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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Research Paper
Vascularized Tissue-Engineered Model for Studying Drug Resistance in Neuroblastoma
A. Villasante, K. Sakaguchi, J. Kim, N.K. Cheung, M. Nakayama, H. Parsa, T. Okano, T. Shimizu, G. Vunjak-Novakovic
Theranostics 2017; 7(17): 4099-4117. doi:10.7150/thno.20730
[Abstract] [Full text] [PDF]


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Research Paper
Enhanced Radiotherapy using Bismuth Sulfide Nanoagents Combined with Photo-thermal Treatment
Xiaju Cheng, Yuan Yong, Yiheng Dai, Xin Song, Gang Yang, Yue Pan, Cuicui Ge
Theranostics 2017; 7(17): 4087-4098. doi:10.7150/thno.20548
[Abstract] [Full text] [PDF]


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Research Paper
Transforming doxorubicin into a cancer stem cell killer via EpCAM aptamer-mediated delivery
Dongxi Xiang, Sarah Shigdar, Andrew G Bean, Matthew Bruce, Wenrong Yang, Motilal Mathesh, Tao Wang, Wang Yin, Phuong Ha-Lien Tran, Hadi Al Shamaileh, Roberto A Barrero, Pei-Zhuo Zhang, Yong Li, Lingxue Kong, Ke Liu, Shu-Feng Zhou, Yingchun Hou, Aina He, Wei Duan
Theranostics 2017; 7(17): 4071-4086. doi:10.7150/thno.20168
[Abstract] [Full text] [PDF]


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Research Paper
Multiplexed Nucleic Acid Programmable Protein Arrays
Xiaobo Yu, Lusheng Song, Brianne Petritis, Xiaofang Bian, Haoyu Wang, Jennifer Viloria, Jin Park, Hoang Bui, Han Li, Jie Wang, Lei Liu, Liuhui Yang, Hu Duan, David N. McMurray, Jacqueline M. Achkar, Mitch Magee, Ji Qiu, Joshua LaBaer
Theranostics 2017; 7(16): 4057-4070. doi:10.7150/thno.20151
[Abstract] [Full text] [PDF]


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Research Paper
Notch3 Maintains Luminal Phenotype and Suppresses Tumorigenesis and Metastasis of Breast Cancer via Trans-Activating Estrogen Receptor-α
Xiao-Wei Dou, Yuan-Ke Liang, Hao-Yu Lin, Xiao-Long Wei, Yong-Qu Zhang, Jing-Wen Bai, Chun-Fa Chen, Min Chen, Cai-Wen Du, Yao-Chen Li, Jie Tian, Kwan Man, Guo-Jun Zhang
Theranostics 2017; 7(16): 4041-4056. doi:10.7150/thno.19989
[Abstract] [Full text] [PDF]


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Research Paper
Investigating the Effect of Chemical Structure of Semiconducting Polymer Nanoparticle on Photothermal Therapy and Photoacoustic Imaging
Dongdong Li, Guobing Zhang, Weiguo Xu, Junxia Wang, Yucai Wang, Longzhen Qiu, Jianxun Ding, Xianzhu Yang
Theranostics 2017; 7(16): 4029-4040. doi:10.7150/thno.19538
[Abstract] [Full text] [PDF]


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Research Paper
The Use of PET Imaging for Prognostic Integrin α2β1 Phenotyping to Detect Non-Small Cell Lung Cancer and Monitor Drug Resistance Responses
Chiun-Wei Huang, Wen-Chuan Hsieh, Shih-Ting Hsu, Yi-Wen Lin, Yi-Hsiu Chung, Wen-Chi Chang, Han Chiu, Yun Han Lin, Chung-Pu Wu, Tzu-Chen Yen, Feng-Ting Huang
Theranostics 2017; 7(16): 4013-4028. doi:10.7150/thno.19304
[Abstract] [Full text] [PDF]


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Research Paper
Ginsenoside Rg1 Inhibits Glucagon-Induced Hepatic Gluconeogenesis through Akt-FoxO1 Interaction
Qun Liu, Fei-Ge Zhang, Wen-Song Zhang, An Pan, Yi-Lin Yang, Jin-Feng Liu, Ping Li, Bao-Lin Liu, Lian-Wen Qi
Theranostics 2017; 7(16): 4001-4012. doi:10.7150/thno.18788
[Abstract] [Full text] [PDF]


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Research Paper
Acute Inflammatory Response Following Increased Blood-Brain Barrier Permeability Induced by Focused Ultrasound is Dependent on Microbubble Dose
Dallan McMahon, Kullervo Hynynen
Theranostics 2017; 7(16): 3989-4000. doi:10.7150/thno.21630
[Abstract] [Full text] [PDF]


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Research Paper
MiR-205/YAP1 in Activated Fibroblasts of Breast Tumor Promotes VEGF-independent Angiogenesis through STAT3 Signaling
Yan-e Du, Gang Tu, Guanglun Yang, Genyou Li, Dan Yang, Lei Lang, Lei Xi, Kexin Sun, Yanlin Chen, Kunxian Shu, Huadong Liao, Manran Liu, Yixuan Hou
Theranostics 2017; 7(16): 3972-3988. doi:10.7150/thno.18990
[Abstract] [Full text] [PDF]


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Research Paper
Can molecular profiling enhance radiotherapy? Impact of personalized targeted gold nanoparticles on radiosensitivity and imaging of adenoid cystic carcinoma
Inbal Hazkani, Menachem Motiei, Oshra Betzer, Tamar Sadan, Dimitri Bragilovski, Leon Lubimov, Aviram Mizrachi, Tuvia Hadar, Mattan Levi, Irit Ben-Aharon, Izhack Haviv, Rachela Popovtzer, Aron Popovtzer
Theranostics 2017; 7(16): 3962-3971. doi:10.7150/thno.19615
[Abstract] [Full text] [PDF]


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Review
Aptamer-Based Therapeutic Approaches to Target Cancer Stem Cells
Gang Zhou, Olivier Latchoumanin, Mary Bagdesar, Lionel Hebbard, Wei Duan, Christopher Liddle, Jacob George, Liang Qiao
Theranostics 2017; 7(16): 3948-3961. doi:10.7150/thno.20725
[Abstract] [Full text] [PDF]


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Review
Nucleic Acid-Based Theranostics for Tackling Alzheimer's Disease
Madhuri Chakravarthy, Suxiang Chen, Peter R. Dodd, Rakesh N. Veedu
Theranostics 2017; 7(16): 3933-3947. doi:10.7150/thno.21529
[Abstract] [Full text] [PDF]


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Research Paper
Decrease in Lymphoid Specific Helicase and 5-hydroxymethylcytosine Is Associated with Metastasis and Genome Instability
Jiantao Jia, Ying Shi, Ling Chen, Weiwei Lai, Bin Yan, Yiqun Jiang, Desheng Xiao, Sichuan Xi, Ya Cao, Shuang Liu, Yan Cheng, Yongguang Tao
Theranostics 2017; 7(16): 3920-3932. doi:10.7150/thno.21389
[Abstract] [Full text] [PDF]


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Editorial
Emerging Advances in Nanotheranostics with Intelligent Bioresponsive Systems
Junqing Wang, Wei Tao, Xiaoyuan Chen, Omid C. Farokhzad, Gang Liu
Theranostics 2017; 7(16): 3915-3919. doi:10.7150/thno.21317
[Abstract] [Full text] [PDF]


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Research Paper
“One-Pot” Fabrication of Highly Versatile and Biocompatible Poly(vinyl alcohol)-porphyrin-based Nanotheranostics
Yan Luo, Hao Wu, Caihong Feng, Kai Xiao, Xixiao Yang, Qiangqiang Liu, Tzu-yin Lin, Hongyong Zhang, Jeffrey H. Walton, Yousif Ajena, Yide Hu, Kit S. Lam, Yuanpei Li
Theranostics 2017; 7(16): 3901-3914. doi:10.7150/thno.20190
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD, Chief, Laboratory of Molecular Imaging and Nanomedicine, NIBIB, NIH*
* Dr. Chen is serving in his personal capacity.
Editor-in-chief profile

new Impact factor is 8.712, according to 2017 release of Journal Citation Reports®. Congratulations!

new Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Theme Issue on “Brain Theranostics. Guest Editor: Prof. Rachela Popovtzer, PhD
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Most Cited Paper Award for year 2016: Winners of this year are Lian Jin, Xin Zeng, Ming Liu, Yan Deng, Nongyue He, for the paper "Current Progress in Gene Delivery Technology Based on Chemical Methods and Nano-carriers". Details ...

new Congratulations to Dr. Chen for being recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Congratulations to Dr. Chen for receiving the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues