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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Review
Improving accessibility of EPR-insensitive tumor phenotypes using EPR-adaptive strategies: Designing a new perspective in nanomedicine delivery
Alexander Dhaliwal, Gang Zheng
Theranostics 2019; 9(26): 8091-8108. doi:10.7150/thno.37204
[Abstract] [Full text] [PDF]


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Review
Alliance with EPR Effect: Combined Strategies to Improve the EPR Effect in the Tumor Microenvironment
Jooho Park, Yongwhan Choi, Hyeyoun Chang, Wooram Um, Ju Hee Ryu, Ick Chan Kwon
Theranostics 2019; 9(26): 8073-8090. doi:10.7150/thno.37198
[Abstract] [Full text] [PDF]


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Research Paper
Cyclic RGD-Functionalized and Disulfide-Crosslinked Iodine-Rich Polymersomes as a Robust and Smart Theranostic Agent for Targeted CT Imaging and Chemotherapy of Tumor
Yan Zou, Yaohua Wei, Yinping Sun, Jie Bao, Feirong Yao, Zekun Li, Fenghua Meng, Chunhong Hu, Gert Storm, Zhiyuan Zhong
Theranostics 2019; 9(26): 8061-8072. doi:10.7150/thno.37184
[Abstract] [Full text] [PDF]


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Research Paper
Single enzyme loaded nanoparticles for combinational ultrasound-guided focused ultrasound ablation and hypoxia-relieved chemotherapy
Jianzhi Zhu, Zhicong Li, Changchang Zhang, Lizhou Lin, Shoupeng Cao, Hailong Che, Xiangyang Shi, Han Wang, Jan C. M. van Hest
Theranostics 2019; 9(26): 8048-8060. doi:10.7150/thno.37054
[Abstract] [Full text] [PDF]


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Review
Advances in nanomedicine for cancer starvation therapy
Shuangjiang Yu, Zhaowei Chen, Xuan Zeng, Xuesi Chen, Zhen Gu
Theranostics 2019; 9(26): 8026-8047. doi:10.7150/thno.38261
[Abstract] [Full text] [PDF]


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Review
Transcytosis - An effective targeting strategy that is complementary to “EPR effect” for pancreatic cancer nano drug delivery
Xiangsheng Liu, Jinhong Jiang, Huan Meng
Theranostics 2019; 9(26): 8018-8025. doi:10.7150/thno.38587
[Abstract] [Full text] [PDF]


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Review
Extracellular vesicle-based drug delivery systems for cancer treatment
Sierra Walker, Sara Busatto, Anthony Pham, Ming Tian, Annie Suh, Kelsey Carson, Astrid Quintero, Maria Lafrence, Hanna Malik, Moises X. Santana, Joy Wolfram
Theranostics 2019; 9(26): 8001-8017. doi:10.7150/thno.37097
[Abstract] [Full text] [PDF]


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Review
Engineering Nanoparticles to Reprogram the Tumor Immune Microenvironment for Improved Cancer Immunotherapy
Madiha Saeed, Jing Gao, Yang Shi, Twan Lammers, Haijun Yu
Theranostics 2019; 9(26): 7981-8000. doi:10.7150/thno.37568
[Abstract] [Full text] [PDF]


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Research Paper
miR-27a regulates vascular remodeling by targeting endothelial cells' apoptosis and interaction with vascular smooth muscle cells in aortic dissection
Yudong Sun, Yu Xiao, Huiying Sun, Zhiqing Zhao, Jiang Zhu, Lei Zhang, Jian Dong, Tonglei Han, Qing Jing, Jian Zhou, Zaiping Jing
Theranostics 2019; 9(25): 7961-7975. doi:10.7150/thno.35737
[Abstract] [Full text] [PDF]


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Research Paper
Integrin αvβ3-targeted radionuclide therapy combined with immune checkpoint blockade immunotherapy synergistically enhances anti-tumor efficacy
Haojun Chen, Liang Zhao, Kaili Fu, Qiuming Lin, Xuejun Wen, Orit Jacobson, Long Sun, Hua Wu, Xianzhong Zhang, Zhide Guo, Qin Lin, Xiaoyuan Chen
Theranostics 2019; 9(25): 7948-7960. doi:10.7150/thno.39203
[Abstract] [Full text] [PDF]


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Review
Imaging of T-cells and their responses during anti-cancer immunotherapy
Massis Krekorian, Gilbert O. Fruhwirth, Mangala Srinivas, Carl G. Figdor, Sandra Heskamp, Timothy H. Witney, Erik H.J.G. Aarntzen
Theranostics 2019; 9(25): 7924-7947. doi:10.7150/thno.37924
[Abstract] [Full text] [PDF]


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Review
Recent advances and challenges of repurposing nanoparticle-based drug delivery systems to enhance cancer immunotherapy
Seungho Lim, Jooho Park, Man Kyu Shim, Wooram Um, Hong Yeol Yoon, Ju Hee Ryu, Dong-Kwon Lim, Kwangmeyung Kim
Theranostics 2019; 9(25): 7906-7923. doi:10.7150/thno.38425
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Review
Advances in Engineering Cells for Cancer Immunotherapy
Xiao Xu, Teng Li, Shiyang Shen, Jinqiang Wang, Peter Abdou, Zhen Gu, Ran Mo
Theranostics 2019; 9(25): 7889-7905. doi:10.7150/thno.38583
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Review
Quantitative Proteomics and Metabolomics Reveal Biomarkers of Disease as Potential Immunotherapy Targets and Indicators of Therapeutic Efficacy
Melanie A. MacMullan, Zachary S. Dunn, Nicolas Graham, Lili Yang, Pin Wang
Theranostics 2019; 9(25): 7872-7888. doi:10.7150/thno.37373
[Abstract] [Full text] [PDF]


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Review
Small molecules as theranostic agents in cancer immunology
Jindian Li, Juno Van Valkenburgh, Xingfang Hong, Peter S. Conti, Xianzhong Zhang, Kai Chen
Theranostics 2019; 9(25): 7849-7871. doi:10.7150/thno.37218
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Review
Nanoparticle Delivery of Immunostimulatory Agents for Cancer Immunotherapy
Jia Zhuang, Maya Holay, Joon Ho Park, Ronnie H. Fang, Jie Zhang, Liangfang Zhang
Theranostics 2019; 9(25): 7826-7848. doi:10.7150/thno.37216
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

newNanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Microbubble enhanced ultrasound for the antivascular treatment and monitoring of hepatocellular carcinoma
Julia C. D'Souza, Laith R. Sultan, Stephen J. Hunt, Terence P. Gade, Mrigendra B. Karmacharya, Susan M. Schultz, Angela K. Brice, Andrew K. W. Wood, Chandra M. Sehgal
Nanotheranostics 2019; 3(4): 331-341. doi:10.7150/ntno.39514
[Abstract] [Full text] [PDF]


Research Paper
Enhanced blood-brain-barrier penetrability and tumor-targeting efficiency by peptide-functionalized poly(amidoamine) dendrimer for the therapy of gliomas
Changliang Liu, Zijian Zhao, Houqian Gao, Iman Rostami, Qing You, Xinru Jia, Chen Wang, Ling Zhu, Yanlian Yang
Nanotheranostics 2019; 3(4): 311-330. doi:10.7150/ntno.38954
[Abstract] [Full text] [PDF]


Research Paper
Theranostic nanoparticles enhance the response of glioblastomas to radiation
Wei Wu, Jessica L. Klockow, Suchismita Mohanty, Kimberly S. Ku, Maryam Aghighi, Stavros Melemenidis, Zixin Chen, Kai Li, Goreti Ribeiro Morais, Ning Zhao, Jürgen Schlegel, Edward E. Graves, Jianghong Rao, Paul M. Loadman, Robert A. Falconer, Sudip Mukherjee, Frederick T. Chin, Heike E. Daldrup-Link
Nanotheranostics 2019; 3(4): 299-310. doi:10.7150/ntno.35342
[Abstract] [Full text] [PDF]


Research Paper
Bacterial magnetosomes loaded with doxorubicin and transferrin improve targeted therapy of hepatocellular carcinoma
Jiaojiao Wang, Yuanyuan Geng, Yunpeng Zhang, Xi Wang, Junquan Liu, Abdul Basit, Ting Miao, Weiquan Liu, Wei Jiang
Nanotheranostics 2019; 3(3): 284-298. doi:10.7150/ntno.34601
[Abstract] [Full text] [PDF] [PubMed] [PMC]

new CFP - Special Issue: Noble-metal Nanostructures for Theranostics. Guest Editors: Xiaohu Xia, University of Central Florida and Hui Wei, Nanjing University
Special Issue Targeting the Cancer Stem Cells. Guest Editor: Fei Chen, PhD, Professor, Wayne State University
Special Issue Progress in Critical Reviews of Immunotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH), Mingnan Chen (University of Utah)
Special Issue Progress in Gene Editing Nanotheranostics. Guest Editors: Gang Han (University of Massachusetts Medical School), Wen Xue (University of Massachusetts Medical School), Qiaobing Xu (Tufts University)
Special Issue The EPR effect and beyond: Strategies to improve tumor targeting and nanomedicine efficacy. Guest Editors: Yang Shi (RWTH Aachen University), Roy van der Meel (Eindhoven University of Technology), Twan Lammers (RWTH Aachen University), Xiaoyuan (Shawn) Chen (NIBIB/NIH)
Special Issue Progress in Supramolecular Nanotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH); Gang Zheng (University of Toronto); Jianjun Cheng (University of Illinois Urbana-Champaign); Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, Singapore)

Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues