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Volume 7 (2); 2017

Research Paper

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Comprehensive Metaproteomic Analyses of Urine in the Presence and Absence of Neutrophil-Associated Inflammation in the Urinary Tract
Yanbao Yu, Patricia Sikorski, Madeline Smith, Cynthia Bowman-Gholston, Nicolas Cacciabeve, Karen E. Nelson, Rembert Pieper
Theranostics 2017; 7(2): 238-252. doi:10.7150/thno.16086
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Enhancing Nanoparticle Accumulation and Retention in Desmoplastic Tumors via Vascular Disruption for Internal Radiation Therapy
Andrew B. Satterlee, Juan D. Rojas, Paul A. Dayton, Leaf Huang
Theranostics 2017; 7(2): 253-269. doi:10.7150/thno.16681
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Nanosized UCMSC-derived extracellular vesicles but not conditioned medium exclusively inhibit the inflammatory response of stimulated T cells: implications for nanomedicine
Marta Monguió-Tortajada, Santiago Roura, Carolina Gálvez-Montón, Josep Maria Pujal, Gemma Aran, Lucía Sanjurjo, Marcel·la Franquesa, Maria-Rosa Sarrias, Antoni Bayes-Genis, Francesc E. Borràs
Theranostics 2017; 7(2): 270-284. doi:10.7150/thno.16154
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Visualization, Quantification and Characterization of Caerulein-Induced Acute Pancreatitis in Rats by 3.0T Clinical MRI, Biochemistry and Histomorphology
Ting Yin, Ronald Peeters, Yewei Liu, Yuanbo Feng, Xinyuan Zhang, Yansheng Jiang, Jie Yu, Steven Dymarkowski, Uwe Himmelreich, Raymond Oyen, Yicheng Ni
Theranostics 2017; 7(2): 285-294. doi:10.7150/thno.16282
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Targeting of Magnetic Nanoparticle-coated Microbubbles to the Vascular Wall Empowers Site-specific Lentiviral Gene Delivery in vivo
Yvonn Heun, Staffan Hildebrand, Alexandra Heidsieck, Bernhard Gleich, Martina Anton, Joachim Pircher, Andrea Ribeiro, Olga Mykhaylyk, Dietmar Eberbeck, Daniela Wenzel, Alexander Pfeifer, Markus Woernle, Florian Krötz, Ulrich Pohl, Hanna Mannell
Theranostics 2017; 7(2): 295-307. doi:10.7150/thno.16192
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
Greta Hultqvist, Stina Syvänen, Xiaotian T Fang, Lars Lannfelt, Dag Sehlin
Theranostics 2017; 7(2): 308-318. doi:10.7150/thno.17155
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Improved Tumor Uptake by Optimizing Liposome Based RES Blockade Strategy
Xiaolian Sun, Xuefeng Yan, Orit Jacobson, Wenjing Sun, Zhantong Wang, Xiao Tong, Yuqiong Xia, Daishun Ling, Xiaoyuan Chen
Theranostics 2017; 7(2): 319-328. doi:10.7150/thno.18078
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Tumor Stiffening, a Key Determinant of Tumor Progression, is Reversed by Nanomaterial-Induced Photothermal Therapy
Iris Marangon, Amanda A. K. Silva, Thomas Guilbert, Jelena Kolosnjaj-Tabi, Carmen Marchiol, Sharuja Natkhunarajah, Foucault Chamming's, Cécilia Ménard-Moyon, Alberto Bianco, Jean-Luc Gennisson, Gilles Renault, Florence Gazeau
Theranostics 2017; 7(2): 329-343. doi:10.7150/thno.17574
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Inhibition by Multifunctional Magnetic Nanoparticles Loaded with Alpha-Synuclein RNAi Plasmid in a Parkinson's Disease Model
Shuiqin Niu, Ling-Kun Zhang, Li Zhang, Siyi Zhuang, Xiuyu Zhan, Wu-Ya Chen, Shiwei Du, Liang Yin, Rong You, Chu-Hua Li, Yan-Qing Guan
Theranostics 2017; 7(2): 344-356. doi:10.7150/thno.16562
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Systemic siRNA Delivery with a Dual pH-Responsive and Tumor-targeted Nanovector for Inhibiting Tumor Growth and Spontaneous Metastasis in Orthotopic Murine Model of Breast Carcinoma
Bo Fan, Lin Kang, Liqing Chen, Ping Sun, Mingji Jin, Qiming Wang, You Han Bae, Wei Huang, Zhonggao Gao
Theranostics 2017; 7(2): 357-376. doi:10.7150/thno.16855
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Anti-angiogenic Nanotherapy Inhibits Airway Remodeling and Hyper-responsiveness of Dust Mite Triggered Asthma in the Brown Norway Rat
Gregory M. Lanza, John Jenkins, Anne H. Schmieder, Aigul Moldobaeva, Grace Cui, Huiying Zhang, Xiaoxia Yang, Qiong Zhong, Jochen Keupp, Ismail Sergin, Krishna S. Paranandi, Lindsey Eldridge, John S. Allen, Todd Williams, Michael J. Scott, Babak Razani, Elizabeth M. Wagner
Theranostics 2017; 7(2): 377-389. doi:10.7150/thno.16627
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The Landscape of Clinical Trials Evaluating the Theranostic Role of PET Imaging in Oncology: Insights from an Analysis of ClinicalTrials.gov Database
Yu-Pei Chen, Jia-Wei Lv, Xu Liu, Yuan Zhang, Ying Guo, Ai-Hua Lin, Ying Sun, Yan-Ping Mao, Jun Ma
Theranostics 2017; 7(2): 390-399. doi:10.7150/thno.17087
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Limited Tumor Tissue Drug Penetration Contributes to Primary Resistance against Angiogenesis Inhibitors
Szilvia Torok, Melinda Rezeli, Olga Kelemen, Akos Vegvari, Kenichi Watanabe, Yutaka Sugihara, Anna Tisza, Timea Marton, Ildiko Kovacs, Jozsef Tovari, Viktoria Laszlo, Thomas H. Helbich, Balazs Hegedus, Thomas Klikovits, Mir Alireza Hoda, Walter Klepetko, Sandor Paku, Gyorgy Marko-Varga, Balazs Dome
Theranostics 2017; 7(2): 400-412. doi:10.7150/thno.16767
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Noninvasive Imaging of Myocardial Inflammation in Myocarditis using 68Ga-tagged Mannosylated Human Serum Albumin Positron Emission Tomography
Seung-Pyo Lee, Hyung-Jun Im, Shinae Kang, Seock-Jin Chung, Ye Seul Cho, Hyejeong Kang, Ho Seon Park, Do-Won Hwang, Jun-Bean Park, Jin-Chul Paeng, Gi-Jeong Cheon, Yun-Sang Lee, Jae Min Jeong, Yong-Jin Kim
Theranostics 2017; 7(2): 413-424. doi:10.7150/thno.15712
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action
Xiao-yu Ai, Hui-juan Liu, Cheng Lu, Cai-li Liang, Yan Sun, Shuang Chen, Bo Sun, Yang Li, Yan-rong Liu, Qiang Zhang, Xue-qiang Liu, Ting Xiao, Xue-shuang Jing, Tao Sun, Hong-gang Zhou, Cheng Yang
Theranostics 2017; 7(2): 425-435. doi:10.7150/thno.17073
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Proton MR Spectroscopy and Diffusion MR Imaging Monitoring to Predict Tumor Response to Interstitial Photodynamic Therapy for Glioblastoma
Magali Toussaint, Sophie Pinel, Florent Auger, Nicolas Durieux, Magalie Thomassin, Eloise Thomas, Albert Moussaron, Dominique Meng, François Plénat, Marine Amouroux, Thierry Bastogne, Céline Frochot, Olivier Tillement, François Lux, Muriel Barberi-Heyob
Theranostics 2017; 7(2): 436-451. doi:10.7150/thno.17218
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Dual-targeted and pH-sensitive Doxorubicin Prodrug-Microbubble Complex with Ultrasound for Tumor Treatment
Wanxian Luo, Ge Wen, Li Yang, Jiao Tang, Jianguo Wang, Jihui Wang, Shiyu Zhang, Li Zhang, Fei Ma, Liling Xiao, Ying Wang, Yingjia Li
Theranostics 2017; 7(2): 452-465. doi:10.7150/thno.16677
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Hyaluronic Acid Conjugated Magnetic Prussian Blue@Quantum Dot Nanoparticles for Cancer Theranostics
Yongbo Yang, Lijia Jing, Xiaoda Li, Li Lin, Xiuli Yue, Zhifei Dai
Theranostics 2017; 7(2): 466-481. doi:10.7150/thno.17411
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Functional Genomic mRNA Profiling of Colorectal Adenomas: Identification and in vivo Validation of CD44 and Splice Variant CD44v6 as Molecular Imaging Targets
Elmire Hartmans, Veronique Orian-Rousseau, Alexandra Matzke-Ogi, Arend Karrenbeld, Derk Jan A. de Groot, Steven de Jong, Gooitzen M. van Dam, Rudolf S.N. Fehrmann, Wouter B. Nagengast
Theranostics 2017; 7(2): 482-492. doi:10.7150/thno.16816
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A specific dietary intervention to restore brain structure and function after ischemic stroke
Maximilian Wiesmann, Bastian Zinnhardt, Dirk Reinhardt, Sarah Eligehausen, Lydia Wachsmuth, Sven Hermann, Pieter J Dederen, Marloes Hellwich, Michael T Kuhlmann, Laus M Broersen, Arend Heerschap, Andreas H Jacobs, Amanda J Kiliaan
Theranostics 2017; 7(2): 493-512. doi:10.7150/thno.17559
[Abstract] [Full text] [PDF] [PubMed] [PMC]