ISSN: 1838-7640Theranostics
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Theranostics 2024; 14(10):3859-3899. doi:10.7150/thno.96516 This issue Cite
Review
Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies
1. Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. China.
2. Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan 430060, P.R. China.
#: These authors contributed equally to this work.
Citation:
Chen J, Hao Z, Li H, Wang J, Chen T, Wang Y, Shi G, Wang J, Wang Z, Zhang Z, Li J. Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies. Theranostics 2024; 14(10):3859-3899. doi:10.7150/thno.96516. https://www.thno.org/v14p3859.htm
Other stylesAbstract
Osteoporosis is a systemic skeletal disease caused by an imbalance between bone resorption and formation. Current treatments primarily involve systemic medication and hormone therapy. However, these systemic treatments lack directionality and are often ineffective for locally severe osteoporosis, with the potential for complex adverse reactions. Consequently, treatment strategies using bioactive materials or external interventions have emerged as the most promising approaches. This review proposes twelve microenvironmental treatment targets for osteoporosis-related pathological changes, including local accumulation of inflammatory factors and reactive oxygen species (ROS), imbalance of mitochondrial dynamics, insulin resistance, disruption of bone cell autophagy, imbalance of bone cell apoptosis, changes in neural secretions, aging of bone cells, increased local bone tissue vascular destruction, and decreased regeneration. Additionally, this review examines the current research status of effective or potential biophysical and biochemical stimuli based on these microenvironmental treatment targets and summarizes the advantages and optimal parameters of different bioengineering stimuli to support preclinical and clinical research on osteoporosis treatment and bone regeneration. Finally, the review addresses ongoing challenges and future research prospects.
Keywords: Bone tissue engineering, Osteoporosis, Bone regeneration, Engineering stimuli, Applications
Citation styles
APA
Chen, J., Hao, Z., Li, H., Wang, J., Chen, T., Wang, Y., Shi, G., Wang, J., Wang, Z., Zhang, Z., Li, J. (2024). Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies. Theranostics, 14(10), 3859-3899. https://doi.org/10.7150/thno.96516.
ACS
Chen, J.; Hao, Z.; Li, H.; Wang, J.; Chen, T.; Wang, Y.; Shi, G.; Wang, J.; Wang, Z.; Zhang, Z.; Li, J. Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies. Theranostics 2024, 14 (10), 3859-3899. DOI: 10.7150/thno.96516.
NLM
Chen J, Hao Z, Li H, Wang J, Chen T, Wang Y, Shi G, Wang J, Wang Z, Zhang Z, Li J. Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies. Theranostics 2024; 14(10):3859-3899. doi:10.7150/thno.96516. https://www.thno.org/v14p3859.htm
CSE
Chen J, Hao Z, Li H, Wang J, Chen T, Wang Y, Shi G, Wang J, Wang Z, Zhang Z, Li J. 2024. Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies. Theranostics. 14(10):3859-3899.
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