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Volume 7 (1); 2017

Research Paper

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Antitumor therapeutic application of self-assembled RNAi-AuNP nanoconstructs: Combination of VEGF-RNAi and photothermal ablation
Sejin Son, Namho Kim, Dong Gil You, Hong Yeol Yoon, Ji Young Yhee, Kwangmeyung Kim, Ick Chan Kwon, Sun Hwa Kim
Theranostics 2017; 7(1): 9-22. doi:10.7150/thno.16042
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Efficient Enhancement of Blood-Brain Barrier Permeability Using Acoustic Cluster Therapy (ACT)
Andreas K.O. Åslund, Sofie Snipstad, Andrew Healey, Svein Kvåle, Sverre H. Torp, Per C. Sontum, Catharina de Lange Davies, Annemieke van Wamel
Theranostics 2017; 7(1): 23-30. doi:10.7150/thno.16577
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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From Interface to Solution: Integrating Immunoassay with Netlike Rolling Circle Amplification for Ultrasensitive Detection of Tumor Biomarker
Chang Feng, Bing Bo, Xiaoxia Mao, Hai Shi, Xiaoli Zhu, Genxi Li
Theranostics 2017; 7(1): 31-39. doi:10.7150/thno.16671
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Localized Delivery of shRNA against PHD2 Protects the Heart from Acute Myocardial Infarction through Ultrasound-Targeted Cationic Microbubble Destruction
Li Zhang, Zhenxing Sun, Pingping Ren, Manjie You, Jing Zhang, Lingyun Fang, Jing Wang, Yihan Chen, Fei Yan, Hairong Zheng, Mingxing Xie
Theranostics 2017; 7(1): 51-66. doi:10.7150/thno.16074
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CD54-NOTCH1 axis controls tumor initiation and cancer stem cell functions in human prostate cancer
Chong Li, Shengwu Liu, Ruping Yan, Ning Han, Kwok-Kin Wong, Lei Li
Theranostics 2017; 7(1): 67-80. doi:10.7150/thno.16752
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model
Shang-Chun Guo, Shi-Cong Tao, Wen-Jing Yin, Xin Qi, Ting Yuan, Chang-Qing Zhang
Theranostics 2017; 7(1): 81-96. doi:10.7150/thno.16803
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Scavenger Receptor-Mediated Targeted Treatment of Collagen-Induced Arthritis by Dextran Sulfate-Methotrexate Prodrug
Modi Yang, Jianxun Ding, Xiangru Feng, Fei Chang, Yinan Wang, Zhongli Gao, Xiuli Zhuang, Xuesi Chen
Theranostics 2017; 7(1): 97-105. doi:10.7150/thno.16844
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Heparin improves BMSC cell therapy: Anticoagulant treatment by heparin improves the safety and therapeutic effect of bone marrow-derived mesenchymal stem cell cytotherapy
Li Liao, Bingzheng Shi, Heran Chang, Xiaoxia Su, Lichao Zhang, Chunsheng Bi, Yi Shuai, Xiaoyan Du, Zhihong Deng, Yan Jin
Theranostics 2017; 7(1): 106-116. doi:10.7150/thno.16911
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Pre-vascularization Enhances Therapeutic Effects of Human Mesenchymal Stem Cell Sheets in Full Thickness Skin Wound Repair
Lei Chen, Qi Xing, Qiyi Zhai, Mitchell Tahtinen, Fei Zhou, Lili Chen, Yingbin Xu, Shaohai Qi, Feng Zhao
Theranostics 2017; 7(1): 117-131. doi:10.7150/thno.17031
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3β-E2F1 Axis Linking Reversely with Survival in Gliomas
Desheng Xiao, Jun Huang, Yu Pan, Hao Li, Chunyan Fu, Chao Mao, Yan Cheng, Ying Shi, Ling Chen, Yiqun Jiang, Rui Yang, Yating Liu, Jianhua Zhou, Ya Cao, Shuang Liu, Yongguang Tao
Theranostics 2017; 7(1): 132-143. doi:10.7150/thno.17032
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Microbubble gas volume: A unifying dose parameter in blood-brain barrier opening by focused ultrasound
Kang-Ho Song, Alexander C. Fan, Joshua J. Hinkle, Joshua Newman, Mark A. Borden, Brandon K. Harvey
Theranostics 2017; 7(1): 144-152. doi:10.7150/thno.15987
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Mapping Sentinel Lymph Node Metastasis by Dual-probe Optical Imaging
Xiangyu Yang, Zhe Wang, Fuwu Zhang, Guizhi Zhu, Jibin Song, Gao-Jun Teng, Gang Niu, Xiaoyuan Chen
Theranostics 2017; 7(1): 153-163. doi:10.7150/thno.17085
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Smart Cu(II)-aptamer complexes based gold nanoplatform for tumor micro-environment triggered programmable intracellular prodrug release, photodynamic treatment and aggregation induced photothermal therapy of hepatocellular carcinoma
Da Zhang, Aixian Zheng, Juan Li, Ming Wu, Lingjie Wu, Zuwu Wei, Naishun Liao, Xiaolong Zhang, Zhixiong Cai, Huanghao Yang, Gang Liu, Xiaolong Liu, Jingfeng Liu
Theranostics 2017; 7(1): 164-179. doi:10.7150/thno.17099
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model
Shi-Cong Tao, Ting Yuan, Yue-Lei Zhang, Wen-Jing Yin, Shang-Chun Guo, Chang-Qing Zhang
Theranostics 2017; 7(1): 180-195. doi:10.7150/thno.17133
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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3-D Ultrasound Localization Microscopy for Identifying Microvascular Morphology Features of Tumor Angiogenesis at a Resolution Beyond the Diffraction Limit of Conventional Ultrasound
Fanglue Lin, Sarah E. Shelton, David Espíndola, Juan D. Rojas, Gianmarco Pinton, Paul A. Dayton
Theranostics 2017; 7(1): 196-204. doi:10.7150/thno.16899
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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[68Ga]Pentixafor-PET/CT for imaging of chemokine receptor CXCR4 expression in multiple myeloma - Comparison to [18F]FDG and laboratory values
Constantin Lapa, Martin Schreder, Andreas Schirbel, Samuel Samnick, Klaus Martin Kortüm, Ken Herrmann, Saskia Kropf, Herrmann Einsele, Andreas K. Buck, Hans-Jürgen Wester, Stefan Knop, Katharina Lückerath
Theranostics 2017; 7(1): 205-212. doi:10.7150/thno.16576
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Genome-Wide lncRNA Microarray Profiling Identifies Novel Circulating lncRNAs for Detection of Gastric Cancer
Kecheng Zhang, Hongzhi Shi, Hongqing Xi, Xiaosong Wu, Jianxin Cui, Yunhe Gao, Wenquan Liang, Chong Hu, Yi Liu, Jiyang Li, Ning Wang, Bo Wei, Lin Chen
Theranostics 2017; 7(1): 213-227. doi:10.7150/thno.16044
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Comparison of 68Ga-HBED-CC PSMA-PET/CT and multiparametric MRI for gross tumour volume detection in patients with primary prostate cancer based on slice by slice comparison with histopathology
Constantinos Zamboglou, Vanessa Drendel, Cordula A. Jilg, Hans C. Rischke, Teresa I. Beck, Wolfgang Schultze-Seemann, Tobias Krauss, Michael Mix, Florian Schiller, Ulrich Wetterauer, Martin Werner, Mathias Langer, Michael Bock, Philipp T. Meyer, Anca L. Grosu
Theranostics 2017; 7(1): 228-237. doi:10.7150/thno.16638
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Short Research Communication

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Preventing Radiobleaching of Cyanine Fluorophores Enhances Stability of Nuclear/NIRF Multimodality Imaging Agents
Reinier Hernandez, Sandra Heskamp, Mark Rijpkema, Desirée L. Bos, David M. Goldenberg, William J. McBride, Alfred Morgenstern, Frank Bruchertseifer, Weibo Cai, Otto C. Boerman
Theranostics 2017; 7(1): 1-8. doi:10.7150/thno.15124
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review

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Preclinical Applications of 3'-Deoxy-3'-[18F] Fluoro-thymidine in Oncology - A Systematic Review
Sonja Schelhaas, Kathrin Heinzmann, Vikram R. Bollineni, Gerbrand M. Kramer, Yan Liu, John C. Waterton, Eric O. Aboagye, Anthony F. Shields, Dmitry Soloviev, Andreas H. Jacobs
Theranostics 2017; 7(1): 40-50. doi:10.7150/thno.16676
[Abstract] [Full text] [PDF] [PubMed] [PMC]