Theranostics 2018; 8(20):5660-5661. doi:10.7150/thno.31152 This issue

Erratum

In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Stem-Like Cancer Cell: Erratum

Kuan Hu1*, Feng Yin1*, Mengyin Yu1, Chengjie Sun1, Jingxu Li1, Yujie Liang1, Wenjun Li1, Mingsheng Xie1, Yuanzhi Lao3, Wei Liang2 Corresponding address, Zi-gang Li1 Corresponding address

1. School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China
2. Department of Radiation Oncology, the First Affiliated Hospital, Anhui Medical University, Hefei, 230022, China
3. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China
* These authors contributed equally to this work.

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Citation:
Hu K, Yin F, Yu M, Sun C, Li J, Liang Y, Li W, Xie M, Lao Y, Liang W, Li Zg. In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Stem-Like Cancer Cell: Erratum. Theranostics 2018; 8(20):5660-5661. doi:10.7150/thno.31152. Available from https://www.thno.org/v08p5660.htm

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Corrected-article in Theranostics, Volume 7, 4566

 

In our paper [1], Figure 3 should be corrected as follows.

 Figure 3 

(A, B) MeR/PhR stabilize p53 and elevate protein levels of p53 and its targets MDM2 and MDMX. Log-phase PA-1 and MCF-7 cells were incubated with 40 μM peptides (MeR/S, PhR/S) or 1 μM nutlin-3a, and cell lysates were analyzed by Western blotting. (C, D) PhR shows induction of p53 and p53 target genes in p53wt cell lines. Exponentially growing p53wt cancer cell lines were incubated with 40 μM peptides or 1 μM nutlin-3a for 48 h, and mRNA level of p53 and p53 targets MDM2, MDMX, and MIC or stemness-related genes were analyzed by quantitative PCR and expressed as fold increase. Error bars represent SEMs for triplicates of three independent experiments, **, P<0.01. *, P<0.05.

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References

1. Hu K, Yin F, Yu M, Sun C, Li J, Liang Y, Li W, Xie M, Lao Y, Liang W, Li Zg. In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Stem-Like Cancer Cell. Theranostics. 2017;7(18):4566-4576 doi:10.7150/thno.19840

Author contact

Corresponding address Corresponding authors: Zi-gang Li, email: lizgedu.cn Wei Liang, email: williamleungcom


Published 2018-11-10