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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Research Paper
Radiopaque and uniform alginate microspheres loaded with tantalum nanoparticles for real-time imaging during transcatheter arterial embolization
Jian Zeng, Ling Li, Hongsen Zhang, Jianye Li, Lingli Liu, Guofeng Zhou, Qing Du, Chuansheng Zheng, Xiangliang Yang
Theranostics 2018; 8(17): 4591-4600. doi:10.7150/thno.27379
[Abstract] [Full text] [PDF]


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Research Paper
Combination of NIR therapy and regulatory T cell modulation using layer-by-layer hybrid nanoparticles for effective cancer photoimmunotherapy
Wenquan Ou, Liyuan Jiang, Raj Kumar Thapa, Zar Chi Soe, Kishwor Poudel, Jae-Hoon Chang, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Theranostics 2018; 8(17): 4574-4590. doi:10.7150/thno.26758
[Abstract] [Full text] [PDF]


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Research Paper
[18F]Fludarabine-PET as a promising tool for differentiating CNS lymphoma and glioblastoma: Comparative analysis with [18F]FDG in human xenograft models
Narinée Hovhannisyan, Fabien Fillesoye, Stéphane Guillouet, Méziane Ibazizene, Jérôme Toutain, Fabienne Gourand, Samuel Valable, Benoit Plancoulaine, Louisa Barré
Theranostics 2018; 8(16): 4563-4573. doi:10.7150/thno.26754
[Abstract] [Full text] [PDF]


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Research Paper
Liver-heart crosstalk controls IL-22 activity in cardiac protection after myocardial infarction
Ting-Ting Tang, Yuan-Yuan Li, Jing-Jing Li, Ke Wang, Yue Han, Wen-Yong Dong, Zheng-Feng Zhu, Ni Xia, Shao-Fang Nie, Min Zhang, Zhi-Peng Zeng, Bing-Jie Lv, Jiao Jiao, Heng Liu, Zong-Shu Xian, Xiang-Ping Yang, Yu Hu, Yu-Hua Liao, Qing Wang, Xin Tu, Ziad Mallat, Yu Huang, Guo-Ping Shi, Xiang Cheng
Theranostics 2018; 8(16): 4552-4562. doi:10.7150/thno.24723
[Abstract] [Full text] [PDF]


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Review
AMPK: Potential Therapeutic Target for Ischemic Stroke
Shuai Jiang, Tian Li, Ting Ji, Wei Yi, Zhi Yang, Simeng Wang, Yang Yang, Chunhu Gu
Theranostics 2018; 8(16): 4535-4551. doi:10.7150/thno.25674
[Abstract] [Full text] [PDF]


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Research Paper
Rewiring of cisplatin-resistant bladder cancer cells through epigenetic regulation of genes involved in amino acid metabolism
Austin Yeon, Sungyong You, Minhyung Kim, Amit Gupta, Myung Hee Park, Daniel J. Weisenberger, Gangning Liang, Jayoung Kim
Theranostics 2018; 8(16): 4520-4534. doi:10.7150/thno.25130
[Abstract] [Full text] [PDF]


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Research Paper
CD28null pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death
Alejandra Pera, Stefano Caserta, Fabio Albanese, Pinar Blowers, George Morrow, Nadia Terrazzini, Helen E Smith, Chakravarthi Rajkumar, Bernhard Reus, James R Msonda, Murielle Verboom, Michael Hallensleben, Rainer Blasczyk, Kevin A Davies, Florian Kern
Theranostics 2018; 8(16): 4509-4519. doi:10.7150/thno.27428
[Abstract] [Full text] [PDF]


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Research Paper
Therapeutic mesopore construction on 2D Nb2C MXenes for targeted and enhanced chemo-photothermal cancer therapy in NIR-II biowindow
Xiaoxia Han, Xiangxiang Jing, Dayan Yang, Han Lin, Zhigang Wang, Haitao Ran, Pan Li, Yu Chen
Theranostics 2018; 8(16): 4491-4508. doi:10.7150/thno.26291
[Abstract] [Full text] [PDF]


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Research Paper
Integration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis
Stephanie Herman, Payam Emami Khoonsari, Andreas Tolf, Julia Steinmetz, Henrik Zetterberg, Torbjörn Åkerfeldt, Per-Johan Jakobsson, Anders Larsson, Ola Spjuth, Joachim Burman, Kim Kultima
Theranostics 2018; 8(16): 4477-4490. doi:10.7150/thno.26249
[Abstract] [Full text] [PDF]


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Research Paper
Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate: proof-of-principle in a murine model
Bogdan Mitran, Rezan Güler, Francis P. Roche, Elin Lindström, Ram Kumar Selvaraju, Filippa Fleetwood, Sara S. Rinne, Lena Claesson-Welsh, Vladimir Tolmachev, Stefan Ståhl, Anna Orlova, John Löfblom
Theranostics 2018; 8(16): 4462-4476. doi:10.7150/thno.24395
[Abstract] [Full text] [PDF]


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Research Paper
Aspirin cooperates with p300 to activate the acetylation of H3K9 and promote FasL-mediated apoptosis of cancer stem-like cells in colorectal cancer
Zhigang Chen, Wenlu Li, Fuming Qiu, Qi Huang, Zhou Jiang, Jun Ye, Pu Cheng, Cho Low, Yikun Guo, Xinchi Yi, Wenteng Chen, Yongpin Yu, YueHua Han, Jun Wu, Shenghang Jin, Dong Kong, Jian Huang
Theranostics 2018; 8(16): 4447-4461. doi:10.7150/thno.24284
[Abstract] [Full text] [PDF]


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Research Paper
Novel multi-drug delivery hydrogel using scar-homing liposomes improves spinal cord injury repair
Qingqing Wang, Hongyu Zhang, Helin Xu, Yingzheng Zhao, Zhengmao Li, Jiawei Li, Haoli Wang, Deli Zhuge, Xin Guo, Huazi Xu, Salazar Jones, Xiaokun Li, Xiaofeng Jia, Jian Xiao
Theranostics 2018; 8(16): 4429-4446. doi:10.7150/thno.26717
[Abstract] [Full text] [PDF]


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Research Paper
Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1
Ki Cheon Kim, Jaesuk Yun, Dong Ju Son, Ji Young Kim, Jae-Kyung Jung, Jeong Soon Choi, Yu Ri Kim, Ju Kyung Song, Sun Young Kim, Sin Kook Kang, Dae Hwan Shin, Yoon-Seok Roh, Sang-Bae Han, Jin Tae Hong
Theranostics 2018; 8(16): 4409-4428. doi:10.7150/thno.26467
[Abstract] [Full text] [PDF]


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Review
State-of-the-art of microbubble-assisted blood-brain barrier disruption
Kang-Ho Song, Brandon K. Harvey, Mark A. Borden
Theranostics 2018; 8(16): 4393-4408. doi:10.7150/thno.26869
[Abstract] [Full text] [PDF]


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Research Paper
3D printing of Mo-containing scaffolds with activated anabolic responses and bi-lineage bioactivities
Wentao Dang, Xiaoya Wang, Jiayi Li, Cuijun Deng, Yaqin Liu, Qingqiang Yao, Liming Wang, Jiang Chang, Chengtie Wu
Theranostics 2018; 8(16): 4372-4392. doi:10.7150/thno.27088
[Abstract] [Full text] [PDF]


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Research Paper
Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival
Wu Zhang, Chen Zhao, Junmei Zhao, Yongmei Zhu, Xiangqin Weng, Qiusheng Chen, Huiping Sun, Jian-Qing Mi, Junmin Li, Jiang Zhu, Zhu Chen, Pier Paolo Pandolfi, Saijuan Chen, Xiaojing Yan, Jie Xu
Theranostics 2018; 8(16): 4359-4371. doi:10.7150/thno.26900
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD, Chief, Laboratory of Molecular Imaging and Nanomedicine, NIBIB, NIH*
* Dr. Chen is serving in his personal capacity.
Editor-in-chief profile

Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Nanotheranostics in PubMed Central

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Most Cited Paper Award for year 2016: Winners of this year are Lian Jin, Xin Zeng, Ming Liu, Yan Deng, Nongyue He, for the paper "Current Progress in Gene Delivery Technology Based on Chemical Methods and Nano-carriers". Details ...

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues