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Volume 15 (10); 2025
Research Papers
EphA2-targeted alpha-particle theranostics for enhancing PDAC treatment Ajay Kumar Sharma, Kuldeep Gupta, Akhilesh Mishra, Gabriela Lofland, Sophia Y. Chen, Ian Marsh, Peyton T Fair, Robert F. Hobbs, Todd M. Armstrong, Elizabeth M. Jaffee, Edward W. Gabrielson, Lei Zheng, Sridhar Nimmagadda
Theranostics 2025; 15(10): 4229-4246. doi:10.7150/thno.106948
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LRG1 inhibition promotes acute pancreatitis recovery by inducing cholecystokinin Type 1 receptor expression via Akt Seok Ting Lim, Xinmei Zhao, Shuqing Liu, Wenjuan Zhang, Yuanyang Tan, Nidula Mullappilly, Sandip M Swain, Mei Ling Leong, Ravisankar Rajarethinam, Kah Fei Wan, Christiane Ruedl, Rodger A. Liddle, Liang Li, Xiaomeng Wang
Theranostics 2025; 15(10): 4247-4269. doi:10.7150/thno.110116
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Improved optogenetic modification of the spiral ganglion neurons for future optical cochlear implants Anupriya Thirumalai, Jana Henseler, Marzieh Enayati, Kathrin Kusch, Roland Hessler, Tobias Moser, Antoine Tarquin Huet
Theranostics 2025; 15(10): 4270-4286. doi:10.7150/thno.104474
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Nanoparticle-assisted targeting of heart lesions with cardiac myofibroblasts: Combined gene and cell therapy Miriam Schiffer, Kevin Wagner, Esther Carls, Julia Nicke, Michael Hesse, Raluca M. Fratila, Staffan Hildebrand, Dietmar Eberbeck, Timo Mohr, Mona Malek Mohammadi, Jesus Martinez de la Fuente, Bernd K. Fleischmann, Wilhelm Roell
Theranostics 2025; 15(10): 4287-4307. doi:10.7150/thno.103816
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Colorectal cancer stem cells develop NK cell resistance via homotypic cell-in-cell structures suppressed by Stathmin1 Yen-Yu Lin, Hsin-Yi Lan, Hao-Wei Teng, Ya-Pei Wang, Wen-Chun Lin, Wei-Lun Hwang
Theranostics 2025; 15(10): 4308-4324. doi:10.7150/thno.110379
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A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY Zhidan Zhang, Meijie Chen, Yitong Xu, Zhihua Wang, Zhenghong Liu, Chenyang He, Fanshun Zhang, Xiaojun Feng, Xiayun Ni, Yuanli Chen, Jixia Wang, Xinmiao Liang, Zhifu Xie, Jingya Li, Maciej Banach, Jaroslav Pelisek, Yuqing Huo, Yunhui Hu, Paul C Evans, Li Wang, Xiao-yu Tian, Jianbo Xiao, Yuhua Shang, Yijun Zheng, Xunde Xian, Jianping Weng, Suowen Xu
Theranostics 2025; 15(10): 4325-4344. doi:10.7150/thno.105782
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GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation Yanfei Cheng, Guobin Zheng, Heming Huang, Jingyu Ni, Yun Zhao, Yuting Sun, Yingxin Chang, Shangjing Liu, Feng He, Dan Li, Yuying Guo, Yaodong Miao, Mengxin Xu, Dongyue Wang, Yunsha Zhang, Yunqing Hua, Shu Yang, Guanwei Fan, Chuanrui Ma
Theranostics 2025; 15(10): 4345-4367. doi:10.7150/thno.110324
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AMBP protects against aortic valve calcification by inhibiting ERK1/2 and JNK pathways mediated by FHL3 Chenghu Guo, Xiaoling Liu, Zeyuan Mei, Meiling Chang, Jiaqi Li, Baiqiang Wang, Wei Ji, Meng Zhang, Mei Zhang, Cheng Zhang, Guipeng An
Theranostics 2025; 15(10): 4398-4415. doi:10.7150/thno.109182
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RNF138 regulates skeletal muscle differentiation via the Wnt/β-catenin signaling pathway Wenhao Wang, Zhuohua Wang, Rourong Li, Weiyi Huang, Qiao Ling, Xiaoxiao Li, Zan Li, Manqi Cao, Zhihui Zhang, Qingrong Sun, Zhijuan Liang, Hua-an Zhang, Xuan Jiang, Chuwen Lin, Yaoqing Chen, Bo Zhao, Yu Zhao, Ji-An Pan, Xiaoxue Peng
Theranostics 2025; 15(10): 4446-4464. doi:10.7150/thno.110925
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Injectable cellular vesicle-based bone meal for inflammatory bone defect repair through restoring immune homeostasis Yu-Yue Zhao, Qian-Fang Meng, Hao Cui, Wei Liu, Yan Chen, Zhou Lan, Hao Chen, Dan-Dan Ma, Lang Rao, Guang-Tao Yu
Theranostics 2025; 15(10): 4465-4480. doi:10.7150/thno.110795
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Two-plex in vivo molecular imaging in the second near-infrared window for immunotherapeutic response Yupeng Sun, Rui Li, Yike Cai, Yan Liu, Peiyuan Wang, Ming Wu, Xiaolong Zhang, Naishun Liao, Cuilin Zhang, Aixian Zheng, Haipo Xu, Rui Zeng, Yongyi Zeng, Xiaolong Liu
Theranostics 2025; 15(10): 4481-4494. doi:10.7150/thno.108880
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Targeting formyl peptide receptor 2 to suppress neuroinflammation in neuromyelitis optica spectrum disorder Caiyun Qi, Hongying Hao, Wei Zhang, Yiwei Fu, Yali Han, Jinyi Li, Lixiang Chen, Guiyun Cui, Qing Liu, Yuan Li, Xiaozhen Wang, Ming-Wei Wang, Qiang Liu
Theranostics 2025; 15(10): 4495-4506. doi:10.7150/thno.107303
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Hyperglycemia-induced DNA damage response activates DNA-PK complex to promote endothelial ferroptosis in type 2 diabetic cardiomyopathy Cheng Luo, Chen Fang, Rongjun Zou, Jingwei Jiang, Miao Zhang, Teng Ge, Hao Zhou, Xiaoping Fan, Baoshi Zheng, Zhiyu Zeng
Theranostics 2025; 15(10): 4507-4525. doi:10.7150/thno.109514
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Targeting USP11 counteracts SFTPCI73T-associated interstitial lung disease in hiPSCs-derived alveolar organoids and in vivo models Janardhan Keshav Karapurkar, Sripriya Rajkumar, Ji-Hye Jung, Ji-Young Kim, Girish Birappa, D. A. Ayush Gowda, Jencia Carminha Colaco, Bharathi Suresh, Jung-Yun Choi, Sang Hyeon Woo, Won-Jun Jo, Jong-Hee Lee, Kye-Seong Kim, Seok-Ho Hong, Suresh Ramakrishna
Theranostics 2025; 15(10): 4526-4549. doi:10.7150/thno.105994
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Toward the clinical translation of safe intravenous long circulating ILNEs contrast agent for CT imaging Mohamed F. Attia, Ryan N. Marasco, Samuel Kwain, Charity Foxx, Daniel C. Whitehead, Alexander Kabanov, Yueh Z. Lee
Theranostics 2025; 15(10): 4550-4565. doi:10.7150/thno.110014
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ROS-responsive MnO2 mesoporous hydrogel to modulate liver-muscle crosstalk and mitigate NAFLD-associated sarcopenia via exosomal miR-582-5p delivery Songling Jiang, Tae Min Kim, Sung Young Park, Eun-Jung Jin
Theranostics 2025; 15(10): 4579-4592. doi:10.7150/thno.108280
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FOS-driven inflammatory CAFs promote colorectal cancer liver metastasis via the SFRP1-FGFR2-HIF1 axis Long Liu, Yuhao Ba, Shuaixi Yang, Aning Zuo, Shutong Liu, Yuyuan Zhang, Shuqin Xu, Siyuan Weng, Benyu Liu, Peng Luo, Quan Cheng, Jinhai Deng, Hui Xu, Yukang Chen, Chuhan Zhang, Xing Zhou, Yuqing Ren, Xinwei Han, Zhenyu Hou, Zaoqu Liu
Theranostics 2025; 15(10): 4593-4613. doi:10.7150/thno.111625
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The basolateral amygdala-anterior cingulate cortex circuit contributes to postherpetic neuralgia-anxiety comorbidity Xiaofeng Jiang, Yi Yan, Ziming Chen, Jiaxin Xiong, Xuexue Zhang, Lili Gu, Yong Zhang, Mengye Zhu, Daying Zhang, Jian Jiang
Theranostics 2025; 15(10): 4614-4637. doi:10.7150/thno.111130
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DNA nanorobot for mitochondria-targeted microRNAs detection and tailored regulation Ping Huang, Xiaoqi Tang, Shuang Zhao, Jie Luo, Yu Tang, Binpan Wang, Zuowei Xie, Xianlan Wu, Shuang Xie, Ming Chen, Kai Chang
Theranostics 2025; 15(10): 4638-4653. doi:10.7150/thno.105762
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A brain-accessible peptide modulates stroke inflammatory response and neurotoxicity by targeting BDNF-receptor TrkB-T1 specific interactome Lola Ugalde-Triviño, Gonzalo S. Tejeda, Gema M. Esteban-Ortega, Margarita Díaz-Guerra
Theranostics 2025; 15(10): 4654-4672. doi:10.7150/thno.111272
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A new nano-encapsulated TSPO ligand reduces neuroinflammation and improves cognitive functions in Alzheimer's disease model Antonella Casamassa, Paola Brancaccio, Virginia Campani, Angela Corvino, Serenella Anzilotti, Giovanni Pecoraro, Giorgia Andreozzi, Raffaella Daniele, Ilaria Piccialli, Anna Pannaccione, Pierluigi Reveglia, Lucia Lecce, Carmela Paolillo, Ferdinando Fiorino, Giuseppe De Rosa, Giuseppe Caliendo, Lucio Annunziato, Giuseppe Pignataro
Theranostics 2025; 15(10): 4673-4692. doi:10.7150/thno.106083
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In vivo spatiotemporal mapping of proliferation activity in gliomas via water-exchange dynamic contrast-enhanced MRI Ruiliang Bai, Yinhang Jia, Bao Wang, Zejun Wang, Guangxu Han, Lijun Liang, Lin Chen, Yang Ming, Guidong Zhu, Yi-Cheng Hsu, Peng Zhao, Yi Zhang, Zhiqiang Liu, Chong Liu, Zhaoqing Li, Yingchao Liu
Theranostics 2025; 15(10): 4693-4707. doi:10.7150/thno.108479
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Microglial Lcn2 knockout enhances chronic intracerebral hemorrhage recovery by restoring myelin and reducing inflammation Li Wang, Lei Zhang, Kai Wang, Jun He, Liang Yuan, Yangang Wang, Weihao Lv, Zehan Zhang, Yuan Feng, Hongchen Zhang, Min Zhang, Rui Lv, Ya-nan Dou, Xiaowei Fei, Jialiang Wei
Theranostics 2025; 15(10): 4763-4784. doi:10.7150/thno.109440
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Deciphering single-cell landscape unravels cell-type-specific functional roles of RNA m6A modification in atherosclerosis Xiaorui Ping, Xiaoyun Liang, Wenlu Xing, Saiqi Wang, Fengcongzhe Gong, Yaqi Cheng, Songqi Duan, Xueqi Lv, Xueying Li, Tianli Zhang, Chunxiao Chen, Yuxin Zhang, Chengzhu Yuan, Shangyu Liu, Gang Liu, Baofa Sun
Theranostics 2025; 15(10): 4785-4807. doi:10.7150/thno.104179
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Acupuncture alleviates CSDS-induced depressive-like behaviors by modulating synaptic plasticity in vCA1 Lin Cong, Shengkai Ding, Yu Guo, Jiamin Tian, Lu Liu, Mengqi Su, Ruilin Xie, Yinuo Wang, Tongrui Wu, Lianbin Zhao, Xiaogang Pang, Yuhong Jing, Hao Wu, Hui Shen, Yuanyuan Li
Theranostics 2025; 15(10): 4808-4822. doi:10.7150/thno.106751
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Neutrophil hitchhiking liposomal drugs for starvation therapy in endometriosis Mengni Zhou, Ying Wang, Caihua Li, Jinfu Li, Renbin Dou, Huanhuan Jiang, Yunjiao Zhang, Dawei Chen, Jiqian Zhang, Shasha Zhu
Theranostics 2025; 15(10): 4848-4860. doi:10.7150/thno.107758
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Reviews
Targeted radioligand therapy: physics and biology, internal dosimetry and other practical aspects during 177Lu/225Ac treatment in neuroendocrine tumors and metastatic prostate cancer Habibollah Dadgar, Ali Pashazadeh, Nasim Norouzbeigi, Majid Assadi, Batool Al-balooshi, Richard P. Baum, Akram Al-Ibraheem, Mohamad Haidar, Mohsen Beheshti, Parham Geramifar, Reza Vali, Seyed Mohammadi, Swagat Dash, Vindhya Malasani, Andrea Cimini, Maria Ricci, Abdulredha A. Esmail, Sarah Murad, Fahad Marafi, Giorgio Treglia, Aysar Najeh Khalaf, Farah M. Anwar, Sharjeel Usmani, Yehia Omar, Haider Muhsin, Igore E. Tyurin, Andrew Zakhary, Sahar Al-Sebaie, Danny Mena Cortes, Maryam AlHashim, Hossein Arabi, Habib Zaidi
Theranostics 2025; 15(10): 4368-4397. doi:10.7150/thno.107963
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Targeted spleen modulation: a novel strategy for next-generation disease immunotherapy Wei Dong, Yucheng Li, Qiaoman Fei, Senyang Li, Xinrui He, Yichao Chai, Junyi Zhou, Yujin Zong, Jing Geng, Zongfang Li
Theranostics 2025; 15(10): 4416-4445. doi:10.7150/thno.111116
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Artificial intelligence in chronic kidney disease management: a scoping review Charumathi Sabanayagam, Riswana Banu, Cynthia Lim, Yih Chung Tham, Ching-Yu Cheng, Gavin Tan, Elif Ekinci, Bin Sheng, Gareth McKay, Jonathan E. Shaw, Kunihiro Matsushita, Navdeep Tangri, Jason Choo, Tien Y. Wong
Theranostics 2025; 15(10): 4566-4578. doi:10.7150/thno.108552
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Leveraging adenosine triphosphate for cancer theranostics Yuhan Li, Xinyu Zhang, Jianhua Wang, Kexin Wang, Boya Li, Xianghe Qiao, Wei He, Jinghua Cai, Danfeng Liu, Lei-Lei Yang
Theranostics 2025; 15(10): 4708-4733. doi:10.7150/thno.106291
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Nanocatalytic system releases overloaded zinc ions and ROS to induce Znproptosis and interrupt cell cycle through inhibiting Akt/mTOR pathway Zi-Yue Xi, Chuan-Yong Fan, Ying-Ying Jiang, Xin-Ran Xi, Gan-Yu Nie, Shuang Zhu, Jun-Jie Zhang, Lu Xu
Theranostics 2025; 15(10): 4734-4762. doi:10.7150/thno.107025
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Macrophage membrane-functionalized nanotherapeutics for tumor targeted therapy Mubassir Khan, Razi Ullah, Guixue Wang, Maoquan Chu
Theranostics 2025; 15(10): 4823-4847. doi:10.7150/thno.108875
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