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Volume 11 (16); 2021

Research Papers

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Fiber scaffold bioartificial liver therapy relieves acute liver failure and extrahepatic organ injury in pigs
Jun Weng, Xu Han, Fanhong Zeng, Yue Zhang, Lei Feng, Lei Cai, Kangyan Liang, Shusong Liu, Shao Li, Gongbo Fu, Min Zeng, Yi Gao
Theranostics 2021; 11(16): 7620-7639. doi:10.7150/thno.58515
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Silencing of METTL3 effectively hinders invasion and metastasis of prostate cancer cells
Yabing Chen, Chun Pan, Xiaotong Wang, Dihui Xu, Yuhan Ma, Jianhang Hu, Peilin Chen, Zou Xiang, Qiu Rao, Xiaodong Han
Theranostics 2021; 11(16): 7640-7657. doi:10.7150/thno.61178
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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STK39 promotes breast cancer invasion and metastasis by increasing SNAI1 activity upon phosphorylation
Zhaoping Qiu, Bo Dong, Weijie Guo, Rychahou Piotr, Greg Longmore, Xiuwei Yang, Zhiyong Yu, Jiong Deng, B. Mark Evers, Yadi Wu
Theranostics 2021; 11(16): 7658-7670. doi:10.7150/thno.62406
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Snail1 expression in endothelial cells controls growth, angiogenesis and differentiation of breast tumors
David Cabrerizo-Granados, Raúl Peña, Laura Palacios, Laura Carrillo-Bosch, Josep Lloreta-Trull, Laura Comerma, Mar Iglesias, Antonio García de Herreros
Theranostics 2021; 11(16): 7671-7684. doi:10.7150/thno.61881
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Attenuation of tonic inhibition prevents chronic neurovascular impairments in a Thy1-ChR2 mouse model of repeated, mild traumatic brain injury
James R Mester, Paolo Bazzigaluppi, Adrienne Dorr, Tina Beckett, Matthew Burke, JoAnne McLaurin, John G Sled, Bojana Stefanovic
Theranostics 2021; 11(16): 7685-7699. doi:10.7150/thno.60190
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Low-dose total body irradiation facilitates antitumoral Th1 immune responses
Dominik Sonanini, Christoph M. Griessinger, Barbara F. Schörg, Philipp Knopf, Klaus Dittmann, Martin Röcken, Bernd J. Pichler, Manfred Kneilling
Theranostics 2021; 11(16): 7700-7714. doi:10.7150/thno.61459
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Exosomal lncRNA-H19 promotes osteogenesis and angiogenesis through mediating Angpt1/Tie2-NO signaling in CBS-heterozygous mice
Jyotirmaya Behera, Anil Kumar, Michael J. Voor, Neetu Tyagi
Theranostics 2021; 11(16): 7715-7734. doi:10.7150/thno.58410
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Orthogonal targeting of osteoclasts and myeloma cells for radionuclide stimulated dynamic therapy induces multidimensional cell death pathways
Alexander Zheleznyak, Matthew Mixdorf, Lynne Marsala, Julie Prior, Xiaoxia Yang, Grace Cui, Baogang Xu, Steven Fletcher, Francesca Fontana, Gregory Lanza, Samuel Achilefu
Theranostics 2021; 11(16): 7735-7754. doi:10.7150/thno.60757
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Molecular imaging of fibroblast activation protein after myocardial infarction using the novel radiotracer [68Ga]MHLL1
Laura B.N. Langer, Annika Hess, Zekiye Korkmaz, Jochen Tillmanns, Laura M. Reffert, Jens P. Bankstahl, Frank M. Bengel, James T. Thackeray, Tobias L. Ross
Theranostics 2021; 11(16): 7755-7766. doi:10.7150/thno.51419
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Long-term live-cell lipid droplet-targeted biosensor development for nanoscopic tracking of lipid droplet-mitochondria contact sites
Chengying Zhang, Huarong Shao, Jie Zhang, Xinyan Guo, Yue Liu, Zhigang Song, Fei Liu, Peixue Ling, Longguang Tang, Kang-Nan Wang, Qixin Chen
Theranostics 2021; 11(16): 7767-7778. doi:10.7150/thno.59848
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castration-resistant prostate cancer
Meng-Jen Wu, Chih-Jung Chen, Ting-Yu Lin, Ying-Yuan Liu, Lin-Lu Tseng, Mei-Ling Cheng, Chih-Pin Chuu, Huai-Kuang Tsai, Wen-Ling Kuo, Hsing-Jien Kung, Wen-Ching Wang
Theranostics 2021; 11(16): 7779-7796. doi:10.7150/thno.58729
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Twist1 contributes to developing and sustaining corticosteroid resistance in ulcerative colitis
Changqin Liu, Li-Hua Mo, Bai-Sui Feng, Qiao-Ruo Jin, Yan Li, Jianli Lin, Qing Shu, Zhi-Gang Liu, Zhanju Liu, Xiaomin Sun, Ping-Chang Yang
Theranostics 2021; 11(16): 7797-7812. doi:10.7150/thno.62256
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Chemotherapeutic effects on breast tumor hemodynamics revealed by eigenspectra multispectral optoacoustic tomography (eMSOT)
Evangelos Liapis, Angelos Karlas, Uwe Klemm, Vasilis Ntziachristos
Theranostics 2021; 11(16): 7813-7828. doi:10.7150/thno.56173
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MicroRNA-185-5p inhibits hepatic gluconeogenesis and reduces fasting blood glucose levels by suppressing G6Pase
Hui Zheng, Jian Wan, Yi Shan, Xi Song, Jie Jin, Qing Su, Song Chen, Xinyuan Lu, Jialin Yang, Quanmin Li, Yuping Song, Bo Li
Theranostics 2021; 11(16): 7829-7843. doi:10.7150/thno.46882
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy
Anna Mukha, Uğur Kahya, Annett Linge, Oleg Chen, Steffen Löck, Vasyl Lukiyanchuk, Susan Richter, Tiago C. Alves, Mirko Peitzsch, Vladyslav Telychko, Sergej Skvortsov, Giulia Negro, Bertram Aschenbrenner, Ira-Ida Skvortsova, Peter Mirtschink, Fabian Lohaus, Tobias Hölscher, Hans Neubauer, Mahdi Rivandi, Vera Labitzky, Tobias Lange, André Franken, Bianca Behrens, Nikolas H. Stoecklein, Marieta Toma, Ulrich Sommer, Sebastian Zschaeck, Maximilian Rehm, Graeme Eisenhofer, Christian Schwager, Amir Abdollahi, Christer Groeben, Leoni A. Kunz-Schughart, Gustavo B. Baretton, Michael Baumann, Mechthild Krause, Claudia Peitzsch, Anna Dubrovska
Theranostics 2021; 11(16): 7844-7868. doi:10.7150/thno.58655
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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ATP-triggered mitochondrial cascade reactions for cancer therapy with nanoscale zeolitic imidazole framework-90
Wei Pan, Bingjie Cui, Kaiye Wang, Mingwan Shi, Fei Lu, Na Li, Bo Tang
Theranostics 2021; 11(16): 7869-7878. doi:10.7150/thno.59593
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Thymosin β4 increases cardiac cell proliferation, cell engraftment, and the reparative potency of human induced-pluripotent stem cell-derived cardiomyocytes in a porcine model of acute myocardial infarction
Shi Hua Tan, Sze Jie Loo, Yu Gao, Zhong Hao Tao, Li Ping Su, Chen Xu Wang, Sophia L. Zhang, Yong Hui Mu, Ying Hua Cui, Desiree Abdurrachim, Wei Hsin Wang, Janise Lalic, Kheng Choon Lim, Jun Bu, Ru San Tan, Teck Hock Lee, Jianyi Zhang, Lei Ye
Theranostics 2021; 11(16): 7879-7895. doi:10.7150/thno.56757
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Probing the fluorination effect on the self-assembly characteristics, in vivo fate and antitumor efficacy of paclitaxel prodrug nanoassemblies
Xin Wang, Bin Yang, Lingxiao Li, Tian Liu, Shiyi Zuo, Dongxu Chi, Zhonggui He, Bingjun Sun, Jin Sun
Theranostics 2021; 11(16): 7896-7910. doi:10.7150/thno.61337
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Environmentally-induced mdig contributes to the severity of COVID-19 through fostering expression of SARS-CoV-2 receptor NRPs and glycan metabolism
Qian Zhang, Priya Wadgaonkar, Liping Xu, Chitra Thakur, Yao Fu, Zhuoyue Bi, Yiran Qiu, Bandar Almutairy, Wenxuan Zhang, Paul Stemmer, Fei Chen
Theranostics 2021; 11(16): 7970-7983. doi:10.7150/thno.62138
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Molecular imaging of inflammation crosstalk along the cardio-renal axis following acute myocardial infarction
Rudolf A. Werner, Annika Hess, Tobias Koenig, Johanna Diekmann, Thorsten Derlin, Anette Melk, James T. Thackeray, Johann Bauersachs, Frank M. Bengel
Theranostics 2021; 11(16): 7984-7994. doi:10.7150/thno.61423
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Ablation of lncRNA Miat attenuates pathological hypertrophy and heart failure
Liu Yang, Jianxin Deng, Wenxia Ma, Aijun Qiao, Shiyue Xu, Yang Yu, Chan Boriboun, Xiang Kang, Dunzheng Han, Patrick Ernst, Lufang Zhou, Jiawei Shi, Eric Zhang, Tao-Sheng Li, Hongyu Qiu, Shinichi Nakagawa, Seth Blackshaw, Jianyi Zhang, Gangjian Qin
Theranostics 2021; 11(16): 7995-8007. doi:10.7150/thno.50990
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Multi-omic profiling of plasma reveals molecular alterations in children with COVID-19
Chong Wang, Xufang Li, Wanshan Ning, Sitang Gong, Fengxia Yang, Chunxiao Fang, Yu Gong, Di Wu, Muhan Huang, Yujie Gou, Shanshan Fu, Yujie Ren, Ruyi Yang, Yang Qiu, Yu Xue, Yi Xu, Xi Zhou
Theranostics 2021; 11(16): 8008-8026. doi:10.7150/thno.61832
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Bioengineering CXCR4-overexpressing cell membrane functionalized ROS-responsive nanotherapeutics for targeting cerebral ischemia-reperfusion injury
Li Luo, Guangchao Zang, Boyan Liu, Xian Qin, Yuchan Zhang, Yidan Chen, Haijun Zhang, Wei Wu, Guixue Wang
Theranostics 2021; 11(16): 8043-8056. doi:10.7150/thno.60785
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Endothelial cell infection and dysfunction, immune activation in severe COVID-19
Zhongnan Qin, Fengming Liu, Robert Blair, Chenxiao Wang, Haoran Yang, Joseph Mudd, Joshua M Currey, Naoki Iwanaga, Jibao He, Ren Mi, Kun Han, Cecily C. Midkiff, Mohammad Afaque Alam, Bertal H Aktas, Richard S Vander Heide, Ronald Veazey, Giovanni Piedimonte, Nicholas J Maness, Süleyman Ergün, Franck Mauvais-Jarvis, Jay Rappaport, Jay K. Kolls, Xuebin Qin
Theranostics 2021; 11(16): 8076-8091. doi:10.7150/thno.61810
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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N-terminus-independent activation of c-Src via binding to a tetraspan(in) TM4SF5 in hepatocellular carcinoma is abolished by the TM4SF5 C-terminal peptide application
Haeng Eun Song, Yoonji Lee, Eunmi Kim, Chang Yun Cho, Oisun Jung, Doohyung Lee, Eun Goo Lee, Seo Hee Nam, Minkyung Kang, Stephani Joy Y. Macalino, Ji Eon Kim, Jae Woo Jung, Sung Won Kwon, Sun Choi, Jung Weon Lee
Theranostics 2021; 11(16): 8092-8111. doi:10.7150/thno.58739
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CCDC65 as a new potential tumor suppressor induced by metformin inhibits activation of AKT1 via ubiquitination of ENO1 in gastric cancer
Tongyuan Deng, Peng Shen, Aimin Li, Ziyan Zhang, Huiling Yang, Xiaojie Deng, Xuemei Peng, Zhe Hu, Zibo Tang, Jiahao Liu, Rentao Hou, Zhen Liu, Weiyi Fang
Theranostics 2021; 11(16): 8112-8128. doi:10.7150/thno.54961
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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A perspective on the radiopharmaceutical requirements for imaging and therapy of glioblastoma
Julie Bolcaen, Janke Kleynhans, Shankari Nair, Jeroen Verhoeven, Ingeborg Goethals, Mike Sathekge, Charlot Vandevoorde, Thomas Ebenhan
Theranostics 2021; 11(16): 7911-7947. doi:10.7150/thno.56639
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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3D bioprinting in cardiac tissue engineering
Zihan Wang, Ling Wang, Ting Li, Sitian Liu, Baolin Guo, Wenhua Huang, Yaobin Wu
Theranostics 2021; 11(16): 7948-7969. doi:10.7150/thno.61621
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Radiomics in prostate cancer imaging for a personalized treatment approach - current aspects of methodology and a systematic review on validated studies
Simon K.B. Spohn, Alisa S. Bettermann, Fabian Bamberg, Matthias Benndorf, Michael Mix, Nils H. Nicolay, Tobias Fechter, Tobias Hölscher, Radu Grosu, Arturo Chiti, Anca L. Grosu, Constantinos Zamboglou
Theranostics 2021; 11(16): 8027-8042. doi:10.7150/thno.61207
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Emerging role of circulating tumor cells in immunotherapy
Alexey Rzhevskiy, Alina Kapitannikova, Polina Malinina, Arthur Volovetsky, Hamidreza Aboulkheyr Es, Arutha Kulasinghe, Jean Paul Thiery, Anna Maslennikova, Andrei V. Zvyagin, Majid Ebrahimi Warkiani
Theranostics 2021; 11(16): 8057-8075. doi:10.7150/thno.59677
[Abstract] [Full text] [PDF] [PubMed] [PMC]