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Volume 15 (7); 2025

Research Papers

Cancer-control outcomes with [¹⁷⁷Lu]Lu-PSMA Radioligand Therapy in elderly, frail or comorbid mCRPC patients
Mike Wenzel, Carolin Siech, Cristina Cano Garcia, Clara Humke, Daniel Groener, Maximilian Kriegmair, Markus Graefen, Tobias Maurer, Georg Salomon, Severine Banek, Felix K. H. Chun, Philipp Mandel
Theranostics 2025; 15(7): 2672-2679. doi:10.7150/thno.108963
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YBX1-driven TUBB6 upregulation facilitates ocular angiogenesis via WNT3A-FZD8 pathway
Ye-Ran Zhang, Wei-Qi Li, Zhong-Hong Zhang, Ru-Xu Sun, Hong-Jing Zhu, Hui-Ming Qian, Song-Tao Yuan, Yu-Liang Wang
Theranostics 2025; 15(7): 2680-2699. doi:10.7150/thno.104573
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Bioeliminable Pt@Bi₂Se₃-RGD Nanoassembly for Enhancing Photoacoustic Imaging-Guided Tumor Immuno-Radiotherapy by Inducing Apoptosis via the Areg Pathway
Huanhuan Tan, Shiyan Fu, Li Shen, Qinyang Lin, Wenrun Li, Yonghong Ran, Yazhen Zhao, Longfei Tan, Yuhui Hao
Theranostics 2025; 15(7): 2720-2736. doi:10.7150/thno.106479
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A p-n heterojunction sonosensitizer for improved sono-immunotherapy via induction of multimodal cell death mechanisms
Sijia Wu, Qian Wang, Jun Du, Qingxuan Meng, Yuhao Li, Yuqing Miao, Qing Miao, Jingxiang Wu
Theranostics 2025; 15(7): 2737-2756. doi:10.7150/thno.106999
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NSUN2-mediated m⁵C modification drives alternative splicing reprogramming and promotes multidrug resistance in anaplastic thyroid cancer through the NSUN2/SRSF6/UAP1 signaling axis
Xiukun Hou, Qiman Dong, Jie Hao, Min Liu, Junya Ning, Mei Tao, Zhongyu Wang, Fengli Guo, Dongmei Huang, Xianle Shi, Ming Gao, Dapeng Li, Xiangqian Zheng
Theranostics 2025; 15(7): 2757-2777. doi:10.7150/thno.104713
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The TMBIM1-YBX1 axis orchestrates MDSC recruitment and immunosuppressive microenvironment in pancreatic cancer
Xuhui Tong, Mingming Xiao, Jing Yang, Jin Xu, Wei Wang, Xianjun Yu, Si Shi
Theranostics 2025; 15(7): 2794-2813. doi:10.7150/thno.111180
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FBXW7/GSK3β-mediated proline-rich 11 degradation promotes oxidative DNA damage and inhibits tumor progression in renal cell carcinoma
Siming Chen, Kangping Xiong, Jianmin Liu, Shijie Yao, Mingxing Li, Jingtian Yu, Gang Wang, Sheng Tu, Wan Jin, Jiageng Shi, Yu Xiao, Yi Zhang, Kaiyu Qian, Lingao Ju, Xinghuan Wang
Theranostics 2025; 15(7): 2814-2833. doi:10.7150/thno.106018
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Ironomycin induces mantle cell lymphoma cell death by targeting iron metabolism addiction
Sara Ovejero, Laura Alibert, Julie Devin, Tatiana Cañeque, Valentin Jacquier, Andrea Romero, Salome Amar, Matthieu Abouladze, Elvira Garcia de Paco, Ouissem Karmous Gadacha, Guilhem Requirand, Nicolas Robert, Miss Leriem Zellagui, Hugues de Boussac, Guillaume Cartron, Johanna Chiche, Jean-Ehrland Ricci, Charles Herbaux, Raphael Rodriguez, Jerome Moreaux, Caroline Bret
Theranostics 2025; 15(7): 2834-2851. doi:10.7150/thno.101821
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Tumor-derived exosomes induce neutrophil infiltration and reprogramming to promote T-cell exhaustion in hepatocellular carcinoma
Wenchao Bi, Xue Li, Yu Jiang, Tongtong Gao, Huajun Zhao, Qiuju Han, Jian Zhang
Theranostics 2025; 15(7): 2852-2869. doi:10.7150/thno.104557
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Coupling CRISPR-Cas and a personal glucose meter with an enzymatic reporter for portable detection of human papillomavirus in biological samples
Xuena Zhu, Shanshan Wang, Yuanyuan Xue, Xiaoyan Wang, Shaoqi Hu, Tingbo Liang, Wenjun Liu
Theranostics 2025; 15(7): 2870-2882. doi:10.7150/thno.106490
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7-nm Mn_0.5 Zn_0.5Fe₂O₄ superparamagnetic iron oxide nanoparticle (SPION): a high-performance theranostic for MRI and hyperthermia applications
Joo Young Lee, Yi Rang Na, Chul Min Na, Pyung Won Im, Hyung Woo Park, Min Kyu Kim, Yona Kim, Ji Hyeon You, Dong Su Kang, Hyo Eun Moon, Hye Ran Park, Min Gyu Kim, Pilhan Kim, Sung Hye Park, Hye Won Youn, Young Don Son, Yasushi Takemura, Chang Won Song, Daishun Ling, Yuanzhe Piao, Sun Ha Paek
Theranostics 2025; 15(7): 2883-2902. doi:10.7150/thno.103503
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3D bioprinting of prefabricated artificial skin with multicomponent hydrogel for skin and hair follicle regeneration
Xiaoxiao Ma, Xiaohui Zhu, Sheng Lv, Chunyan Yang, Zihao Wang, Meilan Liao, Bohao Zhou, Yiming Zhang, Shiyu Sun, Ping Chen, Zhonghua Liu, Haiyan Chen
Theranostics 2025; 15(7): 2933-2950. doi:10.7150/thno.104854
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The inter-organelle cross-talk finely orchestrated in the amyloidogenic processing of amyloid precursor protein in dendritic arborization neurons of Drosophila
Guo Cheng, Jin Chang, Shanshan Ke, Zimin Dai, Deyong Gong, Hui Gong, Wei Zhou
Theranostics 2025; 15(7): 2951-2966. doi:10.7150/thno.104345
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LCN2 deficiency mitigates the neuroinflammatory damage following acute glaucoma
Tu Hu, Shuhan Meng, Can Liu, Weizhou Fang, Zhaohua Xia, Yiqun Hu, Jia Luo, Xiaobo Xia
Theranostics 2025; 15(7): 2967-2990. doi:10.7150/thno.104752
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TFEB promotes Ginkgetin-induced ferroptosis via TRIM25 mediated GPX4 lysosomal degradation in EGFR wide-type lung adenocarcinoma
Hao-Jie Wang, Ling-feng Dong, Li-Li Ding, Xiu-Yuan Miao, Yu-Wen Zhang, Li-Ping Zhao, Li-Hua Yu, Zhen-Rong Guan, Ya-Ping Jiang, Xiao-Qi Tang, Ya-Xin Yan, Jian-Shu Lou
Theranostics 2025; 15(7): 2991-3012. doi:10.7150/thno.106469
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Spatial Metabolomics and Transcriptomics Reveal Metabolic Reprogramming and Cellular Interactions in Nasopharyngeal Carcinoma with High PD-1 Expression and Therapeutic Response
Lili Ji, Dujuan Wang, Guangzheng Zhuo, Zhe Chen, Liping Wang, Qian Zhang, Yuhang Wan, Guohong Liu, Yunbao Pan
Theranostics 2025; 15(7): 3035-3054. doi:10.7150/thno.102822
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Targeting platinum-resistant ovarian cancer by disrupting histone and RAD51 lactylation
Chenggong Sun, Xiao Li, Qiuli Teng, Xihan Liu, Li Song, Helgi B. Schiöth, Huan Wu, Xinyue Ma, Zhaoyang Zhang, Changjian Qi, Haocheng Zhang, Kun Song, Qing Zhang, Beihua Kong
Theranostics 2025; 15(7): 3055-3075. doi:10.7150/thno.104858
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Glioblastoma progression is hindered by melatonin-primed mesenchymal stromal cells through dynamic intracellular and extracellular reorganizations
Laura Olmedo-Moreno, Concepción Panadero-Morón, Jesús María Sierra-Párraga, Rubén Bueno-Fernández, Emily S. Norton, Yolanda Aguilera, Nuria Mellado-Damas, Patricia García-Tárraga, Raquel Morales-Gallel, María Antequera-Martínez, Raúl V. Durán, Jaime Ferrer-Lozano, Germaine Escames, José Manuel García-Verdugo, Alejandro Martin-Montalvo, Hugo Guerrero-Cázares, Vivian Capilla-González
Theranostics 2025; 15(7): 3076-3097. doi:10.7150/thno.104143
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NAE1-mediated neddylation coordinates ubiquitination regulation of meiotic recombination during spermatogenesis
Yu Xi, Chenjia Gong, Zhe Zhang, Feiyin Zhu, Ying Zhang, Yanlin Tang, Liying Yan, Hui Jiang, Jie Qiao, Qiang Liu
Theranostics 2025; 15(7): 3122-3142. doi:10.7150/thno.107843
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The allogenic non-proteinogenic amino acid BMAA-based vaccine breaks up the immune tolerance against colorectal cancer
Baorui Tian, Shijian Wang, Jixuan Ding, Weiao Qu, Chen Zhang, Fangqun Luan, Nan Wang, Yigong Hou, Mengying Suo, Huimin Liu, Yanan Chen, Yanhua Liu, Jie Yan, Jianbo Zhang, Jia Li, Longlong Wang, Yi Shi, Rong Xiang
Theranostics 2025; 15(7): 3143-3158. doi:10.7150/thno.104722
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Hippocampal P2X7 and A2A purinoceptors mediate cognitive impairment caused by long-lasting epileptic seizures
Meng-Juan Sun, Wen-Jing Ren, Ya-Fei Zhao, Xuan Li, Muhammad Tahir Khan, Xin-Yi Cheng, Hai-Yan Yin, Alexei Verkhratsky, Tobias Engel, Patrizia Rubini, Yong Tang, Peter Illes
Theranostics 2025; 15(7): 3159-3184. doi:10.7150/thno.100365
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Interleukin-34 orchestrates bone formation through its binding to bone morphogenic proteins
Javier Muñoz-Garcia, Jorge W. Vargas-Franco, Kristina Schiavone, Marcus T. Keatinge, Robin Young, Jérôme Amiaud, Laurie Fradet, Jean-François Jégou, Hideo Yagita, Claudine Blin-Wakkach, Abdelilah Wakkach, Denis Cochonneau, Emilie Ollivier, Martine Pugière, Corinne Henriquet, Marie Legendre, Irina Giurgea, Serge Amselem, Marie-Françoise Heymann, Stéphane Télétchéa, Frédéric Lézot, Dominique Heymann
Theranostics 2025; 15(7): 3185-3202. doi:10.7150/thno.107340
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Enhanced therapeutic efficacy of anti-PD-1 blockade by targeting LAMP2A inhibits lysosomal degradation of STING and TBK1
Xueying Wang, Diekuo Zhang, Jiaqing Xiao, Lei Wang, Junrong Wang, Xiaoqiao Cui, Jiaqi Tan, Yong Liu, Susheng Miao
Theranostics 2025; 15(7): 3207-3222. doi:10.7150/thno.103426
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Reviews

Recent advances in the mechanisms, current treatment status, and application of multifunctional biomaterials for radiation-induced skin injury
Yang Xu, Quanying Liu, Wenfeng Li, Zhihe Hu, Chunmeng Shi
Theranostics 2025; 15(7): 2700-2719. doi:10.7150/thno.108309
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Multiple regulatory mechanisms, functions and therapeutic potential of chaperone-mediated autophagy
Yuhan Wang, Jingwei Liu, Hao Wang, Pengcheng Jiang, Liangzi Cao, Songming Lu, Siyi Zhang, Ruohan Yang, Hao Feng, Liu Cao, Xiaoyu Song
Theranostics 2025; 15(7): 2778-2793. doi:10.7150/thno.107761
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Unveiling the potential of biomechanics in pioneering innovative strategies for cancer therapy
Xiaodong Wu, Weidong Fei, Tao Shen, Lei Ye, Chaoqun Li, Siran Chu, Mingqi Liu, Xiaodong Cheng, Jiale Qin
Theranostics 2025; 15(7): 2903-2932. doi:10.7150/thno.108605
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Perfluorocarbon nanoemulsions in drug delivery: design, development, and manufacturing
Riddhi Vichare, Jelena Janjic
Theranostics 2025; 15(7): 3013-3034. doi:10.7150/thno.103820
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Nanovaccines empowering CD8⁺ T cells: a precision strategy to enhance cancer immunotherapy
Yunfan Lin, Pei Lin, Rongwei Xu, Xu Chen, Ye Lu, Jiarong Zheng, Yucheng Zheng, Zihao Zhou, Zizhao Mai, Xinyuan Zhao, Li Cui
Theranostics 2025; 15(7): 3098-3121. doi:10.7150/thno.107856
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Errata

Vitamin D binding protein (VDBP) hijacks twist1 to inhibit vasculogenic mimicry in hepatocellular carcinoma: Erratum
Lu-ning Qin, Heng Zhang, Qing-qing Li, Ting Wu, Shan-bin Cheng, Kai-wen Wang, Yue Shi, Hao-ran Ren, Xue-wu Xing, Cheng Yang, Tao Sun
Theranostics 2025; 15(7): 3203-3205. doi:10.7150/thno.110724
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Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling: Erratum
Qian Wu, Xuemeng Miao, Jingjing Zhang, Ludan Xiang, Xiuchun Li, Xiaomei Bao, Siyu Du, Mianxian Wang, Shuangda Miao, Yiren Fan, Wei Wang, Xingxing Xu, Xiya Shen, Danlu Yang, Xiwu Wang, Yuanyuan Fang, Lixin Hu, Xuyi Pan, Haoru Dong, Hui Wang, Ying Wang, Jia Li, Zhihui Huang
Theranostics 2025; 15(7): 3206. doi:10.7150/thno.100784
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