lemée, Emmanuel Garcion, Michel Chérel
Theranostics 2025; 15(11): 4861-4889. doi:10.7150/thno.106081
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Nanomaterials-mediated adenosine pathway inhibition for strengthening cancer immunotherapy
Wenhu Zhu, Fei Wu, Zhanhong Qiao, Ming Zhao, Haiyang Hu
Theranostics 2025; 15(11): 5007-5028. doi:10.7150/thno.108931
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Sex bias in tumor immunity: insights from immune cells
Xuerui Tao, Yiling Wang, Binghua Xiang, Dongmei Hu, Wei Xiong, Wenjun Liao, Shichuan Zhang, Chi Liu, Xiaoxiao Wang, Yue Zhao
Theranostics 2025; 15(11): 5045-5072. doi:10.7150/thno.106465
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Decoding the role of microtubules: a trafficking road for vesicle
Jiaorong Qu, Jianan Li, Hong Wang, Jianhang Lan, Zixuan Huo, Xiaojiaoyang Li
Theranostics 2025; 15(11): 5138-5152. doi:10.7150/thno.110120
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Recent progress in ROS-responsive biomaterials for the diagnosis and treatment of cardiovascular diseases
Zhiyu Yuan, Ying Li, Ming Sun, Mujie Yuan, Zeyu Han, Xiaojing Li, Song Liu, Yong Sun, Jie Cao, Fan Li
Theranostics 2025; 15(11): 5172-5219. doi:10.7150/thno.106991
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Old players and new insights: unraveling the role of RNA-binding proteins in brain tumors
Xu Wang, Jiang Li, Chengkai Zhang, Xiudong Guan, Xingang Li, Wang Jia, Anjing Chen
Theranostics 2025; 15(11): 5238-5257. doi:10.7150/thno.113312
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Exosomes: innovative biomarkers leading the charge in non-invasive cancer diagnostics
Jiale Li, Ailin Wang, Haijun Guo, Wei Zheng, Rui Chen, Changfeng Miao, Dandan Zheng, Jun Peng, Jiachong Wang, Zigui Chen
Theranostics 2025; 15(11): 5277-5311. doi:10.7150/thno.113650
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Nano drug delivery systems for advanced immune checkpoint blockade therapy
Chenqi Guo, Ling Lin, Yihan Wang, Jing Jing, Qiyong Gong, Kui Luo
Theranostics 2025; 15(11): 5440-5480. doi:10.7150/thno.112475
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