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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Editorial
S100-SPECT uncovers cellular and molecular events of pre-metastatic niche formation and following organ-specific cancer metastasis
Masakiyo Sakaguchi
Theranostics 2017; 7(10): 2649-2651. doi:10.7150/thno.19866
[Abstract] [Full text] [PDF]


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Research Paper
Co-Activation of PKC-δ by CRIF1 Modulates Oxidative Stress in Bone Marrow Multipotent Mesenchymal Stromal Cells after Irradiation by Phosphorylating NRF2 Ser40
Lili Chen, Qian Ran, Yang Xiang, Lixin Xiang, Li Chen, Fengjie Li, Jiang Wu, Chun Wu, Zhongjun Li
Theranostics 2017; 7(10): 2634-2648. doi:10.7150/thno.17853
[Abstract] [Full text] [PDF]


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Research Paper
A High-Affinity Repebody for Molecular Imaging of EGFR-Expressing Malignant Tumors
Misun Yun, Dong-Yeon Kim, Joong-jae Lee, Hyeon-Sik Kim, Hyung-Seok Kim, Ayoung Pyo, Yiseul Ryu, Tae-Yoon Kim, Jin Hai Zheng, Su Woong Yoo, Hoon Hyun, Gyungseok Oh, Jaeho Jeong, Myeongju Moon, Jung-Hyun Min, Seong Young Kwon, Jung Young Kim, Euiheon Chung, Yeongjin Hong, Wansik Lee, Hak-Sung Kim, Jung-Joon Min
Theranostics 2017; 7(10): 2620-2633. doi:10.7150/thno.18096
[Abstract] [Full text] [PDF]


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Review
Circulating Tumor Cells: Moving Biological Insights into Detection
Lichan Chen, Ann M Bode, Zigang Dong
Theranostics 2017; 7(10): 2606-2619. doi:10.7150/thno.18588
[Abstract] [Full text] [PDF]


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Research Paper
Self-Assembly DNA Polyplex Vaccine inside Dissolving Microneedles for High-Potency Intradermal Vaccination
Jing-Fong Liao, Jin-Ching Lee, Chun-Kuang Lin, Kuo-Chen Wei, Pin-Yuan Chen, Hung-Wei Yang
Theranostics 2017; 7(10): 2593-2605. doi:10.7150/thno.19894
[Abstract] [Full text] [PDF]


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Review
Preparation and Application of Cell Membrane-Camouflaged Nanoparticles for Cancer Therapy
Yihui Zhai, Jinghan Su, Wei Ran, Pengcheng Zhang, Qi Yin, Zhiwen Zhang, Haijun Yu, Yaping Li
Theranostics 2017; 7(10): 2575-2592. doi:10.7150/thno.20118
[Abstract] [Full text] [PDF]


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Research Paper
Targeting Activated Platelets: A Unique and Potentially Universal Approach for Cancer Imaging
May Lin Yap, James D McFadyen, Xiaowei Wang, Nicholas A Zia, Jan David Hohmann, Melanie Ziegler, Yu Yao, Alan Pham, Matthew Harris, Paul S Donnelly, P Mark Hogarth, Geoffrey A Pietersz, Bock Lim, Karlheinz Peter
Theranostics 2017; 7(10): 2565-2574. doi:10.7150/thno.19900
[Abstract] [Full text] [PDF]


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Research Paper
Incremental Value of Circulating MiR-122-5p to Predict Outcome after Out of Hospital Cardiac Arrest
Yvan Devaux, Antonio Salgado-Somoza, Josef Dankiewicz, Adeline Boileau, Pascal Stammet, Anna Schritz, Lu Zhang, Mélanie Vausort, Patrik Gilje, David Erlinge, Christian Hassager, Matthew P. Wise, Michael Kuiper, Hans Friberg, Niklas Nielsen, the TTM-trial investigators
Theranostics 2017; 7(10): 2555-2564. doi:10.7150/thno.19851
[Abstract] [Full text] [PDF]


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Research Paper
Regulation on Toll-like Receptor 4 and Cell Barrier Function by Rab26 siRNA-loaded DNA Nanovector in Pulmonary Microvascular Endothelial Cells
Hongli Li, Binfeng He, Xueping Liu, Jingtong Li, Qian Liu, Weijie Dong, Zhi Xu, Guisheng Qian, Hua Zuo, Changhua Hu, Hang Qian, Chengde Mao, Guansong Wang
Theranostics 2017; 7(9): 2537-2554. doi:10.7150/thno.17584
[Abstract] [Full text] [PDF]


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Research Paper
Rapid In Situ MRI Traceable Gel-forming Dual-drug Delivery for Synergistic Therapy of Brain Tumor
Feng-Wei Lin, Pin-Yuan Chen, Kuo-Chen Wei, Chiung-Yin Huang, Chih-Kuang Wang, Hung-Wei Yang
Theranostics 2017; 7(9): 2524-2536. doi:10.7150/thno.19856
[Abstract] [Full text] [PDF]


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Research Paper
Fabrication of Tissue-Engineered Bionic Urethra Using Cell Sheet Technology and Labeling By Ultrasmall Superparamagnetic Iron Oxide for Full-Thickness Urethral Reconstruction
Shukui Zhou, Ranxin Yang, Qingsong Zou, Kaile Zhang, Ting Yin, Weixin Zhao, Joseph G. Shapter, Guo Gao, Qiang Fu
Theranostics 2017; 7(9): 2509-2523. doi:10.7150/thno.18833
[Abstract] [Full text] [PDF]


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Research Paper
High-Yield Synthesis of Monomeric LMWP(CPP)-siRNA Covalent Conjugate for Effective Cytosolic Delivery of siRNA
Junxiao Ye, Ergang Liu, Junbo Gong, Jianxin Wang, Yongzhuo Huang, Huining He, Victor C. Yang
Theranostics 2017; 7(9): 2495-2508. doi:10.7150/thno.19863
[Abstract] [Full text] [PDF]


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Research Paper
PSMA-Targeted Theranostic Nanocarrier for Prostate Cancer
Orielyz Flores, Santimukul Santra, Charalambos Kaittanis, Rania Bassiouni, Amr S Khaled, Annette R. Khaled, Jan Grimm, J Manuel Perez
Theranostics 2017; 7(9): 2477-2494. doi:10.7150/thno.18879
[Abstract] [Full text] [PDF]


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Research Paper
Ultrasonographic Imaging and Anti-inflammatory Therapy of Muscle and Tendon Injuries Using Polymer Nanoparticles
Gi-Wook Kim, Changsun Kang, Young-Bin Oh, Myoung-Hwan Ko, Jeong-Hwan Seo, Dongwon Lee
Theranostics 2017; 7(9): 2463-2476. doi:10.7150/thno.18922
[Abstract] [Full text] [PDF]


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Research Paper
miR-196a Enhances Neuronal Morphology through Suppressing RANBP10 to Provide Neuroprotection in Huntington's Disease
Lu-Shiun Her, Su-Han Mao, Chih-Yi Chang, Pei-Hsun Cheng, Yu-Fan Chang, Han-In Yang, Chuan-Mu Chen, Shang-Hsun Yang
Theranostics 2017; 7(9): 2452-2462. doi:10.7150/thno.18813
[Abstract] [Full text] [PDF]


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Research Paper
Gut Microbiota-Mediated Personalized Treatment of Hyperlipidemia Using Berberine
Yan Wang, Qian Tong, Jia-Wen Shou, Zhen-Xiong Zhao, Xiao-Yang Li, Xian-Feng Zhang, Shu-Rong Ma, Chi-Yu He, Yuan Lin, Bao-Ying Wen, Fang Guo, Jie Fu, Jian-Dong Jiang
Theranostics 2017; 7(9): 2443-2451. doi:10.7150/thno.18290
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD, Chief, Laboratory of Molecular Imaging and Nanomedicine, NIBIB, NIH*
* Dr. Chen is serving in his personal capacity.
Editor-in-chief profile

new Impact factor is 8.712, according to 2017 release of Journal Citation Reports®. Congratulations!

new Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Theme Issue on “Brain Theranostics. Guest Editor: Prof. Rachela Popovtzer, PhD
Theme Issue on “Stem Cell Theranostics. Guest Editors: Kristopher Kilian, PhD, and Deok-Ho Kim, PhD
Theme Issue on “Biomolecular and biomimetic materials for theranostics. Guest Editors: Haiyun Song, PhD, and Chunhai Fan, PhD
Theme Issue on “Translational theranostics for infectious diseases. Guest Editor: Dr. Tony Y. Hu, Houston Methodist Research Institute
Theme Issue on “Light-Mediated Deep-Tissue Theranostics. Guest Editors: Dr. Gang Han, University of Massachusetts Medical School, and Dr. Jin Xie, University of Georgia
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Most Cited Paper Award for year 2016: Winners of this year are Lian Jin, Xin Zeng, Ming Liu, Yan Deng, Nongyue He, for the paper "Current Progress in Gene Delivery Technology Based on Chemical Methods and Nano-carriers". Details ...
new Congratulations to Dr. Chen for receiving the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.
NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues