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Volume 11 (19); 2021

Research Papers

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BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators
Olivier Castellanet, Fahmida Ahmad, Yaron Vinik, Gordon B. Mills, Bianca Habermann, Jean-Paul Borg, Sima Lev, Fabienne Lamballe, Flavio Maina
Theranostics 2021; 11(19): 9180-9197. doi:10.7150/thno.60503
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LOXL2-enriched small extracellular vesicles mediate hypoxia-induced premetastatic niche and indicates poor outcome of head and neck cancer
Guiquan Zhu, Linlin Wang, Wanrong Meng, Shun Lu, Bangrong Cao, Xinhua Liang, Chuanshi He, Yaying Hao, Xueyu Du, Xiaoyi Wang, Longjiang Li, Ling Li
Theranostics 2021; 11(19): 9198-9216. doi:10.7150/thno.62455
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Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma
Verena Panitz, Saša Končarević, Ahmed Sadik, Dennis Friedel, Tobias Bausbacher, Saskia Trump, Vadim Farztdinov, Sandra Schulz, Philipp Sievers, Stefan Schmidt, Ina Jürgenson, Stephan Jung, Karsten Kuhn, Irada Pflüger, Suraj Sharma, Antje Wick, Pauline Pfänder, Stefan Selzer, Philipp Vollmuth, Felix Sahm, Andreas von Deimling, Ines Heiland, Carsten Hopf, Peter Schulz-Knappe, Ian Pike, Michael Platten, Wolfgang Wick, Christiane A. Opitz
Theranostics 2021; 11(19): 9217-9233. doi:10.7150/thno.60679
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Silicon nanowires decorated with platinum nanoparticles were applied for photothermal-enhanced sonodynamic therapy
Lina Sun, Xianwen Wang, Fei Gong, Kui Yin, Wenxiang Zhu, Nailin Yang, Shang Bai, Fan Liao, Mingwang Shao, Liang Cheng
Theranostics 2021; 11(19): 9234-9242. doi:10.7150/thno.58755
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Tissue factor cytoplasmic domain exacerbates post-infarct left ventricular remodeling via orchestrating cardiac inflammation and angiogenesis
Suet Yen Chong, Olga Zharkova, Siti Maryam J.M. Yatim, Xiaoyuan Wang, Xiong Chang Lim, Chenyuan Huang, Chia Yee Tan, Jianming Jiang, Lei Ye, Michelle Siying Tan, Veronique Angeli, Henri H. Versteeg, Mieke Dewerchin, Peter Carmeliet, Carolyn S.P. Lam, Mark Y. Chan, Dominique P.V. de Kleijn, Jiong-Wei Wang
Theranostics 2021; 11(19): 9243-9261. doi:10.7150/thno.63354
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Upregulated NMDAR-enhanced GABAergic transmission underlies autistic-like deficits in Htr3a knockout mice
Lang Huang, Jing Wang, Guanmei Liang, Yue Gao, Shi-Yang Jin, Jian Hu, Xiaoxue Yang, Jianpei Lao, Jinfa Chen, Zhou-Cai Luo, Cuixia Fan, Li Xiong, Xinhong Zhu, Tian-Ming Gao, Mei Zhong, Xinping Yang
Theranostics 2021; 11(19): 9296-9310. doi:10.7150/thno.60531
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Therapeutic potential of garlic chive-derived vesicle-like nanoparticles in NLRP3 inflammasome-mediated inflammatory diseases
Baolong Liu, Xingzhi Li, Han Yu, Xuan Shi, You Zhou, Sophie Alvarez, Michael J. Naldrett, Stephen D. Kachman, Seung-Hyun Ro, Xinghui Sun, Soonkyu Chung, Lili Jing, Jiujiu Yu
Theranostics 2021; 11(19): 9311-9330. doi:10.7150/thno.60265
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Pyruvate kinase M2 regulates fibrosis development and progression by controlling glycine auxotrophy in myofibroblasts
Ganesh Satyanarayana, Ravi Chakra Turaga, Malvika Sharma, Siming Wang, Falguni Mishra, Guangda Peng, Xiaonan Deng, Jenny Yang, Zhi-Ren Liu
Theranostics 2021; 11(19): 9331-9341. doi:10.7150/thno.60385
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Neuromedin B receptor stimulation of Cav3.2 T-type Ca2+ channels in primary sensory neurons mediates peripheral pain hypersensitivity
Yuan Zhang, Zhiyuan Qian, Dongsheng Jiang, Yufang Sun, Shangshang Gao, Xinghong Jiang, Hua Wang, Jin Tao
Theranostics 2021; 11(19): 9342-9357. doi:10.7150/thno.62255
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IRGM/Irgm1 facilitates macrophage apoptosis through ROS generation and MAPK signal transduction: Irgm1+/- mice display increases atherosclerotic plaque stability
Shaohong Fang, Song Sun, Hengxuan Cai, Xiaoyi Zou, Shanjie Wang, Xinran Hao, Xin Wan, Jiangtian Tian, Zhaoying Li, Zhongze He, Wei Huang, Chenchen Liang, Zhenming Zhang, Liming Yang, Jinwei Tian, Bo Yu, Bo Sun
Theranostics 2021; 11(19): 9358-9375. doi:10.7150/thno.62797
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LncRNA Snhg1-driven self-reinforcing regulatory network promoted cardiac regeneration and repair after myocardial infarction
Mengsha Li, Hao zheng, Yuan Han, Yijin Chen, Bing Li, Guojun Chen, Xiaoqiang Chen, Senlin Huang, Xiang He, Guoquan Wei, Tong Xu, Xiaofei Feng, Wangjun Liao, Yulin Liao, Yanmei Chen, Jianping Bin
Theranostics 2021; 11(19): 9397-9414. doi:10.7150/thno.57037
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Accelerating precision anti-cancer therapy by time-lapse and label-free 3D tumor slice culture platform
Fuqiang Xing, Yu-Cheng Liu, Shigao Huang, Xueying Lyu, Sek Man Su, Un In Chan, Pei-Chun Wu, Yinghan Yan, Nana Ai, Jianjie Li, Ming Zhao, Barani Kumar Rajendran, Jianlin Liu, Fangyuan Shao, Heng Sun, Tak Kan Choi, Wenli Zhu, Guanghui Luo, Shuiming Liu, De Li Xu, Kin Long Chan, Qi Zhao, Kai Miao, Kathy Qian Luo, Wei Ge, Xiaoling Xu, Guanyu Wang, Tzu-Ming Liu, Chu-Xia Deng
Theranostics 2021; 11(19): 9415-9430. doi:10.7150/thno.59533
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Interruption of neutrophil extracellular traps formation dictates host defense and tubular HOXA5 stability to augment efficacy of anti-Fn14 therapy against septic AKI
Yin Ni, Bang-Chuan Hu, Guo-Hua Wu, Zi-Qiang Shao, Yang Zheng, Run Zhang, Jun Jin, Jun Hong, Xiang-Hong Yang, Ren-Hua Sun, Jin-Quan Liu, Shi-Jing Mo
Theranostics 2021; 11(19): 9431-9451. doi:10.7150/thno.61902
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TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG
Chong Xu, Jialin Wu, Yiqun Wu, Zhichu Ren, Yuyuan Yao, Guobing Chen, Evandro F. Fang, Ji Heon Noh, Yong U. Liu, Libin Wei, Xijing Chen, Jian Sima
Theranostics 2021; 11(19): 9452-9469. doi:10.7150/thno.62376
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Ultrasound (US)-activated redox dyshomeostasis therapy reinforced by immunogenic cell death (ICD) through a mitochondrial targeting liposomal nanosystem
Junjie Ren, Jing Zhou, Han Liu, Xiaodan Jiao, Yang Cao, Zhigang Xu, Yuejun Kang, Peng Xue
Theranostics 2021; 11(19): 9470-9491. doi:10.7150/thno.62984
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Neuroprotective effects of minocycline and KML29, a potent inhibitor of monoacylglycerol lipase, in an experimental stroke model: a small-animal positron emission tomography study
Tomoteru Yamasaki, Akiko Hatori, Yiding Zhang, Wakana Mori, Yusuke Kurihara, Masanao Ogawa, Hidekatsu Wakizaka, Jian Rong, Lu Wang, Steven Liang, Ming-Rong Zhang
Theranostics 2021; 11(19): 9492-9502. doi:10.7150/thno.64320
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The kinase PDK1 regulates regulatory T cell survival via controlling redox homeostasis
Peiran Feng, Quanli Yang, Liang Luo, Yadong Sun, Wenkai Lv, Shuo Wan, Zerong Guan, Zhiqiang Xiao, Feng Liu, Zehua Li, Zhongjun Dong, Meixiang Yang
Theranostics 2021; 11(19): 9503-9518. doi:10.7150/thno.63992
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Glycoproteome remodeling in MLL-rearranged B-cell precursor acute lymphoblastic leukemia
Tiago Oliveira, Mingfeng Zhang, Eun Ji Joo, Hisham Abdel-Azim, Chun-Wei Chen, Lu Yang, Chih-Hsing Chou, Xi Qin, Jianjun Chen, Kathirvel Alagesan, Andreia Almeida, Francis Jacob, Nicolle H Packer, Mark von Itzstein, Nora Heisterkamp, Daniel Kolarich
Theranostics 2021; 11(19): 9519-9537. doi:10.7150/thno.65398
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Effects of contrast-enhanced ultrasound treatment on neoadjuvant chemotherapy in breast cancer
Anne Rix, Marion Piepenbrock, Barbara Flege, Saskia von Stillfried, Patrick Koczera, Tatjana Opacic, Nina Simons, Peter Boor, Sven Thoröe-Boveleth, Roel Deckers, Jan-Niklas May, Twan Lammers, Georg Schmitz, Elmar Stickeler, Fabian Kiessling
Theranostics 2021; 11(19): 9557-9570. doi:10.7150/thno.64767
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The Polo-like kinase 1 inhibitor onvansertib represents a relevant treatment for head and neck squamous cell carcinoma resistant to cisplatin and radiotherapy
Anais Hagege, Damien Ambrosetti, Julien Boyer, Alexandre Bozec, Jérôme Doyen, Emmanuel Chamorey, Xingkang He, Isabelle Bourget, Julie Rousset, Esma Saada, Olivia Rastoin, Julien Parola, Frederic Luciano, Yihai Cao, Gilles Pagès, Maeva Dufies
Theranostics 2021; 11(19): 9571-9586. doi:10.7150/thno.61711
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Lysyl hydroxylase 1 (LH1) deficiency promotes angiotensin II (Ang II)-induced dissecting abdominal aortic aneurysm
Hao Li, Haochen Xu, Hongyan Wen, Hongyue Wang, Ranxu Zhao, Yingying Sun, Congxia Bai, Jiedan Ping, Li Song, Mingyao Luo, Jingzhou Chen
Theranostics 2021; 11(19): 9587-9604. doi:10.7150/thno.65277
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Visualization of endogenous p27 and Ki67 reveals the importance of a c-Myc-driven metabolic switch in promoting survival of quiescent cancer cells
Ting La, Song Chen, Tao Guo, Xiao Hong Zhao, Liu Teng, Dandan Li, Michael Carnell, Yuan Yuan Zhang, Yu Chen Feng, Nicole Cole, Alexandra C. Brown, Didi Zhang, Qihan Dong, Jenny Y. Wang, Huixia Cao, Tao Liu, Rick F. Thorne, Feng-Min Shao, Xu Dong Zhang, Lei Jin
Theranostics 2021; 11(19): 9605-9622. doi:10.7150/thno.63763
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A novel lncRNA linc-AhRA negatively regulates innate antiviral response in murine microglia upon neurotropic herpesvirus infection
Yiliang Wang, Weisheng Luo, Lianzhou Huang, Ji Xiao, Xiaowei Song, Feng Li, Yuying Ma, Xiaohui Wang, Fujun Jin, Ping Liu, Yexuan Zhu, Kaio Kitazato, Yifei Wang, Zhe Ren
Theranostics 2021; 11(19): 9623-9651. doi:10.7150/thno.64880
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Polyamino acid calcified nanohybrids induce immunogenic cell death for augmented chemotherapy and chemo-photodynamic synergistic therapy
Wei Qiu, Mengyun Liang, Yuan Gao, Xuelian Yang, Xingyao Zhang, Xiaoli Zhang, Peng Xue, Yuejun Kang, Zhigang Xu
Theranostics 2021; 11(19): 9652-9666. doi:10.7150/thno.64354
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Tumor microenvironment-based screening repurposes drugs targeting cancer stem cells and cancer-associated fibroblasts
Pei-Jung Lee, Chao-Chi Ho, Hao Ho, Wan-Jiun Chen, Chiu-Hua Lin, Yi-Hua Lai, Yi-Chen Juan, Wen-Chung Chu, Jia-Hua Lee, Sheng-Fang Su, Hsuan-Yu Chen, Jeremy J. W. Chen, Gee-Chen Chang, Ker-Chau Li, Pan-Chyr Yang, Huei-Wen Chen
Theranostics 2021; 11(19): 9667-9686. doi:10.7150/thno.62676
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Inhibition of tumor progression and M2 microglial polarization by extracellular vesicle-mediated microRNA-124 in a 3D microfluidic glioblastoma microenvironment
Soohyun Hong, Jae Young You, Kyurim Paek, Jubin Park, Su Jin Kang, Eun Hee Han, Nakwon Choi, Seok Chung, Won Jong Rhee, Jeong Ah Kim
Theranostics 2021; 11(19): 9687-9704. doi:10.7150/thno.60851
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Proteomic analysis of lung cancer cells reveals a critical role of BCAT1 in cancer cell metastasis
Lin Mao, Jin Chen, Xue Lu, Canlin Yang, Yi Ding, Mingming Wang, Yunpeng Zhang, Yuying Tian, Xing Li, Yunyun Fu, Yueying Yang, Yunyun Gu, Fei Gao, Junxing Huang, Lujian Liao
Theranostics 2021; 11(19): 9705-9720. doi:10.7150/thno.61731
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Reviews

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Shining light on chiral inorganic nanomaterials for biological issues
Yining Shao, Guilin Yang, Jiaying Lin, Xiaofeng Fan, Yue Guo, Wentao Zhu, Ying Cai, Huiyu Huang, Die Hu, Wei Pang, Yanjun Liu, Yiwen Li, Jiaji Cheng, Xiaoqian Xu
Theranostics 2021; 11(19): 9262-9295. doi:10.7150/thno.64511
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Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function
Yu Ding, Yongwen Zhou, Ping Ling, Xiaojun Feng, Sihui Luo, Xueying Zheng, Peter J. Little, Suowen Xu, Jianping Weng
Theranostics 2021; 11(19): 9376-9396. doi:10.7150/thno.64706
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Benefits of functional assays in personalized cancer medicine: more than just a proof-of-concept
Christophe Bounaix Morand du Puch, Mathieu Vanderstraete, Stéphanie Giraud, Christophe Lautrette, Niki Christou, Muriel Mathonnet
Theranostics 2021; 11(19): 9538-9556. doi:10.7150/thno.55954
[Abstract] [Full text] [PDF] [PubMed] [PMC]