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Volume 11 (18); 2021
Editorial
High-performance renal imaging with a radiolabeled, non-excretable chimeric fusion protein Dawei Jiang, Muhsin H. Younis, Xiaoli Lan, Weibo Cai
Theranostics 2021; 11(18): 9177-9179. doi:10.7150/thno.66417
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Research Papers
Angiotensin IV attenuates diabetic cardiomyopathy via suppressing FoxO1-induced excessive autophagy, apoptosis and fibrosis Meng Zhang, Wenhai Sui, Yanqiu Xing, Jing Cheng, Cheng Cheng, Fei Xue, Jie Zhang, Xiaohong Wang, Cheng Zhang, Panpan Hao, Yun Zhang
Theranostics 2021; 11(18): 8624-8639. doi:10.7150/thno.48561
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Inhibiting microglia proliferation after spinal cord injury improves recovery in mice and nonhuman primates Gaëtan Poulen, Emilie Aloy, Claire M. Bringuier, Nadine Mestre-Francés, Emaëlle V.F. Artus, Maïda Cardoso, Jean-Christophe Perez, Christophe Goze-Bac, Hassan Boukhaddaoui, Nicolas Lonjon, Yannick N. Gerber, Florence E. Perrin
Theranostics 2021; 11(18): 8640-8659. doi:10.7150/thno.61833
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Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys Sheng Zhao, Wei Li, Weimin Yu, Ting Rao, Haoyong Li, Yuan Ruan, Run Yuan, Chenglong Li, Jinzhuo Ning, Siqi Li, Wu Chen, Fan Cheng, Xiangjun Zhou
Theranostics 2021; 11(18): 8660-8673. doi:10.7150/thno.62820
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Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis Qian Zheng, Pengfei Li, Xin Zhou, Yulong Qiang, Jiachen Fan, Yan Lin, Yurou Chen, Jing Guo, Fan Wang, Haihua Xue, Jie Xiong, Feng Li
Theranostics 2021; 11(18): 8674-8691. doi:10.7150/thno.60233
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Co-delivery of autophagy inhibitor and gemcitabine using a pH-activatable core-shell nanobomb inhibits pancreatic cancer progression and metastasis Xiaoxiao Chen, Yuan Tao, Manmin He, Miao Deng, Rong Guo, Qinglin Sheng, Xuhui Wang, Kebai Ren, Ting Li, Xuan He, Shuya Zang, Zhirong Zhang, Man Li, Qin He
Theranostics 2021; 11(18): 8692-8705. doi:10.7150/thno.60437
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An “eat me” combinatory nano-formulation for systemic immunotherapy of solid tumors Hend Mohamed Abdel-Bar, Adam A Walters, Yau Lim, Nadia Rouatbi, Yue Qin, Fatemeh Gheidari, Shunping Han, Rihab Osman, Julie Tzu-Wen Wang, Khuloud T. Al-Jamal
Theranostics 2021; 11(18): 8738-8754. doi:10.7150/thno.56936
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Aberrant activation of the CD45-Wnt signaling axis promotes stemness and therapy resistance in colorectal cancer cells So-Yeon Park, Ji-Young Kim, Gyu-Beom Jang, Jang-Hyun Choi, Jee-Heun Kim, Choong-Jae Lee, Sunjae Lee, Jeong-Heum Baek, Kwan-Kyu Park, Jin-Man Kim, Hee Jin Chang, Nam-Chul Cho, Jeong-Seok Nam
Theranostics 2021; 11(18): 8755-8770. doi:10.7150/thno.63446
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Activating AhR alleviates cognitive deficits of Alzheimer's disease model mice by upregulating endogenous Aβ catabolic enzyme Neprilysin Cheng Qian, Chunjie Yang, Mengting Lu, Jiaxin Bao, Haiyan Shen, Bingquan Deng, Shensen Li, Wenwen Li, Mu Zhang, Changchun Cao
Theranostics 2021; 11(18): 8797-8812. doi:10.7150/thno.61601
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Alzheimer's disease-causing presenilin-1 mutations have deleterious effects on mitochondrial function Jihoon Han, Heejin Park, Chinmoyee Maharana, A-Ryeong Gwon, Jinsu Park, Seung Hyun Baek, Han-Gyu Bae, Yoonsuk Cho, Hark Kyun Kim, Jae Hoon Sul, Jeongmi Lee, Eunae Kim, Junsik Kim, Yongeun Cho, Sunyoung Park, Leon F. Palomera, Thiruma V. Arumugam, Mark P. Mattson, Dong-Gyu Jo
Theranostics 2021; 11(18): 8855-8873. doi:10.7150/thno.59776
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Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque Joon Woo Song, Hyeong Soo Nam, Jae Won Ahn, Hyun-Sang Park, Dong Oh Kang, Hyun Jung Kim, Yeon Hoon Kim, Jeongmoo Han, Jah Yeon Choi, Seung-Yul Lee, Sunwon Kim, Wang-Yuhl Oh, Hongki Yoo, Kyeongsoon Park, Jin Won Kim
Theranostics 2021; 11(18): 8874-8893. doi:10.7150/thno.59759
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A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency Sichen Zhang, Dashuai Zhu, Zhenhua Li, Ke Huang, Shiqi Hu, Halle Lutz, Mengjie Xie, Xuan Mei, Junlang Li, Genevieve Neal-Perry, Shaowei Wang, Ke Cheng
Theranostics 2021; 11(18): 8894-8908. doi:10.7150/thno.61690
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A tumor microenvironment responsive nanosystem for chemodynamic/chemical synergistic theranostics of colorectal cancer Liying Wang, Jingya Xia, Hongjie Fan, Min Hou, Huiyang Wang, Xiaoyan Wang, Ke Zhang, Liping Cao, Xiangrui Liu, Jun Ling, Hong Yu, Xia Wu, Jihong Sun
Theranostics 2021; 11(18): 8909-8925. doi:10.7150/thno.61651
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The methods and advances of adaptive immune receptors repertoire sequencing Hongmei Liu, Wenjing Pan, Congli Tang, Yujie Tang, Haijing Wu, Akihiko Yoshimura, Yan Deng, Nongyue He, Song Li
Theranostics 2021; 11(18): 8945-8963. doi:10.7150/thno.61390
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Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation Gloria Biechele, Tanja Blume, Maximilian Deussing, Benedikt Zott, Yuan Shi, Xianyuan Xiang, Nicolai Franzmeier, Gernot Kleinberger, Finn Peters, Katharina Ochs, Carola Focke, Christian Sacher, Karin Wind, Claudio Schmidt, Simon Lindner, Franz-Josef Gildehaus, Florian Eckenweber, Leonie Beyer, Barbara von Ungern-Sternberg, Peter Bartenstein, Karlheinz Baumann, Mario M. Dorostkar, Axel Rominger, Paul Cumming, Michael Willem, Helmuth Adelsberger, Jochen Herms, Matthias Brendel
Theranostics 2021; 11(18): 8964-8976. doi:10.7150/thno.64022
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Elucidating the anticancer activities of guanidinium-functionalized amphiphilic random copolymers by varying the structure and composition in the hydrophobic monomer Joyce Tay, Yanli Zhao, James L. Hedrick, Yi Yan Yang
Theranostics 2021; 11(18): 8977-8992. doi:10.7150/thno.60711
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Activation of Hippo signaling pathway mediates mitochondria dysfunction and dilated cardiomyopathy in mice Wei Wu, Mark Ziemann, Kevin Huynh, Gang She, Zheng-Da Pang, Yi Zhang, Thy Duong, Helen Kiriazis, Tian-Tian Pu, Ru-Yue Bai, Jing-Jing Li, Yu Zhang, Ming-Xia Chen, Junichi Sadoshima, Xiu-Ling Deng, Peter J. Meikle, Xiao-Jun Du
Theranostics 2021; 11(18): 8993-9008. doi:10.7150/thno.62302
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CD4+ T cell-mimicking nanoparticles encapsulating DIABLO/SMAC mimetics broadly neutralize HIV-1 and selectively kill HIV-1-infected cells Grant R. Campbell, Jia Zhuang, Gang Zhang, Igor Landa, Luke J. Kubiatowicz, Diana Dehaini, Ronnie H. Fang, Liangfang Zhang, Stephen A. Spector
Theranostics 2021; 11(18): 9009-9021. doi:10.7150/thno.59728
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Mapping the landscape of synthetic lethal interactions in liver cancer Chen Yang, Yuchen Guo, Ruolan Qian, Yiwen Huang, Linmeng Zhang, Jun Wang, Xiaowen Huang, Zhicheng Liu, Wenxin Qin, Cun Wang, Huimin Chen, Xuhui Ma, Dayong Zhang
Theranostics 2021; 11(18): 9038-9053. doi:10.7150/thno.63416
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Monoethanolamine-induced glucose deprivation promotes apoptosis through metabolic rewiring in prostate cancer Chakravarthy Garlapati, Shriya Joshi, Ravi Chakra Turaga, Manjari Mishra, Michelle D Reid, Shobhna Kapoor, Liana Artinian, Vincent Rehder, Ritu Aneja
Theranostics 2021; 11(18): 9089-9106. doi:10.7150/thno.62724
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Synthesis of precision antibody conjugates using proximity-induced chemistry Yu J. Cao, Chenfei Yu, Kuan-Lin Wu, Xuechun Wang, Dong Liu, Zeru Tian, Lijun Zhao, Xuexiu Qi, Axel Loredo, Anna Chung, Han Xiao
Theranostics 2021; 11(18): 9107-9117. doi:10.7150/thno.62444
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Targeted design of a recombinant tracer for SPECT renal imaging Pan Liu, Steven E. Johnson, Xinfang Xie, Li Gao, Chad R. Haney, Ming Zhao, Jing Jin
Theranostics 2021; 11(18): 9118-9132. doi:10.7150/thno.60132
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PRMT5 disruption drives antitumor immunity in cervical cancer by reprogramming T cell-mediated response and regulating PD-L1 expression Yongshuai Jiang, Yuanyang Yuan, Ming Chen, Shengzhe Li, Jun Bai, Yuanteng Zhang, Ying Sun, Guojue Wang, Haiyan Xu, Ziyu Wang, Yingxia Zheng, Hong Nie
Theranostics 2021; 11(18): 9162-9176. doi:10.7150/thno.59605
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Reviews
Smart magnetic resonance imaging-based theranostics for cancer Beatriz Brito, Thomas W. Price, Juan Gallo, Manuel Bañobre-López, Graeme J. Stasiuk
Theranostics 2021; 11(18): 8706-8737. doi:10.7150/thno.57004
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Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry Peipei Wang, Yue Zhou, Arthur M. Richards
Theranostics 2021; 11(18): 8771-8796. doi:10.7150/thno.62642
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Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment Sheng-Kai Hsu, Chia-Yang Li, I-Ling Lin, Wun-Jyun Syue, Yih-Fung Chen, Kai-Chun Cheng, Yen-Ni Teng, Yi-Hsiung Lin, Chia-Hung Yen, Chien-Chih Chiu
Theranostics 2021; 11(18): 8813-8835. doi:10.7150/thno.62521
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Role of prostaglandin E2 in tissue repair and regeneration Hui Cheng, Haoyan Huang, Zhikun Guo, Ying Chang, Zongjin Li
Theranostics 2021; 11(18): 8836-8854. doi:10.7150/thno.63396
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Engineered exosomes: desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies Meng Xu, Tao Feng, Bowen Liu, Fen Qiu, Youhua Xu, Yonghua Zhao, Ying Zheng
Theranostics 2021; 11(18): 8926-8944. doi:10.7150/thno.62330
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Targeting of promising transmembrane proteins for diagnosis and treatment of pancreatic ductal adenocarcinoma Vida Mashayekhi, Orsola Mocellin, Marcel H.A.M. Fens, Gerard C. Krijger, Lodewijk A.A. Brosens, Sabrina Oliveira
Theranostics 2021; 11(18): 9022-9037. doi:10.7150/thno.60350
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Recent Advances in Photosensitizers as Multifunctional Theranostic Agents for Imaging-Guided Photodynamic Therapy of Cancer Paromita Sarbadhikary, Blassan P. George, Heidi Abrahamse
Theranostics 2021; 11(18): 9054-9088. doi:10.7150/thno.62479
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Oligonucleotide aptamers for pathogen detection and infectious disease control Quanyuan Wan, Xiaohui Liu, Youli Zu
Theranostics 2021; 11(18): 9133-9161. doi:10.7150/thno.61804
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