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Volume 12 (3); 2022

Research Papers

Graphic abstract

Simultaneous imaging of calcium and contraction in the beating heart of zebrafish larvae
Jussep Salgado-Almario, Manuel Vicente, Yillcer Molina, Antonio Martinez-Sielva, Pierre Vincent, Beatriz Domingo, Juan Llopis
Theranostics 2022; 12(3): 1012-1029. doi:10.7150/thno.64734
[Abstract] [Full text] [PDF]


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Macropinocytic dextran facilitates KRAS-targeted delivery while reducing drug-induced tumor immunity depletion in pancreatic cancer
Fang Yuan, Mengnan Sun, Zhengsheng Liu, Huiqin Liu, Weijian Kong, Rui Wang, Feng Qian
Theranostics 2022; 12(3): 1061-1073. doi:10.7150/thno.65299
[Abstract] [Full text] [PDF]


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Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis
Yue Chen, Hua Wang, Qiudong Yang, Wenhua Zhao, Yuyi Chen, Qiaoqi Ni, Wenlei Li, Jiali Shi, Wei Zhang, Lu Li, Yan Xu, Hengwei Zhang, Dengshun Miao, Lianping Xing, Wen Sun
Theranostics 2022; 12(3): 1074-1096. doi:10.7150/thno.65694
[Abstract] [Full text] [PDF]


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Overexpression of BACH1 mediated by IGF2 facilitates hepatocellular carcinoma growth and metastasis via IGF1R and PTK2
Meng Xie, Mengyu Sun, Xiaoyu Ji, Dongxiao Li, Xiaoping Chen, Bixiang Zhang, Wenjie Huang, Tongyue Zhang, Yijun Wang, Dean Tian, Limin Xia
Theranostics 2022; 12(3): 1097-1116. doi:10.7150/thno.65775
[Abstract] [Full text] [PDF]


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Bioorthogonal catalytic nanozyme-mediated lysosomal membrane leakage for targeted drug delivery
Zhiyuan Sun, Qiqi Liu, Xinyue Wang, Jin Wu, Xueyan Hu, Miaomiao Liu, Xiangyun Zhang, Yonghua Wei, Zhijun Liu, Hongjiang Liu, Rui Chen, Fei Wang, Adam C. Midgley, Aitao Li, Xiyun Yan, Yanming Wang, Jie Zhuang, Xinglu Huang
Theranostics 2022; 12(3): 1132-1147. doi:10.7150/thno.66325
[Abstract] [Full text] [PDF]


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A T-cell independent universal cellular therapy strategy through antigen depletion
Dan Li, Wenbing Wang, Shufeng Xie, Maolin Ge, Ruiheng Wang, Qiongyu Xu, Yan Sun, Jiang Zhu, Han Liu
Theranostics 2022; 12(3): 1148-1160. doi:10.7150/thno.66832
[Abstract] [Full text] [PDF]


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Type 2 innate immunity drives distinct neonatal immune profile conducive for heart regeneration
Francis M. Chen, Joyce KY Tse, Leigang Jin, Chui Yiu Bamboo Chook, Fung Ping Leung, Gary Tse, Connie W. Woo, Aimin Xu, Ajay Chawla, Xiao Yu Tian, Ting-Fung Chan, Wing Tak Wong
Theranostics 2022; 12(3): 1161-1172. doi:10.7150/thno.67515
[Abstract] [Full text] [PDF]


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α-Catulin promotes cancer stemness by antagonizing WWP1-mediated KLF5 degradation in lung cancer
Chia-Hao Tung, Meng-Fan Huang, Chen-Hsien Liang, Yi-Ying Wu, Jia-En Wu, Cheng-Lung Hsu, Yuh-Ling Chen, Tse-Ming Hong
Theranostics 2022; 12(3): 1173-1186. doi:10.7150/thno.63627
[Abstract] [Full text] [PDF]


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Antibiotic Azithromycin inhibits brown/beige fat functionality and promotes obesity in human and rodents
Jian Yu, Xin Chen, Yuanjin Zhang, Xiangdi Cui, Zhe Zhang, Wenxiu Guo, Dongmei Wang, Shengbo Huang, Yanru Chen, Yepeng Hu, Cheng Zhao, Jin Qiu, Yu Li, Meiyao Meng, Mingwei Guo, Fei Shen, Mengdi Zhang, Ben Zhou, Xuejiang Gu, Jiqiu Wang, Xin Wang, Xinran Ma, Lingyan Xu
Theranostics 2022; 12(3): 1187-1203. doi:10.7150/thno.63067
[Abstract] [Full text] [PDF]


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Overcoming resistance to EGFR monotherapy in HNSCC by identification and inhibition of individualized cancer processes
Maria R. Jubran, Daniela Vilenski, Efrat Flashner-Abramson, Efraim Shnaider, Swetha Vasudevan, Ariel M. Rubinstein, Amichay Meirovitz, Shay Sharon, David Polak, Nataly Kravchenko-Balasha
Theranostics 2022; 12(3): 1204-1219. doi:10.7150/thno.64347
[Abstract] [Full text] [PDF]


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Garlic exosome-like nanoparticles reverse high-fat diet induced obesity via the gut/brain axis
Kumaran Sundaram, Jingyao Mu, Anil Kumar, Jyotirmaya Behera, Chao Lei, Mukesh K Sriwastva, Fangyi Xu, Gerald W Dryden, Lifeng Zhang, ShaoYu Chen, Jun Yan, Xiang Zhang, Juw Won Park, Michael L Merchant, Neetu Tyagi, Yun Teng, Huang-Ge Zhang
Theranostics 2022; 12(3): 1220-1246. doi:10.7150/thno.65427
[Abstract] [Full text] [PDF]


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Engineered extracellular vesicle-based sonotheranostics for dual stimuli-sensitive drug release and photoacoustic imaging-guided chemo-sonodynamic cancer therapy
Thuy Giang Nguyen Cao, Ji Hee Kang, Wangyu Kim, Junha Lim, Su Jin Kang, Jae Young You, Quan Truong Hoang, Won Jong Kim, Won Jong Rhee, Chulhong Kim, Young Tag Ko, Min Suk Shim
Theranostics 2022; 12(3): 1247-1266. doi:10.7150/thno.65516
[Abstract] [Full text] [PDF]


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Overexpression of MFN2 alleviates sorafenib-induced cardiomyocyte necroptosis via the MAM-CaMKIIδ pathway in vitro and in vivo
Ziping Song, Haixu Song, Dan Liu, Bing Yan, Daowen Wang, Yan Zhang, Xiaojie Zhao, Xiaoxiang Tian, Chenghui Yan, Yaling Han
Theranostics 2022; 12(3): 1267-1285. doi:10.7150/thno.65716
[Abstract] [Full text] [PDF]


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Mitochondrion-targeted supramolecular “nano-boat” simultaneously inhibiting dual energy metabolism for tumor selective and synergistic chemo-radiotherapy
Jie Gao, Zhilong Wang, Qingxiang Guo, Huan Tang, Zhongyan Wang, Cuihong Yang, Huirong Fan, Wenxue Zhang, Chunhua Ren, Jianfeng Liu
Theranostics 2022; 12(3): 1286-1302. doi:10.7150/thno.67543
[Abstract] [Full text] [PDF]


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Hedgehog signaling is controlled by Rac1 activity
Chao Tang, Ximei Wu, Qianlei Ren, Minli Yao, Shouying Xu, Ziyi Yan
Theranostics 2022; 12(3): 1303-1320. doi:10.7150/thno.67702
[Abstract] [Full text] [PDF]


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Three-dimensional colon cancer organoids model the response to CEA-CD3 T-cell engagers
Alvaro Teijeira, Itziar Migueliz, Saray Garasa, Vaios Karanikas, Carlos Luri, Asunta Cirella, Irene Olivera, Marta Cañamero, Maite Alvarez, Maria C. Ochoa, Ana Rouzaut, Maria E. Rodriguez-Ruiz, Miguel F. Sanmamed, Christian Klein, Pablo Umaña, Mariano Ponz, Marina Bacac, Ignacio Melero
Theranostics 2022; 12(3): 1373-1387. doi:10.7150/thno.63359
[Abstract] [Full text] [PDF]


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Ginger nanoparticles mediated induction of Foxa2 prevents high-fat diet-induced insulin resistance
Anil Kumar, Kumaran Sundaram, Yun Teng, Jingyao Mu, Mukesh K Sriwastva, Lifeng Zhang, Joshua L. Hood, Jun Yan, Xiang Zhang, Juw Won Park, Michael L Merchant, Huang-Ge Zhang
Theranostics 2022; 12(3): 1388-1403. doi:10.7150/thno.62514
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Dysfunction of striatal MeCP2 is associated with cognitive decline in a mouse model of Alzheimer's disease
Sangjoon Lee, Tae Kyoo Kim, Ji Eun Choi, Yunjung Choi, Minsu You, Jeewon Ryu, Yoo Lim Chun, Suji Ham, Seung Jae Hyeon, Hoon Ryu, Hye-Sun Kim, Heh-In Im
Theranostics 2022; 12(3): 1404-1418. doi:10.7150/thno.68439
[Abstract] [Full text] [PDF]


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Downregulation of low-density lipoprotein receptor mRNA in lymphatic endothelial cells impairs lymphatic function through changes in intracellular lipids
Laurent Vachon, Ali Smaani, Nolwenn Tessier, Gabriel Jean, Annie Demers, Andreea Milasan, Nadine Ardo, Stéphanie Jarry, Louis Villeneuve, Azadeh Alikashani, Vincent Finherty, Matthieu Ruiz, Mary G. Sorci-Thomas, Gaétan Mayer, Catherine Martel
Theranostics 2022; 12(3): 1440-1458. doi:10.7150/thno.58780
[Abstract] [Full text] [PDF]

Reviews

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Novel insights into the roles and therapeutic implications of MUC1 oncoprotein via regulating proteins and non-coding RNAs in cancer
Wei Li, Yineng Han, Chenmin Sun, Xue Li, Junhua Zheng, Jianping Che, Xudong Yao, Donald Kufe
Theranostics 2022; 12(3): 999-1011. doi:10.7150/thno.63654
[Abstract] [Full text] [PDF]


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Nanocarriers for pancreatic cancer imaging, treatments, and immunotherapies
Luman Liu, Prakash G. Kshirsagar, Shailendra K. Gautam, Mansi Gulati, Emad I. Wafa, John C. Christiansen, Brianna M. White, Surya K. Mallapragada, Michael J. Wannemuehler, Sushil Kumar, Joyce C. Solheim, Surinder K. Batra, Aliasger K. Salem, Balaji Narasimhan, Maneesh Jain
Theranostics 2022; 12(3): 1030-1060. doi:10.7150/thno.64805
[Abstract] [Full text] [PDF]


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Modulation of lymphatic transport in the central nervous system
Wenzhong Li, Dawei Chen, Nan Liu, Yongxin Luan, Shoujun Zhu, Haifeng Wang
Theranostics 2022; 12(3): 1117-1131. doi:10.7150/thno.66026
[Abstract] [Full text] [PDF]


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Exploiting macropinocytosis for drug delivery into KRAS mutant cancer
Huiqin Liu, Feng Qian
Theranostics 2022; 12(3): 1321-1332. doi:10.7150/thno.67889
[Abstract] [Full text] [PDF]


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Integrative biology of extracellular vesicles in diabetes mellitus and diabetic complications
Jing Liu, Yanyan Zhang, Yan Tian, Wei Huang, Nanwei Tong, Xianghui Fu
Theranostics 2022; 12(3): 1342-1372. doi:10.7150/thno.65778
[Abstract] [Full text] [PDF]


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Oral delivery of protein and peptide drugs: from non-specific formulation approaches to intestinal cell targeting strategies
Guanyu Chen, Weirong Kang, Wanqiong Li, Shaomeng Chen, Yanfeng Gao
Theranostics 2022; 12(3): 1419-1439. doi:10.7150/thno.61747
[Abstract] [Full text] [PDF]


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Activated molecular probes for enzyme recognition and detection
Meng Yuan, Ying Wu, Caiyan Zhao, Zhongxiang Chen, Lichao Su, Huanghao Yang, Jibin Song
Theranostics 2022; 12(3): 1459-1485. doi:10.7150/thno.66676
[Abstract] [Full text] [PDF]

Errata

Fusobacterium nucleatum Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression: Erratum
Yongyu Chen, Yan Chen, Jixiang Zhang, Pan Cao, Wenhao Su, Yunchao Deng, Na Zhan, Xiangsheng Fu, Yun Huang, Weiguo Dong
Theranostics 2022; 12(3): 1333-1334. doi:10.7150/thno.69114
[Abstract] [Full text] [PDF]


circPTCH1 promotes invasion and metastasis in renal cell carcinoma via regulating miR-485-5p/MMP14 axis: Erratum
Huan Liu, Guanghui Hu, Zaoyu Wang, Qunlong Liu, Jin Zhang, Yonghui Chen, Yiran Huang, Wei Xue, Yunfei Xu, Wei Zhai
Theranostics 2022; 12(3): 1335-1336. doi:10.7150/thno.69378
[Abstract] [Full text] [PDF]


Low-intensity Pulsed Ultrasound regulates alveolar bone homeostasis in experimental Periodontitis by diminishing Oxidative Stress: Erratum
Siqi Ying, Minmin Tan, Ge Feng, Yunchun Kuang, Duanjing Chen, Jie Li, Jinlin Song
Theranostics 2022; 12(3): 1337-1340. doi:10.7150/thno.69529
[Abstract] [Full text] [PDF]


Focused ultrasound activates voltage-gated calcium channels through depolarizing TRPC1 sodium currents in kidney and skeletal muscle
Scott R. Burks, Rebecca M. Lorsung, Matthew E. Nagle, Tsang-Wei Tu, Joseph A. Frank
Theranostics 2022; 12(3): 1341. doi:10.7150/thno.69908
[Abstract] [Full text] [PDF]