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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Research Paper
Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB2 expression
Dong-liang Chen, Yun-xin Lu, Jia-xing Zhang, Xiao-li Wei, Feng Wang, Zhao-lei Zeng, Zhi-zhong Pan, Yun-fei Yuan, Feng-hua Wang, Helene Pelicano, Paul J. Chiao, Peng Huang, Dan Xie, Yu-hong Li, Huai-qiang Ju, Rui-hua Xu
Theranostics 2017; 7(19): 4836-4849. doi:10.7150/thno.20942
[Abstract] [Full text] [PDF]


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Research Paper
The Changing Therapeutic Role of Chemo-radiotherapy for Loco-regionally Advanced Nasopharyngeal Carcinoma from Two/Three-Dimensional Radiotherapy to Intensity-Modulated Radiotherapy: A Network Meta-Analysis
Rui You, Ying-Shu Cao, Pei-Yu Huang, Lei Chen, Qi Yang, You-Ping Liu, Xiong Zou, Yi-Nuan Zhang, Rou Jiang, Meng-Xia Zhang, Chong-Yang Duan, Ai-Hua Lin, Ming-Huang Hong, Ming-Yuan Chen
Theranostics 2017; 7(19): 4825-4835. doi:10.7150/thno.21815
[Abstract] [Full text] [PDF]


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Research Paper
Nanoparticle Delivery of miR-34a Eradicates Long-term-cultured Breast Cancer Stem Cells via Targeting C22ORF28 Directly
Xiaoti Lin, Weiyu Chen, Fengqin Wei, Binhua P. Zhou, Mien-Chie Hung, Xiaoming Xie
Theranostics 2017; 7(19): 4805-4824. doi:10.7150/thno.20771
[Abstract] [Full text] [PDF]


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Research Paper
Multimodality Imaging of Angiogenesis in a Rabbit Atherosclerotic Model by GEBP11 Peptide Targeted Nanoparticles
Tao Su, Ya-Bin Wang, Dong Han, Jing Wang, Shun Qi, Lei Gao, Ya-Hui Shao, Hong-Yu Qiao, Jiang-Wei Chen, Shu-Hui Liang, Yong-Zhan Nie, Jia-Yi Li, Feng Cao
Theranostics 2017; 7(19): 4791-4804. doi:10.7150/thno.20767
[Abstract] [Full text] [PDF]


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Research Paper
miR34a/GOLPH3 Axis abrogates Urothelial Bladder Cancer Chemoresistance via Reduced Cancer Stemness
Qing Zhang, Junlong Zhuang, Yongming Deng, Lin Yang, Wenmin Cao, Wei Chen, Tingsheng Lin, Xiaoyu Lv, Hang Yu, Yanshi Xue, Hongqian Guo
Theranostics 2017; 7(19): 4777-4790. doi:10.7150/thno.21713
[Abstract] [Full text] [PDF]


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Research Paper
Copper Manganese Sulfide Nanoplates: A New Two-Dimensional Theranostic Nanoplatform for MRI/MSOT Dual-Modal Imaging-Guided Photothermal Therapy in the Second Near-Infrared Window
Kaimei Ke, Wen Yang, Xiaoli Xie, Rui Liu, Li-Li Wang, Wei-Wen Lin, Guoming Huang, Chun-Hua Lu, Huang-Hao Yang
Theranostics 2017; 7(19): 4763-4776. doi:10.7150/thno.21694
[Abstract] [Full text] [PDF]


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Research Paper
Mutational Landscape of cfDNA Identifies Distinct Molecular Features Associated With Therapeutic Response to First-Line Platinum-Based Doublet Chemotherapy in Patients with Advanced NSCLC
Tao Jiang, Xuefei Li, Jianfei Wang, Chunxia Su, Wenbo Han, Chao Zhao, Fengying Wu, Guanghui Gao, Wei Li, Xiaoxia Chen, Jiayu Li, Fei Zhou, Jing Zhao, Weijing Cai, Henghui Zhang, Bo Du, Jun Zhang, Shengxiang Ren, Caicun Zhou, Hui Yu, Fred R. Hirsch
Theranostics 2017; 7(19): 4753-4762. doi:10.7150/thno.21687
[Abstract] [Full text] [PDF]


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Research Paper
The cytotoxic effects of dimethyl sulfoxide in mouse preimplantation embryos: a mechanistic study
Min-Hee Kang, Joydeep Das, Sangiliyandi Gurunathan, Hwan-Woo Park, Hyuk Song, Chankyu Park, Jin-Hoi Kim
Theranostics 2017; 7(19): 4735-4752. doi:10.7150/thno.21662
[Abstract] [Full text] [PDF]


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Research Paper
Optimizing fresh specimen staining for rapid identification of tumor biomarkers during surgery
Connor W. Barth, Jasmin M. Schaefer, Vincent M. Rossi, Scott C. Davis, Summer L. Gibbs
Theranostics 2017; 7(19): 4722-4734. doi:10.7150/thno.21527
[Abstract] [Full text] [PDF]


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Research Paper
Precisely Enumerating Circulating Tumor Cells Utilizing a Multi-Functional Microfluidic Chip and Unique Image Interpretation Algorithm
Mingxing Zhou, Hui Zheng, Zhaoba Wang, Ren Li, Xiaoran Liu, Weikai Zhang, Zihua Wang, Huiping Li, Zewen Wei, Zhiyuan Hu
Theranostics 2017; 7(19): 4710-4721. doi:10.7150/thno.20440
[Abstract] [Full text] [PDF]


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Research Paper
Glycan and Peptide IgE Epitopes of the TNF-alpha Blockers Infliximab and Adalimumab - Precision Diagnostics by Cross-Reactivity Immune Profiling of Patient Sera
Arne Homann, Niels Röckendorf, Arno Kromminga, Andreas Frey, Thomas A Platts-Mills, Uta Jappe
Theranostics 2017; 7(19): 4699-4709. doi:10.7150/thno.20654
[Abstract] [Full text] [PDF]


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Research Paper
CO2-based amphiphilic polycarbonate micelles enable a reliable and efficient platform for tumor imaging
Yuanyuan Li, Shunjie Liu, Xun Zhao, Ying Wang, Jianhua Liu, Xianhong Wang, Lehui Lu
Theranostics 2017; 7(19): 4689-4698. doi:10.7150/thno.21672
[Abstract] [Full text] [PDF]


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Research Paper
Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression
Xiaosa Li, Weiyu Chen, Ping Li, Jinzhi Wei, Yang Cheng, Pei Liu, Qing Yan, Xingyan Xu, Yuhong Cui, Zhengtian Gu, Tommaso Simoncini, Xiaodong Fu
Theranostics 2017; 7(19): 4671-4688. doi:10.7150/thno.21216
[Abstract] [Full text] [PDF]


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Research Paper
Material-induced Senescence (MIS): Fluidity Induces Senescent Type Cell Death of Lung Cancer Cells via Insulin-Like Growth Factor Binding Protein 5
Sharmy Saimon Mano, Koichiro Uto, Mitsuhiro Ebara
Theranostics 2017; 7(19): 4658-4670. doi:10.7150/thno.20582
[Abstract] [Full text] [PDF]


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Research Paper
Detection of Treatment Success after Photodynamic Therapy Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging
Tom J. L. Schreurs, Igor Jacobs, Klaas Nicolay, Jeanine J. Prompers, Gustav J. Strijkers
Theranostics 2017; 7(19): 4643-4657. doi:10.7150/thno.20418
[Abstract] [Full text] [PDF]


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Research Paper
MMPP Attenuates Non-Small Cell Lung Cancer Growth by Inhibiting the STAT3 DNA-Binding Activity via Direct Binding to the STAT3 DNA-Binding Domain
Dong Ju Son, Jie Zheng, Yu Yeon Jung, Chul Ju Hwang, Hee Pom Lee, Ju Rang Woo, Song Yi Baek, Young Wan Ham, Min Woong Kang, Minho Shong, Gi Ryang Kweon, Min Jong Song, Jae Kyung Jung, Sang-Bae Han, Bo Yeon Kim, Do Young Yoon, Bu Young Choi, Jin Tae Hong
Theranostics 2017; 7(18): 4632-4642. doi:10.7150/thno.18630
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD, Chief, Laboratory of Molecular Imaging and Nanomedicine, NIBIB, NIH*
* Dr. Chen is serving in his personal capacity.
Editor-in-chief profile

new Impact factor is 8.712, according to 2017 release of Journal Citation Reports®. Congratulations!

new Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Theme Issue on “Brain Theranostics. Guest Editor: Prof. Rachela Popovtzer, PhD
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Most Cited Paper Award for year 2016: Winners of this year are Lian Jin, Xin Zeng, Ming Liu, Yan Deng, Nongyue He, for the paper "Current Progress in Gene Delivery Technology Based on Chemical Methods and Nano-carriers". Details ...

new Congratulations to Dr. Chen for being recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Congratulations to Dr. Chen for receiving the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues