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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Review
Current Strategies and Challenges for Purification of Cardiomyocytes Derived from Human Pluripotent Stem Cells
Kiwon Ban, Seongho Bae, Young-sup Yoon
Theranostics 2017; 7(7): 2067-2077. doi:10.7150/thno.19427
[Abstract] [Full text] [PDF]


Editorial
In Molecular Pursuit of Bone Metastasis by Fluciclovine PET
Liza Lindenberg
Theranostics 2017; 7(7): 2065-2066. doi:10.7150/thno.20622
[Abstract] [Full text] [PDF]


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Research Paper
PET Tracer 18F-Fluciclovine Can Detect Histologically Proven Bone Metastatic Lesions: A Preclinical Study in Rat Osteolytic and Osteoblastic Bone Metastasis Models
Shuntaro Oka, Masaru Kanagawa, Yoshihiro Doi, David M. Schuster, Mark M. Goodman, Hirokatsu Yoshimura
Theranostics 2017; 7(7): 2048-2064. doi:10.7150/thno.19883
[Abstract] [Full text] [PDF]


Editorial
PSMA-PET for Lymph Node Detection in Recurrent Prostate Cancer: How do we use the Magic Bullet?
Tobias Maurer, Declan G. Murphy, Michael S. Hofman, Matthias Eiber
Theranostics 2017; 7(7): 2046-2047. doi:10.7150/thno.20855
[Abstract] [Full text] [PDF]


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Research Paper
Parkin Knockout Inhibits Neuronal Development via Regulation of Proteasomal Degradation of p21
Mi Hee Park, Hwa-Jeong Lee, Hye Lim Lee, Dong Ju Son, Jung Hoon Ju, Byung Kook Hyun, Sung Hee Jung, Ju-Kyoung Song, Dong-Hoon Lee, Chul Ju Hwang, Sang Bae Han, Sanghyeon Kim, Jin Tae Hong
Theranostics 2017; 7(7): 2033-2045. doi:10.7150/thno.19824
[Abstract] [Full text] [PDF]


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Research Paper
Melatonin Suppresses Neuropathic Pain via MT2-Dependent and -Independent Pathways in Dorsal Root Ganglia Neurons of Mice
Jia-Ji Lin, Ye Lin, Tian-Zhi Zhao, Chun-Kui Zhang, Ting Zhang, Xiao-Li Chen, Jia-Qi Ding, Ting Chang, Zhuo Zhang, Chao Sun, Dai-Di Zhao, Jun-Lin Zhu, Zhu-Yi Li, Jin-Lian Li
Theranostics 2017; 7(7): 2015-2032. doi:10.7150/thno.19500
[Abstract] [Full text] [PDF]


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Research Paper
Drug-Bearing Supramolecular Filament Hydrogels as Anti-Inflammatory Agents
Zhipeng Chen, Lei Xing, Qin Fan, Andrew G. Cheetham, Ran Lin, Barbara Holt, Liwen Chen, Yanyu Xiao, Honggang Cui
Theranostics 2017; 7(7): 2003-2014. doi:10.7150/thno.19404
[Abstract] [Full text] [PDF]


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Research Paper
Surface De-PEGylation Controls Nanoparticle-Mediated siRNA Delivery In Vitro and In Vivo
Xi Zhu, Wei Tao, Danny Liu, Jun Wu, Zilei Guo, Xiaoyuan Ji, Zameer Bharwani, Lili Zhao, Xiaoping Zhao, Omid C. Farokhzad, Jinjun Shi
Theranostics 2017; 7(7): 1990-2002. doi:10.7150/thno.18136
[Abstract] [Full text] [PDF]


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Research Paper
Thermoacoustic Imaging and Therapy Guidance based on Ultra-short Pulsed Microwave Pumped Thermoelastic Effect Induced with Superparamagnetic Iron Oxide Nanoparticles
Liewei Wen, Sihua Yang, Junping Zhong, Quan Zhou, Da Xing
Theranostics 2017; 7(7): 1976-1989. doi:10.7150/thno.17846
[Abstract] [Full text] [PDF]


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Research Paper
Implantable and Biodegradable Macroporous Iron Oxide Frameworks for Efficient Regeneration and Repair of Infracted Heart
Wenshuo Wang, Hongyue Tao, Yun Zhao, Xiaotian Sun, Jing Tang, Cordelia Selomulya, Jia Tang, Tianchan Chen, Yang Wang, Minglei Shu, Lei Wei, Guanyu Yi, Jixue Zhou, Lai Wei, Chunsheng Wang, Biao Kong
Theranostics 2017; 7(7): 1966-1975. doi:10.7150/thno.16866
[Abstract] [Full text] [PDF]


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Research Paper
Neonatal Heart-Enriched miR-708 Promotes Proliferation and Stress Resistance of Cardiomyocytes in Rodents
Shengqiong Deng, Qian Zhao, Chuyi Zhang, Lixiao Zhen, Cuicui Liu, Guangxue Wang, Lin Zhang, Luer Bao, Ying Lu, Lingyu Meng, Jinhui Lü, Ping Yu, Xin Lin, Yuzhen Zhang, Yi-Han Chen, Huimin Fan, William C. Cho, Zhongmin Liu, Zuoren Yu
Theranostics 2017; 7(7): 1953-1965. doi:10.7150/thno.16478
[Abstract] [Full text] [PDF]


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Research Paper
Mouse IP-10 Gene Delivered by Folate-modified Chitosan Nanoparticles and Dendritic/tumor Cells Fusion Vaccine Effectively Inhibit the Growth of Hepatocellular Carcinoma in Mice
Zixi Hu, Jiaojiao Chen, Sufang Zhou, Nuo Yang, Siliang Duan, Zhenghua Zhang, Jing Su, Jian He, Zhiyong Zhang, Xiaoling Lu, Yongxiang Zhao
Theranostics 2017; 7(7): 1942-1952. doi:10.7150/thno.16236
[Abstract] [Full text] [PDF]


Editorial
Should Low Molecular Weight PSMA Targeted Ligands Get Bigger and Use Albumin Ligands for PSMA Targeting?
Steve S. Huang, Warren D.W. Heston
Theranostics 2017; 7(7): 1940-1941. doi:10.7150/thno.20284
[Abstract] [Full text] [PDF]


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Research Paper
177Lu-Labeled Phosphoramidate-Based PSMA Inhibitors: The Effect of an Albumin Binder on Biodistribution and Therapeutic Efficacy in Prostate Tumor-Bearing Mice
Cindy J. Choy, Xiaoxi Ling, Jonathan J. Geruntho, Sophia K. Beyer, Joseph D. Latoche, Beatrice Langton-Webster, Carolyn J. Anderson, Clifford E. Berkman
Theranostics 2017; 7(7): 1928-1939. doi:10.7150/thno.18719
[Abstract] [Full text] [PDF]


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Research Paper
Triptolide Inhibits the AR Signaling Pathway to Suppress the Proliferation of Enzalutamide Resistant Prostate Cancer Cells
Yangyang Han, Weiwei Huang, Jiakuan Liu, Dandan Liu, Yangyan Cui, Ruimin Huang, Jun Yan, Ming Lei
Theranostics 2017; 7(7): 1914-1927. doi:10.7150/thno.17852
[Abstract] [Full text] [PDF]


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Research Paper
Therapeutic Inhibition of miR-4260 Suppresses Colorectal Cancer via Targeting MCC and SMAD4
Junjie Xiao, Dongchao Lv, Jinzhe Zhou, Yihua Bei, Ting Chen, Muren Hu, Qiulian Zhou, Siyi Fu, Qi Huang
Theranostics 2017; 7(7): 1901-1913. doi:10.7150/thno.19168
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD, Chief, Laboratory of Molecular Imaging and Nanomedicine, NIBIB, NIH*
* Dr. Chen is serving in his personal capacity.
Editor-in-chief profile

new Impact factor is 8.854, according to 2016 release of Journal Citation Reports®. Congratulations!

new Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Theme Issue on “Brain Theranostics. Guest Editor: Prof. Rachela Popovtzer, PhD
Theme Issue on “Stem Cell Theranostics. Guest Editors: Kristopher Kilian, PhD, and Deok-Ho Kim, PhD
Theme Issue on “Biomolecular and biomimetic materials for theranostics. Guest Editors: Haiyun Song, PhD, and Chunhai Fan, PhD
Theme Issue on “Translational theranostics for infectious diseases. Guest Editor: Dr. Tony Y. Hu, Houston Methodist Research Institute
Theme Issue on “Light-Mediated Deep-Tissue Theranostics. Guest Editors: Dr. Gang Han, University of Massachusetts Medical School, and Dr. Jin Xie, University of Georgia
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Most Cited Paper Award for year 2016: Winners of this year are Lian Jin, Xin Zeng, Ming Liu, Yan Deng, Nongyue He, for the paper "Current Progress in Gene Delivery Technology Based on Chemical Methods and Nano-carriers". Details ...
new Congratulations to Dr. Chen for receiving the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.
NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues