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Theranostics 2023; 13(8):2471-2491. doi:10.7150/thno.82189 This issue Cite

Review

Perturbing plasma membrane lipid: a new paradigm for tumor nanotherapeutics

Weidong Fei1#, Jingjing Yan1#, Xiaodong Wu2, Shan Yang1, Xiao Zhang1, Rong Wang1, Yue Chen1, Junjun Xu3✉, Caihong Zheng1✉

1. Department of Pharmacy, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
2. Department of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
3. Department of Pharmacy, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
# These authors contributed equally.

✉ Corresponding authors: E-mail address: xujunjun90edu.cn (JJ. Xu) and chzhengedu.cn (CH. Zheng).

Citation:
Fei W, Yan J, Wu X, Yang S, Zhang X, Wang R, Chen Y, Xu J, Zheng C. Perturbing plasma membrane lipid: a new paradigm for tumor nanotherapeutics. Theranostics 2023; 13(8):2471-2491. doi:10.7150/thno.82189. https://www.thno.org/v13p2471.htm
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Abstract

Graphic abstract

Cancer is generally considered a result of genetic mutations that cause epigenetic changes, leading to anomalous cellular behavior. Since 1970s, an increasing understanding of the plasma membrane and specifically the lipid alterations in tumor cells have provided novel insights for cancer therapy. Moreover, the advances in nanotechnology offer a potential opportunity to target the tumor plasma membrane while minimizing side effects on normal cells. To further develop membrane lipid perturbing tumor therapy, the first section of this review demonstrates the association between plasma membrane physicochemical properties and tumor signaling, metastasis, and drug resistance. The second section highlights existing nanotherapeutic strategies for membrane disruption, including lipid peroxide accumulation, cholesterol regulation, membrane structure disruption, lipid raft immobilization, and energy-mediated plasma membrane perturbation. Finally, the third section evaluates the prospects and challenges of plasma membrane lipid perturbing therapy as a therapeutic strategy for cancers. The reviewed membrane lipid perturbing tumor therapy strategies are expected to bring about necessary changes in tumor therapy in the coming decades.

Keywords: plasma membrane, nanotechnology, tumor, lipid, perturbing

Citation styles

APA
Fei, W., Yan, J., Wu, X., Yang, S., Zhang, X., Wang, R., Chen, Y., Xu, J., Zheng, C. (2023). Perturbing plasma membrane lipid: a new paradigm for tumor nanotherapeutics. Theranostics, 13(8), 2471-2491. https://doi.org/10.7150/thno.82189.

ACS
Fei, W.; Yan, J.; Wu, X.; Yang, S.; Zhang, X.; Wang, R.; Chen, Y.; Xu, J.; Zheng, C. Perturbing plasma membrane lipid: a new paradigm for tumor nanotherapeutics. Theranostics 2023, 13 (8), 2471-2491. DOI: 10.7150/thno.82189.

NLM
Fei W, Yan J, Wu X, Yang S, Zhang X, Wang R, Chen Y, Xu J, Zheng C. Perturbing plasma membrane lipid: a new paradigm for tumor nanotherapeutics. Theranostics 2023; 13(8):2471-2491. doi:10.7150/thno.82189. https://www.thno.org/v13p2471.htm

CSE
Fei W, Yan J, Wu X, Yang S, Zhang X, Wang R, Chen Y, Xu J, Zheng C. 2023. Perturbing plasma membrane lipid: a new paradigm for tumor nanotherapeutics. Theranostics. 13(8):2471-2491.

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