Theranostics 2022; 12(9):4147-4162. doi:10.7150/thno.72803 This issue
1. Department of Oncology, The Second Affiliate Hospital of Xi'an Jiaotong University; Xi'an, Shaanxi, 710004, China
2. Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School; Boston, MA 02114, USA
3. School of Pharmacy, Jining Medical College; Rizhao, Shandong, 276826, China
4. Department of Pathology, The Second Affiliate Hospital of Xi'an Jiaotong University; Xi'an, Shaanxi, 710004, China
5. Department of Pathology, Shaanxi Province People's Hospital, Xi'an; Shaanxi, 710068, China
*These authors contributed equally to this work.
Enormous efforts have been made to integrate various therapeutic interventions into multifunctional nanoplatforms, resulting in the advance of nanomedicine. Image-guided drug delivery plays a pivotal role in this field by providing specific targeting as well as image navigation for disease prognosis.
Methods: We demonstrate image-guided surgery and drug delivery for the treatment of lung cancer using nanotheranostic H-dots loaded with gefitinib and genistein.
Results: The surgical margin for lung tumors is determined by image guidance for precise tumor resection, while targeted anti-cancer drugs function simultaneously for synergistic combination therapy. Compared to conventional chemotherapies, H-dot complexes could improve the therapeutic efficacy of drugs while reducing the risk of adverse effects and drug resistance owing to their ideal biodistribution profiles, high targetability, low nonspecific tissue uptake, and fast renal excretion.
Conclusions: These H-dot complexes have unlocked a unique framework for integrating multiple therapeutic and diagnostic modalities into one nanoplatform.
Keywords: Theranostics, Cancer therapy, Image-guided surgery, Combination therapy, Renal clearance