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Volume 14 (7); 2024

Research Papers

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AXL-specific single domain antibodies show diagnostic potential and anti-tumor activity in Acute Myeloid Leukemia Niels Vandewalle, Hatice Satilmis, Emma Verheye, Rong Fan, Yanmeng Wang, Timo W.M. De Groof, Jessica Bridoux, Tessa Kerre, Nathan De Beule, Ann De Becker, Elke De Bruyne, Eline Menu, Karin Vanderkerken, Karine Breckpot, Nick Devoogdt, Kim De Veirman Theranostics 2024; 14(7): 2656-2674. doi:10.7150/thno.91456 Full text PDF PubMed PMC

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Albumin-seeking dyes with adjustable assemblies in situ enable programmable imaging windows and targeting tumor imaging Yijing Du, Jiajun Xu, Tianyang Han, Zijian Jiang, Yuewei Zhang, Jia Li, Xiaoyuan Chen, Shoujun Zhu Theranostics 2024; 14(7): 2675-2686. doi:10.7150/thno.92991 Full text PDF PubMed PMC

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Abnormal mitochondrial iron metabolism damages alveolar type II epithelial cells involved in bleomycin-induced pulmonary fibrosis Min Shao, Haipeng Cheng, Xiaohong Li, Yujia Qiu, Yunna Zhang, Yanfen Chang, Jiafeng Fu, Mengxia Shen, Xinxin Xu, Dandan Feng, Yang Han, ShaoJie Yue, Yan Zhou, Ziqiang Luo Theranostics 2024; 14(7): 2687-2705. doi:10.7150/thno.94072 Full text PDF PubMed PMC

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Hyperglycemia facilitates EV71 replication: Insights into miR-206-mediated regulation of G3BP2 promoting EV71 IRES activity Rai-Hua Lai, Yen-Hung Chow, Yi-Wen Lin, Nai-Hsiang Chung, Shu-Wei Nien, Jyh-Lyh Juang Theranostics 2024; 14(7): 2706-2718. doi:10.7150/thno.93883 Full text PDF PubMed PMC

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Bifidobacterium breve-derived indole-3-lactic acid ameliorates colitis-associated tumorigenesis by directing the differentiation of immature colonic macrophages Yuke Li, Qingxiang Li, Ruoshui Yuan, Yifei Wang, Chuanbin Guo, Lin Wang Theranostics 2024; 14(7): 2719-2735. doi:10.7150/thno.92350 Full text PDF PubMed PMC

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Targeting tumor cell-to-macrophage communication by blocking Vtn-C1qbp interaction inhibits tumor progression via enhancing macrophage phagocytosis Chen Zhang, Yi Liu, Jiayu Jiang, Chong Chen, Zhaojun Duan, Huifang Su, Shijian Wang, Baorui Tian, Yi Shi, Rong Xiang, Yunping Luo Theranostics 2024; 14(7): 2757-2776. doi:10.7150/thno.94537 Full text PDF PubMed PMC

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Small extracellular vesicles (sEVs)-based gene delivery platform for cell-specific CRISPR/Cas9 genome editing Sunil Dubey, Zhe Chen, Yuxiao Jarvan Jiang, Austin Talis, Andrei Molotkov, Alessandra Ali, Akiva Mintz, Fatemeh Momen-Heravi Theranostics 2024; 14(7): 2777-2793. doi:10.7150/thno.92133 Full text PDF PubMed PMC

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Nicotinamide phosphoribosyltransferase prompts bleomycin-induced pulmonary fibrosis by driving macrophage M2 polarization in mice Yaling Chen, Tong Wang, Fuxiang Liang, Jia Han, Zhiling Lou, Yifan Yu, Jinsheng Li, Tianwei Zhan, Yuqing Gu, Lingjun Dong, Bo Jiang, Weiping Zhang, Ming Wu, Yunbi Lu Theranostics 2024; 14(7): 2794-2815. doi:10.7150/thno.94482 Full text PDF PubMed PMC

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In situ single-cell therapeutic response imaging facilitated by the TRIPODD fluorescence imaging platform Nathan P. McMahon, Allison Solanki, Lei G. Wang, Antonio R. Montaño, Jocelyn A. Jones, Kimberley S. Samkoe, Kenneth M. Tichauer, Summer L. Gibbs Theranostics 2024; 14(7): 2816-2834. doi:10.7150/thno.93256 Full text PDF PubMed PMC

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CRISPR-Cas9 library screening combined with an exosome-targeted delivery system addresses tumorigenesis/TMZ resistance in the mesenchymal subtype of glioblastoma Jixing Zhao, Xiaoteng Cui, Qi Zhan, Kailiang Zhang, Dongyuan Su, Shixue Yang, Biao Hong, Qixue Wang, Jiasheng Ju, Chunchao Cheng, Chen Li, Chunxiao Wan, Yunfei Wang, Junhu Zhou, Chunsheng Kang Theranostics 2024; 14(7): 2835-2855. doi:10.7150/thno.92703 Full text PDF PubMed PMC

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Activation of the hypoxia-inducible factor pathway protects against acute ischemic stroke by reprogramming central carbon metabolism Sarah Madai, Pinar Kilic, Rolf M. Schmidt, Carlos Bas-Orth, Thomas Korff, Michael Büttner, Glynis Klinke, Gernot Poschet, Hugo H. Marti, Reiner Kunze Theranostics 2024; 14(7): 2856-2880. doi:10.7150/thno.88223 Full text PDF PubMed PMC

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Distinct eLPBChAT projections for methamphetamine withdrawal anxiety and primed reinstatement of conditioned place preference Wenwen Chen, Hao Guo, Ning Zhou, Yuning Mai, Tao Hu, Xing Xu, Teng He, Jun Wen, Shan Qin, Chengyong Liu, Wenzhong Wu, Hee Young Kim, Yu Fan, Feifei Ge, Xiaowei Guan Theranostics 2024; 14(7): 2881-2896. doi:10.7150/thno.95383 Full text PDF PubMed PMC

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Adaptive plasticity of natural interleukin-35-induced regulatory T cells (Tr35) that are required for T-cell immune regulation Xundong Wei, Jianhua Zhang, Jian Cui, Wei Xu, Gang Zhao, Chang Guo, Wei Yuan, Xuyu Zhou, Jie Ma Theranostics 2024; 14(7): 2897-2914. doi:10.7150/thno.90608 Full text PDF PubMed PMC

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Comprehensive multi-omics analysis of pyroptosis for optimizing neoadjuvant immunotherapy in patients with gastric cancer Jia-Bin Wang, You-Xin Gao, Yin-Hua Ye, Qiao-Ling Zheng, Hua-You Luo, Shuan-Hu Wang, Tao Zhang, Qin-Wen Jin, Chao-Hui Zheng, Ping Li, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Ying-Hong Yang, Chang-Ming Huang, Jian-Wei Xie Theranostics 2024; 14(7): 2915-2933. doi:10.7150/thno.93124 Full text PDF PubMed PMC

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A non-lipid nucleic acid delivery vector with dendritic cell tropism and stimulation Hyung Shik Kim, Elias A. Halabi, Noah Enbergs, Rainer H. Kohler, Fan Fei, Christopher S. Garris, Ralph Weissleder Theranostics 2024; 14(7): 2934-2945. doi:10.7150/thno.95267 Full text PDF PubMed PMC

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Cancer-associated fibroblast-derived periostin promotes papillary thyroid tumor growth through integrin-FAK-STAT3 signaling Xiaorui Jin, Qianmei Deng, Shuting Ye, Shuting Liu, Yilong Fu, Yingfu Liu, Guoyang Wu, Gaoliang Ouyang, Tiantian Wu Theranostics 2024; 14(7): 3014-3028. doi:10.7150/thno.94207 Full text PDF PubMed PMC

Reviews

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Prostate-specific membrane antigen-targeted surgery in prostate cancer: Accurate identification, real-time diagnosis, and precise resection Jianhua Jiao, Jingjing Zhang, Weihong Wen, Weijun Qin, Xiaoyuan Chen Theranostics 2024; 14(7): 2736-2756. doi:10.7150/thno.95039 Full text PDF PubMed PMC

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Spatial Transcriptomics: A Powerful Tool in Disease Understanding and Drug Discovery Junxian Cao, Caifeng Li, Zhao Cui, Shiwen Deng, Tong Lei, Wei Liu, Hongjun Yang, Peng Chen Theranostics 2024; 14(7): 2946-2968. doi:10.7150/thno.95908 Full text PDF PubMed PMC

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Actinium-225 targeted alpha particle therapy for prostate cancer Anil P. Bidkar, Luann Zerefa, Surekha Yadav, Henry F. VanBrocklin, Robert R. Flavell Theranostics 2024; 14(7): 2969-2992. doi:10.7150/thno.96403 Full text PDF PubMed PMC

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Mitochondrial Sirtuins in Cancer: A Revisited Review from Molecular Mechanisms to Therapeutic Strategies Hui Shen, Wei Ma, Yue Hu, Yuan Liu, Yaowen Song, Leilei Fu, Zheng Qin Theranostics 2024; 14(7): 2993-3013. doi:10.7150/thno.97320 Full text PDF PubMed PMC

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