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Volume 12 (10); 2022

Research Papers

Graphic abstract

Selective brain entry of lipid nanoparticles in haemorrhagic stroke is linked to biphasic blood-brain barrier disruption
Zahraa S. Al-Ahmady, Ben R. Dickie, Isabelle Aldred, Dhifaf A. Jasim, Jack Barrington, Michael Haley, Eloise Lemarchand, Graham Coutts, Satinderdeep Kaur, Jessica Bates, Sarah Curran, Ruth Goddard, Megan Walker, Adrian Parry-jones, Kostas Kostarelos, Stuart M. Allan
Theranostics 2022; 12(10): 4477-4497. doi:10.7150/thno.72167
[Abstract] [Full text] [PDF]


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Specific (sialyl-)Lewis core 2 O-glycans differentiate colorectal cancer from healthy colon epithelium
Katarina Madunić, Oleg A. Mayboroda, Tao Zhang, Julia Weber, Geert-Jan Boons, Hans Morreau, Ronald van Vlierberghe, Tom van Wezel, Guinevere S.M. Lageveen-Kammeijer, Manfred Wuhrer
Theranostics 2022; 12(10): 4498-4512. doi:10.7150/thno.72818
[Abstract] [Full text] [PDF]


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Blockade of phosphotyrosine pathways suggesting SH2 superbinder as a novel therapy for pulmonary fibrosis
Meng Wang, An-Dong Liu, Qian Niu, Xiao Feng, Yuan-Yi Zheng, Shuai-Jun Chen, Hui Xu, Qian Li, Guo-Qing Hou, Xiao-Yang Bi, Yu-Zhi Lu, Pei-Pei Cheng, Li-Mei Liang, Ye-Han Jiang, Li-Qin Zhao, Fei Liu, Lin-Jie Song, Li-Ling Zhou, Ling-Yan Xiao, Feng Chen, Shawn Shun-Cheng Li, Wan-Li Ma, Xuan Cao, Hong Ye
Theranostics 2022; 12(10): 4513-4535. doi:10.7150/thno.72269
[Abstract] [Full text] [PDF]


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Super-stable cyanine@albumin fluorophore for enhanced NIR-II bioimaging
Lang Bai, Zhubin Hu, Tianyang Han, Yajun Wang, Jiajun Xu, Guanyu Jiang, Xin Feng, Bin Sun, Xiangping Liu, Rui Tian, Haitao Sun, Songling Zhang, Xiaoyuan Chen, Shoujun Zhu
Theranostics 2022; 12(10): 4536-4547. doi:10.7150/thno.71443
[Abstract] [Full text] [PDF]


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NOTCH1 signaling regulates the latent neurogenic program in adult reactive astrocytes after spinal cord injury
Zijian Tan, Shangyao Qin, Yimin Yuan, Xin Hu, Xiao Huang, Hong Liu, Yingyan Pu, Cheng He, Zhida Su
Theranostics 2022; 12(10): 4548-4563. doi:10.7150/thno.71378
[Abstract] [Full text] [PDF]


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FGFR blockade boosts T cell infiltration into triple-negative breast cancer by regulating cancer-associated fibroblasts
Yushen Wu, Ziying Yi, Jie Li, Yuxian Wei, Rui Feng, Jiazhou Liu, Jiefeng Huang, Yuru Chen, Xiaoyu Wang, Jiazheng Sun, Xuedong Yin, Yunhai Li, Jingyuan Wan, Li Zhang, Jing Huang, Huimin Du, Xiaoyi Wang, Qin Li, Guosheng Ren, Hongzhong Li
Theranostics 2022; 12(10): 4564-4580. doi:10.7150/thno.68972
[Abstract] [Full text] [PDF]


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Promising alternatives of CD47 monoclonal antibody: an injectable degradable hydrogel loaded with PQ912 for postoperative immunotherapy effectively blocks CD47-SIRPα signal
Chang Li, Yubo Liu, Dan Li, Qiu Wang, Shuang Zhou, Haotian Zhang, Yongjun Wang, Zhonggui He, Hongzhuo Liu, Jin Sun
Theranostics 2022; 12(10): 4581-4598. doi:10.7150/thno.72310
[Abstract] [Full text] [PDF]


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Single-cell transcriptome profiling of the immune space-time landscape reveals dendritic cell regulatory program in polymicrobial sepsis
Ren-qi Yao, Zhi-xuan Li, Li-xue Wang, Yu-xuan Li, Li-yu Zheng, Ning Dong, Yao Wu, Zhao-fan Xia, Timothy R. Billiar, Chao Ren, Yong-ming Yao
Theranostics 2022; 12(10): 4606-4628. doi:10.7150/thno.72760
[Abstract] [Full text] [PDF]


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Acellular cardiac scaffolds enriched with MSC-derived extracellular vesicles limit ventricular remodelling and exert local and systemic immunomodulation in a myocardial infarction porcine model
Marta Monguió-Tortajada, Cristina Prat-Vidal, Daina Martínez-Falguera, Albert Teis, Carolina Soler-Botija, Yvan Courageux, Micaela Munizaga-Larroudé, Miriam Moron-Font, Antoni Bayes-Genis, Francesc E. Borràs, Santiago Roura, Carolina Gálvez-Montón
Theranostics 2022; 12(10): 4656-4670. doi:10.7150/thno.72289
[Abstract] [Full text] [PDF]


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Plasma lipids signify the progression of precancerous gastric lesions to gastric cancer: a prospective targeted lipidomics study
Zong-Chao Liu, Wen-Hui Wu, Sha Huang, Zhong-Wu Li, Xue Li, Guang-Hou Shui, Sin Man Lam, Bo-Wen Li, Zhe-Xuan Li, Yang Zhang, Tong Zhou, Wei-Cheng You, Kai-Feng Pan, Wen-Qing Li
Theranostics 2022; 12(10): 4671-4683. doi:10.7150/thno.74770
[Abstract] [Full text] [PDF]


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3D culturing of human pluripotent stem cells-derived endothelial cells for vascular regeneration
Edit Gara, Eleonora Zucchelli, Annamária Nemes, Zoltán Jakus, Kitti Ajtay, Éva Kemecsei, Gábor Kiszler, Nikolett Hegedűs, Krisztián Szigeti, Iván Földes, Kristóf Árvai, János Kósa, Kraszimir Kolev, Erzsébet Komorowicz, Parasuraman Padmanabhan, Pál Maurovich-Horvat, Edit Dósa, György Várady, Miklós Pólos, István Hartyánszky, Sian E. Harding, Béla Merkely, Domokos Máthé, Gábor Szabó, Tamás Radovits, Gábor Földes
Theranostics 2022; 12(10): 4684-4702. doi:10.7150/thno.69938
[Abstract] [Full text] [PDF]


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Genome instability is associated with ethnic differences between Asians and Europeans in hepatocellular carcinoma
Neslihan A. Kaya, Jianbin Chen, Hannah Lai, Hechuan Yang, Liang Ma, Xiaodong Liu, Jacob Santiago Alvarez, Jin Liu, Axel M. Hillmer, David Tai, Joe Yeong Poh Sheng, Zheng Hu, Yun Shen Chan, Pierce K.H Chow, Yuguang Mu, Torsten Wuestefeld, Weiwei Zhai
Theranostics 2022; 12(10): 4703-4717. doi:10.7150/thno.71676
[Abstract] [Full text] [PDF]


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Norepinephrine acting on adventitial fibroblasts stimulates vascular smooth muscle cell proliferation via promoting small extracellular vesicle release
Chao Ye, Fen Zheng, Tao Xu, Nan Wu, Ying Tong, Xiao-Qing Xiong, Ye-Bo Zhou, Jue-Jin Wang, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Ying Han
Theranostics 2022; 12(10): 4718-4733. doi:10.7150/thno.70974
[Abstract] [Full text] [PDF]


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MiR-155 deficiency protects renal tubular epithelial cells from telomeric and genomic DNA damage in cisplatin-induced acute kidney injury
Qing Yin, Ya-Jie Zhao, Wei-Jie Ni, Tao-Tao Tang, Yao Wang, Jing-Yuan Cao, Di Yin, Yi Wen, Zuo-Lin Li, Yi-Lin Zhang, Wei Jiang, Yue Zhang, Xiao-Yu Lu, Ai-Qing Zhang, Wei-Hua Gan, Lin-Li Lv, Bi-Cheng Liu, Bin Wang
Theranostics 2022; 12(10): 4753-4766. doi:10.7150/thno.72456
[Abstract] [Full text] [PDF]


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Internally inlaid SaCas9 base editors enable window specific base editing
Lurong Jiang, Jie Long, Yang Yang, Lifang Zhou, Jing Su, Fengming Qin, Wenling Tang, Rui Tao, Qiang Chen, Shaohua Yao
Theranostics 2022; 12(10): 4767-4778. doi:10.7150/thno.70869
[Abstract] [Full text] [PDF]


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Ultrasound-directed enzyme-prodrug therapy (UDEPT) using self-immolative doxorubicin derivatives
Karolin Roemhild, Helena C. Besse, Bi Wang, Quim Peña, Qingxue Sun, Daiki Omata, Burcin Ozbakir, Clemens Bos, Hans W. Scheeren, Gert Storm, Josbert M. Metselaar, Haijun Yu, Ruth Knüchel-Clarke, Fabian Kiessling, Chrit T.W. Moonen, Roel Deckers, Yang Shi, Twan Lammers
Theranostics 2022; 12(10): 4791-4801. doi:10.7150/thno.69168
[Abstract] [Full text] [PDF]


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N6-methyladenosine-mediated LDHA induction potentiates chemoresistance of colorectal cancer cells through metabolic reprogramming
Kun Zhang, Tao Zhang, Yuhan Yang, Wenling Tu, Hongbin Huang, Yujun Wang, Yuzhuo Chen, Kejian Pan, Zhuojia Chen
Theranostics 2022; 12(10): 4802-4817. doi:10.7150/thno.73746
[Abstract] [Full text] [PDF]


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Dual-sensitive antibacterial peptide nanoparticles prevent dental caries
Peng Zhang, Saizhi Wu, Jinting Li, Xiaoshuang Bu, Xiaoping Dong, Ninglin Chen, Fengjiao Li, Jingyu Zhu, Longkang Sang, Youlin Zeng, Songping Liang, Zhilin Yu, Zhonghua Liu
Theranostics 2022; 12(10): 4818-4833. doi:10.7150/thno.73181
[Abstract] [Full text] [PDF]

Reviews

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How to improve photodynamic therapy-induced antitumor immunity for cancer treatment?
Min Zhang, Yifan Zhao, He Ma, Yusong Sun, Jie Cao
Theranostics 2022; 12(10): 4629-4655. doi:10.7150/thno.72465
[Abstract] [Full text] [PDF]


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Challenges and opportunities to penetrate the blood-brain barrier for brain cancer therapy
Dannielle H. Upton, Caitlin Ung, Sandra M. George, Maria Tsoli, Maria Kavallaris, David S. Ziegler
Theranostics 2022; 12(10): 4734-4752. doi:10.7150/thno.69682
[Abstract] [Full text] [PDF]


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Engineering viral genomics and nano-liposomes in microfluidic platforms for patient-specific analysis of SARS-CoV-2 variants
Sandro Satta, Fahimeh Shahabipour, Wei Gao, Steven R. Lentz, Stanley Perlman, Nureddin Ashammakhi, Tzung Hsiai
Theranostics 2022; 12(10): 4779-4790. doi:10.7150/thno.72339
[Abstract] [Full text] [PDF]

Errata

Bioactive antibacterial silica-based nanocomposites hydrogel scaffolds with high angiogenesis for promoting diabetic wound healing and skin repair: Erratum
Yannan Li, Tianzhen Xu, Zhuolong Tu, Wentong Dai, Yumeng Xue, Chengxuan Tang, Weiyang Gao, Cong Mao, Bo Lei, Cai Lin
Theranostics 2022; 12(10): 4599-4600. doi:10.7150/thno.73263
[Abstract] [Full text] [PDF]


3D-bioprinting ready-to-implant anisotropic menisci recapitulate healthy meniscus phenotype and prevent secondary joint degeneration: Erratum
Ye Sun, Yuxin Zhang, Qiang Wu, Feng Gao, Yongzhong Wei, Yimin Ma, Wenbo Jiang, Kerong Dai
Theranostics 2022; 12(10): 4601-4602. doi:10.7150/thno.73783
[Abstract] [Full text] [PDF]


Microenvironment Activatable Nanoprodrug Based on Gripper-like Cyclic Phenylboronic Acid to Precisely and Effectively Alleviate Drug-induced Hepatitis: Erratum
Qixiong Zhang, Shanshan Li, Lulu Cai, Yuxuan Zhu, Xingmei Duan, Peidu Jiang, Lei Zhong, Kun Guo, Rongsheng Tong
Theranostics 2022; 12(10): 4603. doi:10.7150/thno.74167
[Abstract] [Full text] [PDF]


H3K27 acetylation activated-COL6A1 promotes osteosarcoma lung metastasis by repressing STAT1 and activating pulmonary cancer-associated fibroblasts: Erratum
Ying Zhang, Zhaoyong Liu, Xia Yang, Weiqing Lu, Yelong Chen, Youbin Lin, Jin Wang, Suxia Lin, Jing-Ping Yun
Theranostics 2022; 12(10): 4604-4605. doi:10.7150/thno.74233
[Abstract] [Full text] [PDF]