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Volume 16 (8); 2026

Research Papers

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A ribonucleotide carbohydrate system (iRNC) enhances antigen presentation and controls glioblastoma
Hyung Shik Kim, Juhyun Oh, Jueun Jeon, Fan Fei, Sepideh Parvanian, Rainer Kohler, Christopher Garris, Ralph Weissleder
Theranostics 2026; 16(8): 3912-3927. doi:10.7150/thno.127558
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Modeling immunotherapies in live 3D human cancer tissue bioreactors
Yizheng Zhang, Ivan Foth, Ahmad Makky, Philip Bucher, Melanie Grimm, Peter-Martin Bruch, Ilona Hagelstein, Sascha Dietrich, Josef Leibold, Lukas Flatz, Judith Feucht, Sven Becker, Christian M. Schürch
Theranostics 2026; 16(8): 3928-3945. doi:10.7150/thno.118298
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Use of Dual-Modality Antibody Imaging for Assessment of Lymph Node Metastases in Head and Neck Cancer
Nicole Meeks, Ashtyn G. McAdoo, Yu-Jin Lee, Ramsha Akhund, Gary Smith, Jared Grice, Joseph Hoang, Kurt R. Zinn, Marisa E. Hom, Michael C. Topf, Adam J. Rosenberg, Eben L. Rosenthal
Theranostics 2026; 16(8): 3946-3958. doi:10.7150/thno.116640
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Myeloid cell-specific β2-adrenergic receptor deletion improves early cardiac injury resolution via de-repression of Anxa1
Tapas K. Nayak, Anamika Bajpai, Viren Patwa, Rhonda L. Carter, Nitya Enjamuri, Erhe Gao, Sudarsan Rajan, Yang K. Xiang, Douglas G. Tilley
Theranostics 2026; 16(8): 3959-3977. doi:10.7150/thno.123651
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Safety and Engraftment of Aligned Cardiac Patches Loaded with hiPSC-CMs in a Large Animal Model of Myocardial Infarction
Divya Sridharan, Salman Pervaiz, Nikita C. Nair, Muhamad M. Mergaye, Helena Islam, Britani N Blackstone, Syed A. Ashraf, Syed B. Alvi, Matthew Joseph, Juliet Varghese, Yuchi Han, Orlando P. Simonetti, Heather M. Powell, Konstantinos Dean Boudoulas, Robert L. Hamlin, Mahmood Khan
Theranostics 2026; 16(8): 3978-3995. doi:10.7150/thno.121105
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Hyperglycemia in combination with excess fat intake promotes renal pyroptosis and fibrosis through Gα12-dependent endoplasmic reticulum stress
Muhammad Sohaib Khan, Boram Kim, Yerim Jeon, Jihoon Tak, Yun Seok Kim, Sang Gil Lee, Eun Byul Lee, Chang-hoon Lee, Cheol Bin Eom, Hyun Sook Lee, Hyeon-Ki Jang, Nakyeom Lee, Jeong Hae Kie, Jee Myung Yang, Yoon Mee Yang, Sang Geon Kim
Theranostics 2026; 16(8): 3996-4018. doi:10.7150/thno.124015
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Panax notoginseng-Derived Carbon Dots Herbzymes Ameliorate Renal Ischemia-Reperfusion Injury via Anti-Inflammation, Antioxidation and Gut-Kidney Axis Regulation
Mei Yang, Zhenting Zhao, Zhichao Deng, Shirui Sun, Yingcong Guo, Zepeng Li, Bingxuan Zheng, Chengbo Zhang, Jianhui Li, Hongbao Li, Mingzhen Zhang, Hua Wang, Kun Ye, Wujun Xue, Chenguang Ding
Theranostics 2026; 16(8): 4019-4041. doi:10.7150/thno.126643
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Non-invasive identification of brain signatures of acute liver injury
Santhoshi P. Palandira, Aidan Falvey, Joseph Carrion, Qiong Zeng, Saher Chaudhry, Kira Grossman, Lauren Turecki, Leann Mahadeo, Nha Nguyen, Michael Brines, Christine N. Metz, Yousef Al-Abed, Sangeeta S. Chavan, Eric H. Chang, Yilong Ma, David Eidelberg, An Vo, Kevin J. Tracey, Valentin A. Pavlov
Theranostics 2026; 16(8): 4058-4075. doi:10.7150/thno.127621
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A cochlea-sparing strategy for non-invasive control of intracranial schwannomas via peripheral irradiation and anti-PD-1 therapy enhanced by STING activation
Zhenzhen Yin, Simeng Lu, Limeng Wu, Yao Sun, Day Caven Blake, Jie Chen, Lukas D. Landegger, William Ho, Bingyu Xiu, Adam P. Jones, Alona Muzikansky, Helen A. Shih, Konstantina M. Stankovic, Scott R. Plotkin, Lei Xu
Theranostics 2026; 16(8): 4076-4089. doi:10.7150/thno.123726
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Injured cardiac targeting magnetic nanovesicles for mRNA treatment of myocardial infarction
Dasom Mun, Ji-Young Kang, Malgeum Park, Gyeongseo Yoo, Jaewoong Lee, Nuri Yun, Boyoung Joung
Theranostics 2026; 16(8): 4090-4112. doi:10.7150/thno.124754
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Why 11β-HSD1 inhibitors show variable efficacy in Alzheimer's therapy: an APOE4-dependent HSD11B1 mechanism
RaiHua Lai, FengShiun Shie, RenHua Chung, Paul WeiChe Hsu, YiChung Chen, KaHei Lam, JyhLyh Juang
Theranostics 2026; 16(8): 4113-4127. doi:10.7150/thno.126244
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ROS-sensitive liposomal co-delivery of photosensitizer, factor Xa inhibitor, and PD-L1 blockade enhances photodynamic immunotherapy
Yuhan Mai, Yanling Chen, Chao Li, Tongyao Wang, Shangli Ding, Hao Zhang, Haili Lin, Longguang Jiang, Cai Yuan, Xiaolei Zhou, Mingdong Huang, Peng Xu
Theranostics 2026; 16(8): 4128-4146. doi:10.7150/thno.125408
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Red blood cell-conjugated biomimetic nanomedicine for enhanced therapy of non-small cell lung cancer
Seok Theng Chiang, Yueping Jin, Qian Zhao, Hongju Ling, Qinghua Xia, Tianzhen Han, Rongxiu Li, Weidong Li, Zhaohui Lan, Xiangzhao Ai, Haijiao Lu
Theranostics 2026; 16(8): 4147-4168. doi:10.7150/thno.121646
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Engineering a modular FAP-targeting ferritin-based drug nanocarrier for enhanced glioblastoma theranostics
Yi-Hsiang Tseng, Jia-Yu Lin, Chia-Pao Chuang, Hsiao-Ching Su, Teh-Wei Wang, Kuo-Chen Wei, Feng-Ting Huang, Chiun-Wei Huang
Theranostics 2026; 16(8): 4169-4189. doi:10.7150/thno.125403
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Colostrum extracellular vesicles are neuroprotective in models of Parkinson's disease
Dawson Hollingsworth, Shefali Srivastava, Samia Akter, Mohit Kumar, Soumya Sagar Dey, Sudipta Panja, Xiaoqing Du, Arnab Saha, Pravin Yeapuri, Shaurav Bhattarai, Emma G. Foster, Rana Kadry, Nada Fayez, Davina Oludipe, Emma Ehrenkranz, R Lee Mosley, John Oehlerking, Keith Swarts, Guoku Hu, Howard E. Gendelman, Susmita Sil
Theranostics 2026; 16(8): 4190-4223. doi:10.7150/thno.128257
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NPM1 phosphorylation-mediated telomere maintenance via stabilization of POLD3 in ALT-positive osteosarcoma: unraveling mechanisms and therapeutic opportunities
Rui Zhao, Tingfang Li, Qiuhui Yang, Duo Jiang, Yanan Xue, Haomeng Kou, Qianqian Wang, Yuwen Wang, Xinyu Han, Wenbin Ma, Guowen Wang, Jinyan Feng, Xiuxin Han, Yancheng Liu, Yaqing Jing, Xin Geng, Fei Wang, Yang Liu, Qiang Zhang, Feng Wang
Theranostics 2026; 16(8): 4224-4244. doi:10.7150/thno.108662
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CAR-T manufacturing reduces heterogeneity between CIDP and multiple myeloma patient-derived T cells
Xu Wang, Pu Wang, Qi Zhou, Xianzheng Wei, Yuhang Jin, Ying Liao, Xuan Zhao, Rui Hou, Sijin Li, Zhangchun Guan, Wen Ma, Dan Liu, Ming Shi
Theranostics 2026; 16(8): 4245-4259. doi:10.7150/thno.125983
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Therapeutic targeting of the AMPK-Has1 complex formation ameliorates metabolic dysfunction-associated steatohepatitis in mice
Xunzhe Yin, Wenjing Zhao, Li Yang, Chang Li, Xiangyu Guo, Lihao Lin, Zuojia Liu, Jin Wang
Theranostics 2026; 16(8): 4260-4282. doi:10.7150/thno.120527
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Biodegradable piezoelectric PHB-BT nanofiber scaffolds combined with ultrasound stimulation to accelerate bone regeneration by regulating Ca2+/CaN/NFAT
Yangyang Qu, Yifeng Shang, Shixing Luo, Xiaomin Pei, Yuanming Xiao, Jinmin Zhao, Li Zheng, Chuanan Liao, Ruiming Liang
Theranostics 2026; 16(8): 4283-4303. doi:10.7150/thno.124648
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Systemic CSF1R Targeting Depletes Pathogenic MPS Bubs and Ameliorates Psoriasis via PPARα-mediated Resolution
Zhen-Jia Lin, Ying Li, Yangyinhui Yu, Mei-Jia Fang, Ying Xiong, Rui Xu, Zhuo Wang, Jun Zhang, Ya-Nan Xu, Jun-Ya Wan, Xiang Ji, Yu-Fan Zheng, Kai-Lang Zhang, Ming Wei, Jun-Tao Zou, Li-Xuan Jia, Hui Zhang, Chang-Lin Li, Li-Jun Zhou, Zhi Tan
Theranostics 2026; 16(8): 4336-4357. doi:10.7150/thno.128248
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Sono-piezoelectric cues regulate neuroinflammatory reflex-arc-mediated α7nAChR-P2RX7 axis to dampen osteoarthritis-correlated pain with osteoarthritis attenuation
Qiuling Zhong, Junqi Xie, Maocheng Zuo, Chuanan Liao, Qiuxia Peng, Simeng Yu, Pan Hu, Yuanyuan Liu, Li Zheng, Kun Zhang, Zhenhui Lu, Jinmin Zhao
Theranostics 2026; 16(8): 4358-4373. doi:10.7150/thno.125686
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MUC20 alleviates kidney fibrosis by modulating pyroptosis through the MET/RAS/STING axis
Jiaxin Huang, Zhoutong Chen, Fengbo Zhong, Rui Zheng, Dexin Zhang, Jingyi Su, Yi Zhong, Xiaoliang Fang, Dali Li, Yuting Guan, Hongquan Geng
Theranostics 2026; 16(8): 4374-4393. doi:10.7150/thno.123986
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Epigenetic and O-glycosylation regulation of p66Shc mitigates mitochondrial oxidative stress in aortic dissection
Wenjun Zhang, Wanjun Liu, Xiaodan Zhong, Lei Dai, Xiaolei Liu, Shiliang Li, Hongcheng Jiang, Xingwei He, Wei Dong, Lijuan Lu, Li Zhu, Thati Madhusudhan, Hongjie Wang, Hesong Zeng
Theranostics 2026; 16(8): 4394-4410. doi:10.7150/thno.124508
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Harnessing nucleotide metabolism to control glycosylase base editing outcomes
Rui Tao, Min Li, Junyi Fei, Minhai Tang, Zhi Yang, Yun Hu, Yaoge Jiao, Zhangxue Hu, Shaohua Yao
Theranostics 2026; 16(8): 4411-4426. doi:10.7150/thno.125705
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Histone H4K8 lactylation promotes glioblastoma progression by inducing NUPR1-mediated autophagosome‒lysosome fusion
Jiangli Zhao, Xuchen Liu, Yanya He, Qingyuan Sun, Zhiwei Xue, Ziyi Tang, Junzhi Liu, Jiwei Wang, Chao Li, Xinyu Wang, Ning Yang, Chen Qiu
Theranostics 2026; 16(8): 4427-4451. doi:10.7150/thno.126579
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Cardiomyocyte-derived OTUD7B promotes cardiac hypertrophy by deubiquitinating SERCA2a
Zhuqi Huang, Xue Han, Yuxing Hou, Xingchen Wang, Fuyu Qiu, Yingchao Gong, Nipon Chattipakorn, Guosheng Fu, Guang Liang, Dongwu Lai
Theranostics 2026; 16(8): 4452-4470. doi:10.7150/thno.129105
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Reviews

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From 2D cultures to 3D systems: evolving cancer models at the interface of functional precision medicine and theranostics
Yizheng Zhang, Naray Payab, Bettina Weigelin, Christian M. Schürch
Theranostics 2026; 16(8): 4042-4057. doi:10.7150/thno.127053
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Therapeutic Promise of Mitophagy in Cancer: Advancing from Small-Molecule Regulation to Nanotechnology-Enhanced Targeting Therapy
Ping Chen, Guohao Liu, Jiani Yin, Ling Sun, Xiaoming Wang, Bing Wang, Qiyong Gong, Kui Luo
Theranostics 2026; 16(8): 4308-4335. doi:10.7150/thno.129867
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Errata

MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation: Erratum
Jyun-Ni Chi, Jhih-Yu Yang, Chia-Hsin Hsueh, Ching-Yi Tsai, Huai-Chia Chuang, Tse-Hua Tan
Theranostics 2026; 16(8): 4304-4305. doi:10.7150/thno.125465
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Improved Tumor Targeting and Longer Retention Time of NIR Fluorescent Probes Using Bioorthogonal Chemistry: Erratum
Xianghan Zhang, Bo Wang, Na Zhao, Zuhong Tian, Yunpeng Dai, Yongzhan Nie, Jie Tian, Zhongliang Wang, Xiaoyuan Chen
Theranostics 2026; 16(8): 4306-4307. doi:10.7150/thno.128809
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