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Volume 15 (11); 2025

Research Papers

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Pharmacological targeting of mitophagy via ALT001 improves herpes simplex virus 1 (HSV1)-mediated microglial inflammation and promotes amyloid β phagocytosis by restricting HSV1 infection
Soo-Jin Oh, Young Yeon Kim, Ruiying Ma, Seok Tae Choi, Se Myeong Choi, Jong Hyun Cho, Ji-Yeun Hur, Yongjin Yoo, Kihoon Han, Hosun Park, Jeanho Yun, Ok Sarah Shin
Theranostics 2025; 15(11): 4890-4908. doi:10.7150/thno.105953
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Mitochondria-targeting natural product rhein conjugated with dichloroacetate as the dual inhibitor of glycolysis and oxidative phosphorylation to off energize cancer cells and induce ROS storm
Zhili Zhang, Shiming Tang, Minghui Qi, Hongyang Zhao, Meng Wu, Shi-Wen Huang
Theranostics 2025; 15(11): 4909-4929. doi:10.7150/thno.107812
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AIG1 protects against doxorubicin-induced cardiomyocyte ferroptosis and cardiotoxicity by promoting ubiquitination-mediated p53 degradation
Yuekai Shi, Jieru Cai, Lu Chen, Hao Cheng, Xiaoyue Song, Junqiang Xue, Rende Xu, Jianying Ma, Junbo Ge
Theranostics 2025; 15(11): 4931-4954. doi:10.7150/thno.108410
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Biomimetic piezoelectric hydrogel system for energy metabolism reprogramming in spinal cord injury repair
Guoliang Shi, Tianqi Su, Junyang Li, Aoao Wang, Gan Gao, Benzhang Tao, Nantian Chen, Lu Tian, Jun Yan, Lingzhou Zhao, Jianning Zhang, Yantao Zhao
Theranostics 2025; 15(11): 4955-4969. doi:10.7150/thno.108329
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KMV-mediated cardiomyocyte-to-endothelial cell signaling drives capillary rarefaction to promote heart failure following pressure overload
Chenxi Gao, Yudong Xia, Chaofang Li, Tao Zhou, Wenyu Zhang, Hao Cheng, Xiaojin Zhang, Yunhao Yu, Chuanfu Li, Zhengnian Ding, Jun Wu, Li Liu
Theranostics 2025; 15(11): 4970-4988. doi:10.7150/thno.104899
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Inhibition of CAV1 attenuates diabetic cardiomyopathy through reducing ferroptosis via activating NRF2/GCLC signaling pathway
Guangru Li, Ruiqing Liu, Zeyan Peng, Shengzheng Zhang, Runjia Sun, Ziwei Wang, Jing Li, Yang Gao, Yang Xu, Jianlin Cui, Jie Liu, Jie Yan, Lei Cao, Shan Ren, Yushun Chu, Lifeng Feng, Liang Yang, Yanna Shen, Zhi Qi
Theranostics 2025; 15(11): 4989-5006. doi:10.7150/thno.107367
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PD-1 activation mitigates lupus nephritis by suppressing hyperactive and heterogeneous PD-1+CD8+ T cells
Jun Deng, Junling Zhu, Xiaoyue Jiang, Chao Yao, Haifeng Chen, Yanjie Ding, Peng Niu, Qian Chen, Huihua Ding, Nan Shen
Theranostics 2025; 15(11): 5029-5044. doi:10.7150/thno.107418
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Reviews

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Current landscape and future directions of targeted-alpha-therapy for glioblastoma treatment
Loris Roncali, François Hindré, Edouard Samarut, Franck Lacoeuille, Audrey Rousseau, Jean-Michel Lemée, Emmanuel Garcion, Michel Chérel
Theranostics 2025; 15(11): 4861-4889. doi:10.7150/thno.106081
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Nanomaterials-mediated adenosine pathway inhibition for strengthening cancer immunotherapy
Wenhu Zhu, Fei Wu, Zhanhong Qiao, Ming Zhao, Haiyang Hu
Theranostics 2025; 15(11): 5007-5028. doi:10.7150/thno.108931
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Sex bias in tumor immunity: insights from immune cells
Xuerui Tao, Yiling Wang, Binghua Xiang, Dongmei Hu, Wei Xiong, Wenjun Liao, Shichuan Zhang, Chi Liu, Xiaoxiao Wang, Yue Zhao
Theranostics 2025; 15(11): 5045-5072. doi:10.7150/thno.106465
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