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Volume 14 (15); 2024

Research Papers

Graphic abstract

Collagen type I PET/MRI enables evaluation of treatment response in pancreatic cancer in pre-clinical and first-in-human translational studies
Shadi A. Esfahani, Hua Ma, Shriya Krishna, Sergey Shuvaev, Mark Sabbagh, Caitlin Deffler, Nicholas Rotile, Jonah Weigand-Whittier, Iris Y. Zhou, Ciprian Catana, Onofrio A. Catalano, David T. Ting, Pedram Heidari, Eric Abston, Michael Lanuti, Genevieve M. Boland, Priyanka Pathak, Hannah Roberts, Kenneth K. Tanabe, Motaz Qadan, Carlos Fernandez-del Castillo, Angela Shih, Aparna R. Parikh, Colin D. Weekes, Theodore S. Hong, Peter Caravan
Theranostics 2024; 14(15): 5745-5761. doi:10.7150/thno.100116
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Graphic abstract

ROCK inhibitor enhances mitochondrial transfer via tunneling nanotubes in retinal pigment epithelium
Jing Yuan, Fangxuan Chen, Dan Jiang, Zehua Xu, Hang Zhang, Zi-Bing Jin
Theranostics 2024; 14(15): 5762-5777. doi:10.7150/thno.96508
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Graphic abstract

Hypoxia-induced TGFBI maintains glioma stem cells by stabilizing EphA2
Zirong Chen, Junhong Wang, Peng Peng, Guohao Liu, Minhai Dong, Xiaolin Zhang, Yang Zhang, Xue Yang, Lijun Wan, Wang Xiang, Suojun Zhang, Bin Zhang, Qiuxia Wu, Xingjiang Yu, Feng Wan
Theranostics 2024; 14(15): 5778-5792. doi:10.7150/thno.95141
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Graphic abstract

Knocking out USP7 attenuates cardiac fibrosis and endothelial-to-mesenchymal transition by destabilizing SMAD3 in mice with heart failure with preserved ejection fraction
Shuai Yuan, Zimu Wang, Shun Yao, Yanyan Wang, Zhonglei Xie, Jingfeng Wang, Xueting Yu, Yu Song, Xiaotong Cui, Jingmin Zhou, Junbo Ge
Theranostics 2024; 14(15): 5793-5808. doi:10.7150/thno.97767
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Graphic abstract

Single-cell RNA-Seq analysis of molecular changes during radiation-induced skin injury: the involvement of Nur77
Tao Yan, Ping Yang, Hao Bai, Bin Song, Yulan Liu, Jiajia Wang, Yuehua Zhang, Wenling Tu, Daojiang Yu, Shuyu Zhang
Theranostics 2024; 14(15): 5809-5825. doi:10.7150/thno.100417
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Graphic abstract

Hepatocyte-specific Smad4 deficiency inhibits hepatocarcinogenesis by promoting CXCL10/CXCR3-dependent CD8+- T cell-mediated anti-tumor immunity
Xin Xin, Zhao Li, Xuanxuan Yan, Ting Liu, Zuyin Li, Zhuomiaoyu Chen, Xinlong Yan, Fanxin Zeng, Lingling Hou, Jinhua Zhang
Theranostics 2024; 14(15): 5853-5868. doi:10.7150/thno.97276
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Graphic abstract

Developing an enhanced chimeric permuted intron-exon system for circular RNA therapeutics
Lei Wang, Chunbo Dong, Weibing Zhang, Xu Ma, Wei Rou, Kai Yang, Tong Cui, Shaolong Qi, Lijun Yang, Jun Xie, Guocan Yu, Lianqing Wang, Xiaoyuan Chen, Zhida Liu
Theranostics 2024; 14(15): 5869-5882. doi:10.7150/thno.98214
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Graphic abstract

Air bag-embedded MIL-101(Fe) metal-organic frameworks for an amplified tumor microenvironment activation loop through strategic delivery of iron ions and lentinan
Tao Han, Yan Sun, Xi Jiang, Chengming Gong, Fei Kong, Yi Luo, Chang Ge, Congyan Liu, Yuping Liu, Yanfei Mou, Huangqin Zhang, Jianming Ju, Yan Chen, Ding Qu
Theranostics 2024; 14(15): 5883-5902. doi:10.7150/thno.99303
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Graphic abstract

Selenoprotein S maintains intestinal homeostasis in ulcerative colitis by inhibiting necroptosis of colonic epithelial cells through modulation of macrophage polarization
Yujie Yao, Tong Xu, Xiaojing Li, Xu Shi, Hao Wu, Ziwei Zhang, Shiwen Xu
Theranostics 2024; 14(15): 5903-5925. doi:10.7150/thno.97005
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Graphic abstract

Cardiomyocyte-derived small extracellular vesicle: a new mechanism driving diabetic cardiac fibrosis and cardiomyopathy
Yu Li, Yunhui Du, Yang Liu, Xiuhuan Chen, Xinxin Li, Yanru Duan, Yanwen Qin, Huirong Liu, Xinliang Ma, Shaoping Nie, Huina Zhang
Theranostics 2024; 14(15): 5926-5944. doi:10.7150/thno.99507
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Graphic abstract

Enhancing photothermal therapy of tumors with image-guided thermal control of gene-expressing bacteria
Fengyi Zeng, Meng Du, Yaozhang Yang, Jinghui Fang, Yuanyuan Wang, MeeiChyn Goh, Yan Lin, Huaiyu Wang, Fei Yan, Zhiyi Chen
Theranostics 2024; 14(15): 5945-5964. doi:10.7150/thno.98257
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Graphic abstract

Noninvasive closed-loop acoustic brain-computer interface for seizure control
Junjie Zou, Houminji Chen, Xiaoyan Chen, Zhengrong Lin, Qihang Yang, Changjun Tie, Hong Wang, Lili Niu, Yanwu Guo, Hairong Zheng
Theranostics 2024; 14(15): 5965-5981. doi:10.7150/thno.99820
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A hierarchically acidity-unlocking nanoSTING stimulant enables cascaded STING activation for potent innate and adaptive antitumor immunity
Shunyao Zhu, Tao He, Yan Wang, Yushan Ma, Wenmei Li, Songlin Gong, Yanghui Zhu, Xiangwei Wang, Xu Xu, Qinjie Wu, Changyang Gong, Yanjie You
Theranostics 2024; 14(15): 5984-5998. doi:10.7150/thno.98272
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Graphic abstract

Nicotinamide mononucleotide enhances fracture healing by promoting skeletal stem cell proliferation
Yitian Shi, Jiayin Peng, Mengfan Liu, Xiling Qi, Siyu Li, Qiangqiang Li, Qing Jiang, Liming Zheng, Jiankun Xu, Yun Zhao, Yifeng Zhang
Theranostics 2024; 14(15): 5999-6015. doi:10.7150/thno.98149
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Graphic abstract

Multifunctionally disordered TiO2 nanoneedles prevent periprosthetic infection and enhance osteointegration by killing bacteria and modulating the osteoimmune microenvironment
Yangmengfan Chen, Liqiang Zhou, Ming Guan, Shue Jin, Peng Tan, Xiaoxue Fu, Zongke Zhou
Theranostics 2024; 14(15): 6016-6035. doi:10.7150/thno.98219
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Graphic abstract

p-STAT3-elevated E3 ubiquitin ligase DTX4 confers the stability of HBV cccDNA by ubiquitinating APOBEC3B in liver
Lina Zhao, Hongfeng Yuan, Yufei Wang, Chunyu Hou, Pan Lv, Huihui Zhang, Guang Yang, Xiaodong Zhang
Theranostics 2024; 14(15): 6036-6052. doi:10.7150/thno.99407
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Graphic abstract

Subarachnoid hemorrhage distinctively disrupts the glymphatic and meningeal lymphatic systems in beagles
Jiaqi Wang, Tao Lv, Feng Jia, Yang Li, Weiwei Ma, Zhi-Peng Xiao, Weifeng Yu, Heng Zhao, Xiaohua Zhang, Qin Hu
Theranostics 2024; 14(15): 6053-6070. doi:10.7150/thno.100982
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Graphic abstract

Hypoxanthine is a metabolic biomarker for inducing GSDME-dependent pyroptosis of endothelial cells during ischemic stroke
Jing Ye, Xinyuan Bi, Shiyu Deng, Xianghui Wang, Ze Liu, Qian Suo, Jiao Wu, Haoran Chen, Yong Wang, Kun Qian, Rubing Shi, Jing Zhao, Guo-Yuan Yang, Jian Ye, Yaohui Tang
Theranostics 2024; 14(15): 6071-6087. doi:10.7150/thno.100090
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Review

Graphic abstract

Ferroptosis at the nexus of metabolism and metabolic diseases
Shuangwen Li, Guixiang Zhang, Jiankun Hu, Yan Tian, Xianghui Fu
Theranostics 2024; 14(15): 5826-5852. doi:10.7150/thno.100080
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Erratum

A thermosensitive, reactive oxygen species-responsive, MR409-encapsulated hydrogel ameliorates disc degeneration in rats by inhibiting the secretory autophagy pathway: Erratum
Qiangqiang Zheng, Haotian Shen, Zongrui Tong, Linxiang Cheng, Yuzi Xu, Zhiyun Feng, Shiyao Liao, Xiaojian Hu, Zongyou Pan, Zhengwei Mao, Yue Wang
Theranostics 2024; 14(15): 5982-5983. doi:10.7150/thno.103020
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