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Theranostics 2023; 13(11):3524-3549. doi:10.7150/thno.83383 This issue Cite

Review

Intrinsic mechanism and pharmacologic treatments of noise-induced hearing loss

Ke Xu2,3,4, Baoying Xu1, Jiayi Gu2,3,4, Xueling Wang2,3,4, Dehong Yu1✉, Yu Chen1✉

1. Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, China.
2. Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
3. Ear Institute, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
4. Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China.

✉ Corresponding authors: Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, China. E-mail address: chenyueduedu.cn; dehongyuedu.cn.

Citation:
Xu K, Xu B, Gu J, Wang X, Yu D, Chen Y. Intrinsic mechanism and pharmacologic treatments of noise-induced hearing loss. Theranostics 2023; 13(11):3524-3549. doi:10.7150/thno.83383. https://www.thno.org/v13p3524.htm
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Abstract

Graphic abstract

Noise accounts for one-third of hearing loss worldwide. Regretfully, noise-induced hearing loss (NIHL) is deemed to be irreversible due to the elusive pathogenic mechanisms that have not been fully elucidated. The complex interaction between genetic and environmental factors, which influences numerous downstream molecular and cellular events, contributes to the NIHL. In clinical settings, there are no effective therapeutic drugs other than steroids, which are the only treatment option for patients with NIHL. Therefore, the need for treatment of NIHL that is currently unmet, along with recent progress in our understanding of the underlying regulatory mechanisms, has led to a lot of new literatures focusing on this therapeutic field. The emergence of novel technologies that modify local drug delivery to the inner ear has led to the development of promising therapeutic approaches, which are currently under clinical investigation. In this comprehensive review, we focus on outlining and analyzing the basics and potential therapeutics of NIHL, as well as the application of biomaterials and nanomedicines in inner ear drug delivery. The objective of this review is to provide an incentive for NIHL's fundamental research and future clinical translation.

Keywords: noise-induced hearing loss, pharmacologic strategies, drug delivery systems, nanoparticles

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APA
Xu, K., Xu, B., Gu, J., Wang, X., Yu, D., Chen, Y. (2023). Intrinsic mechanism and pharmacologic treatments of noise-induced hearing loss. Theranostics, 13(11), 3524-3549. https://doi.org/10.7150/thno.83383.

ACS
Xu, K.; Xu, B.; Gu, J.; Wang, X.; Yu, D.; Chen, Y. Intrinsic mechanism and pharmacologic treatments of noise-induced hearing loss. Theranostics 2023, 13 (11), 3524-3549. DOI: 10.7150/thno.83383.

NLM
Xu K, Xu B, Gu J, Wang X, Yu D, Chen Y. Intrinsic mechanism and pharmacologic treatments of noise-induced hearing loss. Theranostics 2023; 13(11):3524-3549. doi:10.7150/thno.83383. https://www.thno.org/v13p3524.htm

CSE
Xu K, Xu B, Gu J, Wang X, Yu D, Chen Y. 2023. Intrinsic mechanism and pharmacologic treatments of noise-induced hearing loss. Theranostics. 13(11):3524-3549.

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