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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Research Paper
Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation
Matthias Brendel, Anna Jaworska, Felix Overhoff, Tanja Blume, Federico Probst, Franz-Josef Gildehaus, Peter Bartenstein, Christian Haass, Bernd Bohrmann, Jochen Herms, Michael Willem, Axel Rominger
Theranostics 2018; 8(18): 4957-4968. doi:10.7150/thno.27868
[Abstract] [Full text] [PDF]


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Review
Theranostics based on AIEgens
Dong Wang, Michelle Mei Suet Lee, Wenhan Xu, Ryan Tsz Kin Kwok, Jacky Wing Yip Lam, Ben Zhong Tang
Theranostics 2018; 8(18): 4925-4956. doi:10.7150/thno.27787
[Abstract] [Full text] [PDF]


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Research Paper
Blood exosomes regulate the tissue distribution of grapefruit-derived nanovector via CD36 and IGFR1 pathways
Qi-long Wang, XiaoYing Zhuang, Mukesh K. Sriwastva, Jingyao Mu, Yun Teng, Zhongbin Deng, Lifeng Zhang, Kumaran Sundaram, Anil Kumar, Donald Miller, Jun Yan, Huang-Ge Zhang
Theranostics 2018; 8(18): 4912-4924. doi:10.7150/thno.27608
[Abstract] [Full text] [PDF]


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Research Paper
Two-stage oxygen delivery for enhanced radiotherapy by perfluorocarbon nanoparticles
Zaigang Zhou, Baoli Zhang, Haoran Wang, Ahu Yuan, Yiqiao Hu, Jinhui Wu
Theranostics 2018; 8(18): 4898-4911. doi:10.7150/thno.27598
[Abstract] [Full text] [PDF]


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Research Paper
Enhanced bioreduction-responsive diselenide-based dimeric prodrug nanoparticles for triple negative breast cancer therapy
Xi He, Jinxiao Zhang, Chao Li, Yu Zhang, Yifei Lu, Yujie Zhang, Lisha Liu, Chunhui Ruan, Qinjun Chen, Xinli Chen, Qin Guo, Tao Sun, Jianjun Cheng, Chen Jiang
Theranostics 2018; 8(18): 4884-4897. doi:10.7150/thno.27581
[Abstract] [Full text] [PDF]


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Research Paper
Platelet bio-nanobubbles as microvascular recanalization nanoformulation for acute ischemic stroke lesion theranostics
Mingxi Li, Yang Liu, Jinpeng Chen, Taotao Liu, Zhuxiao Gu, Jianqiong Zhang, Xiaochun Gu, Gaojun Teng, Fang Yang, Ning Gu
Theranostics 2018; 8(18): 4870-4883. doi:10.7150/thno.27466
[Abstract] [Full text] [PDF]


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Research Paper
Evaluation of antibody fragment properties for near-infrared fluorescence imaging of HER3-positive cancer xenografts
Ayman El-Sayed, Wendy Bernhard, Kris Barreto, Carolina Gonzalez, Wayne Hill, Landon Pastushok, Humphrey Fonge, C. Ronald Geyer
Theranostics 2018; 8(17): 4856-4869. doi:10.7150/thno.24252
[Abstract] [Full text] [PDF]


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Research Paper
MRI and histological evaluation of pulsed focused ultrasound and microbubbles treatment effects in the brain
Zsofia I Kovacs, Tsang-Wei Tu, Maggie Sundby, Farhan Qureshi, Bobbi K Lewis, Neekita Jikaria, Scott R Burks, Joseph A Frank
Theranostics 2018; 8(17): 4837-4855. doi:10.7150/thno.24512
[Abstract] [Full text] [PDF]


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Research Paper
Neurogliovascular dysfunction in a model of repeated traumatic brain injury
Conner Adams, Paolo Bazzigaluppi, Tina L. Beckett, Jossana Bishay, Iliya Weisspapir, Adrienne Dorr, James R. Mester, Joe Steinman, Lydiane Hirschler, Jan M. Warnking, Emmanuel L. Barbier, JoAnne McLaurin, John G. Sled, Bojana Stefanovic
Theranostics 2018; 8(17): 4824-4836. doi:10.7150/thno.24747
[Abstract] [Full text] [PDF]


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Research Paper
WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma
Céline S. Gonçalves, Joana Vieira de Castro, Marta Pojo, Eduarda P. Martins, Sandro Queirós, Emmanuel Chautard, Ricardo Taipa, Manuel Melo Pires, Afonso A. Pinto, Fernando Pardal, Carlos Custódia, Cláudia C. Faria, Carlos Clara, Rui M. Reis, Nuno Sousa, Bruno M. Costa
Theranostics 2018; 8(17): 4805-4823. doi:10.7150/thno.25025
[Abstract] [Full text] [PDF]


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Research Paper
Inhibition of Notch1 induces population and suppressive activity of regulatory T cell in inflammatory arthritis
Bo Youn Choi, Yuri Choi, Jong-Sung Park, Li-Jung Kang, Seung Hyun Baek, Jin Su Park, Gahee Bahn, Yoonsuk Cho, Hark Kyun Kim, Jihoon Han, Jae Hoon Sul, Sang-Ha Baik, Dong Hoon Hyun, Thiruma V. Arumugam, Siyoung Yang, Jeung-Whan Han, Young Mo Kang, Yong-Woo Cho, Jae Hyung Park, Dong-Gyu Jo
Theranostics 2018; 8(17): 4795-4804. doi:10.7150/thno.26093
[Abstract] [Full text] [PDF]


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Research Paper
RGS4 deficit in prefrontal cortex contributes to the behaviors related to schizophrenia via system xc--mediated glutamatergic dysfunction in mice
Min-Wei Huang, Yu-Jung Lin, Chi-Wei Chang, Fu-Ju Lei, En-Peng Ho, Ren-Shyan Liu, Woei-Cherng Shyu, Chia-Hung Hsieh
Theranostics 2018; 8(17): 4781-4794. doi:10.7150/thno.25189
[Abstract] [Full text] [PDF]


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Research Paper
Simultaneous characterization of tumor cellularity and the Warburg effect with PET, MRI and hyperpolarized 13C-MRSI
Christian Hundshammer, Miriam Braeuer, Christoph A. Müller, Adam E. Hansen, Mathias Schillmaier, Stephan Düwel, Benedikt Feuerecker, Steffen J. Glaser, Axel Haase, Wilko Weichert, Katja Steiger, Jorge Cabello, Franz Schilling, Jan-Bernd Hövener, Andreas Kjær, Stephan G. Nekolla, Markus Schwaiger
Theranostics 2018; 8(17): 4765-4780. doi:10.7150/thno.25162
[Abstract] [Full text] [PDF]


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Research Paper
Optogenetic sensors in the zebrafish heart: a novel in vivo electrophysiological tool to study cardiac arrhythmogenesis
Chantal J.M. van Opbergen, Charlotte D. Koopman, Bart J.M. Kok, Thomas Knöpfel, Sabine L. Renninger, Michael B. Orger, Marc A. Vos, Toon A.B. van Veen, Jeroen Bakkers, Teun P. de Boer
Theranostics 2018; 8(17): 4750-4764. doi:10.7150/thno.26108
[Abstract] [Full text] [PDF]


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Research Paper
Mesenchymal glioblastoma constitutes a major ceRNA signature in the TGF-β pathway
Qixue Wang, Jinquan Cai, Chuan Fang, Chao Yang, Junhu Zhou, Yanli Tan, Yunfei Wang, Yansheng Li, Xiangqi Meng, Kai Zhao, Kaikai Yi, Sijing Zhang, Jianning Zhang, Chuanlu Jiang, Jing Zhang, Chunsheng Kang
Theranostics 2018; 8(17): 4733-4749. doi:10.7150/thno.26550
[Abstract] [Full text] [PDF]


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Research Paper
Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches
Julian Bejarano, Mario Navarro-Marquez, Francisco Morales-Zavala, Javier O. Morales, Ivonne Garcia-Carvajal, Eyleen Araya-Fuentes, Yvo Flores, Hugo E. Verdejo, Pablo F. Castro, Sergio Lavandero, Marcelo J. Kogan
Theranostics 2018; 8(17): 4710-4732. doi:10.7150/thno.26284
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD, Chief, Laboratory of Molecular Imaging and Nanomedicine, NIBIB, NIH*
* Dr. Chen is serving in his personal capacity.
Editor-in-chief profile

Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Nanotheranostics in PubMed Central

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Most Cited Paper Award for year 2016: Winners of this year are Lian Jin, Xin Zeng, Ming Liu, Yan Deng, Nongyue He, for the paper "Current Progress in Gene Delivery Technology Based on Chemical Methods and Nano-carriers". Details ...

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues