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Volume 11 (14); 2021

Research Papers

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Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study
Aisling M Chaney, Francisco R Lopez-Picon, Sophie Serrière, Rui Wang, Daniela Bochicchio, Samuel D Webb, Matthias Vandesquille, Michael K Harte, Christina Georgiadou, Catherine Lawrence, Julie Busson, Johnny Vercouillie, Clovis Tauber, Frédéric Buron, Sylvain Routier, Tristan Reekie, Anniina Snellman, Michael Kassiou, Johanna Rokka, Karen E Davies, Juha O Rinne, Dervis A Salih, Frances A Edwards, Llwyd D Orton, Stephen R Williams, Sylvie Chalon, Hervé Boutin
Theranostics 2021; 11(14): 6644-6667. doi:10.7150/thno.56059
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation
Lingjuan Chen, Hongqi Chen, Junjie Ye, Yan Ge, Haiyan Wang, Enyong Dai, Jinghua Ren, Weilin Liu, Congrong Ma, Songguang Ju, Z. Sheng Guo, Zuqiang Liu, David L. Bartlett
Theranostics 2021; 11(14): 6668-6681. doi:10.7150/thno.56494
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Machine learning-assisted immune profiling stratifies peri-implantitis patients with unique microbial colonization and clinical outcomes
Chin-Wei Wang, Yuning Hao, Riccardo Di Gianfilippo, James Sugai, Jiaqian Li, Wang Gong, Kenneth S. Kornman, Hom-Lay Wang, Nobuhiko Kamada, Yuying Xie, William V. Giannobile, Yu Leo Lei
Theranostics 2021; 11(14): 6703-6716. doi:10.7150/thno.57775
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Bi-directional regulation functions of lanthanum-substituted layered double hydroxide nanohybrid scaffolds via activating osteogenesis and inhibiting osteoclastogenesis for osteoporotic bone regeneration
Min Chu, Zhenyu Sun, Zhanghao Fan, Degang Yu, Yuanqing Mao, Yaping Guo
Theranostics 2021; 11(14): 6717-6734. doi:10.7150/thno.56607
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Rapid and simple single-chamber nucleic acid detection system prepared through nature-inspired surface engineering
Jihyo Park, Sangwon Woo, Jiyeon Kim, Hakho Lee, Yeong-Eun Yoo, Seonki Hong
Theranostics 2021; 11(14): 6735-6745. doi:10.7150/thno.57153
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A novel cell-penetrating peptide targeting calpain-cleavage of PSD-95 induced by excitotoxicity improves neurological outcome after stroke
Sara Ayuso-Dolado, Gema M. Esteban-Ortega, Óscar G. Vidaurre, Margarita Díaz-Guerra
Theranostics 2021; 11(14): 6746-6765. doi:10.7150/thno.60701
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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N-cadherin mediates the migration of bone marrow-derived mesenchymal stem cells toward breast tumor cells
Sanghyuk Choi, Jinyeong Yu, Wootak Kim, Ki-Sook Park
Theranostics 2021; 11(14): 6786-6799. doi:10.7150/thno.59703
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Radionuclide-based molecular imaging allows CAR-T cellular visualization and therapeutic monitoring
Fuqiang Shao, Yu Long, Hao Ji, Dawei Jiang, Ping Lei, Xiaoli Lan
Theranostics 2021; 11(14): 6800-6817. doi:10.7150/thno.56989
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The utility of biomedical scaffolds laden with spheroids in various tissue engineering applications
SooJung Chae, Jiyoung Hong, Hanjun Hwangbo, GeunHyung Kim
Theranostics 2021; 11(14): 6818-6832. doi:10.7150/thno.58421
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A nano-predator of pathological MDMX construct by clearable supramolecular gold(I)-thiol-peptide complexes achieves safe and potent anti-tumor activity
Siqi Yan, Jin Yan, Dan Liu, Xiang Li, Qianyan Kang, Weiming You, Jinghua Zhang, Lei Wang, Zhiqi Tian, Wuyuan Lu, Wenjia Liu, Wangxiao He
Theranostics 2021; 11(14): 6833-6846. doi:10.7150/thno.59020
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B
Jing Xun, Lingfang Du, Ruifang Gao, Long Shen, Dekun Wang, Lichun Kang, Chuan'ai Chen, Zhujun Zhang, Yuying Zhang, Shijing Yue, Shuxin Feng, Rong Xiang, Xue Mi, Xiaoyue Tan
Theranostics 2021; 11(14): 6847-6859. doi:10.7150/thno.51864
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Magnetism-mediated targeting hyperthermia-immunotherapy in “cold” tumor with CSF1R inhibitor
Yuefei Fang, Yang He, Canhao Wu, Meng Zhang, Zeyun Gu, Jiaxin Zhang, Ergang Liu, Qin Xu, Akmal M. Asrorov, Yongzhuo Huang
Theranostics 2021; 11(14): 6860-6872. doi:10.7150/thno.57511
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Pharmacological inhibition of noncanonical EED-EZH2 signaling overcomes chemoresistance in prostate cancer
Xin Li, Lajos Gera, Shumin Zhang, Yanhua Chen, Lei Lou, Lauren Marie Wilson, Zhong-Ru Xie, Giuseppe Sautto, Degang Liu, Alira Danaher, Kenza Mamouni, Yang Yang, Yuhong Du, Haian Fu, Omer Kucuk, Adeboye O. Osunkoya, Jia Zhou, Daqing Wu
Theranostics 2021; 11(14): 6873-6890. doi:10.7150/thno.49235
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2
Ying Huang, Shan-He Yu, Wen-Xuan Zhen, Tao Cheng, Dan Wang, Jie-Bo Lin, Yu-Han Wu, Yi-Fan Wang, Yi Chen, Li-Ping Shu, Yi Wang, Xiao-Jian Sun, Yi Zhou, Fan Yang, Chih-Hung Hsu, Peng-Fei Xu
Theranostics 2021; 11(14): 6891-6904. doi:10.7150/thno.53170
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Site-specific glycoproteomic analysis revealing increased core-fucosylation on FOLR1 enhances folate uptake capacity of HCC cells to promote EMT
Li Jia, Jun Li, Pengfei Li, Didi Liu, Jing Li, Jiechen Shen, Bojing Zhu, Chen Ma, Ting Zhao, Rongxia Lan, Liuyi Dang, Wang Li, Shisheng Sun
Theranostics 2021; 11(14): 6905-6921. doi:10.7150/thno.56882
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Molecular ultrasound imaging of neutrophil membrane-derived biomimetic microbubbles for quantitative evaluation of hepatic ischemia-reperfusion injury
Zheng Zhang, Xiaoyan Miao, Weifeng Yao, Jie Ren, Chaojin Chen, Xiang Li, Jing Yang, Yujia You, Yuejun Lin, Tinghui Yin, Ziqing Hei
Theranostics 2021; 11(14): 6922-6935. doi:10.7150/thno.57794
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A spontaneous multifunctional hydrogel vaccine amplifies the innate immune response to launch a powerful antitumor adaptive immune response
Xiuqi Liang, Lu Li, Xinchao Li, Tao He, Songlin Gong, Shunyao Zhu, Miaomiao Zhang, Qinjie Wu, Changyang Gong
Theranostics 2021; 11(14): 6936-6949. doi:10.7150/thno.58173
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer
Xuan Qin, Jia Li, Shiqing Wang, Jianying Lv, Fangkun Luan, Yanhua Liu, Yanan Chen, Xiaosu Chen, Yujia Zhao, Jingjin Zhu, Yongjun Piao, Wenwen Zhang, Yi Shi, Rong Xiang, Pengpeng Qu, Longlong Wang
Theranostics 2021; 11(14): 6950-6965. doi:10.7150/thno.58956
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Improving the sensitivity of T1 contrast-enhanced MRI and sensitive diagnosing tumors with ultralow doses of MnO octahedrons
Lijiao Yang, Lili Wang, Guoming Huang, Xuan Zhang, Lanlan Chen, Ao Li, Jinhao Gao, Zijian Zhou, Lichao Su, Huanghao Yang, Jibin Song
Theranostics 2021; 11(14): 6966-6982. doi:10.7150/thno.59096
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity
Petra I. Lorenzo, Eugenia Martin Vazquez, Livia López-Noriega, Esther Fuente-Martín, José M. Mellado-Gil, Jaime M. Franco, Nadia Cobo-Vuilleumier, José A. Guerrero Martínez, Silvana Y. Romero-Zerbo, Jesús A. Perez-Cabello, Sabrina Rivero Canalejo, Antonio Campos-Caro, Christian Claude Lachaud, Alejandra Crespo Barreda, Manuel Aguilar-Diosdado, Eduardo García Fuentes, Alejandro Martin-Montalvo, Manuel Álvarez Dolado, Franz Martin, Gemma Rojo-Martinez, David Pozo, Francisco J. Bérmudez-Silva, Valentine Comaills, José C. Reyes, Benoit R. Gauthier
Theranostics 2021; 11(14): 6983-7004. doi:10.7150/thno.57237
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Nanoparticle encapsulation of non-genotoxic p53 activator Inauhzin-C for improved therapeutic efficacy
Nimisha Bhattarai, Jieqiong Wang, Daniel Nguyen, Xiaoxiao Yang, Linh Helmers, Jennifer Paruch, Li Li, Yiwei Zhang, Kun Meng, Alun Wang, Janarthanan Jayawickramarajah, Binghe Wang, Shelya Zeng, Hua Lu
Theranostics 2021; 11(14): 7005-7017. doi:10.7150/thno.57404
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Dynamic monitoring of circulating tumor DNA to predict prognosis and efficacy of adjuvant chemotherapy after resection of colorectal liver metastases
De-Shen Wang, Hui Yang, Xiao-Yun Liu, Zhi-Gang Chen, Yun Wang, William Pat Fong, Ming-Tao Hu, Yuan-Chao Zheng, Yun Zheng, Bin-Kui Li, Yun-Fei Yuan, Gong Chen, Zhi-Zhong Pan, Lele Song, Yu-Hong Li, Rui-Hua Xu
Theranostics 2021; 11(14): 7018-7028. doi:10.7150/thno.59644
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment
I-Ying Kuo, You-En Yang, Pei-Shan Yang, Yu-Jou Tsai, Hong-Tai Tzeng, Hung-Chi Cheng, Wan-Ting Kuo, Wu-Chou Su, Chih-Peng Chang, Yi-Ching Wang
Theranostics 2021; 11(14): 7029-7044. doi:10.7150/thno.60040
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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γ-Glutamyl transpeptidase-activatable near-infrared nanoassembly for tumor fluorescence imaging-guided photothermal therapy
Fangyuan Zhou, Shikui Yang, Chao Zhao, Wangwang Liu, Xufeng Yao, Hui Yu, Xiaolian Sun, Yi Liu
Theranostics 2021; 11(14): 7045-7056. doi:10.7150/thno.60586
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Macrophage-mediated tumor homing of hyaluronic acid nanogels loaded with polypyrrole and anticancer drug for targeted combinational photothermo-chemotherapy
Tingting Xiao, Wei Hu, Yu Fan, Mingwu Shen, Xiangyang Shi
Theranostics 2021; 11(14): 7057-7071. doi:10.7150/thno.60427
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment
Chih-Hsiung Hsieh, Hung-Chia Hsieh, Fu-Shiuan Shih, Pei-Wen Wang, Li-Xing Yang, Dar-Bin Shieh, Yi-Ching Wang
Theranostics 2021; 11(14): 7072-7091. doi:10.7150/thno.57803
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Genomic and transcriptional alterations in first-line chemotherapy exert a potentially unfavorable influence on subsequent immunotherapy in NSCLC
Yayi He, Linsong Chen, Lishu Zhao, Shiying Dang, Guifeng Liu, Shinji Sasada, Patrick C. Ma, Nico van Zandwijk, Rafael Rosell, Helmut H. Popper, Hao Wang, Minlin Jiang, Haoyue Guo, Xinyi Liu, Shifu Chen, Xiaoni Zhang, Mingyan Xu, Bo Zhu, Ming Liu, Caicun Zhou
Theranostics 2021; 11(14): 7092-7109. doi:10.7150/thno.58039
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition
Qi Wang, Juan Liu, Yinan Hu, Ting Pan, Yongjian Xu, Jun Yu, Weining Xiong, Qing Zhou, Yi Wang
Theranostics 2021; 11(14): 7110-7125. doi:10.7150/thno.61085
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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What Animal Cancers teach us about Human Biology
Patricia Kattner, Katharina Zeiler, Verena J. Herbener, Katia La Ferla-Brühl, Rebecca Kassubek, Michael Grunert, Timo Burster, Oliver Brühl, Anna Sarah Weber, Hannah Strobel, Georg Karpel-Massler, Sibylle Ott, Alexa Hagedorn, Daniel Tews, Ansgar Schulz, Vikas Prasad, Markus D. Siegelin, Lisa Nonnenmacher, Pamela Fischer-Posovszky, Marc-Eric Halatsch, Klaus-Michael Debatin, Mike-Andrew Westhoff
Theranostics 2021; 11(14): 6682-6702. doi:10.7150/thno.56623
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Coronary microvascular injury in myocardial infarction: perception and knowledge for mitochondrial quality control
Xing Chang, Amanda Lochner, Hsueh-Hsiao Wang, Shuyi Wang, Hang Zhu, Jun Ren, Hao Zhou
Theranostics 2021; 11(14): 6766-6785. doi:10.7150/thno.60143
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Errata

Analysis of the In Vivo and In Vitro Effects of Photodynamic Therapy on Breast Cancer by Using a Sensitizer, Sinoporphyrin Sodium: Erratum
Xiaobing Wang, Jianmin Hu, Pan Wang, Shaoliang Zhang, Yichen Liu, Wenli Xiong, Quanhong Liu
Theranostics 2021; 11(14): 7126-7127. doi:10.7150/thno.62096
[Abstract] [Full text] [PDF] [PubMed] [PMC]


CCL16 maintains stem cell-like properties in breast cancer by activating CCR2/GSK3β/β-catenin/OCT4 axis: Erratum
Wenzhi Shen, Xiaoyuan Zhang, Jiaping Tang, Zhixin Zhang, Renle Du, Dehong Luo, Xiaoran Liu, Yong Xia, Yanping Li, Shanshan Wang, Siyuan Yan, Wancai Yang, Rong Xiang, Na Luo, Yunping Luo, Jianjun Li
Theranostics 2021; 11(14): 7128-7129. doi:10.7150/thno.62534
[Abstract] [Full text] [PDF] [PubMed] [PMC]