ISSN: 1838-7640Theranostics
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Theranostics 2023; 13(2):611-620. doi:10.7150/thno.80857 This issue Cite
Research Paper
Tumor polyamines as guest cues attract host-functionalized liposomes for targeting and hunting via a bio-orthogonal supramolecular strategy
1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China.
2. Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering and Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore, 119074, Singapore.
*Q.C. and Z. Y. contributed equally to this work.
Citation:
Cheng Q, Yang Z, Quan X, Ding Y, Li J, Wang Z, Zhao Y, Chen X, Wang R. Tumor polyamines as guest cues attract host-functionalized liposomes for targeting and hunting via a bio-orthogonal supramolecular strategy. Theranostics 2023; 13(2):611-620. doi:10.7150/thno.80857. https://www.thno.org/v13p0611.htm
Other stylesAbstract
Inspired by the attractions of fruit flies to polyamines of rotten food, we developed a facile, bio-orthogonal, supramolecular homing and hunting strategy, relying on the elevated levels of polyamines in tumor as the natural guest cues to attract cucurbit [7] uril (CB[7]) functionalized liposomes to the tumor site, owing to the strong, bio-orthogonal host-guest interactions between CB[7] and polyamines. This supramolecular homing enabled a high targeting efficiency of CB[7] functionalized liposomes, and allowed better tissue penetration and retention in breast tumor. The employment of a receptor functionalized nanomedicine for direct tropism towards endogenous biomarkers as guest cues, reminiscent of natural chemotaxis but in a bio-orthogonal manner, has not been previously reported, offering new sights to the design and development of new nanoformulations that rely on bio-orthogonal interactions for chemotaxis-guided targeting.
Keywords: active target, polyamines, bio-orthogonal, supramolecular homing, host-guest interaction.
Citation styles
APA
Cheng, Q., Yang, Z., Quan, X., Ding, Y., Li, J., Wang, Z., Zhao, Y., Chen, X., Wang, R. (2023). Tumor polyamines as guest cues attract host-functionalized liposomes for targeting and hunting via a bio-orthogonal supramolecular strategy. Theranostics, 13(2), 611-620. https://doi.org/10.7150/thno.80857.
ACS
Cheng, Q.; Yang, Z.; Quan, X.; Ding, Y.; Li, J.; Wang, Z.; Zhao, Y.; Chen, X.; Wang, R. Tumor polyamines as guest cues attract host-functionalized liposomes for targeting and hunting via a bio-orthogonal supramolecular strategy. Theranostics 2023, 13 (2), 611-620. DOI: 10.7150/thno.80857.
NLM
Cheng Q, Yang Z, Quan X, Ding Y, Li J, Wang Z, Zhao Y, Chen X, Wang R. Tumor polyamines as guest cues attract host-functionalized liposomes for targeting and hunting via a bio-orthogonal supramolecular strategy. Theranostics 2023; 13(2):611-620. doi:10.7150/thno.80857. https://www.thno.org/v13p0611.htm
CSE
Cheng Q, Yang Z, Quan X, Ding Y, Li J, Wang Z, Zhao Y, Chen X, Wang R. 2023. Tumor polyamines as guest cues attract host-functionalized liposomes for targeting and hunting via a bio-orthogonal supramolecular strategy. Theranostics. 13(2):611-620.
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