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Volume 9 (8); 2019

Research Papers

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Preclinical efficacy of hK2 targeted [177Lu]hu11B6 for prostate cancer theranostics
Oskar Vilhelmsson Timmermand, Jörgen Elgqvist, Kai A. Beattie, Anders Örbom, Erik Larsson, Sophie E. Eriksson, Daniel L.J. Thorek, Bradley J. Beattie, Thuy A. Tran, David Ulmert, Sven-Erik Strand
Theranostics 2019; 9(8): 2129-2142. doi:10.7150/thno.31179
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Engineering stem cell cardiac patch with microvascular features representative of native myocardium
Zichen Qian, Dhavan Sharma, Wenkai Jia, Daniel Radke, Timothy Kamp, Feng Zhao
Theranostics 2019; 9(8): 2143-2157. doi:10.7150/thno.29552
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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NF-κB hijacking theranostic Pt(ll) complex in cancer therapy
Yingzhong Zhu, Mingzhu Zhang, Lei Luo, Martin R Gill, Cesare De Pace, Giuseppe Battaglia, Qiong Zhang, Hongping Zhou, Jieying Wu, Yupeng Tian, Xiaohe Tian
Theranostics 2019; 9(8): 2158-2166. doi:10.7150/thno.30886
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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GRP78-targeted ferritin nanocaged ultra-high dose of doxorubicin for hepatocellular carcinoma therapy
Bing Jiang, Ruofei Zhang, Jianlin Zhang, Yaxin Hou, Xuehui Chen, Meng Zhou, Xiuyun Tian, Chunyi Hao, Kelong Fan, Xiyun Yan
Theranostics 2019; 9(8): 2167-2182. doi:10.7150/thno.30867
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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High OGT activity is essential for MYC-driven proliferation of prostate cancer cells
Harri M Itkonen, Alfonso Urbanucci, Sara ES Martin, Aziz Khan, Anthony Mathelier, Bernd Thiede, Suzanne Walker, Ian G Mills
Theranostics 2019; 9(8): 2183-2197. doi:10.7150/thno.30834
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Long noncoding RNA TUG1 inhibits osteogenesis of bone marrow mesenchymal stem cells via Smad5 after irradiation
Weiwei Zhang, Li Chen, Jiang Wu, Jiuxuan Li, Xiaomei Zhang, Yang Xiang, Fengjie Li, Chun Wu, Lixin Xiang, Qian Ran, Zhongjun Li
Theranostics 2019; 9(8): 2198-2208. doi:10.7150/thno.30798
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Myeloid cell-derived LL-37 promotes lung cancer growth by activating Wnt/β-catenin signaling
Ping Ji, Yongxin Zhou, Yibao Yang, Junlu Wu, Hao Zhou, Wenqiang Quan, Junjun Sun, Yiwen Yao, Anquan Shang, Chenzheng Gu, Bingjie Zeng, Jenni Firrman, Weidong Xiao, Robert Bals, Zujun Sun, Dong Li
Theranostics 2019; 9(8): 2209-2223. doi:10.7150/thno.30726
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Soluble EMMPRIN levels discriminate aortic ectasia in Marfan syndrome patients
Erica Rurali, Gianluca L. Perrucci, Raffaella Gaetano, Alessandro Pini, Donato Moschetta, Davide Gentilini, Patrizia Nigro, Giulio Pompilio
Theranostics 2019; 9(8): 2224-2234. doi:10.7150/thno.30714
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Sonic hedgehog pathway activation is associated with cetuximab resistance and EPHB3 receptor induction in colorectal cancer
Seong Hye Park, Min Jee Jo, Bo Ram Kim, Yoon A Jeong, Yoo Jin Na, Jung Lim Kim, Soyeon Jeong, Hye Kyeong Yun, Dae Yeong Kim, Bu Gyeom Kim, Sang Hee Kang, Sang Cheul Oh, Dae-Hee Lee
Theranostics 2019; 9(8): 2235-2251. doi:10.7150/thno.30678
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane
Xiaolong Xu, Di Wang, Chao Zheng, Bo Gao, Jing Fan, Pengzhen Cheng, Baohua Liu, Liu Yang, Zhuojing Luo
Theranostics 2019; 9(8): 2252-2267. doi:10.7150/thno.30658
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Using near-infrared enhanced thermozyme and scFv dual-conjugated Au nanorods for detection and targeted photothermal treatment of Alzheimer's disease
Dongni Liu, Wei Li, Xiaoyu Jiang, Shuju Bai, Jiyang Liu, Xutong Liu, Yuhua Shi, Ziyu Kuai, Wei Kong, Renjun Gao, Yaming Shan
Theranostics 2019; 9(8): 2268-2281. doi:10.7150/thno.30649
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Inhibition of protein disulfide isomerase in glioblastoma causes marked downregulation of DNA repair and DNA damage response genes
Shili Xu, Yajing Liu, Kai Yang, Hanxiao Wang, Andrea Shergalis, Anahita Kyani, Armand Bankhead, Shuzo Tamura, Suhui Yang, Xi Wang, Chih-chen Wang, Alnawaz Rehemtulla, Mats Ljungman, Nouri Neamati
Theranostics 2019; 9(8): 2282-2298. doi:10.7150/thno.30621
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Injectable polypeptide hydrogel-based co-delivery of vaccine and immune checkpoint inhibitors improves tumor immunotherapy
Huijuan Song, Pengxiang Yang, Pingsheng Huang, Chuangnian Zhang, Deling Kong, Weiwei Wang
Theranostics 2019; 9(8): 2299-2314. doi:10.7150/thno.30577
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Human LAP+GARP+FOXP3+ regulatory T cells attenuate xenogeneic graft versus host disease
Huihui Wang, Hyo Song, Anha V. Pham, Laurence J. Cooper, Janika J. Schulze, Sven Olek, Dat Q. Tran
Theranostics 2019; 9(8): 2315-2324. doi:10.7150/thno.30254
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Biodistribution of gadolinium- and near infrared-labeled human umbilical cord mesenchymal stromal cell-derived exosomes in tumor bearing mice
Javier Abello, Tuyen Duong Thanh Nguyen, Ramesh Marasini, Santosh Aryal, Mark Louis Weiss
Theranostics 2019; 9(8): 2325-2345. doi:10.7150/thno.30030
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Localized injection of miRNA-21-enriched extracellular vesicles effectively restores cardiac function after myocardial infarction
Yu Song, Cheng Zhang, Jinxiang Zhang, Zhanying Jiao, Nianguo Dong, Guobin Wang, Zheng Wang, Lin Wang
Theranostics 2019; 9(8): 2346-2360. doi:10.7150/thno.29945
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Induction of nuclear protein-1 by thyroid hormone enhances platelet-derived growth factor A mediated angiogenesis in liver cancer
Ching-Ying Chen, Sheng-Ming Wu, Yang-Hsiang Lin, Hsiang-Cheng Chi, Syuan-Ling Lin, Chau-Ting Yeh, Wen-Yu Chuang, Kwang-Huei Lin
Theranostics 2019; 9(8): 2361-2379. doi:10.7150/thno.29628
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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SIRT6, a novel direct transcriptional target of FoxO3a, mediates colon cancer therapy
Yingjie Zhang, Liming Nie, Keqian Xu, Yang Fu, Juchang Zhong, Kongzhen Gu, Lingling Zhang
Theranostics 2019; 9(8): 2380-2394. doi:10.7150/thno.29724
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration
Dan Jiang, Guoyin Xiong, Hong Feng, Zhao Zhang, Peikai Chen, Bin Yan, Ling Chen, Kesavamoorthy Gandhervin, Chuiyan Ma, Cheng Li, Shuo Han, Yuelin Zhang, Can Liao, Tin-Lap Lee, Hung-Fat Tse, Qing-Ling Fu, Kin Chiu, Qizhou Lian
Theranostics 2019; 9(8): 2395-2410. doi:10.7150/thno.29422
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Magnetic ternary nanohybrids for nonviral gene delivery of stem cells and applications on cancer therapy
Rih-Yang Huang, Yee-Hsien Lin, Ssu-Yu Lin, Yi-Nan Li, Chi-Shiun Chiang, Chien-Wen Chang
Theranostics 2019; 9(8): 2411-2423. doi:10.7150/thno.29326
[Abstract] [Full text] [PDF] [PubMed] [PMC]