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Volume 16 (11); 2026
Research Papers
Specific imaging of bacterial infection: a translational approach using positron emission tomography and gallium-68-labeled maltohexaose Sophie M. Wegener, Desiree Weiberg, James T. Thackeray, Christoph P. Czerner, Jasmin S. Hanke, Jan D. Schmitto, Geerd-Jürgen Meyer, Jens P. Bankstahl, Arjang Ruhparwar, Frank M. Bengel, Tobias L. Ross
Theranostics 2026; 16(11): 5788-5803. doi:10.7150/thno.125904
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Human atrial extracellular vesicles suppress NLRP3 inflammasome activation and profibrotic signaling in a patient-specific iPSC model of postoperative atrial fibrillation Noreen Ahmed, Bin Ye, Wenbin Liang, Buu-Khanh Lam, Fraser Rubens, Saad Khan, David Courtman, Duncan John Stewart, Darryl Raymond Davis
Theranostics 2026; 16(11): 5804-5815. doi:10.7150/thno.127433
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Pretargeted 177Lu/225Ac combination therapy of colorectal cancer Sara S. Rinne, Niloufar Salehi, Brett A. Vaughn, Daniela Burnes Vargas, Hongfen Guo, Sang Gyu Lee, Claire Vanpouille-Box, Ileana C. Miranda, Brian W. Miller, Edward K. Fung, Steven M. Larson, Darren R. Veach, Nai-Kong V. Cheung, Sarah M. Cheal
Theranostics 2026; 16(11): 5898-5910. doi:10.7150/thno.126399
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Multi-functional Small Molecule for Regenerative Healing of Avascular Meniscus Tears: Modulation of Inflammation, Differentiation, and Multi-Tissue Crosstalk Meng Feng, David D. Pellei, Ming Wang, Angelyn Nguyen, Sarah Ginsberg, Hun Jin Jeong, Chang H. Lee
Theranostics 2026; 16(11): 5911-5925. doi:10.7150/thno.132326
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EGFR-19del nuclear translocation increases HDAC7 expression inhibiting the Hippo pathway and exacerbating TKI resistance in lung adenocarcinoma Yuheng Feng, Minghao Wang, Yang Liu, Xinhao Wu, Xuyong Lin, Qiang Han, Xuezhu Rong
Theranostics 2026; 16(11): 5992-6010. doi:10.7150/thno.128873
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Edge-rich Cu-N3 single atom nanozyme drives lipid switching to potentiate tumor catalytic therapy Xin Xing, Jiaji Yu, Yajie Zhang, Xue Chen, Liang Chen, Meng Du, Jie Ding, Zhiyi Chen, Li Li, Junjie Cheng
Theranostics 2026; 16(11): 6011-6031. doi:10.7150/thno.128026
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Enzyme-responsive hydrogel coating for in situ re-endothelialization of bioprosthetic heart valves Xuyue Liang, Qi Tong, Zhongwu Bei, Tianying Luo, Lin Ye, Meng Pan, Yun Yang, Bingyang Chu, Yongjun Qian, Zhiyong Qian
Theranostics 2026; 16(11): 6032-6050. doi:10.7150/thno.131155
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Simultaneous inhibition of ID1 and ID3 mitigates fibroblast activation via cell cycle and MEK/ERK pathways in pulmonary fibrosis Samar A Antar, Eric Mensah, Jacob Dahlka, Mark C. Renton, Ahmed A Raslan, Michael Aziz, Aymen Halouani, Seun Imani, Aanandi Parashar, Scott R. Johnstone, Robert Benezra, Diego Fraidenraich, Giovanni Ligresti, Yassine Sassi
Theranostics 2026; 16(11): 6081-6098. doi:10.7150/thno.127118
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Local and systemic cytokine signatures for outcome prediction after transarterial chemoembolization in hepatocellular carcinoma Emine Y. Yilmaz, Robin Schmidt, Luisa Heidemann, Yubei He, Yu Liu, Ornela Sulejmani, Dominik N. Müller, Andreas Wilhelm, Timo A. Auer, Charlie A. Hamm, Salma A. S. Abosabie, Sara A. Abosabie, Bernhard Gebauer, Lynn J. Savic
Theranostics 2026; 16(11): 6099-6112. doi:10.7150/thno.130031
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A MAM-targeting therapeutic peptide restores autophagy homeostasis and ameliorates atherosclerosis Jungmin Ha, Minjeong Ko, Yong-Beom Lim, Ho Jeong Kwon
Theranostics 2026; 16(11): 6113-6131. doi:10.7150/thno.132357
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Integrated radio-theranostics using a [89Zr]Zr-/[177Lu]Lu-labeled B7-H3 antibody-drug conjugate for prostate cancer Yongkang Qiu, Tingfei Gu, Tianyao Wang, Yelin Mulati, Xinyao Sun, Qi Yang, Lele Song, Tingting Yuan, Yu Fan, Lei Kang, Weibo Cai
Theranostics 2026; 16(11): 6132-6144. doi:10.7150/thno.125878
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Bioinspired Nanoplatform Potentiates Sonodynamic Immunotherapy by Remodeling the Antioxidant Tumor Microenvironment and Activating STING pathway Yuanyuan Zhang, Wenxiang Zhu, Kaimin Li, Yun Xie, Zhichao Deng, Yuanyuan Zhu, Bowen Gao, Chenxi Xu, Junlong Fu, Mingzhen Zhang, Xiaoliang Zheng, Haifeng Zhang
Theranostics 2026; 16(11): 6145-6163. doi:10.7150/thno.129765
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Dual ROS modulation by MnO2-integrated collagen hydrogel enhances hiPSC-derived endothelial progenitor cell therapy for critical limb ischemia Zhen Zhang, Liang Huang, Gaocheng Gai, Bingbing Xie, Yijing Zhao, Lei Xu, Qiuling Xiang
Theranostics 2026; 16(11): 6164-6183. doi:10.7150/thno.127711
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Elevated target expression by dual PD-L1 and 4-1BB engagement is associated with 89Zr-PD-L1x4-1BB bispecific Mabcalin tumor uptake Claudia A.J. van Winkel, Xiaoyu Fan, Danique Giesen, Glenn Gauderat, Steven de Jong, Thomas Jaquin, Wim Timens, Agathe Lepissier, Marleen Richter, Stefan Grüner, Nicole Andersen, Laurent Laboureur, Lucia Pattarini, Helene Lelièvre, Elisabeth G.E. de Vries, Aizea Morales-Kastresana, Marjolijn N. Lub-de Hooge
Theranostics 2026; 16(11): 6184-6201. doi:10.7150/thno.123930
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Quantitative assessment of extravasation of IL-15-secreting MSLN-CAR-NK-92 cells using tumor transparency imaging Sera Hong, Dohyeon Moon, Seoin Hwang, Mijeong Lee, Duck Cho, Joon Myong Song
Theranostics 2026; 16(11): 6202-6219. doi:10.7150/thno.125194
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Glycine promotes cardiomyocyte proliferation and heart regeneration via the GCN2/AKT signaling axis Feng Wang, Xia Zhang, Yang Tang, Yanji He, Wei Wang, Andy Zeng, Lijia Liang, Jing Wang, Chunyu Zeng
Theranostics 2026; 16(11): 6220-6239. doi:10.7150/thno.127992
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Esterase-responsive albumin-binding PROTAC-mediated BRD4 degradation for cancer immunotherapy Hoyeon Lee, Sojin Jeong, Juwon Park, Hye-jeong Son, Seho Kweon, Steve Seung-Young Lee, Nayeon Shim, Yoojeong Oh, Hyein Kang, Chaerin Lee, Jihyeon Lee, Jinseong Kim, Hanhee Cho, Kwangmeyung Kim
Theranostics 2026; 16(11): 6240-6265. doi:10.7150/thno.130510
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A peptide-based PROTAC targeting FOXM1 suppresses fibrosis-associated hepatocarcinogenesis Dingyu Wu, Lei Duan, Di Tan, Xinyi Hua, Anping Liang, Ruiping Huai, Shanshan Qi, Zhixian Shang, Shijie Jia, Hui Qi, Xinrong Liu, Jieling Zhao, Yuhong Jiang, Rui Tan, Canquan Mao
Theranostics 2026; 16(11): 6266-6284. doi:10.7150/thno.129569
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CIAPIN1 functions as a redox-sensitive transcriptional repressor of Tp53 during vascular remodeling Seongpyo Lee, Joo-Hui Han
Theranostics 2026; 16(11): 6350-6365. doi:10.7150/thno.124965
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A tumor-targeted heptamethine cyanine dye suppresses triple-negative breast cancer by induction of lethal autophagy Sang-Hyo Kim, Yoonbin Park, Hwa-yeong Jin, Taewon Lee, Sungsu Lee, Moon Suk Kim, Hoon Hyun
Theranostics 2026; 16(11): 6366-6379. doi:10.7150/thno.130353
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Reviews
Future opportunities and nuances with the use of PSMA PET in prostate cancer (MD PET 1) Alicia K. Morgans, Christopher M. Pieczonka, Evan Y. W. Yu, Himanshu Nagar, Leonard G. Gomella, Medhat M. Osman, Phillip J. Koo, Steven E. Finkelstein
Theranostics 2026; 16(11): 5816-5829. doi:10.7150/thno.132930
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STK17A (DRAK1) at the crossroads of apoptosis, immunity, and cancer: Emerging roles and therapeutic opportunities Leticia Christina Pires Gonçalves, Olivia Rastoin, Vira Morozova, Clément Buzet, Audrey Bennetot, Gilles Pagès, Cyril Ronco, Maeva Dufies
Theranostics 2026; 16(11): 5830-5855. doi:10.7150/thno.129910
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Biomaterials in pancreatic surgery: progress and challenges in preoperative, intraoperative and postoperative care Qiang Guo, Shuwen Xiao, Xing Huang, Shengzhong Hou, Binxu Qiu, Ning Xia, Kai Xiao, Zhenyu Duan, Bole Tian, Kui Luo
Theranostics 2026; 16(11): 5856-5897. doi:10.7150/thno.131228
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Mechanistic role of APOE lipidation in Alzheimer's disease pathogenesis Dong Yan Zhang, Jian Wang, Nikolay V. Dokholyan
Theranostics 2026; 16(11): 5926-5950. doi:10.7150/thno.131926
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Unraveling the pleiotropic effects of CCR2-dependent signal transduction in fibrosis development Guozheng Sun, Jiaxing Wang, Jiayou Tang, Mingzhe Chen, Zhe Zhang, Huadong Zhao, Zhenxiao Jin, Xuezeng Xu, Yang Yang, Jincheng Liu
Theranostics 2026; 16(11): 5951-5991. doi:10.7150/thno.130426
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Small molecules targeting the PD-1/PD-L1 axis for cancer immunotherapy Jia-Yi Yin, Hui-Min Liu, Shao-long Li, Xin-Qian Ji, Jun-Jie Wang, Meng-Jie Fu, Cong-Jun Liu, Ning Wang, Guo-Liang Lu, Yan Li, Hong-Min Liu, Yi-Chao Zheng, Xing-Jie Dai, Ying Liu
Theranostics 2026; 16(11): 6051-6080. doi:10.7150/thno.130935
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Mechanomedicine in digestive surgery: a theranostic framework integrating mechanical diagnostics and therapeutic modulation across the perioperative continuum Ning Liu, Xiang Wang, Na Liu, Feng Xu, Ting Wen
Theranostics 2026; 16(11): 6285-6314. doi:10.7150/thno.133908
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Unraveling autophagy-metabolism crosstalk in cancer: Molecular insights and therapeutic strategies Haoyou Wang, Qianqian Yang, Yingying Lu, Cheng Du, Wei Wang, Lan Zhang
Theranostics 2026; 16(11): 6315-6349. doi:10.7150/thno.132362
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Current trends regarding types, properties, self-healing mechanisms, and therapeutic strategies for diabetic wounds addressed with polysaccharide-based self-repairing hydrogels: a review Hongkun Xue, Yuxin Bian, Ruoshi Zhang, Ziye Yuan, Haipeng Liu, Chuan Wang, Jiaqi Tan
Theranostics 2026; 16(11): 6380-6436. doi:10.7150/thno.132479
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