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Volume 15 (8); 2025

Research Papers

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CRISPR screening reveals ZNF217 as a vulnerability in high-risk B-cell acute lymphoblastic leukemia
Xi Qin, Keren Zhou, Lei Dong, Lu Yang, Wei Li, Zhenhua Chen, Chao Shen, Li Han, Yangchan Li, Anthony K.N. Chan, Sheela Pangeni Pokharel, Ying Qing, Meiling Chen, Kitty Wang, Keith Leung, Lillian Sau, Chun-Wei Chen, Xiaolan Deng, Rui Su, Jianjun Chen
Theranostics 2025; 15(8): 3234-3256. doi:10.7150/thno.100295
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Oxytocin modulates inhibitory balance in the prelimbic cortex to support social memory consolidation during REM sleep
Yan-chao Liu, Yu-chen Deng, Zi-tao Zhu, Bo Rao, Hong-lei Shang, Li-ke Wang, Tao Li, Ya-rong Wang, Jian-Zhi Wang, Qing-ping Zhang, Yang Gao, Hai-bo Xu
Theranostics 2025; 15(8): 3257-3274. doi:10.7150/thno.109104
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SPEAR: CRISPR-mediated ultrasensitive, specific and rapid one-pot detection strategy for cancer-related SNPs
Linlin Bai, Yanan Pang, Ting Wang, Shengzhou Wang, Kaiming Guo, Tian Xuan, Ziqin Zhang, Dianwei Liu, Feng Qian, Yan Zheng, Gang Jin, Rui Wang
Theranostics 2025; 15(8): 3275-3288. doi:10.7150/thno.107488
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PBRM1 deficiency enhances PD1 immunotherapeutic sensitivity via chromosomal accessibility in colorectal cancer
Rui Li, Jie He, Chaoqun Liu, Zesheng Jiang, Jiasheng Qin, Kun Liang, Zhuocheng Ji, Liang Zhao
Theranostics 2025; 15(8): 3316-3331. doi:10.7150/thno.100793
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Sex- and age-specific sensitivities of the endocannabinoid system in Alzheimer's disease revealed by PET imaging with [18F]FMPEP-d2 and [18F]MAGL-2102
Anna Pees, Christopher Daniel Morrone, Junchao Tong, Jian Rong, Tuo Shao, Darcy Wear, Steven H. Liang, Wai Haung Yu, Neil Vasdev
Theranostics 2025; 15(8): 3368-3385. doi:10.7150/thno.106592
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Microglial circDlg1 modulates neuroinflammation by blocking PDE4B ubiquitination-dependent degradation associated with Alzheimer's disease
Jiyun Shi, Chenghuan Song, Pingao Zhang, Jing Wang, Wanying Huang, Ting Yu, Zijie Wei, Lufeng Wang, Lanxue Zhao, Rui Zhang, Lina Hou, Yongfang Zhang, Hongzhuan Chen, Hao Wang
Theranostics 2025; 15(8): 3401-3423. doi:10.7150/thno.104709
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Active microneedle patch equipped with spontaneous bubble generation for enhanced rheumatoid arthritis treatment
Ting Liu, Jintao Fu, Ziyang Zheng, Minglong Chen, Wenhao Wang, Chuanbin Wu, Guilan Quan, Xin Pan
Theranostics 2025; 15(8): 3424-3438. doi:10.7150/thno.103080
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A novel pathway for stemness propagation and chemoresistance in non-small cell lung cancer via phosphorylated PKM2-loaded small extracellular vesicles
Jingyi Wang, Liu Liu, Xinyu Gao, Xiyu Liu, Yitian Dai, Zijun Mao, Shengzhe Huang, Junjian Li, Dongliang Wang, Yu Qi, Yingwen Han, Yunjing Xu, Corrine Ying Xuan Chua, Alessandro Grattoni, Wenhui Xie, Hao Yang, Gang Huang
Theranostics 2025; 15(8): 3439-3461. doi:10.7150/thno.103722
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Nanoparticle contrast-enhanced computed tomography of sporadic aortic aneurysm and dissection: Effect of nanoparticle size and contrast agent dose
Laxman Devkota, Chen Zhang, Deborah Vela, Poonam Sarkar, Prajwal Bhandari, Zbigniew Starosolski, Renuka Menon, Dianna M. Milewicz, Ying H. Shen, Scott A. LeMaire, Ketan B. Ghaghada
Theranostics 2025; 15(8): 3462-3473. doi:10.7150/thno.109325
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NIR light-driven nanomotor with cascade photodynamic therapy for MRSA biofilm eradication and diabetic wound healing
Yuanyuan Deng, Jia Zheng, Jianghua Li, Bo Liu, Ke Chen, Yiling Xu, Liu Deng, Huixia Liu, You-Nian Liu
Theranostics 2025; 15(8): 3474-3489. doi:10.7150/thno.109356
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A versatile nanoplatform with excellent biofilm permeability and spatiotemporal ROS regulation for peri-implantitis treatment
Zeyu Han, Ying Li, Xin Zhan, Ming Sun, Yan Liang, Mujie Yuan, Yong Sun, Jie Cao, Baodong Zhao, Fan Li
Theranostics 2025; 15(8): 3490-3516. doi:10.7150/thno.108830
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Comparison of 5-aminolevulinic acid and MMP-14 targeted peptide probes in preclinical models of GBM
Benjamin B. Kasten, Tingting Dai, Ke Jiang, Jennifer Coleman Clements, Kaixiang Zhou, Carlos A. Gallegos, Seth N. Lee, Anna G. Sorace, Hailey A. Houson, Logan D. Stone, James M. Markert, Jianghong Rao, Jason M. Warram
Theranostics 2025; 15(8): 3517-3531. doi:10.7150/thno.107210
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The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy
He Sun, Xinan Qiao, Xiangyan Peng, Hanzhao Zhu, Liyun Zhang, Liqing Jiang, Longteng Wang, Chao Xue, Jian Yang, Wei Yi, Bin Zhang, Jincheng Liu, Weixun Duan
Theranostics 2025; 15(8): 3532-3550. doi:10.7150/thno.103809
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THSD4 promotes hair growth by facilitating dermal papilla and hair matrix interactions
Miaomiao Wang, Mengyue Wang, Jingwei Jiang, Ke Li, Huan Liang, Nian'ou Wang, Yi Zou, Dehuan Wang, Siyi Zhou, Yuchun Tang, Wang Wu, Weiming Qiu, Xinxin Li, Xusheng Wang, Qiaoli Xie, Xiao Xiang, Wei Zhou, Li Yang, Cheng-Ming Chuong, Mingxing Lei
Theranostics 2025; 15(8): 3571-3588. doi:10.7150/thno.103221
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CD19-targeted HSP90 inhibitor nanoparticle combined with TKIs reduces tumor burden and enhances T-cell immunity in murine B-cell malignancies
Mengting Qin, Juan Ren, Xiaodong Chen, Wen Zhou, Shuyuan Zhang, Weile Zhang, Mengxin Shi, Mingzhen Zhang, Huashen Liu, Yunfeng Ma, Mei Yang, Yanhong Ji
Theranostics 2025; 15(8): 3589-3609. doi:10.7150/thno.106758
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Interleukin 35-producing B cells prolong the survival of GVHD mice by secreting exosomes with membrane-bound IL-35 and upregulating PD-1/LAG-3 checkpoint proteins
Jin Kyeong Choi, Evaristus C. Mbanefo, Manoj Kumar Yadav, Sahar A. Alhakeem, Vijayaraj Nagarajan, Natalia S. Nunes, Christopher G. Kanakry, Charles E. Egwuagu
Theranostics 2025; 15(8): 3610-3626. doi:10.7150/thno.105069
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Circular RNA CHACR is involved in the pathogenesis of cardiac hypertrophy
Lili Chen, Wenjing Wang, Yiheng Zhao, Shuchen Zhang, Xiang Zhou
Theranostics 2025; 15(8): 3627-3642. doi:10.7150/thno.104695
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Clinical value of [18F]AlF-Thretide PET/CT and early-time-point PET acquisition in the detection and staging of prostate cancer
Xin Cheng, Guozhu Hou, Mingshuai Wang, Shan Zheng, Wei Yao, Xuejuan Wang, Rong Zheng, Nianzeng Xing, Jingjing Zhang
Theranostics 2025; 15(8): 3643-3654. doi:10.7150/thno.103667
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Plasma extracellular vesicles from recurrent GBMs carrying LDHA to activate glioblastoma stemness by enhancing glycolysis
Xin Zhang, JunJie Li, Yiyao Huang, Anming Yang, Xiaoliu Liu, Yunhao Luo, Hao Tian, Minghui Wen, Chengzong Zhong, Bin Peng, Haitao Sun, Lei Zheng
Theranostics 2025; 15(8): 3655-3672. doi:10.7150/thno.102014
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Transcriptomic profiling of murine GnRH neurons reveals developmental trajectories linked to human reproduction and infertility
Yassine Zouaghi, Daniel Alpern, Vincent Gardeux, Julie Russeil, Bart Deplancke, Federico Santoni, Nelly Pitteloud, Andrea Messina
Theranostics 2025; 15(8): 3673-3692. doi:10.7150/thno.91873
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Zwitterionic lipid nanoparticles for efficient siRNA delivery and hypercholesterolemia therapy with rational charge self-transformation
Ruichen Zhao, Jing Guo, Ziqi Liu, Yusheng Zhang, Jiamin Zuo, Songzhang Lv, Xianyu Li, Wenlong Yao, Xin Zhang
Theranostics 2025; 15(8): 3693-3712. doi:10.7150/thno.111685
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Reviews

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Artificial intelligence-enhanced retinal imaging as a biomarker for systemic diseases
Jinyuan Wang, Ya Xing Wang, Dian Zeng, Zhuoting Zhu, Dawei Li, Yuchen Liu, Bin Sheng, Andrzej Grzybowski, Tien Yin Wong
Theranostics 2025; 15(8): 3223-3233. doi:10.7150/thno.100786
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Engineered Probiotic-Based Biomaterials for Inflammatory Bowel Disease Treatment
Guangze Sang, Bingkai Wang, Yujie Xie, Yu Chen, Feng Yang
Theranostics 2025; 15(8): 3289-3315. doi:10.7150/thno.103983
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Antigen-presenting fibroblasts: emerging players in immune modulation and therapeutic targets
Xiaoyun Chen, Fangqi Chen, Sujie Jia, Qianjin Lu, Ming Zhao
Theranostics 2025; 15(8): 3332-3344. doi:10.7150/thno.104900
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Supercharging CAR-T cells through transcriptional and epigenetic armoring
Diyuan Qin, Yanna Lei, Pei Shu, Yugu Zhang, Yuin-Han Loh, Yongsheng Wang, Qijing Li
Theranostics 2025; 15(8): 3345-3367. doi:10.7150/thno.107908
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Time for action: actinium-225 PSMA-targeted alpha therapy for metastatic prostate cancer - a systematic review and meta-analysis
Gaia Ninatti, Pietro Scilipoti, Cristiano Pini, Francesco Barletta, Mattia Longoni, Fabrizia Gelardi, Martina Sollini, Giorgio Gandaglia, Mike Sathekge, Francesco Montorsi, Arturo Chiti, Alberto Briganti
Theranostics 2025; 15(8): 3386-3399. doi:10.7150/thno.106574
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Recent advances and prospects of nanoparticle-based drug delivery for diabetic ocular complications
Siqi Wang, Hongyu Yang, Jiaying Zheng, Aiyang Tong, Sen Mu, Dongkai Wang, Ming Zhao, Ji Li
Theranostics 2025; 15(8): 3551-3570. doi:10.7150/thno.108691
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