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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Review
Bioengineering of Artificial Antigen Presenting Cells and Lymphoid Organs
Chao Wang, Wujin Sun, Yanqi Ye, Hunter N. Bomba, Zhen Gu
Theranostics 2017; 7(14): 3504-3516. doi:10.7150/thno.19017
[Abstract] [Full text] [PDF]


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Research Paper
Glioma Dual-Targeting Nanohybrid Protein Toxin Constructed by Intein-Mediated Site-Specific Ligation for Multistage Booster Delivery
Yingzhi Chen, Meng Zhang, Hongyue Jin, Dongdong Li, Fan Xu, Aihua Wu, Jinyu Wang, Yongzhuo Huang
Theranostics 2017; 7(14): 3489-3503. doi:10.7150/thno.20578
[Abstract] [Full text] [PDF]


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Research Paper
CBX8 Suppresses Tumor Metastasis via Repressing Snail in Esophageal Squamous Cell Carcinoma
Gang Wang, Jianjun Tang, Weixiang Zhan, Ruhua Zhang, Meifang Zhang, Dan Liao, Xin Wang, Yuanzhong Wu, Tiebang Kang
Theranostics 2017; 7(14): 3478-3488. doi:10.7150/thno.20717
[Abstract] [Full text] [PDF]


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Research Paper
Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells
Anna Lewinska, Jagoda Adamczyk-Grochala, Anna Deregowska, Maciej Wnuk
Theranostics 2017; 7(14): 3461-3477. doi:10.7150/thno.20657
[Abstract] [Full text] [PDF]


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Research Paper
rSj16 Protects against DSS-Induced Colitis by Inhibiting the PPAR-α Signaling Pathway
Lifu Wang, Hui Xie, Lian Xu, Qi Liao, Shuo Wan, Zilong Yu, Datao Lin, Beibei Zhang, Zhiyue Lv, Zhongdao Wu, Xi Sun
Theranostics 2017; 7(14): 3446-3460. doi:10.7150/thno.20359
[Abstract] [Full text] [PDF]


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Research Paper
The pH-Triggered Triblock Nanocarrier Enabled Highly Efficient siRNA Delivery for Cancer Therapy
Lili Du, Junhui Zhou, Lingwei Meng, Xiaoxia Wang, Changrong Wang, Yuanyu Huang, Shuquan Zheng, Liandong Deng, Huiqing Cao, Zicai Liang, Anjie Dong, Qiang Cheng
Theranostics 2017; 7(14): 3432-3445. doi:10.7150/thno.20297
[Abstract] [Full text] [PDF]


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Research Paper
Brusatol-Mediated Inhibition of c-Myc Increases HIF-1α Degradation and Causes Cell Death in Colorectal Cancer under Hypoxia
Eun-Taex Oh, Chan Woo Kim, Ha Gyeong Kim, Jae-Seon Lee, Heon Joo Park
Theranostics 2017; 7(14): 3415-3431. doi:10.7150/thno.20861
[Abstract] [Full text] [PDF]


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Research Paper
Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo
Genna Davies, Anna-Maria Rolle, Andreas Maurer, Philipp R. Spycher, Claudia Schillinger, Djamschid Solouk-Saran, Mike Hasenberg, Juliane Weski, Jesper Fonslet, Adrien Dubois, Frederic Boschetti, Franck Denat, Matthias Gunzer, Martin Eichner, Lauren S Ryder, Mikael Jensen, Roger Schibli, Bernd J. Pichler, Stefan Wiehr, Christopher R. Thornton
Theranostics 2017; 7(14): 3398-3414. doi:10.7150/thno.20919
[Abstract] [Full text] [PDF]


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Research Paper
Bone-Inspired Spatially Specific Piezoelectricity Induces Bone Regeneration
Peng Yu, Chengyun Ning, Yu Zhang, Guoxin Tan, Zefeng Lin, Shaoxiang Liu, Xiaolan Wang, Haoqi Yang, Kang Li, Xin Yi, Ye Zhu, Chuanbin Mao
Theranostics 2017; 7(13): 3387-3397. doi:10.7150/thno.19748
[Abstract] [Full text] [PDF]


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Research Paper
Sensitive in vivo Visualization of Breast Cancer Using Ratiometric Protease-activatable Fluorescent Imaging Agent, AVB-620
Marcel Miampamba, Junjie Liu, Alec Harootunian, Andrew J Gale, Stephen Baird, Steven L Chen, Quyen T Nguyen, Roger Y Tsien, Jesús E González
Theranostics 2017; 7(13): 3369-3386. doi:10.7150/thno.20678
[Abstract] [Full text] [PDF]


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Research Paper
Fluorocarbons Enhance Intracellular Delivery of Short STAT3-sensors and Enable Specific Imaging
Valeriy Metelev, Surong Zhang, Shaokuan Zheng, Anand T.N. Kumar, Alexei Bogdanov
Theranostics 2017; 7(13): 3354-3368. doi:10.7150/thno.19704
[Abstract] [Full text] [PDF]


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Research Paper
MicroRNA-647 Targets SRF-MYH9 Axis to Suppress Invasion and Metastasis of Gastric Cancer
Gengtai Ye, Kunzhai Huang, Jiang Yu, Liying Zhao, Xianjun Zhu, Qingbin Yang, Wende Li, Yuming Jiang, Baoxiong Zhuang, Hao Liu, Zhiyong Shen, Da Wang, Li Yan, Lei Zhang, Haipeng Zhou, Yanfeng Hu, Haijun Deng, Hao Liu, Guoxin Li, Xiaolong Qi
Theranostics 2017; 7(13): 3338-3353. doi:10.7150/thno.20512
[Abstract] [Full text] [PDF]


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Research Paper
In Vivo Cancer Cells Elimination Guided by Aptamer-Functionalized Gold-Coated Magnetic Nanoparticles and Controlled with Low Frequency Alternating Magnetic Field
Irina V. Belyanina, Tatiana N. Zamay, Galina S. Zamay, Sergey S. Zamay, Olga S. Kolovskaya, Tatiana I. Ivanchenko, Valery V. Denisenko, Andrey K. Kirichenko, Yury E. Glazyrin, Irina V. Garanzha, Valentina V. Grigorieva, Alexandr V. Shabanov, Dmitry V. Veprintsev, Alexey E. Sokolov, Vladimir M. Sadovskii, Ana Gargaun, Maxim V. Berezovski, Anna S. Kichkailo
Theranostics 2017; 7(13): 3326-3337. doi:10.7150/thno.17089
[Abstract] [Full text] [PDF]


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Research Paper
Aptavalve-gated Mesoporous Carbon Nanospheres image Cellular Mucin and provide On-demand Targeted Drug Delivery
Chengyi Li, Min Qian, Shanshan Wang, Huilin Jiang, Yilin Du, Jianxin Wang, Weiyue Lu, Niren Murthy, Rongqin Huang
Theranostics 2017; 7(13): 3319-3325. doi:10.7150/thno.18692
[Abstract] [Full text] [PDF]


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Research Paper
A Nanosystem of Amphiphilic Oligopeptide-Drug Conjugate Actualizing Both αvβ3 Targeting and Reduction-Triggered Release for Maytansinoid
Yanqin Liang, Suxin Li, Xiaoyou Wang, Bo He, Bing He, Wenbing Dai, Hua Zhang, Xueqing Wang, Yiguang Wang, Demin Zhou, Qiang Zhang
Theranostics 2017; 7(13): 3306-3318. doi:10.7150/thno.20242
[Abstract] [Full text] [PDF]


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Research Paper
EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes
Yiqun Jiang, Chao Mao, Rui Yang, Bin Yan, Ying Shi, Xiaoli Liu, Weiwei Lai, Yating Liu, Xiang Wang, Desheng Xiao, Hu Zhou, Yan Cheng, Fenglei Yu, Ya Cao, Shuang Liu, Qin Yan, Yongguang Tao
Theranostics 2017; 7(13): 3293-3305. doi:10.7150/thno.19988
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD, Chief, Laboratory of Molecular Imaging and Nanomedicine, NIBIB, NIH*
* Dr. Chen is serving in his personal capacity.
Editor-in-chief profile

new Impact factor is 8.712, according to 2017 release of Journal Citation Reports®. Congratulations!

new Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Theme Issue on “Brain Theranostics. Guest Editor: Prof. Rachela Popovtzer, PhD
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Most Cited Paper Award for year 2016: Winners of this year are Lian Jin, Xin Zeng, Ming Liu, Yan Deng, Nongyue He, for the paper "Current Progress in Gene Delivery Technology Based on Chemical Methods and Nano-carriers". Details ...

new Congratulations to Dr. Chen for being recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Congratulations to Dr. Chen for receiving the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues