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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Research Paper
The gRNA-miRNA-gRNA Ternary Cassette Combining CRISPR/Cas9 with RNAi Approach Strongly Inhibits Hepatitis B Virus Replication
Jie Wang, Ran Chen, Ruiyang Zhang, Shanlong Ding, Tianying Zhang, Quan Yuan, Guiwen Guan, Xiangmei Chen, Ting Zhang, Hui Zhuang, Frederick Nunes, Timothy Block, Shuang Liu, Zhongping Duan, Ningshao Xia, Zhongwei Xu, Fengmin Lu
Theranostics 2017; 7(12): 3090-3105. doi:10.7150/thno.18114
[Abstract] [Full text] [PDF]


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Research Paper
FKBP3 Promotes Proliferation of Non-Small Cell Lung Cancer Cells through Regulating Sp1/HDAC2/p27
Wenzhuo Zhu, Zhao Li, Liwen Xiong, Xiaobo Yu, Xi Chen, Qiang Lin
Theranostics 2017; 7(12): 3078-3089. doi:10.7150/thno.18067
[Abstract] [Full text] [PDF]


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Research Paper
Chelator-Free Radiolabeling of SERRS Nanoparticles for Whole-Body PET and Intraoperative Raman Imaging
Matthew A. Wall, Travis M. Shaffer, Stefan Harmsen, Darjus-Felix Tschaharganeh, Chun-Hao Huang, Scott W. Lowe, Charles Michael Drain, Moritz F. Kircher
Theranostics 2017; 7(12): 3068-3077. doi:10.7150/thno.18019
[Abstract] [Full text] [PDF]


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Research Paper
TGFβ1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer
Junlong Zhuang, Lan Shen, Lin Yang, Xiaojing Huang, Qun Lu, Yangyan Cui, Xi Zheng, Xiaozhi Zhao, Dianzheng Zhang, Ruimin Huang, Hongqian Guo, Jun Yan
Theranostics 2017; 7(12): 3053-3067. doi:10.7150/thno.19542
[Abstract] [Full text] [PDF]


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Research Paper
Albumin-Gold Nanorod Nanoplatform for Cell-Mediated Tumoritropic Delivery with Homogenous ChemoDrug Distribution and Enhanced Retention Ability
Hsien-Ting Chiu, Cheng-Kuan Su, Yuh-Chang Sun, Chi-Shiun Chiang, Yu-Fen Huang
Theranostics 2017; 7(12): 3034-3052. doi:10.7150/thno.19279
[Abstract] [Full text] [PDF]


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Research Paper
Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling
Yuan Cao, Shu-Hai Lin, Yongbin Wang, Y. Eugene Chin, Lan Kang, Jun Mi
Theranostics 2017; 7(12): 3021-3033. doi:10.7150/thno.18992
[Abstract] [Full text] [PDF]


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Research Paper
Degradable Hollow Mesoporous Silicon/Carbon Nanoparticles for Photoacoustic Imaging-Guided Highly Effective Chemo-Thermal Tumor Therapy in Vitro and in Vivo
Jinfeng Zhang, Jun Zhang, Wenyue Li, Rui Chen, Zhenyu Zhang, Wenjun Zhang, Yongbing Tang, Xiaoyuan Chen, Gang Liu, Chun-Sing Lee
Theranostics 2017; 7(12): 3007-3020. doi:10.7150/thno.18460
[Abstract] [Full text] [PDF]


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Research Paper
Using Multifunctional Peptide Conjugated Au Nanorods for Monitoring β-amyloid Aggregation and Chemo-Photothermal Treatment of Alzheimer's Disease
Meng Li, Yijia Guan, Andong Zhao, Jinsong Ren, Xiaogang Qu
Theranostics 2017; 7(12): 2996-3006. doi:10.7150/thno.18459
[Abstract] [Full text] [PDF]


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Research Paper
Discovery of Aptamer Ligands for Hepatic Stellate Cells Using SELEX
Zhijin Chen, Hao Liu, Akshay Jain, Li Zhang, Chang Liu, Kun Cheng
Theranostics 2017; 7(12): 2982-2995. doi:10.7150/thno.19374
[Abstract] [Full text] [PDF]


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Review
Ambient Ionization and Miniature Mass Spectrometry Systems for Disease Diagnosis and Therapeutic Monitoring
Wenpeng Zhang, Xiao Wang, Yu Xia, Zheng Ouyang
Theranostics 2017; 7(12): 2968-2981. doi:10.7150/thno.19410
[Abstract] [Full text] [PDF]


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Research Paper
In Vivo Cancer Cells Elimination Guided by Aptamer-Functionalized Gold-Coated Magnetic Nanoparticles and Controlled with Low Frequency Alternating Magnetic Field
Irina V. Belyanina, Tatiana N. Zamay, Galina S. Zamay, Sergey S. Zamay, Olga S. Kolovskaya, Tatiana I. Ivanchenko, Valery V. Denisenko, Andrey K. Kirichenko, Yury E. Glazyrin, Irina V. Garanzha, Valentina V. Grigorieva, Alexandr V. Shabanov, Dmitry V. Veprintsev, Alexey E. Sokolov, Vladimir M. Sadovskii, Ana Gargaun, Maxim V. Berezovski, Anna S. Kichkailo
Theranostics 2017; 7(11): 2956-2967. doi:10.7150/thno.17089
[Abstract] [Full text] [PDF]


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Research Paper
Placental Homing Peptide-microRNA Inhibitor Conjugates for Targeted Enhancement of Intrinsic Placental Growth Signaling
Frances Beards, Lisa E Jones, Jayne Charnock, Karen Forbes, Lynda K Harris
Theranostics 2017; 7(11): 2940-2955. doi:10.7150/thno.18845
[Abstract] [Full text] [PDF]


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Research Paper
Al18F-Labeling Of Heat-Sensitive Biomolecules for Positron Emission Tomography Imaging
Frederik Cleeren, Joan Lecina, Muneer Ahamed, Geert Raes, Nick Devoogdt, Vicky Caveliers, Paul McQuade, Daniel J Rubins, Wenping Li, Alfons Verbruggen, Catarina Xavier, Guy Bormans
Theranostics 2017; 7(11): 2924-2939. doi:10.7150/thno.20094
[Abstract] [Full text] [PDF]


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Research Paper
Mutational Landscapes of Smoking-Related Cancers in Caucasians and African Americans: Precision Oncology Perspectives at Wake Forest Baptist Comprehensive Cancer Center
Ville Kytola, Umit Topaloglu, Lance D. Miller, Rhonda L. Bitting, Michael M. Goodman, Ralph B. D`Agostino, Rodwige J. Desnoyers, Carol Albright, George Yacoub, Shadi A. Qasem, Barry DeYoung, Vesteinn Thorsson, Ilya Shmulevich, Meng Yang, Anastasia Shcherban, Matthew Pagni, Liang Liu, Matti Nykter, Kexin Chen, Gregory A. Hawkins, Stefan C. Grant, W. Jeffrey Petty, Angela Tatiana Alistar, Edward A. Levine, Edgar D. Staren, Carl D. Langefeld, Vincent Miller, Gaurav Singal, Robin M. Petro, Mac Robinson, William Blackstock, Bayard L. Powell, Lynne I. Wagner, Kristie L. Foley, Edward Abraham, Boris Pasche, Wei Zhang
Theranostics 2017; 7(11): 2914-2923. doi:10.7150/thno.20355
[Abstract] [Full text] [PDF]


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Research Paper
Oxygen Enhanced Optoacoustic Tomography (OE-OT) Reveals Vascular Dynamics in Murine Models of Prostate Cancer
Michal R Tomaszewski, Isabel Quiros Gonzalez, James PB O'Connor, Oshaani Abeyakoon, Geoff JM Parker, Kaye J Williams, Fiona J Gilbert, Sarah E Bohndiek
Theranostics 2017; 7(11): 2900-2913. doi:10.7150/thno.19841
[Abstract] [Full text] [PDF]


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Research Paper
A Normalization-Free and Nonparametric Method Sharpens Large-Scale Transcriptome Analysis and Reveals Common Gene Alteration Patterns in Cancers
Qi-Gang Li, Yong-Han He, Huan Wu, Cui-Ping Yang, Shao-Yan Pu, Song-Qing Fan, Li-Ping Jiang, Qiu-Shuo Shen, Xiao-Xiong Wang, Xiao-Qiong Chen, Qin Yu, Ying Li, Chang Sun, Xiangting Wang, Jumin Zhou, Hai-Peng Li, Yong-Bin Chen, Qing-Peng Kong
Theranostics 2017; 7(11): 2888-2899. doi:10.7150/thno.19425
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD, Chief, Laboratory of Molecular Imaging and Nanomedicine, NIBIB, NIH*
* Dr. Chen is serving in his personal capacity.
Editor-in-chief profile

new Impact factor is 8.712, according to 2017 release of Journal Citation Reports®. Congratulations!

new Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Theme Issue on “Brain Theranostics. Guest Editor: Prof. Rachela Popovtzer, PhD
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Most Cited Paper Award for year 2016: Winners of this year are Lian Jin, Xin Zeng, Ming Liu, Yan Deng, Nongyue He, for the paper "Current Progress in Gene Delivery Technology Based on Chemical Methods and Nano-carriers". Details ...

new Congratulations to Dr. Chen for being recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Congratulations to Dr. Chen for receiving the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues