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Volume 11 (9); 2021

Research Papers

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Adenylosuccinate lyase is oncogenic in colorectal cancer by causing mitochondrial dysfunction and independent activation of NRF2 and mTOR-MYC-axis
Stephanie Taha-Mehlitz, Gaia Bianco, Mairene Coto-Llerena, Venkatesh Kancherla, Glenn R. Bantug, John Gallon, Caner Ercan, Federica Panebianco, Serenella Eppenberger-Castori, Marco von Strauss, Sebastian Staubli, Martin Bolli, Ralph Peterli, Matthias S. Matter, Luigi M. Terracciano, Markus von Flüe, Charlotte K.Y. Ng, Savas D Soysal, Otto Kollmar, Salvatore Piscuoglio
Theranostics 2021; 11(9): 4011-4029. doi:10.7150/thno.50051
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Impact of hydroxytyrosol on stroke: tracking therapy response on neuroinflammation and cerebrovascular parameters using PET-MR imaging and on functional outcomes
Cristina Barca, Maximilian Wiesmann, Jesús Calahorra, Lydia Wachsmuth, Christian Döring, Claudia Foray, Ali Heiradi, Sven Hermann, Maria Ángeles Peinado, Eva Siles, Cornelius Faber, Michael Schäfers, Amanda J Kiliaan, Andreas H. Jacobs, Bastian Zinnhardt
Theranostics 2021; 11(9): 4030-4049. doi:10.7150/thno.48110
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Molecular imaging and biochemical response assessment after a single cycle of [225Ac]Ac-PSMA-617/[177Lu]Lu-PSMA-617 tandem therapy in mCRPC patients who have progressed on [177Lu]Lu-PSMA-617 monotherapy
Florian Rosar, Fabian Hau, Mark Bartholomä, Stephan Maus, Tobias Stemler, Johannes Linxweiler, Samer Ezziddin, Fadi Khreish
Theranostics 2021; 11(9): 4050-4060. doi:10.7150/thno.56211
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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miR-375 prevents high-fat diet-induced insulin resistance and obesity by targeting the aryl hydrocarbon receptor and bacterial tryptophanase (tnaA) gene
Anil Kumar, Yi Ren, Kumaran Sundaram, Jingyao Mu, Mukesh K Sriwastva, Gerald W Dryden, Chao Lei, Lifeng Zhang, Jun Yan, Xiang Zhang, Juw Won Park, Michael L Merchant, Yun Teng, Huang-Ge Zhang
Theranostics 2021; 11(9): 4061-4077. doi:10.7150/thno.52558
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Electroacupuncture ameliorates intestinal inflammation by activating α7nAChR-mediated JAK2/STAT3 signaling pathway in postoperative ileus
Na-Na Yang, Jing-Wen Yang, Yang Ye, Jin Huang, Lu Wang, Yu Wang, Xin-Tong Su, Ying Lin, Fang-Ting Yu, Si-Ming Ma, Ling-Yu Qi, Lu-Lu Lin, Li-Qiong Wang, Guang-Xia Shi, Hong-Ping Li, Cun-Zhi Liu
Theranostics 2021; 11(9): 4078-4089. doi:10.7150/thno.52574
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Accurate in vivo tumor detection using plasmonic-enhanced shifted-excitation Raman difference spectroscopy (SERDS)
Pietro Strobbia, Vanessa Cupil-Garcia, Bridget M. Crawford, Andrew M. Fales, T. Joshua Pfefer, Yang Liu, Martin Maiwald, Bernd Sumpf, Tuan Vo-Dinh
Theranostics 2021; 11(9): 4090-4102. doi:10.7150/thno.53101
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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MicroRNA-146a switches microglial phenotypes to resist the pathological processes and cognitive degradation of Alzheimer's disease
Chunmei Liang, Ting Zou, Miaoping Zhang, Weihao Fan, Tianzhen Zhang, Yuling Jiang, Yujie Cai, Feng Chen, Xiongjin Chen, Yuanhong Sun, Bin Zhao, Yan Wang, Lili Cui
Theranostics 2021; 11(9): 4103-4121. doi:10.7150/thno.53418
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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MARCKS cooperates with NKAP to activate NF-kB signaling in smoke-related lung cancer
Jun Liu, Szu-Jung Chen, Ssu-Wei Hsu, Jun Zhang, Ji-Min Li, David C. Yang, Shenwen Gu, Kent E. Pinkerton, Ching-Hsien Chen
Theranostics 2021; 11(9): 4122-4136. doi:10.7150/thno.53558
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Balancing the stability and drug activation in adaptive nanoparticles potentiates chemotherapy in multidrug-resistant cancer
Jianqin Wan, Lingling Huang, Jiangting Cheng, Huangfu Qi, Jiahui Jin, Hangxiang Wang
Theranostics 2021; 11(9): 4137-4154. doi:10.7150/thno.54066
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Pectin supplement significantly enhanced the anti-PD-1 efficacy in tumor-bearing mice humanized with gut microbiota from patients with colorectal cancer
Shi-Long Zhang, Yu-Qin Mao, Zheng-Yan Zhang, Zhan-Ming Li, Chao-Yue Kong, Hui-Ling Chen, Pei-Ran Cai, Bing Han, Tao Ye, Li-Shun Wang
Theranostics 2021; 11(9): 4155-4170. doi:10.7150/thno.54476
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Redox-sensitive carrier-free nanoparticles self-assembled by disulfide-linked paclitaxel-tetramethylpyrazine conjugate for combination cancer chemotherapy
Liang Zou, Xiaowei Liu, Jingjing Li, Wei Li, Lele Zhang, Chaomei Fu, Jinming Zhang, Zhongwei Gu
Theranostics 2021; 11(9): 4171-4186. doi:10.7150/thno.42260
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-κB signaling
Huitao Liu, Jingjing Zhang, Xingxing Xu, Sheng Lu, Danlu Yang, Changnan Xie, Mengxian Jia, Wenbin Zhang, Lingting Jin, Xiwu Wang, Xiya Shen, Fayi Li, Wangfei Wang, Xiaomei Bao, Sijia Li, Minyu Zhu, Wei Wang, Ying Wang, Zhihui Huang, Honglin Teng
Theranostics 2021; 11(9): 4187-4206. doi:10.7150/thno.49054
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis
Jian-Kui Du, Qing Yu, Yu-Jian Liu, Shu-Fang Du, Li-Yang Huang, Dan-Hong Xu, Xin Ni, Xiao-Yan Zhu
Theranostics 2021; 11(9): 4207-4231. doi:10.7150/thno.48530
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma
Ling Lin, Shuyi Chen, Hua Wang, Bin Gao, Bhaskar Kallakury, Krithika Bhuvaneshwar, Katherine Cahn, Yuriy Gusev, Xue Wang, Yunan Wu, John L. Marshall, Xiuling Zhi, Aiwu Ruth He
Theranostics 2021; 11(9): 4232-4250. doi:10.7150/thno.49819
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Dabigatran activates inflammation resolution by promoting fibrinogen-like protein 2 shedding and RvD5n-3 DPA production
Juan Lei, Yu Zhou, Huakan Zhao, Yu Chen, Guifang Yan, Lei Wu, Yanquan Xu, Jiangang Zhang, Xiao Zhang, Jingchun Wang, Dingshan Li, Yongsheng Li
Theranostics 2021; 11(9): 4251-4261. doi:10.7150/thno.50182
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Thymosin β4 released from functionalized self-assembling peptide activates epicardium and enhances repair of infarcted myocardium
Yong-li Wang, Shu-na Yu, Hao-ran Shen, Hai-jie Wang, Xue-ping Wu, Qiang-li Wang, Bin Zhou, Yu-zhen Tan
Theranostics 2021; 11(9): 4262-4280. doi:10.7150/thno.52309
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Combination of long-acting TRAIL and tumor cell-targeted photodynamic therapy as a novel strategy to overcome chemotherapeutic multidrug resistance and TRAIL resistance of colorectal cancer
Tianshan She, Qiuxiao Shi, Zhao Li, Yanru Feng, Hao Yang, Ze Tao, Heng Li, Jie Chen, Shisheng Wang, Yan Liang, Jingqiu Cheng, Xiaofeng Lu
Theranostics 2021; 11(9): 4281-4297. doi:10.7150/thno.51193
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization
Chen Chen, Weitang Yuan, Quanbo Zhou, Bo Shao, Yuying Guo, Weiwei Wang, Shuaixi Yang, Yaxin Guo, Luyang Zhao, Qin Dang, Xiuxiu Yang, Guixian Wang, Qiaozhen Kang, Zhenyu Ji, Jinbo Liu, Zhenqiang Sun
Theranostics 2021; 11(9): 4298-4315. doi:10.7150/thno.51342
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Trio cooperates with Myh9 to regulate neural crest-derived craniofacial development
Shuyu Guo, Li Meng, Haojie Liu, Lichan Yuan, Na Zhao, Jieli Ni, Yang Zhang, Jingjing Ben, Yi-Ping Li, Junqing Ma
Theranostics 2021; 11(9): 4316-4334. doi:10.7150/thno.51745
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Compensatory combination of mTOR and TrxR inhibitors to cause oxidative stress and regression of tumors
Yiqun Xia, Jundixia Chen, Yun Yu, Fengjiao Wu, Xin Shen, Chenyu Qiu, Tingting Zhang, Lin Hong, Peisen Zheng, Rongrong Shao, Chenxin Xu, Fang Wu, Wei Chen, Congying Xie, Ri Cui, Peng Zou
Theranostics 2021; 11(9): 4335-4350. doi:10.7150/thno.52077
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Ultrasound-mediated augmented exosome release from astrocytes alleviates amyloid-β-induced neurotoxicity
Zhiting Deng, Jieqiong Wang, Yang Xiao, Fei Li, Lili Niu, Xin Liu, Long Meng, Hairong Zheng
Theranostics 2021; 11(9): 4351-4362. doi:10.7150/thno.52436
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Hepatic miR-378 modulates serum cholesterol levels by regulating hepatic bile acid synthesis
Chao Sun, Wei Liu, Zhiqiang Lu, Yan Li, Shengnan Liu, Zhili Tang, Ying Yan, Zhiyang Li, Hua Feng, Duo Zhang, Yun Liu, Zhong-Ze Fang, Changtao Jiang, Qiurong Ding, Jingjing Jiang, Hao Ying
Theranostics 2021; 11(9): 4363-4380. doi:10.7150/thno.53624
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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NAD+-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin
Dong-Jie Li, Si-Jia Sun, Jiang-Tao Fu, Shen-Xi Ouyang, Qin-Jie Zhao, Li Su, Qing-Xi Ji, Di-Ynag Sun, Jia-Hui Zhu, Guo-Yan Zhang, Jia-Wei Ma, Xiu-Ting Lan, Yi Zhao, Jie Tong, Guo-Qiang Li, Fu-Ming Shen, Pei Wang
Theranostics 2021; 11(9): 4381-4402. doi:10.7150/thno.53652
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Intratumor heterogeneity of breast cancer detected by epialleles shows association with hypoxic microenvironment
Yihan Wang, Yan Zhang, Yan Huang, Chuangeng Chen, Xingda Zhang, Ying Xing, Yue Gu, Mengyan Zhang, Li Cai, Shouping Xu, Baoqing Sun
Theranostics 2021; 11(9): 4403-4420. doi:10.7150/thno.53737
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer
Zhongyuan Wang, Liang Zhou, Yejun Wang, Quanzhou Peng, Huan Li, Xin Zhang, Zijie Su, Jiaxing Song, Qi Sun, Sapna Sayed, Shanshan Liu, Desheng Lu
Theranostics 2021; 11(9): 4421-4435. doi:10.7150/thno.53901
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Charge-switchable zwitterionic polycarboxybetaine particle as an intestinal permeation enhancer for efficient oral insulin delivery
Yan Li, Weihong Ji, Huan Peng, Ruichen Zhao, Tianlu Zhang, Zhiguo Lu, Jun Yang, Ruiyuan Liu, Xin Zhang
Theranostics 2021; 11(9): 4452-4466. doi:10.7150/thno.54176
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Pancreatic ductal deletion of S100A9 alleviates acute pancreatitis by targeting VNN1-mediated ROS release to inhibit NLRP3 activation
Hong Xiang, Fangyue Guo, Xufeng Tao, Qi Zhou, Shilin Xia, Dawei Deng, Lunxu Li, Dong Shang
Theranostics 2021; 11(9): 4467-4482. doi:10.7150/thno.54245
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The subcellular redistribution of NLRC5 promotes angiogenesis via interacting with STAT3 in endothelial cells
Xu Xu, Yefei Shi, Peipei Luan, Wenxin Kou, Bo Li, Ming Zhai, Shuangjie You, Qing Yu, Jianhui Zhuang, Weixia Jian, Mark W. Feinberg, Wenhui Peng
Theranostics 2021; 11(9): 4483-4501. doi:10.7150/thno.54473
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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LncRNA PRADX-mediated recruitment of PRC2/DDX5 complex suppresses UBXN1 expression and activates NF-κB activity, promoting tumorigenesis
Yansheng Li, Xing Liu, Xiaoteng Cui, Yanli Tan, Qixue Wang, Yunfei Wang, Can Xu, Chuan Fang, Chunsheng Kang
Theranostics 2021; 11(9): 4516-4530. doi:10.7150/thno.54549
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The role of GLS1-mediated glutaminolysis/2-HG/H3K4me3 and GSH/ROS signals in Th17 responses counteracted by PPARγ agonists
Yumeng Miao, Yun Zheng, Yanzhi Geng, Ling Yang, Na Cao, Yue Dai, Zhifeng Wei
Theranostics 2021; 11(9): 4531-4548. doi:10.7150/thno.54803
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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Exosome-inflammasome crosstalk and their roles in inflammatory responses
Chadanat Noonin, Visith Thongboonkerd
Theranostics 2021; 11(9): 4436-4451. doi:10.7150/thno.54004
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Impact of sodium glucose cotransporter 2 (SGLT2) inhibitors on atherosclerosis: from pharmacology to pre-clinical and clinical therapeutics
Zhenghong Liu, Xiaoxuan Ma, Iqra Ilyas, Xueying Zheng, Sihui Luo, Peter J. Little, Danielle Kamato, Amirhossein Sahebkar, Weiming Wu, Jianping Weng, Suowen Xu
Theranostics 2021; 11(9): 4502-4515. doi:10.7150/thno.54498
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The crosstalk between m6A RNA methylation and other epigenetic regulators: a novel perspective in epigenetic remodeling
Yanchun Zhao, Yunhao Chen, Mei Jin, Jin Wang
Theranostics 2021; 11(9): 4549-4566. doi:10.7150/thno.54967
[Abstract] [Full text] [PDF] [PubMed] [PMC]