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Volume 14 (15); 2024

Research Papers

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Collagen type I PET/MRI enables evaluation of treatment response in pancreatic cancer in pre-clinical and first-in-human translational studies Shadi A. Esfahani, Hua Ma, Shriya Krishna, Sergey Shuvaev, Mark Sabbagh, Caitlin Deffler, Nicholas Rotile, Jonah Weigand-Whittier, Iris Y. Zhou, Ciprian Catana, Onofrio A. Catalano, David T. Ting, Pedram Heidari, Eric Abston, Michael Lanuti, Genevieve M. Boland, Priyanka Pathak, Hannah Roberts, Kenneth K. Tanabe, Motaz Qadan, Carlos Fernandez-del Castillo, Angela Shih, Aparna R. Parikh, Colin D. Weekes, Theodore S. Hong, Peter Caravan Theranostics 2024; 14(15): 5745-5761. doi:10.7150/thno.100116 Full text PDF PubMed PMC

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ROCK inhibitor enhances mitochondrial transfer via tunneling nanotubes in retinal pigment epithelium Jing Yuan, Fangxuan Chen, Dan Jiang, Zehua Xu, Hang Zhang, Zi-Bing Jin Theranostics 2024; 14(15): 5762-5777. doi:10.7150/thno.96508 Full text PDF PubMed PMC

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Hypoxia-induced TGFBI maintains glioma stem cells by stabilizing EphA2 Zirong Chen, Junhong Wang, Peng Peng, Guohao Liu, Minhai Dong, Xiaolin Zhang, Yang Zhang, Xue Yang, Lijun Wan, Wang Xiang, Suojun Zhang, Bin Zhang, Qiuxia Wu, Xingjiang Yu, Feng Wan Theranostics 2024; 14(15): 5778-5792. doi:10.7150/thno.95141 Full text PDF PubMed PMC

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Knocking out USP7 attenuates cardiac fibrosis and endothelial-to-mesenchymal transition by destabilizing SMAD3 in mice with heart failure with preserved ejection fraction Shuai Yuan, Zimu Wang, Shun Yao, Yanyan Wang, Zhonglei Xie, Jingfeng Wang, Xueting Yu, Yu Song, Xiaotong Cui, Jingmin Zhou, Junbo Ge Theranostics 2024; 14(15): 5793-5808. doi:10.7150/thno.97767 Full text PDF PubMed PMC

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Single-cell RNA-Seq analysis of molecular changes during radiation-induced skin injury: the involvement of Nur77 Tao Yan, Ping Yang, Hao Bai, Bin Song, Yulan Liu, Jiajia Wang, Yuehua Zhang, Wenling Tu, Daojiang Yu, Shuyu Zhang Theranostics 2024; 14(15): 5809-5825. doi:10.7150/thno.100417 Full text PDF PubMed PMC

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Hepatocyte-specific Smad4 deficiency inhibits hepatocarcinogenesis by promoting CXCL10/CXCR3-dependent CD8+- T cell-mediated anti-tumor immunity Xin Xin, Zhao Li, Xuanxuan Yan, Ting Liu, Zuyin Li, Zhuomiaoyu Chen, Xinlong Yan, Fanxin Zeng, Lingling Hou, Jinhua Zhang Theranostics 2024; 14(15): 5853-5868. doi:10.7150/thno.97276 Full text PDF PubMed PMC

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Developing an enhanced chimeric permuted intron-exon system for circular RNA therapeutics Lei Wang, Chunbo Dong, Weibing Zhang, Xu Ma, Wei Rou, Kai Yang, Tong Cui, Shaolong Qi, Lijun Yang, Jun Xie, Guocan Yu, Lianqing Wang, Xiaoyuan Chen, Zhida Liu Theranostics 2024; 14(15): 5869-5882. doi:10.7150/thno.98214 Full text PDF PubMed PMC

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Air bag-embedded MIL-101(Fe) metal-organic frameworks for an amplified tumor microenvironment activation loop through strategic delivery of iron ions and lentinan Tao Han, Yan Sun, Xi Jiang, Chengming Gong, Fei Kong, Yi Luo, Chang Ge, Congyan Liu, Yuping Liu, Yanfei Mou, Huangqin Zhang, Jianming Ju, Yan Chen, Ding Qu Theranostics 2024; 14(15): 5883-5902. doi:10.7150/thno.99303 Full text PDF PubMed PMC

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Selenoprotein S maintains intestinal homeostasis in ulcerative colitis by inhibiting necroptosis of colonic epithelial cells through modulation of macrophage polarization Yujie Yao, Tong Xu, Xiaojing Li, Xu Shi, Hao Wu, Ziwei Zhang, Shiwen Xu Theranostics 2024; 14(15): 5903-5925. doi:10.7150/thno.97005 Full text PDF PubMed PMC

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Cardiomyocyte-derived small extracellular vesicle: a new mechanism driving diabetic cardiac fibrosis and cardiomyopathy Yu Li, Yunhui Du, Yang Liu, Xiuhuan Chen, Xinxin Li, Yanru Duan, Yanwen Qin, Huirong Liu, Xinliang Ma, Shaoping Nie, Huina Zhang Theranostics 2024; 14(15): 5926-5944. doi:10.7150/thno.99507 Full text PDF PubMed PMC

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Enhancing photothermal therapy of tumors with image-guided thermal control of gene-expressing bacteria Fengyi Zeng, Meng Du, Yaozhang Yang, Jinghui Fang, Yuanyuan Wang, MeeiChyn Goh, Yan Lin, Huaiyu Wang, Fei Yan, Zhiyi Chen Theranostics 2024; 14(15): 5945-5964. doi:10.7150/thno.98257 Full text PDF PubMed PMC

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Noninvasive closed-loop acoustic brain-computer interface for seizure control Junjie Zou, Houminji Chen, Xiaoyan Chen, Zhengrong Lin, Qihang Yang, Changjun Tie, Hong Wang, Lili Niu, Yanwu Guo, Hairong Zheng Theranostics 2024; 14(15): 5965-5981. doi:10.7150/thno.99820 Full text PDF PubMed PMC

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A hierarchically acidity-unlocking nanoSTING stimulant enables cascaded STING activation for potent innate and adaptive antitumor immunity Shunyao Zhu, Tao He, Yan Wang, Yushan Ma, Wenmei Li, Songlin Gong, Yanghui Zhu, Xiangwei Wang, Xu Xu, Qinjie Wu, Changyang Gong, Yanjie You Theranostics 2024; 14(15): 5984-5998. doi:10.7150/thno.98272 Full text PDF PubMed PMC

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Nicotinamide mononucleotide enhances fracture healing by promoting skeletal stem cell proliferation Yitian Shi, Jiayin Peng, Mengfan Liu, Xiling Qi, Siyu Li, Qiangqiang Li, Qing Jiang, Liming Zheng, Jiankun Xu, Yun Zhao, Yifeng Zhang Theranostics 2024; 14(15): 5999-6015. doi:10.7150/thno.98149 Full text PDF PubMed PMC

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Multifunctionally disordered TiO2 nanoneedles prevent periprosthetic infection and enhance osteointegration by killing bacteria and modulating the osteoimmune microenvironment Yangmengfan Chen, Liqiang Zhou, Ming Guan, Shue Jin, Peng Tan, Xiaoxue Fu, Zongke Zhou Theranostics 2024; 14(15): 6016-6035. doi:10.7150/thno.98219 Full text PDF PubMed PMC

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p-STAT3-elevated E3 ubiquitin ligase DTX4 confers the stability of HBV cccDNA by ubiquitinating APOBEC3B in liver Lina Zhao, Hongfeng Yuan, Yufei Wang, Chunyu Hou, Pan Lv, Huihui Zhang, Guang Yang, Xiaodong Zhang Theranostics 2024; 14(15): 6036-6052. doi:10.7150/thno.99407 Full text PDF PubMed PMC

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Subarachnoid hemorrhage distinctively disrupts the glymphatic and meningeal lymphatic systems in beagles Jiaqi Wang, Tao Lv, Feng Jia, Yang Li, Weiwei Ma, Zhi-Peng Xiao, Weifeng Yu, Heng Zhao, Xiaohua Zhang, Qin Hu Theranostics 2024; 14(15): 6053-6070. doi:10.7150/thno.100982 Full text PDF PubMed PMC

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Hypoxanthine is a metabolic biomarker for inducing GSDME-dependent pyroptosis of endothelial cells during ischemic stroke Jing Ye, Xinyuan Bi, Shiyu Deng, Xianghui Wang, Ze Liu, Qian Suo, Jiao Wu, Haoran Chen, Yong Wang, Kun Qian, Rubing Shi, Jing Zhao, Guo-Yuan Yang, Jian Ye, Yaohui Tang Theranostics 2024; 14(15): 6071-6087. doi:10.7150/thno.100090 Full text PDF PubMed PMC

Review

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Ferroptosis at the nexus of metabolism and metabolic diseases Shuangwen Li, Guixiang Zhang, Jiankun Hu, Yan Tian, Xianghui Fu Theranostics 2024; 14(15): 5826-5852. doi:10.7150/thno.100080 Full text PDF PubMed PMC

Erratum

A thermosensitive, reactive oxygen species-responsive, MR409-encapsulated hydrogel ameliorates disc degeneration in rats by inhibiting the secretory autophagy pathway: Erratum Qiangqiang Zheng, Haotian Shen, Zongrui Tong, Linxiang Cheng, Yuzi Xu, Zhiyun Feng, Shiyao Liao, Xiaojian Hu, Zongyou Pan, Zhengwei Mao, Yue Wang Theranostics 2024; 14(15): 5982-5983. doi:10.7150/thno.103020 Full text PDF PubMed PMC

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