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Theranostics 2023; 13(13):4469-4481. doi:10.7150/thno.84164 This issue Cite

Research Paper

Endoscopically guided interventional photodynamic therapy for orthotopic pancreatic ductal adenocarcinoma based on NIR-II fluorescent nanoparticles

Kang Chen1,4,5*, Baoli Yin2*, Quanneng Luo1,4, Yi Liu1,4, Yi Wang1,4, Yan Liao1,4, Yuhang Li1,4, Xu Chen1,4, Bo Sun1,4, Ning Zhou1,4, Hongwen Liu1,4, Chuang Peng1✉, Sulai Liu1,5✉, Wei Cheng1,3,4✉, Guosheng Song2✉

1. Department of Hepatobiliary Surgery, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha 410005, P. R. China.
2. State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China.
3. Xiangyue Hospital Affiliated to Hunan Institute of Parasitic Diseases, National Clinical Center for Schistosomiasis Treatment, Yueyang 414000, P. R. China.
4. Translational Medicine Laboratory of Pancreas Disease of Hunan Normal University, Changsha 410005, P. R. China.
5. Central Laboratory of Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha 410005, P. R. China.
* These authors contributed equally to this work.

✉ Corresponding authors: pengchuangcncom; liusulaiedu.cn; chengweiedu.cn; songgsedu.cn.

Citation:
Chen K, Yin B, Luo Q, Liu Y, Wang Y, Liao Y, Li Y, Chen X, Sun B, Zhou N, Liu H, Peng C, Liu S, Cheng W, Song G. Endoscopically guided interventional photodynamic therapy for orthotopic pancreatic ductal adenocarcinoma based on NIR-II fluorescent nanoparticles. Theranostics 2023; 13(13):4469-4481. doi:10.7150/thno.84164. https://www.thno.org/v13p4469.htm
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Abstract

Graphic abstract

Rationale: Pancreatic cancer, comprising mostly pancreatic ductal adenocarcinoma (PDAC), is a highly malignant disease, typically known as a hypoxic tumor microenvironment. The application of PDT in pancreatic cancer in clinic is still hampered by several shortcomings, including the (i) deep location of pancreatic cancer, (ii) tissue damage induced by optical fibers, (iii) hypoxic microenvironment, (iv) short excitation wavelengths of traditional photosensitizers, and (v) poor delivery efficiency of photosensitizers.

Methods: We designed an organic nanoparticle as photosensitizer for near-infrared II (NIR-II) fluorescent (FL) imaging that exerts a type I PDT effect on deep orthotopic pancreatic tumors under excitation by a NIR (808 nm) laser.

Results: This novel photosensitizer exhibits enhanced accumulation in orthotopic pancreatic cancer in mice and could be used to effectively detect pancreatic cancer and guide subsequent laser irradiation for accurate PDT of deep pancreatic cancer. In addition, we built an endoscopic platform monitored by NIR-II FL imaging to achieve minimally invasive endoscopically guided interventional photodynamic therapy (EG-iPDT) with efficient inhibition of orthotopic pancreatic cancer, which prolonged overall survival up to 78 days compared to PBS + EG-iPDT group (*p < 0.05) in a mouse model.

Conclusions: Minimally invasive EG-iPDT has promise as an intraoperative treatment for early-stage or unresectable or metastatic pancreatic cancer.

Keywords: Endoscopy, NIR-II, Photodynamic therapy, Pancreatic cancer

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APA
Chen, K., Yin, B., Luo, Q., Liu, Y., Wang, Y., Liao, Y., Li, Y., Chen, X., Sun, B., Zhou, N., Liu, H., Peng, C., Liu, S., Cheng, W., Song, G. (2023). Endoscopically guided interventional photodynamic therapy for orthotopic pancreatic ductal adenocarcinoma based on NIR-II fluorescent nanoparticles. Theranostics, 13(13), 4469-4481. https://doi.org/10.7150/thno.84164.

ACS
Chen, K.; Yin, B.; Luo, Q.; Liu, Y.; Wang, Y.; Liao, Y.; Li, Y.; Chen, X.; Sun, B.; Zhou, N.; Liu, H.; Peng, C.; Liu, S.; Cheng, W.; Song, G. Endoscopically guided interventional photodynamic therapy for orthotopic pancreatic ductal adenocarcinoma based on NIR-II fluorescent nanoparticles. Theranostics 2023, 13 (13), 4469-4481. DOI: 10.7150/thno.84164.

NLM
Chen K, Yin B, Luo Q, Liu Y, Wang Y, Liao Y, Li Y, Chen X, Sun B, Zhou N, Liu H, Peng C, Liu S, Cheng W, Song G. Endoscopically guided interventional photodynamic therapy for orthotopic pancreatic ductal adenocarcinoma based on NIR-II fluorescent nanoparticles. Theranostics 2023; 13(13):4469-4481. doi:10.7150/thno.84164. https://www.thno.org/v13p4469.htm

CSE
Chen K, Yin B, Luo Q, Liu Y, Wang Y, Liao Y, Li Y, Chen X, Sun B, Zhou N, Liu H, Peng C, Liu S, Cheng W, Song G. 2023. Endoscopically guided interventional photodynamic therapy for orthotopic pancreatic ductal adenocarcinoma based on NIR-II fluorescent nanoparticles. Theranostics. 13(13):4469-4481.

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