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Volume 6 (12); 2016

Research Paper

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Activation of GLP-1 Receptor Enhances Neuronal Base Excision Repair via PI3K-AKT-Induced Expression of Apurinic/Apyrimidinic Endonuclease 1
Jenq-Lin Yang, Wei-Yu Chen, Yin-Ping Chen, Chao-Ying Kuo, Shang-Der Chen
Theranostics 2016; 6(12): 2015-2027. doi:10.7150/thno.15993
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Optical Imaging of Mesenchymal Epithelial Transition Factor (MET) for Enhanced Detection and Characterization of Primary and Metastatic Hepatic Tumors
Shadi A. Esfahani, Pedram Heidari, Sun A. Kim, Shuji Ogino, Umar Mahmood
Theranostics 2016; 6(12): 2028-2038. doi:10.7150/thno.15718
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Size Dependent Kinetics of Gold Nanorods in EPR Mediated Tumor Delivery
Xiao Tong, Zhantong Wang, Xiaolian Sun, Jibin Song, Orit Jacobson, Gang Niu, Dale O. Kiesewetter, Xiaoyuan Chen
Theranostics 2016; 6(12): 2039-2051. doi:10.7150/thno.17098
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Blocking the 4-1BB Pathway Ameliorates Crystalline Silica-induced Lung Inflammation and Fibrosis in Mice
Chao Li, Sitong Du, Yiping Lu, Xiaowei Lu, Fangwei Liu, Ying Chen, Dong Weng, Jie Chen
Theranostics 2016; 6(12): 2052-2067. doi:10.7150/thno.16180
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Crucial Role of miR-433 in Regulating Cardiac Fibrosis
Lichan Tao, Yihua Bei, Ping Chen, Zhiyong Lei, Siyi Fu, Haifeng Zhang, Jiahong Xu, Lin Che, Xiongwen Chen, Joost PG Sluijter, Saumya Das, Dragos Cretoiu, Bin Xu, Jiuchang Zhong, Junjie Xiao, Xinli Li
Theranostics 2016; 6(12): 2068-2083. doi:10.7150/thno.15007
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Optimization of Early Response Monitoring and Prediction of Cancer Antiangiogenesis Therapy via Noninvasive PET Molecular Imaging Strategies of Multifactorial Bioparameters
Xiao Bao, Ming-Wei Wang, Jian-Min Luo, Si-Yang Wang, Yong-Ping Zhang, Ying-Jian Zhang
Theranostics 2016; 6(12): 2084-2098. doi:10.7150/thno.13917
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Intracellular Trafficking Network of Protein Nanocapsules: Endocytosis, Exocytosis and Autophagy
Jinxie Zhang, Xudong Zhang, Gan Liu, Danfeng Chang, Xin Liang, Xianbing Zhu, Wei Tao, Lin Mei
Theranostics 2016; 6(12): 2099-2113. doi:10.7150/thno.16587
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Gelatin-based Hydrogel Degradation and Tissue Interaction in vivo: Insights from Multimodal Preclinical Imaging in Immunocompetent Nude Mice
Christoph Tondera, Sandra Hauser, Anne Krüger-Genge, Friedrich Jung, Axel T. Neffe, Andreas Lendlein, Robert Klopfleisch, Jörg Steinbach, Christin Neuber, Jens Pietzsch
Theranostics 2016; 6(12): 2114-2128. doi:10.7150/thno.16614
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Proto-Oncogenic Src Phosphorylates EB1 to Regulate the Microtubule-Focal Adhesion Crosstalk and Stimulate Cell Migration
Yijun Zhang, Youguang Luo, Rui Lyu, Jie Chen, Ruming Liu, Dengwen Li, Min Liu, Jun Zhou
Theranostics 2016; 6(12): 2129-2140. doi:10.7150/thno.16356
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A New Concept of Enhancing Immuno-Chemotherapeutic Effects Against B16F10 Tumor via Systemic Administration by Taking Advantages of the Limitation of EPR Effect
Yuting Yang, Xiaowei Tai, Kairong Shi, Shaobo Ruan, Yue Qiu, Zhirong Zhang, Bing Xiang, Qin He
Theranostics 2016; 6(12): 2141-2160. doi:10.7150/thno.16184
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Early Diagnosis of Brain Metastases Using a Biofluids-Metabolomics Approach in Mice
James R. Larkin, Alex M. Dickens, Timothy D. W. Claridge, Claire Bristow, Kleopatra Andreou, Daniel C. Anthony, Nicola R. Sibson
Theranostics 2016; 6(12): 2161-2169. doi:10.7150/thno.16538
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Versatile pH-response Micelles with High Cell-Penetrating Helical Diblock Copolymers for Photoacoustic Imaging Guided Synergistic Chemo-Photothermal Therapy
Shengyu Shi, Yajing Liu, Yu Chen, Zhihuang Zhang, Yunsheng Ding, Zongquan Wu, Jun Yin, Liming Nie
Theranostics 2016; 6(12): 2170-2182. doi:10.7150/thno.16633
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Deficiency of ATP6V1H Causes Bone Loss by Inhibiting Bone Resorption and Bone Formation through the TGF-β1 Pathway
Xiaohong Duan, Jin Liu, Xueni Zheng, Zhe Wang, Yanli Zhang, Ying Hao, Tielin Yang, Hongwen Deng
Theranostics 2016; 6(12): 2183-2195. doi:10.7150/thno.17140
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Biodegradable Nitrogen-Doped Carbon Nanodots for Non-Invasive Photoacoustic Imaging and Photothermal Therapy
Changho Lee, Woosung Kwon, Songeun Beack, Donghyun Lee, Yoonsang Park, Hyemin Kim, Sei Kwang Hahn, Shi-Woo Rhee, Chulhong Kim
Theranostics 2016; 6(12): 2196-2208. doi:10.7150/thno.16923
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Lycorine Downregulates HMGB1 to Inhibit Autophagy and Enhances Bortezomib Activity in Multiple Myeloma
Mridul Roy, Long Liang, Xiaojuan Xiao, Yuanliang Peng, Yuhao Luo, Weihua Zhou, Ji Zhang, Lugui Qiu, Shuaishuai Zhang, Feng Liu, Mao Ye, Wen Zhou, Jing Liu
Theranostics 2016; 6(12): 2209-2224. doi:10.7150/thno.15584
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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In Vitro and In Vivo Evaluation of 89Zr-DS-8273a as a Theranostic for Anti-Death Receptor 5 Therapy
Ingrid J.G. Burvenich, Fook-Thean Lee, Nancy Guo, Hui K. Gan, Angela Rigopoulos, Adam C. Parslow, Graeme J. O'Keefe, Sylvia J. Gong, Henri Tochon-Danguy, Stacey E. Rudd, Paul S. Donnelly, Masakatsu Kotsuma, Toshiaki Ohtsuka, Giorgio Senaldi, Andrew M. Scott
Theranostics 2016; 6(12): 2225-2234. doi:10.7150/thno.16260
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Multivalent Targeting Based Delivery of Therapeutic Peptide using AP1-ELP Carrier for Effective Cancer Therapy
Vijaya Sarangthem, Yunjae Kim, Thoudam Debraj Singh, Bo-Yeon Seo, Sun-Ha Cheon, Young-Jin Lee, Byung-Heon Lee, Rang-Woon Park
Theranostics 2016; 6(12): 2235-2249. doi:10.7150/thno.16425
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Combination Therapy for Ulcerative Colitis: Orally Targeted Nanoparticles Prevent Mucosal Damage and Relieve Inflammation
Bo Xiao, Zhan Zhang, Emilie Viennois, Yuejun Kang, Mingzhen Zhang, Moon Kwon Han, Jiucun Chen, Didier Merlin
Theranostics 2016; 6(12): 2250-2266. doi:10.7150/thno.15710
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A Pretargeted Approach for the Multimodal PET/NIRF Imaging of Colorectal Cancer
Pierre Adumeau, Kathryn E. Carnazza, Christian Brand, Sean D. Carlin, Thomas Reiner, Brian J. Agnew, Jason S. Lewis, Brian M. Zeglis
Theranostics 2016; 6(12): 2267-2277. doi:10.7150/thno.16744
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Highly Effective Auger-Electron Therapy in an Orthotopic Glioblastoma Xenograft Model using Convection-Enhanced Delivery
Helge Thisgaard, Bo Halle, Charlotte Aaberg-Jessen, Birgitte Brinkmann Olsen, Anne Sofie Nautrup Therkelsen, Johan Hygum Dam, Niels Langkjær, Sune Munthe, Kjell Någren, Poul Flemming Høilund-Carlsen, Bjarne Winther Kristensen
Theranostics 2016; 6(12): 2278-2291. doi:10.7150/thno.15898
[Abstract] [Full text] [PDF] [PubMed] [PMC]