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Theranostics 2022; 12(14):6308-6338. doi:10.7150/thno.72152 This issue Cite

Review

Nanozyme-based colorimetric biosensor with a systemic quantification algorithm for noninvasive glucose monitoring

Hee-Jae Jeon^1,2, Hyung Shik Kim³, Euiheon Chung^4,5,6✉, Dong Yun Lee^3,7,8,9✉

1. Weldon School of Biomedical Engineering, Purdue University, Indiana 47906, USA
2. Department of Mechanical and Biomedical Engineering, Kangwon National University, Chuncheon 24341, Republic of Korea
3. Department of Bioengineering, College of Engineering, and BK FOUR Biopharmaceutical Innovation Leader for Education and Research Group, Hanyang University, Seoul 04763, Republic of Korea
4. Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea
5. AI Graduate School, GIST, Gwangju 61005, Republic of Korea
6. Research Center for Photon Science Technology, GIST, Gwangju 61005, Republic of Korea
7. Institute of Nano Science and Technology (INST), Hanyang University, Seoul 04763, Republic of Korea
8. Institute for Bioengineering and Biopharmaceutical Research (IBBR), Hanyang University, Seoul 04763, Republic of Korea
9. Elixir Pharmatech Inc., Seoul 07463, Republic of Korea

✉ Corresponding authors: Dong Yun Lee, Ph.D., Department of Bioengineering, College of Engineering, and BK FOUR Biopharmaceutical Innovation Leader for Education and Research Group, and Institute of Nano Science and Technology (INST) & Institute for Bioengineering and Biopharmaceutical Research (IBBR), Hanyang University, and Elixir Pharmatech Inc., 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea. Tel: +82-2-2220-2348; fax: +82-2-2220-4741; e-mail: dongyunleeac.kr. Euiheon Chung, Ph.D., Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, 123 Cheomdan Gwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea. Tel: +82-62-715-2753; fax: +82-62-715-5309; e-mail: ogong50ac.kr More

Abstract

Diabetes mellitus accompanies an abnormally high glucose level in the bloodstream. Early diagnosis and proper glycemic management of blood glucose are essential to prevent further progression and complications. Biosensor-based colorimetric detection has progressed and shown potential in portable and inexpensive daily assessment of glucose levels because of its simplicity, low-cost, and convenient operation without sophisticated instrumentation. Colorimetric glucose biosensors commonly use natural enzymes that recognize glucose and chromophores that detect enzymatic reaction products. However, many natural enzymes have inherent defects, limiting their extensive application. Recently, nanozyme-based colorimetric detection has drawn attention due to its merits including high sensitivity, stability under strict reaction conditions, flexible structural design with low-cost materials, and adjustable catalytic activities. This review discusses various nanozyme materials, colorimetric analytic methods and mechanisms, recent machine learning based analytic methods, quantification systems, applications and future directions for monitoring and managing diabetes.

Keywords: nanozyme, colorimetric analytic methods, glucose, colorimetric biosensor

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