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Volume 12 (16); 2022

Research Papers

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A sporadic Alzheimer's blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies
Joanna M. Wasielewska, Juliana C. S. Chaves, Rebecca L. Johnston, Laura A. Milton, Damián Hernández, Liyu Chen, Jae Song, Wendy Lee, Gerhard Leinenga, Rebecca M. Nisbet, Alice Pébay, Jürgen Götz, Anthony R. White, Lotta E. Oikari
Theranostics 2022; 12(16): 6826-6847. doi:10.7150/thno.72685
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Addressing antimicrobial resistance with the IDentif.AI platform: Rapidly optimizing clinically actionable combination therapy regimens against nontuberculous mycobacteria
Devika Mukherjee, Peter Wang, Lissa Hooi, Vedant Sandhu, Kui You, Agata Blasiak, Edward Kai-Hua Chow, Dean Ho, Pui Lai Rachel Ee
Theranostics 2022; 12(16): 6848-6864. doi:10.7150/thno.73078
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Identifying the E2F3-MEX3A-KLF4 signaling axis that sustains cancer cells in undifferentiated and proliferative state
Xu Yang, Guilin Li, Yuhua Tian, Xin Wang, Jiuzhi Xu, Ruiqi Liu, Min Deng, Chunlei Shao, Yuwei Pan, Xi Wu, Mengzhen Li, Chaowei Zhang, Rui Liu, Jun Qin, Chen Zhang, Zhanju Liu, Xin Wu, Maksim V. Plikus, Christopher J. Lengner, Zongheng Zheng, Cong Lv, Zhengquan Yu
Theranostics 2022; 12(16): 6865-6882. doi:10.7150/thno.76619
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A novel afterglow nanoreporter for monitoring cancer therapy
Shiyi Liao, Youjuan Wang, Zhe Li, Ying Zhang, Xia Yin, Shuangyan Huan, Xiao-Bing Zhang, Sulai Liu, Guosheng Song
Theranostics 2022; 12(16): 6883-6897. doi:10.7150/thno.77457
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The palmitoylation of AEG-1 dynamically modulates the progression of hepatocellular carcinoma
Binhui Zhou, Ying Wang, Lichen Zhang, Xiaoyi Shi, Hesheng Kong, Mengjie Zhang, Yang Liu, Xia Shao, Zhilong Liu, Hongxu Song, Wushan Li, Xiaoxi Gao, Yanli Chang, Chenzhuo Dou, Wenzhi Guo, Shuijun Zhang, Xiaohong Kang, Jie Gao, Yinming Liang, Junfeng Zheng, Eryan Kong
Theranostics 2022; 12(16): 6898-6914. doi:10.7150/thno.78377
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CUB Domain-Containing Protein 1 (CDCP1) is a rational target for the development of imaging tracers and antibody-drug conjugates for cancer detection and therapy
Tashbib Khan, Nicholas J. Lyons, Madeline Gough, Kayden K.X. Kwah, Tahleesa J. Cuda, Cameron E. Snell, Brian W. Tse, Kamil A. Sokolowski, Lesley A. Pearce, Timothy E. Adams, Stephen E. Rose, Simon Puttick, Marina Pajic, Mark N. Adams, Yaowu He, John D. Hooper, Thomas Kryza
Theranostics 2022; 12(16): 6915-6930. doi:10.7150/thno.78171
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Targeting PI4KA sensitizes refractory leukemia to chemotherapy by modulating the ERK/AMPK/OXPHOS axis
Xiuxing Jiang, Xiangtao Huang, Guoxun Zheng, Guanfei Jia, Zhiqiang Li, Xin Ding, Ling Lei, Liang Yuan, Shuangnian Xu, Ning Gao
Theranostics 2022; 12(16): 6972-6988. doi:10.7150/thno.76563
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Chitinase-3 like-protein-1 promotes glioma progression via the NF-κB signaling pathway and tumor microenvironment reprogramming
Ting Zhao, Jianming Zeng, Yujie Xu, Zhongping Su, Yulong Chong, Tao Ling, Haozhe Xu, Hui Shi, Minggao Zhu, Qi Mo, Xiaoying Huang, Yingchang Li, Xiaoren Zhang, Hongbin Ni, Qiang You
Theranostics 2022; 12(16): 6989-7008. doi:10.7150/thno.75069
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Yap1 modulates cardiomyocyte hypertrophy via impaired mitochondrial biogenesis in response to chronic mechanical stress overload
Peng Yue, Yue Zhang, Lei Liu, Kaiyu Zhou, Shutao Xia, Mou Peng, Hualin Yan, Xiaoqiang Tang, Zhan Chen, Donghui Zhang, Junling Guo, William T. Pu, Yuxuan Guo, Yimin Hua, Yifei Li
Theranostics 2022; 12(16): 7009-7031. doi:10.7150/thno.74563
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TCA-phospholipid-glycolysis targeted triple therapy effectively suppresses ATP production and tumor growth in glioblastoma
Shixue Yang, Jixing Zhao, Xiaoteng Cui, Qi Zhan, Kaikai Yi, Qixue Wang, Menglin Xiao, Yanli Tan, Biao Hong, Chuan Fang, Chunsheng Kang
Theranostics 2022; 12(16): 7032-7050. doi:10.7150/thno.74197
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ERK inactivation enhances stemness of NSCLC cells via promoting Slug-mediated epithelial-to-mesenchymal transition
Shurui Cai, Na Li, Xuetao Bai, Lu Liu, Ananya Banerjee, Kousalya Lavudi, Xiaoli Zhang, Jihe Zhao, Monica Venere, Wenrui Duan, Junran Zhang, Meng X. Welliver, Kai He, Qi-En Wang
Theranostics 2022; 12(16): 7051-7066. doi:10.7150/thno.73099
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Advancing 89Zr-immuno-PET in neuroscience with a bispecific anti-amyloid-beta monoclonal antibody - The choice of chelator is essential
Thomas E. Wuensche, Natascha Stergiou, Iris Mes, Mariska Verlaan, Maxime Schreurs, Esther J. M. Kooijman, Bart Janssen, Albert D. Windhorst, Allan Jensen, Ayodeji A. Asuni, Benny Bang-Andersen, Wissam Beaino, Guus A. M. S. Dongen, Danielle J. Vugts
Theranostics 2022; 12(16): 7067-7079. doi:10.7150/thno.73509
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A new LKB1 activator, piericidin analogue S14, retards renal fibrosis through promoting autophagy and mitochondrial homeostasis in renal tubular epithelial cells
Canzhen Liu, Xiaoxu Wang, Xiaonan Wang, Yunfang Zhang, Wenjian Min, Ping Yu, Jinhua Miao, Weiwei Shen, Shuangqin Chen, Shan Zhou, Xiaolong Li, Ping Meng, Qinyu Wu, Fan Fan Hou, Youhua Liu, Peng Yang, Cheng Wang, Xu Lin, Lan Tang, Xuefeng Zhou, Lili Zhou
Theranostics 2022; 12(16): 7158-7179. doi:10.7150/thno.78376
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Synthesis, preclinical evaluation and radiation dosimetry of a dual targeting PET tracer [68Ga]Ga-FAPI-RGD
Jie Zang, Xuejun Wen, Rong Lin, Xinying Zeng, Chao Wang, Mengqi Shi, Xueyuan Zeng, Jiaying Zhang, Xiaoming Wu, Xianzhong Zhang, Weibing Miao, Pengfei Xu, Zhide Guo, Jingjing Zhang, Xiaoyuan Chen
Theranostics 2022; 12(16): 7180-7190. doi:10.7150/thno.79144
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Near-infrared-II ratiometric fluorescence probes for non-invasive detection and precise navigation surgery of metastatic sentinel lymph nodes
Mengfei Li, Xue Zheng, Tianyang Han, Shengjie Ma, Yajun Wang, Bin Sun, Jiajun Xu, Xin Wang, Songling Zhang, Shoujun Zhu, Xiaoyuan Chen
Theranostics 2022; 12(16): 7191-7202. doi:10.7150/thno.78085
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Reviews

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Artificial intelligence in pancreatic cancer
Bowen Huang, Haoran Huang, Shuting Zhang, Dingyue Zhang, Qingya Shi, Jianzhou Liu, Junchao Guo
Theranostics 2022; 12(16): 6931-6954. doi:10.7150/thno.77949
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Extracellular vesicles: catching the light of intercellular communication in fibrotic liver diseases
Yijie Li, Jianzhi Wu, Runping Liu, Yinhao Zhang, Xiaojiaoyang Li
Theranostics 2022; 12(16): 6955-6971. doi:10.7150/thno.77256
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Natural cell based biomimetic cellular transformers for targeted therapy of digestive system cancer
Xiaomeng Tang, Dan Li, Yongwei Gu, Yunan Zhao, Aixue Li, Fu Qi, Jiyong Liu
Theranostics 2022; 12(16): 7080-7107. doi:10.7150/thno.75937
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Near-infrared photoimmunotherapy: design and potential applications for cancer treatment and beyond
Danfeng Wei, Jinxin Qi, Michael R Hamblin, Xiang Wen, Xian Jiang, Hao Yang
Theranostics 2022; 12(16): 7108-7131. doi:10.7150/thno.74820
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Specificity of oligonucleotide gene therapy (OGT) agents
Daria D. Nedorezova, Mikhail V. Dubovichenko, Ekaterina P. Belyaeva, Ekaterina D. Grigorieva, Arina V. Peresadina, Dmitry M. Kolpashchikov
Theranostics 2022; 12(16): 7132-7157. doi:10.7150/thno.77830
[Abstract] [Full text] [PDF] [PubMed] [PMC]