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Theranostics 2022; 12(11):5103-5124. doi:10.7150/thno.74548 This issue Cite

Review

Silk fibroin-based biomaterials for cartilage/osteochondral repair

Ziyang Zhou^1,2,3,4*, Jin Cui^1,2,5*, Shunli Wu^1,2,3,6*, Zhen Geng^1,2✉, Jiacan Su^1,2✉

1. Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China
2. Musculoskeletal Organoid Research Center, Shanghai University, Shanghai, 200444, China
3. School of Medicine, Shanghai University, Shanghai 200444, China
4. School of Life Sciences, Shanghai University, Shanghai 200444, China
5. Department of Orthopedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China
6. School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China
^*These authors contributed equally to this study.

✉ Corresponding authors: Zhen Geng, nanboshan1987com; Jiacan Su, drsujiacancom.

Abstract

Osteoarthritis (OA) is a common joint disease with a high disability rate. In addition, OA not only causes great physiological and psychological harm to patients, but also puts great pressure on the social healthcare system. Pathologically, the disintegration of cartilage and the lesions of subchondral bone are related to OA. Currently, tissue engineering, which is expected to overcome the defects of existing treatment methods, had a lot of research in the field of cartilage/osteochondral repair. Silk fibroin (SF), as a natural macromolecular material with good biocompatibility, unique mechanical properties, excellent processability and degradability, holds great potential in the field of tissue engineering. Nowadays, SF had been prepared into various materials to adapt to the demands of cartilage/osteochondral repair. SF-based biomaterials can also be functionally modified to enhance repair performance further. In this review, the preparation methods, types, structures, mechanical properties, and functional modifications of SF-based biomaterials used for cartilage/osteochondral repair are summarized and discussed. We hope that this review will provide a reference for the design and development of SF-based biomaterials in cartilage/osteochondral repair field.

Keywords: Silk fibroin, Tissue engineering, Biomaterials, Cartilage repair, Osteochondral repair.

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