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Volume 16 (7); 2026

Research Papers

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Imaging CRISPR-edited CAR-T cell therapies with optical and positron emission tomography reporters
Rafael Enrique Sanchez-Pupo, John Joseph Kelly, Nourhan Shalaby, Ying Xia, Francisco Manuel Martinez-Santiesteban, Jasmine Lau, Ivy Elizabeth Verriet, Matthew Stefan Fox, Justin Wesley Hicks, Jonathan Dale Thiessen, John Andrew Ronald
Theranostics 2026; 16(7): 3227-3245. doi:10.7150/thno.119013
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Tumor cell FAP orchestrates EMT and immune suppression in aggressive localized ccRCC
Teijo Pellinen, Lassi Luomala, Kalle E Mattila, Annabrita Hemmes, Katja Välimäki, Mariliina Arjama, Oscar Brück, Lassi Paavolainen, Elisa Kankkunen, Harry Nisén, Petrus Järvinen, Leticia Castillon, Sakari Vanharanta, Paula Vainio, Olli Kallioniemi, Panu M. Jaakkola, Tuomas Mirtti
Theranostics 2026; 16(7): 3246-3262. doi:10.7150/thno.118400
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Hilnc-mediated UCP1 translation repression contributes to thermogenesis and energy expenditure
Man Jiang, Yu Li, Yiao Jiang, Runze Wang, Jiayin Peng, Yuang Wang, Zhen Qu, Yi Chang, Zhao Zhang, Yun Zhao
Theranostics 2026; 16(7): 3263-3285. doi:10.7150/thno.122688
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Enhancing prestin oligomerization for superior sonogenetics
Hsien-Chu Wang, Thi-Nhan Phan, Tzu-Han Chen, Yun Lin, Ning Hsu, Ching-Hsiang Fan, Po-Han Chiang, Chun-Hao Chen, Chih-Kuang Yeh, Yu-Chun Lin
Theranostics 2026; 16(7): 3321-3337. doi:10.7150/thno.122468
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Targeting the FOSL1/IKKα positive feedback loop attenuates glioblastoma malignancy via suppression of NF-κB signaling
Beichen Zhang, Hao Tian, Haoyu Zhou, Yichang Wang, Ke Gao, Yiyang Cao, Mingjing Zhou, Maode Wang, Wei Wu, Jia Wang
Theranostics 2026; 16(7): 3338-3362. doi:10.7150/thno.121770
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Macrophage-biomimetic nanomedicine for targeted therapy of abdominal aortic aneurysm via Nrf2/NF-κB pathway
Qiujie Luo, Wei Meng, Jiahui Wang, Xiang Zhang, Qingbo Meng, Mengjie Hu, Shunbo Wei, Xiaobo Yu, Dawei Deng, Yuqin Zhang, Zixuan Ma, Shentao Li, Shuang Wang, Binhao Zhang, Jingli Ding, Jinping Liu, Jianliang Zhou
Theranostics 2026; 16(7): 3363-3383. doi:10.7150/thno.123428
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Nanobody Nb07 mitigates sepsis by blocking the PFKM-p53-PD-1 axis to enhance macrophage phagocytosis
Binbin Ji, Hui Guo, Rong Xing, Miaomiao Sun, Yu Cheng, Chen Yao, Hanyong Zhu, Xuerong Wang, Ruihan Jiang, Xin Chen, Zimeng Liu, Suyan Wang, Fei Xu, Fangyu Zhang, Fuxing Dong, Xiucheng Pan, Jing Yang, Yuchen Pan
Theranostics 2026; 16(7): 3408-3425. doi:10.7150/thno.124303
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Tumor microbiome-transcriptome crosstalk identifies Prevotella as an immunotherapeutic predictor in NSCLC
Na Wang, Lifang Ma, Yugang Huang, Xionghui Zhou, Yuan Rong, Fei Long, Wanbo Qiu, Si Wu, Yue Hu, Xin He, Jiurong He, Sufang Tian, Weidong Hu, Chunhui Yuan, Fubing Wang
Theranostics 2026; 16(7): 3426-3446. doi:10.7150/thno.126091
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PLK1 stabilizes β-catenin to drive colorectal carcinogenesis through NFKB2-mediated transcriptional activation of USP2a and site-specific phosphorylation
Yan Li, Lili Zhao, Jiaqiang Deng, Songmei Lu, Jingyu Du, Chen Chen, Li Zhao, Zhiyun Xu, Wencan Wang, Yundi Wang, Fangdong Zou
Theranostics 2026; 16(7): 3488-3506. doi:10.7150/thno.122368
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Autocrine activity of engineered IL-33 mRNA enhances adoptive T-cell therapy for peritoneal carcinomatosis and synergizes with IL-12 mRNA
Leire Arrizabalaga, Claudia Augusta Di Trani, Celia Gomar, Daniel Moreno-Luqui, Nuria Ardaiz, Virginia Belsue, José González-Gomariz, David Ruiz-Guillamon, Aline Risson, Yufei Zheng, Eduardo Huarte, Ignacio Matos, Ignacio Melero, Pedro Berraondo, Fernando Aranda
Theranostics 2026; 16(7): 3541-3555. doi:10.7150/thno.122132
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Characterization and validation of a bone metastatic castration-resistant prostate cancer model as a nanomedicine evaluation platform
Antoni Serrano-Martí, Ana Armiñán, Inmaculada Conejos-Sánchez, Daniela Mittermüller, Shang-Wei Li, Paula Tenhaeff Lackschewitz, Esther Roselló-Sastre, Matthias Gunzer, Horacio Cabral, María J. Vicent
Theranostics 2026; 16(7): 3556-3576. doi:10.7150/thno.123005
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Microvascular endothelial metabolic dysfunction drives cerebral edema through bioenergetic failure after ischemia-reperfusion
Yi-Fan Zhou, Si-Bo Yang, Feng Zhang, Xiao-Di Sun, Bo-Hao Chang, Ya-Nan Li, Jie-Hong Wu, Hui-Juan Jin, Ming Huang, Sheng-Cai Chen, Hang Yang, Dong-Ya Zhu, Bijoy K Menon, Bo Hu
Theranostics 2026; 16(7): 3577-3598. doi:10.7150/thno.127083
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Coupling proteostasis and de novo purine biosynthesis of PSMD14 fuels glioblastoma progression and chemoresistance
Jiazheng Wang, Qun Cao, Zhikai Li, Xuxiu Lu, Zhuo Li, Chenghui Guo, Yuan Pan, Qing Zhang, Wenjie Li, Guo Xiang, Anjing Chen
Theranostics 2026; 16(7): 3599-3615. doi:10.7150/thno.124409
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Polydopamine nanoparticles restore cognition via targeted dopamine delivery and septo-hippocampal cholinergic activation
Pan-Miao Liu, Yu-Ge Wang, Ting-Ting Zhu, Ji-Chun Zhang, Han-Wen Gu, Hui-Juan Li, Wei-Tong Pan, Yan-Bo Zhou, Kui-Cheng Zhu, Kenji Hashimoto, Jian-Jun Yang
Theranostics 2026; 16(7): 3616-3633. doi:10.7150/thno.121735
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Reviews

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Nanomedicine in Organ Transplantation: From Graft Preservation and Repair to Immunomodulation and Monitoring
Leyi Wang, Chen Jin, Junjie Zhou, Jiani Yin, Gang Xu, Zhenyu Duan, Jiayin Yang, Qiyong Gong, Kui Luo
Theranostics 2026; 16(7): 3286-3320. doi:10.7150/thno.128348
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STING signaling pathway: An oasis in the glioblastoma immune desert
Yafei Wang, Weichen Duan, Chuang Yan, Xuenan Li, Rui Xing, Li Yu, Jiajia Chen
Theranostics 2026; 16(7): 3384-3407. doi:10.7150/thno.128135
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From nanotags to precision biomedicine: SERS-driven progress and innovation in tumor biomarker profiling, dynamic bioimaging, AI-enhanced diagnostics and therapy
Xuelin Chen, Tenglong Liu, Weiyuan Chen, Zhexuan Lin, Qiaoxin Zhang, Binbin Zhou, Xia Zhou
Theranostics 2026; 16(7): 3447-3487. doi:10.7150/thno.126530
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Recent advances in nanoparticles targeting TGF-β signaling for cancer treatment
Ziying Li, Xugang Ji, Xiaoyi Cong, Yu Gao, Jianqing Gao
Theranostics 2026; 16(7): 3507-3540. doi:10.7150/thno.126517
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