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Volume 16 (6); 2026
Research Papers
Quantitative dynamic granzyme B PET imaging to characterize novel combination immunotherapy response in preclinical glioblastoma models Carlos A. Gallegos, Yun Lu, Patrick N. Song, Rodrigo Queiroz, Ugur Akca, Sharmila Sridhar, Jennifer L. Bartels, Yujun Zhang, Li Li, Jason M. Warram, Suzanne E. Lapi, Benjamin M. Larimer, James M. Markert, Anna G. Sorace
Theranostics 2026; 16(6): 2649-2664. doi:10.7150/thno.123588
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Mechanosensitive snoRNA-like circular RNA sno-circCNOT1 drives endothelial dysfunction and atherosclerosis Lianru Bi, Yihao Zhu, Ziqi Chen, Yiying Yang, Yanlong Leng, Huijie Wang, Jiajie Pan, Xiaozhe Zhang, Zekai Zeng, Yunjun Liang, Guifu Wu, Wendong Fan
Theranostics 2026; 16(6): 2665-2683. doi:10.7150/thno.122995
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Curcumin coacervates for supramolecular-interaction-responsive cytosolic siRNA delivery to enhance pyroptosis Kai Cheng, Fang Zhang, Yishu Bao, Zhiyi Xu, Hao Kong, Dingdong Yuan, Zhong Zheng, Yuan-Di Zhao, Jiang Xia
Theranostics 2026; 16(6): 2705-2720. doi:10.7150/thno.121865
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Neuron-specific WDR5 epigenetically upregulates ARID5B to impair GABAergic synaptic transmission and promotes epileptogenesis Juan Gu, Ping-Yang Ke, Xin-Yu Zhang, Chao Liu, Yuan Yang, Ming-Lan Yu, Zhen-Zhong Xu, Chun-Xiang Zhang, Wei Dong
Theranostics 2026; 16(6): 2721-2747. doi:10.7150/thno.122246
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Precision radiolabeled B-cell maturation nanobody for targeted PET imaging and radioligand therapy of disseminated multiple myeloma Behnaz Ghaemi, Colleen P. Olkowski, Falguni Basuli, Jianfeng Shi, Ryan Young, Dickran Kazandjian, Ola Landgren, Elizabeth Hill, Peter L. Choyke, Orit Jacobson
Theranostics 2026; 16(6): 2748-2763. doi:10.7150/thno.126920
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A tumor-targeted heptamethine cyanine dye induces suppression of progesterone receptor activity to treat hormone receptor-positive breast cancer Yoonbin Park, Sang-Hyo Kim, Moon Suk Kim, Hoon Hyun
Theranostics 2026; 16(6): 2764-2779. doi:10.7150/thno.126396
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Engineered Dll4-overexpressing osteocyte-derived exosomes enhanced bone regeneration by regulating osteogenesis and angiogenesis Yujie Yan, Pengtao Wang, Xi Tang, Yuhang Wang, Mengting Xiao, Zhenbao Liu, Xiaolin Tu, Xian Li
Theranostics 2026; 16(6): 2780-2797. doi:10.7150/thno.121905
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Optimizing PSMA-617-based inhibitors through charged linker modifications: Insights into structure-activity relationships Nicolas M. Geis, Yvonne Braunwarth, Phillip T. Meyer, Matthias Eder, Ann-Christin Eder
Theranostics 2026; 16(6): 2798-2810. doi:10.7150/thno.118972
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Spatiotemporal NO/O2-releasing cascade nanozyme microneedles enhance diabetic infected wound healing by modulating the immune microenvironment Hanqing Zhao, Wenjun Shao, Man Jiang, Fangyuan Chen, Yingying Li, Xiaoyu Zhang, Tao Ma, Minglong Chen, Baohong Sun, Zekun Wang, Chuanbin Wu, Qingqing Wang
Theranostics 2026; 16(6): 2811-2828. doi:10.7150/thno.123827
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Enhanced formation of tertiary lymphoid structures shapes the anti-tumor microenvironment in gastrointestinal stromal tumors after imatinib targeted therapy Ping Tao, Jiongyuan Wang, Peidang Fan, Wenshuai Liu, Weiqi Lu, Yujie Hu, Qun Lu, Lijie Ma, Hanxing Tong, Yong Zhang
Theranostics 2026; 16(6): 2829-2844. doi:10.7150/thno.123923
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Glucosylceramide regulates depression through activating peroxisome proliferator-activated receptor gamma in dorsal striatum Linhong Jiang, Yuman He, Haxiaoyu Liu, Dingwen Zhang, Yanping Dai, Qian Bu, Quanshan Shi, Huaichuan Duan, Ying Zhao, Shu Li, Shuang Han, Yuanyi Zhou, Yue Zhao, Feng Qin, Yaxing Chen, Liang Wang, Hongchun Li, Chunqi Liu, Meng Qin, Weihong Kuang, Ni Zhang, Yinglan Zhao, Xiaobo Cen
Theranostics 2026; 16(6): 2845-2865. doi:10.7150/thno.123178
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Dual targeting of AMRC12 and Malassezia globosa disrupts MYC liquid condensates-driven nuclear pore complex biogenesis in neuroblastoma Anpei Hu, Chunhui Yang, Zhijie Wang, Xiaolin Wang, Xinyue Li, Shunchen Zhou, Bosen Zhao, Jiaying Qu, Xiaojing Wang, Liduan Zheng, Qiangsong Tong
Theranostics 2026; 16(6): 2866-2886. doi:10.7150/thno.120935
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Targeting CAMK1D-engineered nanoactivator suppresses cancer stem cell maintenance and immune evasion in enzalutamide-resistant prostate cancer Feifei Sun, Yuchuan Yan, Deqing Sun, Shijia Liu, Zhaoru Dong, Guoqiang Pan, Lin Zhang, Xianhao Shao, Yuliang Xu, Ying Qu, Tao Li
Theranostics 2026; 16(6): 2918-2935. doi:10.7150/thno.120826
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A novel whole cancer cell vaccine based on modified β-glucan elicits robust anti-tumor immunity Jianhan Huang, Yuyuan Wang, Junrong Zhu, Li Li, Lang Hu, Yuan Zhou, Baoguo Xiao, Yao Yu
Theranostics 2026; 16(6): 2936-2951. doi:10.7150/thno.121911
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Ligand-directed oral lipidic nanoplatform enables sustained ferroptosis and immune reprogramming via multivalent transporter-mediated metronomic delivery Laxman Subedi, In Ho Im, Arjun Dhwoj Bamjan, Jiwon Jeon, Susmita Phuyal, Yun-Hwa Jeong, Seung Hyun Kim, Jung-Hyun Shim, Jeong Uk Choi, Jin Woo Park
Theranostics 2026; 16(6): 2952-2983. doi:10.7150/thno.124189
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Splicing factor FUS facilitates the progression of PIT1-lineage PitNETs by upregulating MDM2 Xu Wang, Jiang Li, Chenggang Jiang, Chengkai Zhang, Linhao Yuan, Tieqiang Zhang, Yuqi Liu, Shunchang Ma, Peng Kang, Deling Li, Xiudong Guan, Jian Chen, Wang Jia
Theranostics 2026; 16(6): 3032-3049. doi:10.7150/thno.124068
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Engineered Poly (amino acid) Hydrogel Synchronizes Sequential Infection Elimination and Osteogenic Activation for Single-stage Reconstruction of Infected Bone Defects Yutao Cui, Yuhang Tian, Minghan Dou, Shaorong Li, Yi Fan, Gan Wang, Chuangang Peng, Yanbing Wang, Dankai Wu
Theranostics 2026; 16(6): 3206-3226. doi:10.7150/thno.121585
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Reviews
Condensatopathies as a mechanistic framework for disease and integrated theranostic intervention Xin Li, Haiyan Wang, Jinghao Yao, Biwei Han, Xiaoxuan Zhao, Yuepeng Jiang, Huan Chen, Yan Yang, Hongwei Hou, Liang Wang
Theranostics 2026; 16(6): 2684-2704. doi:10.7150/thno.127750
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Lead radionuclides for theranostic applications in nuclear medicine: from atom to bedside Yani Berckmans, Janke Kleynhans, Sara Van Mechelen, Karolien Goffin, Kristof Baete, Michel Koole, An Coosemans, Thomas Elias Cocolios, Christophe M Deroose, Yann Seimbille, Frederik Cleeren
Theranostics 2026; 16(6): 2887-2917. doi:10.7150/thno.126086
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Physical stimuli-responsive CRISPR-Cas9 systems for spatiotemporally precise control of genome engineering Jinbin Pan, Bingjie Li, Yaqiong Wang, Yating Han, Guijun Liu, Shao-Kai Sun
Theranostics 2026; 16(6): 2984-3010. doi:10.7150/thno.122238
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Kidney-targeted nanoplatforms: Strategies and applications Yucen Deng, Ziyu Liu, Xinyuan Zhu, Youfu Wang, Xuesong Feng, Jinghui Yang
Theranostics 2026; 16(6): 3011-3031. doi:10.7150/thno.126217
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Demystifying anti-inflammatory therapeutic strategies against pancreatitis and concomitant diseases: a 2025 perspective Mengli Yue, Sibtain Muhammad, Song Jiang, Madappa C Maridevaru, Yinghe Zhang, Bing Guo, Pi Liu
Theranostics 2026; 16(6): 3050-3104. doi:10.7150/thno.127402
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Stimuli-responsive hydrogels based on cascade reactions: a novel strategy to promote the efficient repair of diabetic wounds Jialin Jia, Xiaosu Wang, Tao Zhang, Qingxia Sun, Shude Yang, Wenna Wu
Theranostics 2026; 16(6): 3105-3135. doi:10.7150/thno.126282
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Piezoelectric Heterojunction-driven Biomedical Revolution: From Construction Principles to Diagnostic and Therapeutic Applications Zhiguang Chen, Wei Zhang, Xiujuan Qu, Yunfei Zhang
Theranostics 2026; 16(6): 3136-3172. doi:10.7150/thno.126489
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Nanotechnology-donated ischemic stroke therapeutics: evolving strategies from the basic to the cutting-edge Yuting Wang, Jiaxu Xu, Wenxuan Yan, Shenwu Zhang, Cong Luo, Yuequan Wang
Theranostics 2026; 16(6): 3173-3205. doi:10.7150/thno.127504
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