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Volume 14 (10); 2024

Research Papers

Targeted delivery of anti-miRNA21 sensitizes PD-L1^high tumor to immunotherapy by promoting immunogenic cell death Eun Hye Kim, Jiwoong Choi, Hochung Jang, Yelee Kim, Jong Won Lee, Youngri Ryu, Jiwon Choi, Yeonho Choi, Sung-Gil Chi, Ick Chan Kwon, Yoosoo Yang, Sun Hwa Kim Theranostics 2024; 14(10): 3777-3792. doi:10.7150/thno.97755 Full text PDF PubMed PMC

CBX4 suppresses CD8⁺ T cell antitumor immunity by reprogramming glycolytic metabolism Jingzeng Wang, Wenlong Jia, Xi zhou, Zhibo Ma, Jing Liu, Peixiang Lan Theranostics 2024; 14(10): 3793-3809. doi:10.7150/thno.95748 Full text PDF PubMed PMC

Environment-responsive dendrobium polysaccharide hydrogel embedding manganese microsphere as a post-operative adjuvant to boost cascaded immune cycle against melanoma Nan Gao, Yiran Huang, Shisuo Jing, Meng Zhang, Ergang Liu, Lu Qiu, Jing Huang, Bahtiyor Muhitdinov, Yongzhuo Huang Theranostics 2024; 14(10): 3810-3826. doi:10.7150/thno.94354 Full text PDF PubMed PMC

Adeno-associated-virus-mediated delivery of CRISPR-CasRx induces efficient RNA knockdown in the mouse testis Kai Li, Mengzhen Li, Yanyun Luo, Dingfeng Zou, Yahui Li, Xinyu Mang, Zexuan Zhang, Pengyu Li, Yan Lu, Shiying Miao, Wei Song Theranostics 2024; 14(10): 3827-3842. doi:10.7150/thno.95633 Full text PDF PubMed PMC

Transfer of cardiomyocyte-derived extracellular vesicles to neighboring cardiac cells requires tunneling nanotubes during heart development Ting Chen, Ditte Gry Ellman, Shu Fang, Sara Thornby Bak, Mikkel Ørnfeldt Nørgård, Per Svenningsen, Ditte Caroline Andersen Theranostics 2024; 14(10): 3843-3858. doi:10.7150/thno.91604 Full text PDF PubMed PMC

A smart hypochlorous acid fluorescent probe enabling Ibuprofen-release for osteoarthritis theranostics Zhenni Lu, Peng Wei, Hongying Peng, Libo Jiang, Peiyi Wu, Tao Yi Theranostics 2024; 14(10): 3900-3908. doi:10.7150/thno.96958 Full text PDF PubMed PMC

Caspase-mediated AURKA cleavage at Asp¹³² is essential for paclitaxel to elicit cell apoptosis Xiaoting Chen, Shujuan Du, Yulin Zhang, Ke Peng, Lina Liu, Ting Wang, Hao Zhang, Shen Cai, Caixia Zhu, Youhai Li, Wen Tuo, Yuyan Wang, Fang Wei, Qiliang Cai Theranostics 2024; 14(10): 3909-3926. doi:10.7150/thno.97842 Full text PDF PubMed PMC

The orchestration of cell-cycle reentry and ribosome biogenesis network is critical for cardiac repair Yanli Wang, Junchu Tu, Weiliang Wu, Yan Xu, Yujie Li, Xiangbin Pan, Bin Liu, Tonggan Lu, Qingfang Han, Huiling Zhang, Lijuan Jiao, Yu Zhang, Xi-Yong Yu, Zhenya Shen, Yangxin Li Theranostics 2024; 14(10): 3927-3944. doi:10.7150/thno.96460 Full text PDF PubMed PMC

Osteoblast-specific down-regulation of NLRP3 inflammasome by aptamer-functionalized liposome nanoparticles improves bone quality in postmenopausal osteoporosis rats Lijun Xu, Jie Zhu, Lingjun Rong, Huinan Yang, Bin Wang, Shuai Lu, Lingxiao Zhang, Fuyi Li, Shihua Yang, Zhifang Wang, Chong Li, Xiao Hu, Ruoyun Liu, Lili Zheng, Hongjian Liu, Haohao Zhang, Yanling Liu, Di Zhao, Shuiying Zhao, Lun Zhang, Yingbo Jia, Shiyu Liang, Zhikang Guo, Xixiu Xie, Ruitian Liu, Lixia Zhang Theranostics 2024; 14(10): 3945-3962. doi:10.7150/thno.95423 Full text PDF PubMed PMC

Lens autophagy protein ATG16L1: a potential target for cataract treatment Yilei Cui, Xiaoning Yu, Jing Bao, Xiyuan Ping, Silu Shi, Yuxin Huang, Qichuan Yin, Hao Yang, Ruoqi Chen, Ke Yao, Xiangjun Chen, Xingchao Shentu Theranostics 2024; 14(10): 3984-3996. doi:10.7150/thno.93864 Full text PDF PubMed PMC

Intraductal photothermal ablation: a noninvasive approach for early breast cancer treatment and prevention Jianhua Liu, Biao Huang, Yan Rao, Liantao Guo, Cheguo Cai, Dongcheng Gao, Deguang Kong, Guannan Wang, Yao Xiong, Ran Cui, Mingxi Zhang, Chuang Chen Theranostics 2024; 14(10): 3997-4013. doi:10.7150/thno.97968 Full text PDF PubMed PMC

Bioinspired soft-hard combined system with mild photothermal therapeutic activity promotes diabetic bone defect healing via synergetic effects of immune activation and angiogenesis Minhao Wu, Huifan Liu, Yufan Zhu, Ping Wu, Yun Chen, Zhouming Deng, Xiaobin Zhu, Lin Cai Theranostics 2024; 14(10): 4014-4057. doi:10.7150/thno.97335 Full text PDF PubMed PMC

Microglial circ-UBE2K exacerbates depression by regulating parental gene UBE2K via targeting HNRNPU Yujie Cai, Yao Ji, Yingxuan Liu, Dandan Zhang, Zheng Gong, Li Li, Xiongjin Chen, Chunmei Liang, Sifan Feng, Jiongtong Lu, Qinjie Qiu, Zhixiong Lin, Yan Wang, Lili Cui Theranostics 2024; 14(10): 4058-4075. doi:10.7150/thno.96890 Full text PDF PubMed PMC

Targeted opening of the blood-brain barrier using VCAM-1 functionalised microbubbles and “whole brain” ultrasound Vanessa A. Johanssen, Jia-Ling Ruan, Oliver Vince, Alec Thomas, Sarah Peeters, Manuel Sarmiento Soto, Jessica Buck, Michael Gray, Eleanor Stride, Nicola R. Sibson Theranostics 2024; 14(10): 4076-4089. doi:10.7150/thno.93172 Full text PDF PubMed PMC

PRMT6-mediated ADMA promotes p62 phase separation to form a negative feedback loop in ferroptosis Lifeng Feng, Lini Chen, Weikai Wang, Qi Wei, Minqiang Chen, Xin Jiang, Shiman Hu, Yuchen Wu, Lian Duan, Liyuan Zhu, Xian Wang, Hongchuan Jin Theranostics 2024; 14(10): 4090-4106. doi:10.7150/thno.94789 Full text PDF PubMed PMC

The CEBPB⁺ glioblastoma subcluster specifically drives the formation of M2 tumor-associated macrophages to promote malignancy growth Yongchang Yang, Xingyu Jin, Yang Xie, Chunlan Ning, Yiding Ai, Haotian Wei, Xing Xu, Xianglian Ge, Tailong Yi, Qiang Huang, Xuejun Yang, Tao Jiang, Xiaoguang Wang, Yingzhe Piao, Xun Jin Theranostics 2024; 14(10): 4107-4126. doi:10.7150/thno.93473 Full text PDF PubMed PMC

FUS-mediated BBB opening leads to transient perfusion decrease and inflammation without acute or chronic brain lesion Sébastien Rigollet, Claire Rome, Thomas Ador, Erik Dumont, Chantal Pichon, Anthony Delalande, Emmanuel L. Barbier, Vasile Stupar Theranostics 2024; 14(10): 4147-4160. doi:10.7150/thno.96721 Full text PDF PubMed PMC

Reviews

Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies Jiayao Chen, Zhuowen Hao, Hanke Li, Jianping Wang, Tianhong Chen, Ying Wang, Guang Shi, Junwu Wang, Zepu Wang, Zheyuan Zhang, Jingfeng Li Theranostics 2024; 14(10): 3859-3899. doi:10.7150/thno.96516 Full text PDF PubMed PMC

The emerging role of Piezo1 in the musculoskeletal system and disease Lei Lei, Zhenkang Wen, Mingde Cao, Haozhi Zhang, Samuel Ka-Kin Ling, Bruma Sai-Chuen Fu, Ling Qin, Jiankun Xu, Patrick Shu-Hang Yung Theranostics 2024; 14(10): 3963-3983. doi:10.7150/thno.96959 Full text PDF PubMed PMC

Biomarker-driven molecular imaging probes in radiotherapy Haonan Li, Qiyong Gong, Kui Luo Theranostics 2024; 14(10): 4127-4146. doi:10.7150/thno.97768 Full text PDF PubMed PMC

From biogenesis to aptasensors: advancements in analysis for tumor-derived extracellular vesicles research Gaojian Yang, Zhiyang Li, Rabia Usman, Yuan Liu, Song Li, Zhu Chen, Hui Chen, Yan Deng, Yile Fang, Nongyue He Theranostics 2024; 14(10): 4161-4183. doi:10.7150/thno.95885 Full text PDF PubMed PMC

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