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Volume 6 (11); 2016

Research Paper

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Ultrasound Molecular Imaging of the Breast Cancer Neovasculature using Engineered Fibronectin Scaffold Ligands: A Novel Class of Targeted Contrast Ultrasound Agent
Lotfi Abou-Elkacem, Katheryne E. Wilson, Sadie M. Johnson, Sayan M. Chowdhury, Sunitha Bachawal, Benjamin J. Hackel, Lu Tian, Jürgen K. Willmann
Theranostics 2016; 6(11): 1740-1752. doi:10.7150/thno.15169
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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PET Imaging with [18F]FSPG Evidences the Role of System xc- on Brain Inflammation Following Cerebral Ischemia in Rats
Maria Domercq, Boguslaw Szczupak, Jon Gejo, Vanessa Gómez-Vallejo, Daniel Padro, Kiran Babu Gona, Frédéric Dollé, Makoto Higuchi, Carlos Matute, Jordi Llop, Abraham Martín
Theranostics 2016; 6(11): 1753-1767. doi:10.7150/thno.15616
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Targeting Amino Acid Metabolism for Molecular Imaging of Inflammation Early After Myocardial Infarction
James T. Thackeray, Jens P. Bankstahl, Yong Wang, Kai C. Wollert, Frank M. Bengel
Theranostics 2016; 6(11): 1768-1779. doi:10.7150/thno.15929
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Active-target T1-weighted MR Imaging of Tiny Hepatic Tumor via RGD Modified Ultra-small Fe3O4 Nanoprobes
Zhengyang Jia, Lina Song, Fengchao Zang, Jiacheng Song, Wei Zhang, Changzhi Yan, Jun Xie, Zhanlong Ma, Ming Ma, Gaojun Teng, Ning Gu, Yu Zhang
Theranostics 2016; 6(11): 1780-1791. doi:10.7150/thno.14280
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Peripheral Blood Cell Gene Expression Diagnostic for Identifying Symptomatic Transthyretin Amyloidosis Patients: Male and Female Specific Signatures
Sunil M. Kurian, Marta Novais, Thomas Whisenant, Terri Gelbart, Joel N. Buxbaum, Jeffery W. Kelly, Teresa Coelho, Daniel R. Salomon
Theranostics 2016; 6(11): 1792-1809. doi:10.7150/thno.14584
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Silica Nanoparticles Target a Wnt Signal Transducer for Degradation and Impair Embryonic Development in Zebrafish
Hongyang Yi, Zhuyao Wang, Xiaojiao Li, Min Yin, Lihua Wang, Ali Aldalbahi, Nahed Nasser El-Sayed, Hui Wang, Nan Chen, Chunhai Fan, Haiyun Song
Theranostics 2016; 6(11): 1810-1820. doi:10.7150/thno.16127
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Potentiation of Peptide Receptor Radionuclide Therapy by the PARP Inhibitor Olaparib
Julie Nonnekens, Melissa van Kranenburg, Cecile E.M.T. Beerens, Mustafa Suker, Michael Doukas, Casper H.J. van Eijck, Marion de Jong, Dik C. van Gent
Theranostics 2016; 6(11): 1821-1832. doi:10.7150/thno.15311
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Polydopamine Coated Single-Walled Carbon Nanotubes as a Versatile Platform with Radionuclide Labeling for Multimodal Tumor Imaging and Therapy
He Zhao, Yu Chao, Jingjing Liu, Jie Huang, Jian Pan, Wanliang Guo, Jizhi Wu, Mao Sheng, Kai Yang, Jian Wang, Zhuang Liu
Theranostics 2016; 6(11): 1833-1843. doi:10.7150/thno.16047
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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In vivo Biocompatibility, Biodistribution and Therapeutic Efficiency of Titania Coated Upconversion Nanoparticles for Photodynamic Therapy of Solid Oral Cancers
Sasidharan Swarnalatha Lucky, Niagara Muhammad Idris, Kai Huang, Jaejung Kim, Zhengquan Li, Patricia Soo Ping Thong, Rong Xu, Khee Chee Soo, Yong Zhang
Theranostics 2016; 6(11): 1844-1865. doi:10.7150/thno.15088
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Blinking Phase-Change Nanocapsules Enable Background-Free Ultrasound Imaging
Alexander S. Hannah, Geoffrey P. Luke, Stanislav Y. Emelianov
Theranostics 2016; 6(11): 1866-1876. doi:10.7150/thno.14961
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Aptamer-Mediated Transparent-Biocompatible Nanostructured Surfaces for Hepatocellular Circulating Tumor Cells Enrichment
Shuyi Wang, Chunxiao Zhang, Guozhou Wang, Boran Cheng, Yulei Wang, Fangfang Chen, Yuanyuan Chen, Maohui Feng, Bin Xiong
Theranostics 2016; 6(11): 1877-1886. doi:10.7150/thno.15284
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Targeting Negative Surface Charges of Cancer Cells by Multifunctional Nanoprobes
Bingdi Chen, Wenjun Le, Yilong Wang, Zhuoquan Li, Dong Wang, Ling Lin, Shaobin Cui, Jennifer J. Hu, Yihui Hu, Pengyuan Yang, Rodney C. Ewing, Donglu Shi, Zheng Cui
Theranostics 2016; 6(11): 1887-1898. doi:10.7150/thno.16358
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Melatonin Treatment Improves Mesenchymal Stem Cells Therapy by Preserving Stemness during Long-term In Vitro Expansion
Yi Shuai, Li Liao, Xiaoxia Su, Yang Yu, Bingyi Shao, Huan Jing, Xinjing Zhang, Zhihong Deng, Yan Jin
Theranostics 2016; 6(11): 1899-1917. doi:10.7150/thno.15412
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CD146-targeted immunoPET and NIRF Imaging of Hepatocellular Carcinoma with a Dual-Labeled Monoclonal Antibody
Reinier Hernandez, Haiyan Sun, Christopher G. England, Hector F. Valdovinos, Emily B. Ehlerding, Todd E. Barnhart, Yunan Yang, Weibo Cai
Theranostics 2016; 6(11): 1918-1933. doi:10.7150/thno.15568
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The Clinical Significance and Potential Therapeutic Role of GPx3 in Tumor Recurrence after Liver Transplantation
Xiang Qi, Kevin Tak-Pan Ng, Yan Shao, Chang Xian Li, Wei Geng, Chang Chun Ling, Yuen Yuen Ma, Xiao Bing Liu, Hui Liu, Jiang Liu, Wai Ho Yeung, Chung Mau Lo, Kwan Man
Theranostics 2016; 6(11): 1934-1946. doi:10.7150/thno.16023
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Depletion of γ-catenin by Histone Deacetylase Inhibition Confers Elimination of CML Stem Cells in Combination with Imatinib
Yanli Jin, Yiwu Yao, Li Chen, Xiaohui Zhu, Bei Jin, Yingying Shen, Juan Li, Xin Du, Yuhong Lu, Sheng Jiang, Jingxuan Pan
Theranostics 2016; 6(11): 1947-1962. doi:10.7150/thno.16139
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Motion Compensated Ultrasound Imaging Allows Thermometry and Image Guided Drug Delivery Monitoring from Echogenic Liposomes
Kalyani Ektate, Ankur Kapoor, Danny Maples, Ahmet Tuysuzoglu, Joshua VanOsdol, Selvarani Ramasami, Ashish Ranjan
Theranostics 2016; 6(11): 1963-1974. doi:10.7150/thno.15922
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Reversal of Vascular Calcification and Aneurysms in a Rat Model Using Dual Targeted Therapy with EDTA- and PGG-Loaded Nanoparticles
Nasim Nosoudi, Aniqa Chowdhury, Steven Siclari, Saketh Karamched, Vaideesh Parasaram, Joe Parrish, Patrick Gerard, Narendra Vyavahare
Theranostics 2016; 6(11): 1975-1987. doi:10.7150/thno.16547
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Specific Inhibition of DNMT3A/ISGF3γ Interaction Increases the Temozolomide Efficiency to Reduce Tumor Growth
Mathilde Cheray, Romain Pacaud, Arulraj Nadaradjane, Lisa Oliver, François M Vallette, Pierre-François Cartron
Theranostics 2016; 6(11): 1988-1999. doi:10.7150/thno.9150
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Magnetic Enrichment of Dendritic Cell Vaccine in Lymph Node with Fluorescent-Magnetic Nanoparticles Enhanced Cancer Immunotherapy
Honglin Jin, Yuan Qian, Yanfeng Dai, Sha Qiao, Chuan Huang, Lisen Lu, Qingming Luo, Jing Chen, Zhihong Zhang
Theranostics 2016; 6(11): 2000-2014. doi:10.7150/thno.15102
[Abstract] [Full text] [PDF] [PubMed] [PMC]