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Volume 7 (7); 2017

Editorial

Should Low Molecular Weight PSMA Targeted Ligands Get Bigger and Use Albumin Ligands for PSMA Targeting?
Steve S. Huang, Warren D.W. Heston
Theranostics 2017; 7(7): 1940-1941. doi:10.7150/thno.20284
[Abstract] [Full text] [PDF] [PubMed] [PMC]


PSMA-PET for Lymph Node Detection in Recurrent Prostate Cancer: How do we use the Magic Bullet?
Tobias Maurer, Declan G. Murphy, Michael S. Hofman, Matthias Eiber
Theranostics 2017; 7(7): 2046-2047. doi:10.7150/thno.20855
[Abstract] [Full text] [PDF] [PubMed] [PMC]


In Molecular Pursuit of Bone Metastasis by Fluciclovine PET
Liza Lindenberg
Theranostics 2017; 7(7): 2065-2066. doi:10.7150/thno.20622
[Abstract] [Full text] [PDF] [PubMed] [PMC]


A Look Inside of the Complex Pathogenesis of B-RAF(V600E)-Driven Cancer
Emilia Caputo
Theranostics 2017; 7(7): 2108-2110. doi:10.7150/thno.20460
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper

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Dual-Responsive Molecular Probe for Tumor Targeted Imaging and Photodynamic Therapy
Xiaoqing Meng, Yueting Yang, Lihua Zhou, li Zhang, Yalin Lv, Sanpeng Li, Yayun Wu, Mingbin Zheng, Wenjun Li, Guanhui Gao, Guanjun Deng, Tao Jiang, Dapeng Ni, Ping Gong, Lintao Cai
Theranostics 2017; 7(7): 1781-1794. doi:10.7150/thno.18437
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Dual-pH Sensitive Charge-reversal Nanocomplex for Tumor-targeted Drug Delivery with Enhanced Anticancer Activity
Qing Zhou, Yilin Hou, Li Zhang, Jianlin Wang, Youbei Qiao, Songyan Guo, Li Fan, Tiehong Yang, Lin Zhu, Hong Wu
Theranostics 2017; 7(7): 1806-1819. doi:10.7150/thno.18607
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Bright Polymer Dots Tracking Stem Cell Engraftment and Migration to Injured Mouse Liver
Dandan Chen, Qiong Li, Zihui Meng, Lei Guo, Ying Tang, Zhihe Liu, Shengyan Yin, Weiping Qin, Zhen Yuan, Xuanjun Zhang, Changfeng Wu
Theranostics 2017; 7(7): 1820-1834. doi:10.7150/thno.18614
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Rapid Detection of Avian Influenza Virus by Fluorescent Diagnostic Assay using an Epitope-Derived Peptide
Duong Tuan Bao, Do Thi Hoang Kim, Hyun Park, Bui Thi Cuc, Nguyen Minh Ngoc, Nguyen Thi Phuong Linh, Nguyen Chien Huu, Trinh Thi Thuy Tien, Nguyen Thi Viet Anh, Tung Dao Duy, Chom-Kyu Chong, Seung-Taek Yu, Do-Young Choi, Seon-Ju Yeo
Theranostics 2017; 7(7): 1835-1846. doi:10.7150/thno.18857
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Rapid fluorescence imaging of spinal cord following epidural administration of a nerve-highlighting fluorophore
Wanguo Liu, Rui Gu, Qingsan Zhu, Chunsheng Xiao, Lanfeng Huang, Xinming Zhuang, Jingzhe Zhang, Lidi Liu, Ben Ma, Huailin Yang, Jianchao Ma, Zhipeng Hu, Chenglin Tang, Shuhua Zhao, Xuesi Chen
Theranostics 2017; 7(7): 1863-1874. doi:10.7150/thno.18962
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Self-Assembly of Gold Nanoparticles Shows Microenvironment-Mediated Dynamic Switching and Enhanced Brain Tumor Targeting
Qishuai Feng, Yajing Shen, Yingjie Fu, Megan E. Muroski, Peng Zhang, Qiaoyue Wang, Chang Xu, Maciej S. Lesniak, Gang Li, Yu Cheng
Theranostics 2017; 7(7): 1875-1889. doi:10.7150/thno.18985
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Tamoxifen activates Nrf2-dependent SQSTM1 transcription to promote endometrial hyperplasia
Lifeng Feng, Jiaqiu Li, Lixian Yang, Libo Zhu, Xiufeng Huang, Shuzheng Zhang, Likang Luo, Zhinong Jiang, Tingting Jiang, Wenxia Xu, Xian Wang, Hongchuan Jin
Theranostics 2017; 7(7): 1890-1900. doi:10.7150/thno.19135
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Therapeutic Inhibition of miR-4260 Suppresses Colorectal Cancer via Targeting MCC and SMAD4
Junjie Xiao, Dongchao Lv, Jinzhe Zhou, Yihua Bei, Ting Chen, Muren Hu, Qiulian Zhou, Siyi Fu, Qi Huang
Theranostics 2017; 7(7): 1901-1913. doi:10.7150/thno.19168
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Triptolide Inhibits the AR Signaling Pathway to Suppress the Proliferation of Enzalutamide Resistant Prostate Cancer Cells
Yangyang Han, Weiwei Huang, Jiakuan Liu, Dandan Liu, Yangyan Cui, Ruimin Huang, Jun Yan, Ming Lei
Theranostics 2017; 7(7): 1914-1927. doi:10.7150/thno.17852
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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177Lu-Labeled Phosphoramidate-Based PSMA Inhibitors: The Effect of an Albumin Binder on Biodistribution and Therapeutic Efficacy in Prostate Tumor-Bearing Mice
Cindy J. Choy, Xiaoxi Ling, Jonathan J. Geruntho, Sophia K. Beyer, Joseph D. Latoche, Beatrice Langton-Webster, Carolyn J. Anderson, Clifford E. Berkman
Theranostics 2017; 7(7): 1928-1939. doi:10.7150/thno.18719
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Mouse IP-10 Gene Delivered by Folate-modified Chitosan Nanoparticles and Dendritic/tumor Cells Fusion Vaccine Effectively Inhibit the Growth of Hepatocellular Carcinoma in Mice
Zixi Hu, Jiaojiao Chen, Sufang Zhou, Nuo Yang, Siliang Duan, Zhenghua Zhang, Jing Su, Jian He, Zhiyong Zhang, Xiaoling Lu, Yongxiang Zhao
Theranostics 2017; 7(7): 1942-1952. doi:10.7150/thno.16236
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Neonatal Heart-Enriched miR-708 Promotes Proliferation and Stress Resistance of Cardiomyocytes in Rodents
Shengqiong Deng, Qian Zhao, Lixiao Zhen, Chuyi Zhang, Cuicui Liu, Guangxue Wang, Lin Zhang, Luer Bao, Ying Lu, Lingyu Meng, Jinhui Lü, Ping Yu, Xin Lin, Yuzhen Zhang, Yi-Han Chen, Huimin Fan, William C. Cho, Zhongmin Liu, Zuoren Yu
Theranostics 2017; 7(7): 1953-1965. doi:10.7150/thno.16478
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Implantable and Biodegradable Macroporous Iron Oxide Frameworks for Efficient Regeneration and Repair of Infracted Heart
Wenshuo Wang, Hongyue Tao, Yun Zhao, Xiaotian Sun, Jing Tang, Cordelia Selomulya, Jia Tang, Tianchan Chen, Yang Wang, Minglei Shu, Lei Wei, Guanyu Yi, Jixue Zhou, Lai Wei, Chunsheng Wang, Biao Kong
Theranostics 2017; 7(7): 1966-1975. doi:10.7150/thno.16866
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Thermoacoustic Imaging and Therapy Guidance based on Ultra-short Pulsed Microwave Pumped Thermoelastic Effect Induced with Superparamagnetic Iron Oxide Nanoparticles
Liewei Wen, Sihua Yang, Junping Zhong, Quan Zhou, Da Xing
Theranostics 2017; 7(7): 1976-1989. doi:10.7150/thno.17846
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Surface De-PEGylation Controls Nanoparticle-Mediated siRNA Delivery In Vitro and In Vivo
Xi Zhu, Wei Tao, Danny Liu, Jun Wu, Zilei Guo, Xiaoyuan Ji, Zameer Bharwani, Lili Zhao, Xiaoping Zhao, Omid C. Farokhzad, Jinjun Shi
Theranostics 2017; 7(7): 1990-2002. doi:10.7150/thno.18136
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Drug-Bearing Supramolecular Filament Hydrogels as Anti-Inflammatory Agents
Zhipeng Chen, Lei Xing, Qin Fan, Andrew G. Cheetham, Ran Lin, Barbara Holt, Liwen Chen, Yanyu Xiao, Honggang Cui
Theranostics 2017; 7(7): 2003-2014. doi:10.7150/thno.19404
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Melatonin Suppresses Neuropathic Pain via MT2-Dependent and -Independent Pathways in Dorsal Root Ganglia Neurons of Mice
Jia-Ji Lin, Ye Lin, Tian-Zhi Zhao, Chun-Kui Zhang, Ting Zhang, Xiao-Li Chen, Jia-Qi Ding, Ting Chang, Zhuo Zhang, Chao Sun, Dai-Di Zhao, Jun-Lin Zhu, Zhu-Yi Li, Jin-Lian Li
Theranostics 2017; 7(7): 2015-2032. doi:10.7150/thno.19500
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Parkin Knockout Inhibits Neuronal Development via Regulation of Proteasomal Degradation of p21
Mi Hee Park, Hwa-Jeong Lee, Hye Lim Lee, Dong Ju Son, Jung Hoon Ju, Byung Kook Hyun, Sung Hee Jung, Ju-Kyoung Song, Dong-Hoon Lee, Chul Ju Hwang, Sang Bae Han, Sanghyeon Kim, Jin Tae Hong
Theranostics 2017; 7(7): 2033-2045. doi:10.7150/thno.19824
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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PET Tracer 18F-Fluciclovine Can Detect Histologically Proven Bone Metastatic Lesions: A Preclinical Study in Rat Osteolytic and Osteoblastic Bone Metastasis Models
Shuntaro Oka, Masaru Kanagawa, Yoshihiro Doi, David M. Schuster, Mark M. Goodman, Hirokatsu Yoshimura
Theranostics 2017; 7(7): 2048-2064. doi:10.7150/thno.19883
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Metabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes
Vijesh J. Bhute, Xiaoping Bao, Kaitlin K. Dunn, Kylie R. Knutson, Eric C. McCurry, Gyuhyung Jin, Wei-Hua Lee, Sarah Lewis, Akihiro Ikeda, Sean P. Palecek
Theranostics 2017; 7(7): 2078-2091. doi:10.7150/thno.19390
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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c-Myc is Required for BRAFV600E-Induced Epigenetic Silencing by H3K27me3 in Tumorigenesis
Yiping Qu, Qi Yang, Juan Liu, Bingyin Shi, Meiju Ji, Gang Li, Peng Hou
Theranostics 2017; 7(7): 2092-2107. doi:10.7150/thno.19884
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Suppression Of β-catenin Nuclear Translocation By CGP57380 Decelerates Poor Progression And Potentiates Radiation-Induced Apoptosis in Nasopharyngeal Carcinoma
Weiyuan Wang, Qiuyuan Wen, Jiadi Luo, Shuzhou Chu, Lingjiao Chen, Lina Xu, Hongjing Zang, Mohannad Ma Alnemah, Jinghe Li, Jianhua Zhou, Songqing Fan
Theranostics 2017; 7(7): 2134-2149. doi:10.7150/thno.17665
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Epigenomic and Functional Characterization of Junctophilin 3 (JPH3) as a Novel Tumor Suppressor Being Frequently Inactivated by Promoter CpG Methylation in Digestive Cancers
Xiaotong Hu, Yeye Kuang, Lili Li, Haimei Tang, Qinglan Shi, Xingsheng Shu, Yanjiao Zhang, Francis KL Chan, Qian Tao, Chao He
Theranostics 2017; 7(7): 2150-2163. doi:10.7150/thno.18185
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review

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Current and emerging techniques for antibiotic susceptibility tests
Karan Syal, Manni Mo, Hui Yu, Rafael Iriya, Wenwen Jing, Sui Guodong, Shaopeng Wang, Thomas E. Grys, Shelley E. Haydel, Nongjian Tao
Theranostics 2017; 7(7): 1795-1805. doi:10.7150/thno.19217
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Advances in the detection of telomerase activity using isothermal amplification
Xiaojin Zhang, Xiaoding Lou, Fan Xia
Theranostics 2017; 7(7): 1847-1862. doi:10.7150/thno.18930
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Current Strategies and Challenges for Purification of Cardiomyocytes Derived from Human Pluripotent Stem Cells
Kiwon Ban, Seongho Bae, Young-sup Yoon
Theranostics 2017; 7(7): 2067-2077. doi:10.7150/thno.19427
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Harnessing Integrative Omics to Facilitate Molecular Imaging of the Human Epidermal Growth Factor Receptor Family for Precision Medicine
Martin Pool, H. Rudolf de Boer, Marjolijn N. Lub-de Hooge, Marcel A.T.M. van Vugt, Elisabeth G.E. de Vries
Theranostics 2017; 7(7): 2111-2133. doi:10.7150/thno.17934
[Abstract] [Full text] [PDF] [PubMed] [PMC]