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Volume 12 (17); 2022

Research Papers

Graphic abstract

Modulating the pharmacokinetic profile of Actinium-225-labeled macropa-derived radioconjugates by dual targeting of PSMA and albumin
Falco Reissig, Kristof Zarschler, Zbynek Novy, Milos Petrik, Katerina Bendova, Daniela Kurfurstova, Jan Bouchal, Marie-Charlotte Ludik, Florian Brandt, Klaus Kopka, Marta Khoylou, Hans-Jürgen Pietzsch, Marian Hajduch, Constantin Mamat
Theranostics 2022; 12(17): 7203-7215. doi:10.7150/thno.78043
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss
Liling Wang, Huan Wang, Jing Luo, Ting Xie, Gil Mor, Aihua Liao
Theranostics 2022; 12(17): 7216-7236. doi:10.7150/thno.78467
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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MMP 9-instructed assembly of bFGF nanofibers in ischemic myocardium to promote heart repair
Yaguang Wang, Di Wang, Chao Wu, Bin Wang, Shufang He, Hua Wang, Gaolin Liang, Ye Zhang
Theranostics 2022; 12(17): 7237-7249. doi:10.7150/thno.77345
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Fibroblast-specific activation of Rnd3 protects against cardiac remodeling in diabetic cardiomyopathy via suppression of Notch and TGF-β signaling
Yan Zhang, Yang Cao, Rui Zheng, Zhenyu Xiong, Zhengru Zhu, Fanya Gao, Wanrong Man, Yu Duan, Jie Lin, Xuebin Zhang, Dexi Wu, Mengyuan Jiang, Xiao Zhang, Congye Li, Xiaoming Gu, Yanhong Fan, Dongdong Sun
Theranostics 2022; 12(17): 7250-7266. doi:10.7150/thno.77043
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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N6-methyladenosine-associated prognostic pseudogenes contribute to predicting immunotherapy benefits and therapeutic agents in head and neck squamous cell carcinoma
Liqiang Tan, Yali Qin, Ruiling Xie, Tianliang Xia, Xiaotong Duan, Lan Peng, Rui You, Youping Liu, Xiong Zou, Mengxia Zhang, Mei Lin, Mingyuan Chen
Theranostics 2022; 12(17): 7267-7288. doi:10.7150/thno.76689
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α
Wenzhong Zheng, Kexin Wang, Yachen Wu, Ge Yan, Chi Zhang, Zhiqiang Li, Lianrong Wang, Shi Chen
Theranostics 2022; 12(17): 7289-7306. doi:10.7150/thno.76138
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Ninj2 regulates Schwann cells development by interfering laminin-integrin signaling
Yuxia Sun, Xiang Chen, Cen Yue, Wenyi Yang, Shu Zhang, Zhimin Ou, Ying Chen
Theranostics 2022; 12(17): 7307-7318. doi:10.7150/thno.76131
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Commensal gut microbiota-derived acetate and propionate enhance heart adaptation in response to cardiac pressure overload in mice
Chen-Ju Lin, Yu-Che Cheng, Hung-Chih Chen, Yu-Kai Chao, Martin W. Nicholson, Eric C.L. Yen, Timothy J. Kamp, Patrick C.H. Hsieh
Theranostics 2022; 12(17): 7319-7334. doi:10.7150/thno.76002
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Cancer-associated fibroblasts facilitate premetastatic niche formation through lncRNA SNHG5-mediated angiogenesis and vascular permeability in breast cancer
Huan Zeng, Yixuan Hou, Xinyue Zhou, Lei Lang, Haojun Luo, Yan Sun, Xueying Wan, Taixian Yuan, Rui Wang, Yongcan Liu, Rui Tang, Shaojie Cheng, Ming Xu, Manran Liu
Theranostics 2022; 12(17): 7351-7370. doi:10.7150/thno.74753
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Single-cell transcriptomics of peripheral blood reveals anti-tumor systemic immunity induced by oncolytic virotherapy
Quanyou Wu, Xiao Hu, Xiaoli Zhang, Defeng Kong, Zhenrong Yang, Guoliang Li, Zhaoru Gu, Qi Zhang, Duo Wan, Shujun Cheng, Binlei Liu, Kaitai Zhang, Wen Zhang
Theranostics 2022; 12(17): 7371-7389. doi:10.7150/thno.74075
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Depletion of gut microbiota improves the therapeutic efficacy of cancer nanomedicine
Ray Putra Prajnamitra, Yuan-Yuan Cheng, Chaw Yee Beh, Chien-Yi Lu, Jen-Hao Lin, Shu-Chian Ruan, Sheng-Lun Chen, Hung-Chih Chen, Ruey-Bing Yang, Patrick Ching-Ho Hsieh
Theranostics 2022; 12(17): 7390-7403. doi:10.7150/thno.73873
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Identification of a miRNA-based non-invasive predictive biomarker of response to target therapy in BRAF-mutant melanoma
Ciro Francesco Ruggiero, Luigi Fattore, Irene Terrenato, Francesca Sperati, Valentina Salvati, Gabriele Madonna, Mariaelena Capone, Fabio Valenti, Simona Di Martino, Chiara Mandoj, Domenico Liguoro, Vittorio Castaldo, Giordana Cafaro, Ester Simeone, Vito Vanella, Michelangelo Russillo, Laura Conti, Giovanni Cuda, Diana Giannarelli, Paolo Antonio Ascierto, Rita Mancini, Gennaro Ciliberto
Theranostics 2022; 12(17): 7420-7430. doi:10.7150/thno.77761
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Elevated ITGA5 facilitates hyperactivated mTORC1-mediated progression of laryngeal squamous cell carcinoma via upregulation of EFNB2
Dapeng Li, Anjiang Sun, Liang Zhang, Zhao Ding, Fangzheng Yi, Xue Yang, Zixi Wang, Xu Chen, Weiwei Liu, Shixian Liu, Hailong Shen, Manli Miao, Ling Zhang, Ping Liu, Yuchen Liu, Shihong Su, Hailiang Huang, Can Huang, Zhongdong Hu, Hongbing Zhang, Xiaojun Zha, Yehai Liu
Theranostics 2022; 12(17): 7431-7449. doi:10.7150/thno.76232
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Hippocalcin-Like 1 blunts liver lipid metabolism to suppress tumorigenesis via directly targeting RUVBL1-mTOR signaling
Tao Chen, Zhiqing Yuan, Zhou Lei, Jinlin Duan, Junyan Xue, Ting Lu, Guouan Yan, Lei Zhang, Yanfeng Liu, Qiwei Li, Yonglong Zhang
Theranostics 2022; 12(17): 7450-7464. doi:10.7150/thno.75936
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Self-immolative nanosensitizer for glutathione depletion- assisted sonodynamic therapy
Chan Ho Kim, Dong Gil You, Pramod Kumar E. K., Kyung Hee Han, Wooram Um, Jeongjin Lee, Jae Ah Lee, Jae Min Jung, Heegun Kang, Jae Hyung Park
Theranostics 2022; 12(17): 7465-7475. doi:10.7150/thno.75007
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The PROTAC selectively degrading Bcl-xL represents a novel Hedgehog pathway inhibitor with capacity of combating resistance to Smoothened inhibitors while sparing bone growth
Shaoqing Zhang, Yue Chen, Zhongli Xu, Jun Yang, Renhong Sun, Juan Wang, Yiming Sun, Biao Jiang, Xiaobao Yang, Wenfu Tan
Theranostics 2022; 12(17): 7476-7490. doi:10.7150/thno.75421
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Enhancer reprogramming promotes the activation of cancer-associated fibroblasts and breast cancer metastasis
Qian Li, Xuejiao Lv, Chunyong Han, Yu Kong, Zhongye Dai, Dawei Huo, Ting Li, Dapeng Li, Wei Li, Xing Wang, Qian Zhao, Jie Ming, Wen Yang, Yang Chen, Xudong Wu
Theranostics 2022; 12(17): 7491-7508. doi:10.7150/thno.75853
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Signatures of EMT, immunosuppression, and inflammation in primary and recurrent human cutaneous squamous cell carcinoma at single-cell resolution
Xin Li, Shuang Zhao, Xiaohui Bian, Lining Zhang, Lixia Lu, Shiyao Pei, Liang Dong, Wensheng Shi, Lingjuan Huang, Xiyuan Zhang, Mingliang Chen, Xiang Chen, Mingzhu Yin
Theranostics 2022; 12(17): 7532-7549. doi:10.7150/thno.77528
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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circHIPK3 prevents cardiac senescence by acting as a scaffold to recruit ubiquitin ligase to degrade HuR
Fengzhi Ding, Lin Lu, Chengjie Wu, Xiangbin Pan, Bin Liu, Yu Zhang, Yanli Wang, Weiliang Wu, Bing Yan, Yuqing Zhang, Xi-Yong Yu, Yangxin Li
Theranostics 2022; 12(17): 7550-7566. doi:10.7150/thno.77630
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A functionalized self-assembling peptide containing E7 and YIGSR sequences enhances neuronal differentiation of spermatogonial stem cells on aligned PCL fibers for spinal cord injury repair
Zhiyuan Wang, Shuaijun Jia, Hailiang Xu, Xiaohui Wang, Botao Lu, Weidong Wu, Dageng Huang, Lingbo Kong, Xin Kang, Fang Tian, Lei Zhu, Dingjun Hao
Theranostics 2022; 12(17): 7567-7585. doi:10.7150/thno.78448
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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TIMM44 is a potential therapeutic target of human glioma
Yi-zhuo Guo, Gang Chen, Man Huang, Yin Wang, Yuan-yuan Liu, Qin Jiang, Cong Cao, Fang Liu
Theranostics 2022; 12(17): 7586-7602. doi:10.7150/thno.78616
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Intravital molecular imaging reveals that ROS-caspase-3-GSDME-induced cell punching enhances humoral immunotherapy targeting intracellular tumor antigens
Bolei Dai, Ren Zhang, Shuhong Qi, Lei Liu, Xian Zhang, Deqiang Deng, Jie Zhang, Yilun Xu, Fanxuan Liu, Zheng Liu, Qingming Luo, Zhihong Zhang
Theranostics 2022; 12(17): 7603-7623. doi:10.7150/thno.75966
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The landscape of cancer-associated fibroblasts in colorectal cancer liver metastases
Ambre Giguelay, Evgenia Turtoi, Lakhdar Khelaf, Guillaume Tosato, Ikrame Dadi, Tommy Chastel, Marie-Alix Poul, Marine Pratlong, Stefan Nicolescu, Dany Severac, Antoine Adenis, Olivia Sgarbura-Popescu, Sébastien Carrère, Philippe Rouanet, François Quenet, Marc Ychou, Didier Pourqier, Pierre-Emmanuel Colombo, Andrei Turtoi, Jacques Colinge
Theranostics 2022; 12(17): 7624-7639. doi:10.7150/thno.72853
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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Paradigm shift in future biophotonics for imaging and therapy: Miniature living lasers to cellular scale optoelectronics
Paromita Sarbadhikary, Blassan P. George, Heidi Abrahamse
Theranostics 2022; 12(17): 7335-7350. doi:10.7150/thno.75905
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Cerenkov radiation-activated probes for deep cancer theranostics: a review
Nian Liu, Xinhui Su, Xiaolian Sun
Theranostics 2022; 12(17): 7404-7419. doi:10.7150/thno.75279
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of in vivo imaging
Han Na Jung, Seok-Yong Lee, Somin Lee, Hyewon Youn, Hyung-Jun Im
Theranostics 2022; 12(17): 7509-7531. doi:10.7150/thno.77259
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Errata

Excretable IR-820 for in vivo NIR-II fluorescence cerebrovascular imaging and photothermal therapy of subcutaneous tumor: Erratum
Zhe Feng, Xiaoming Yu, Minxiao Jiang, Liang Zhu, Yi Zhang, Wei Yang, Wang Xi, Gonghui Li, Jun Qian
Theranostics 2022; 12(17): 7640. doi:10.7150/thno.78444
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles
Wei Tong, Hui Hui, Wenting Shang, Yingqian Zhang, Feng Tian, Qiang Ma, Xin Yang, Jie Tian, Yundai Chen
Theranostics 2022; 12(17): 7641. doi:10.7150/thno.77886
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Biomineralized Bimetallic Oxide Nanotheranostics for Multimodal Imaging-Guided Combination Therapy: Erratum
Jianrong Wu, Gareth R. Williams, Shiwei Niu, Yanbo Yang, Yu Li, Xuejing Zhang, Li-Min Zhu
Theranostics 2022; 12(17): 7642. doi:10.7150/thno.78027
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Focused ultrasound-augmented targeting delivery of nanosonosensitizers from homogenous exosomes for enhanced sonodynamic cancer therapy: Erratum
Yichen Liu, Lianmei Bai, Kaili Guo, Yali Jia, Kun Zhang, Quanhong Liu, Pan Wang, Xiaobing Wang
Theranostics 2022; 12(17): 7643-7644. doi:10.7150/thno.78598
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway: Erratum
Hui-Juan Liu, Yuan Qin, Zi-Han Zhao, Yang Zhang, Jia-Huan Yang, Deng-Hui Zhai, Fang Cui, Ce Luo, Man-Xi Lu, Piao-Piao Liu, Heng-Wei Xu, Kun Li, Bo Sun, Shuang Chen, Hong-Gang Zhou, Cheng Yang, Tao Sun
Theranostics 2022; 12(17): 7645. doi:10.7150/thno.78949
[Abstract] [Full text] [PDF] [PubMed] [PMC]