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Volume 14 (16); 2024
Research Papers
Highly potent and selective PPARδ agonist reverses memory deficits in mouse models of Alzheimer's disease Hyeon Jeong Kim, Haelee Kim, Jaeyoung Song, Jun Young Hong, Elijah Hwejin Lee, Ashwini M. Londhe, Ji Won Choi, Sun Jun Park, Eunseok Oh, Heeseok Yoon, Hoosang Hwang, Dongyup Hahn, Kyungjin Jung, Sugyeong Kwon, Tara Man Kadayat, Min Jung Ma, Jeongmin Joo, Jina Kim, Jae Hyun Bae, Hayoung Hwang, Ae Nim Pae, Sung Jin Cho, Jong-Hyun Park, Jungwook Chin, Heonjoong Kang, Ki Duk Park
Theranostics 2024; 14(16): 6088-6108. doi:10.7150/thno.96707
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Single-cell profiling of brain pericyte heterogeneity following ischemic stroke unveils distinct pericyte subtype-targeted neural reprogramming potential and its underlying mechanisms Allison Loan, Nidaa Awaja, Margarita Lui, Charvi Syal, Yiren Sun, Sailendra N Sarma, Ragav Chona, William B Johnston, Alex Cordova, Devansh Saraf, Anabella Nakhlé, Kaela O'Connor, Jacob Thomas, Joseph Leung, Matthew Seegobin, Ling He, Fredric E Wondisford, David J Picketts, Eve C Tsai, Hing Man Chan, Jing Wang
Theranostics 2024; 14(16): 6110-6137. doi:10.7150/thno.97165
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High-efficiency magnetophoretic labelling of adoptively-transferred T cells for longitudinal in vivo Magnetic Particle Imaging Rong En Tay, Lokamitra P, Shun Toll Pang, Kay En Low, Hui Chien Tay, Charmaine Min Ho, Benoit Malleret, Olaf Rötzschke, Malini Olivo, Zhi Wei Tay
Theranostics 2024; 14(16): 6138-6160. doi:10.7150/thno.95527
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A novel ferroptosis inhibitor, Thonningianin A, improves Alzheimer's disease by activating GPX4 Yuanyuan Yong, Lu Yan, Jing Wei, Chi Feng, Lu Yu, Jianming Wu, Minsong Guo, Dongsheng Fan, Chonglin Yu, Dalian Qin, Xiaogang Zhou, Anguo Wu
Theranostics 2024; 14(16): 6161-6184. doi:10.7150/thno.98172
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Spatial transcriptomic sequencing reveals immune microenvironment features of Mycobacterium tuberculosis granulomas in lung and omentum Xiaochen Qiu, Pengfei Zhong, Liang Yue, Chaofan Li, Zhimin Yun, Guangqian Si, Mengfan Li, Zhi Chen, Yingxia Tan, Pengtao Bao
Theranostics 2024; 14(16): 6185-6201. doi:10.7150/thno.99038
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Tau‑targeting multifunctional nanocomposite based on tannic acid-metal for near-infrared fluorescence/magnetic resonance bimodal imaging-guided combinational therapy in Alzheimer's disease Yutian Gu, Qin Zhang, Honglin Huang, Kwun Hei Willis Ho, Yu Zhang, Changqing Yi, Yifan Zheng, Raymond Chuen Chung Chang, Emma Shujun Wang, Mo Yang
Theranostics 2024; 14(16): 6218-6235. doi:10.7150/thno.98462
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Cardiomyocyte-derived USP28 negatively regulates antioxidant response and promotes cardiac hypertrophy via deubiquitinating TRIM21 Jibo Han, Liming Lin, Zimin Fang, Bozhi Ye, Xue Han, Jiachen Xu, Binjiang Han, Julian Min, Jinfu Qian, Gaojun Wu, Yi Wang, Guang Liang
Theranostics 2024; 14(16): 6236-6248. doi:10.7150/thno.99340
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Development of a CD39 nanobody and its enhancement to chimeric antigen receptor T cells efficacy against ovarian cancer in preclinical studies Yu-Chen Zhang, Xian-Yang Li, Qi Deng, Yan-Jun Ge, Rui-Rong Yi, Hua-Jing Wang, Jian-Tao Wang, Hui Zhou, Xue-Feng Kong, Rong-Jiao Liu, Yu-Ting Zhang, Xiao-Pei Li, Xiao-Wen He, Hai-Yan Zhu
Theranostics 2024; 14(16): 6249-6267. doi:10.7150/thno.97590
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Preoperative PET imaging and fluorescence-guided surgery of human glioblastoma using dual-labeled antibody targeting ETA receptors in a preclinical mouse model: A theranostic approach Marie Hautiere, Delphine Vivier, Paul Dorval, Donovan Pineau, Dimitri Kereselidze, Caroline Denis, Amaury Herbet, Narciso Costa, Claire Bernhard, Victor Goncalves, Erwan Selingue, Benoit Larrat, Pierre Alix Dancer, Jean-Philippe Hugnot, Didier Boquet, Charles Truillet, Franck Denat
Theranostics 2024; 14(16): 6268-6280. doi:10.7150/thno.98163
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Preclinical pharmacology of patient-derived extracellular vesicles for the intraoperative imaging of tumors Alessandro Villa, Daniela Crescenti, Zemira De Mitri, Elisabetta Crippa, Silvia Rosa, Nicoletta Rizzi, Fereshteh Shojaei-Ghahrizjani, Monica Rebecchi, Simona Vincenti, Francesca Selmin, Electra Brunialti, Nicolò Simonotti, Marianna Maspero, Michele Dei Cas, Camilla Recordati, Saverio Paltrinieri, Alessia Giordano, Rita Paroni, Margherita Galassi, Vito Ladisa, Flavio Arienti, Francesco Cilurzo, Vincenzo Mazzaferro, Paolo Ciana
Theranostics 2024; 14(16): 6301-6318. doi:10.7150/thno.98671
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PET imaging of microglia in Alzheimer's disease using copper-64 labeled TREM2 antibodies Monireh Shojaei, Rebecca Schaefer, Kai Schlepckow, Lea H. Kunze, Felix L. Struebing, Bettina Brunner, Michael Willem, Laura M. Bartos, Astrid Feiten, Giovanna Palumbo, Thomas Arzberger, Peter Bartenstein, Gian Carlo Parico, Dan Xia, Kathryn M. Monroe, Christian Haass, Matthias Brendel, Simon Lindner
Theranostics 2024; 14(16): 6319-6336. doi:10.7150/thno.97149
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PET imaging of CXCR4 expression using [18F]AlF-NOTA-QHY-04 for hematologic malignancy and solid tumors Kai Cheng, Shijie Wang, Tianxin Liu, Jinli Pei, Shasha Wang, Jingru Liu, Kunlong Zhao, Yuxi Luo, Shengnan Xu, Jinming Yu, Jie Liu
Theranostics 2024; 14(16): 6337-6349. doi:10.7150/thno.99025
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Tumor-derived extracellular vesicles convey solute transporters to induce bioenergetic dependence shift contributing to treatment resistance Jayshree Hirpara, Win Lwin Thuya, Sok-Hwee Cheow, Kanishka Fernando, Jie Qing Eu, Lingzhi Wang, Andrea Li-Ann Wong, Eliza Li Shan Fong, Azhar Bin Ali, Ling-wen Ding, Wu Zhuoran, Yaw-Chyn Lim, Shazib Pervaiz, Boon-Cher Goh
Theranostics 2024; 14(16): 6350-6369. doi:10.7150/thno.100374
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Targeted sonogenetic modulation of GABAergic interneurons in the hippocampal CA1 region in status epilepticus Tao Xu, Dandan Tan, You Wang, Chen Gong, Jinxian Yuan, Xiaolan Yang, Yuetao Wen, Yuenan Ban, Minxue Liang, Yaqin Hu, Yang Cao, Yangmei Chen, Haitao Ran
Theranostics 2024; 14(16): 6373-6391. doi:10.7150/thno.96598
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Hypoxia-driven M2-polarized macrophages facilitate the epithelial-mesenchymal transition of glioblastoma via extracellular vesicles Liang Liu, Ran Wang, Aogesi Alifu, Yong Xiao, Yong Liu, Chunfa Qian, Mengjie Zhao, Xianglong Tang, Yandong Xie, Yan Shi, Yuanjie Zou, Hong Xiao, Kun Yang, Hongyi Liu
Theranostics 2024; 14(16): 6392-6408. doi:10.7150/thno.95766
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Genetically engineered cellular nanoparticles loaded with curcuminoids for cancer immunotherapy Yifang Liao, Chenchen Zhao, Yuanwei Pan, Yiming Guo, Lujie Liu, Jicheng Wu, Yunjiao Zhang, Lang Rao, Qi Li
Theranostics 2024; 14(16): 6409-6425. doi:10.7150/thno.99033
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Reviews
Engineered mesenchymal stem cell-derived extracellular vesicles: kill tumors and protect organs Yu Li, Yao Wang, Yu Zhang, Yuruchen Zhu, Yuhui Dong, Haobin Cheng, Yinan Zhang, Yue Wang, Zhaoshen Li, Jie Gao
Theranostics 2024; 14(16): 6202-6217. doi:10.7150/thno.99618
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Targeted radiopharmaceuticals: an underexplored strategy for ovarian cancer Melissa Crabbé, Tomas Opsomer, Koen Vermeulen, Maarten Ooms, Charlotte Segers
Theranostics 2024; 14(16): 6281-6300. doi:10.7150/thno.99782
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Errata
Alkaline Phosphatase Controls Lineage Switching of Mesenchymal Stem Cells by Regulating the LRP6/GSK3β Complex in Hypophosphatasia: Erratum Wenjia Liu, Liqiang Zhang, Kun Xuan, Chenghu Hu, Liya Li, Yongjie Zhang, Fang Jin, Yan Jin
Theranostics 2024; 14(16): 6109. doi:10.7150/thno.103686
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Induction of ER stress-mediated apoptosis through SOD1 upregulation by deficiency of CHI3L1 inhibits lung metastasis: Erratum Ji Eun Yu, In Jun Yeo, Seung Sik Yoo, Sung-hyun Kim, Dong Ju Son, Jaesuk Yun, Sang-Bae Han, Jin Tae Hong
Theranostics 2024; 14(16): 6370-6372. doi:10.7150/thno.98971
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