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Theranostics 2023; 13(6):1774-1808. doi:10.7150/thno.82920 This issue Cite

Review

The role of lipid metabolic reprogramming in tumor microenvironment

Kai Yang1,2,*, Xiaokun Wang1,*, Chenghu Song1, Zhao He1, Ruixin Wang1, Yongrui Xu1, Guanyu Jiang1, Yuan Wan3,✉, Jie Mei2,✉, Wenjun Mao1,✉

1. Department of Thoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214023, China.
2. Department of Oncology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing, 210029, China.
3. The Pq Laboratory of BiomeDx/Rx, Department of Biomedical Engineering, Binghamton University, Binghamton 13850, USA.
* equal contribution

✉ Corresponding authors: Wenjun Mao, M.D., Department of Cardiothoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, No. 299 Qingyang Rd., Wuxi, 214023, China. E-mail: maowenjun1edu.cn. Jie Mei, M.D., Department More

Citation:
Yang K, Wang X, Song C, He Z, Wang R, Xu Y, Jiang G, Wan Y, Mei J, Mao W. The role of lipid metabolic reprogramming in tumor microenvironment. Theranostics 2023; 13(6):1774-1808. doi:10.7150/thno.82920. https://www.thno.org/v13p1774.htm
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Abstract

Graphic abstract

Metabolic reprogramming is one of the most important hallmarks of malignant tumors. Specifically, lipid metabolic reprogramming has marked impacts on cancer progression and therapeutic response by remodeling the tumor microenvironment (TME). In the past few decades, immunotherapy has revolutionized the treatment landscape for advanced cancers. Lipid metabolic reprogramming plays pivotal role in regulating the immune microenvironment and response to cancer immunotherapy. Here, we systematically reviewed the characteristics, mechanism, and role of lipid metabolic reprogramming in tumor and immune cells in the TME, appraised the effects of various cell death modes (specifically ferroptosis) on lipid metabolism, and summarized the antitumor therapies targeting lipid metabolism. Overall, lipid metabolic reprogramming has profound effects on cancer immunotherapy by regulating the immune microenvironment; therefore, targeting lipid metabolic reprogramming may lead to the development of innovative clinical applications including sensitizing immunotherapy.

Keywords: lipid metabolic reprogramming, tumor microenvironment, immunotherapy, therapeutic target

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APA
Yang, K., Wang, X., Song, C., He, Z., Wang, R., Xu, Y., Jiang, G., Wan, Y., Mei, J., Mao, W. (2023). The role of lipid metabolic reprogramming in tumor microenvironment. Theranostics, 13(6), 1774-1808. https://doi.org/10.7150/thno.82920.

ACS
Yang, K.; Wang, X.; Song, C.; He, Z.; Wang, R.; Xu, Y.; Jiang, G.; Wan, Y.; Mei, J.; Mao, W. The role of lipid metabolic reprogramming in tumor microenvironment. Theranostics 2023, 13 (6), 1774-1808. DOI: 10.7150/thno.82920.

NLM
Yang K, Wang X, Song C, He Z, Wang R, Xu Y, Jiang G, Wan Y, Mei J, Mao W. The role of lipid metabolic reprogramming in tumor microenvironment. Theranostics 2023; 13(6):1774-1808. doi:10.7150/thno.82920. https://www.thno.org/v13p1774.htm

CSE
Yang K, Wang X, Song C, He Z, Wang R, Xu Y, Jiang G, Wan Y, Mei J, Mao W. 2023. The role of lipid metabolic reprogramming in tumor microenvironment. Theranostics. 13(6):1774-1808.

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