Theranostics 2023; 13(1):20-39. doi:10.7150/thno.76894 This issue Cite

Review

Engineered biomembrane-derived nanoparticles for nanoscale theranostics

Ziqing Wu1,2,3*, Hao Zhang1*, Jing Yan1,2,3*, Yan Wei1,3✉, Jiacan Su1,3,4✉

1. Institute of Translational Medicine, Shanghai University, Shanghai 200444, China.
2. Institute of Medicine, Shanghai University, Shanghai 200444, China.
3. Musculoskeletal Organoid Research Center, Shanghai University, Shanghai 200444, China.
4. Department of Trauma Orthopedics, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
*These authors contributed equally to this work.

Citation:
Wu Z, Zhang H, Yan J, Wei Y, Su J. Engineered biomembrane-derived nanoparticles for nanoscale theranostics. Theranostics 2023; 13(1):20-39. doi:10.7150/thno.76894. https://www.thno.org/v13p0020.htm
Other styles

File import instruction

Abstract

Graphic abstract

Currently, biological membrane-derived nanoparticles (NPs) have shown enormous potential as drug delivery vehicles due to their outstanding biomimetic properties. To make these NPs more adaptive to complex biological systems, some methods have been developed to modify biomembranes and endow them with more functions while preserving their inherent natures. In this review, we introduce five common approaches used for biomembrane decoration: membrane hybridization, the postinsertion method, chemical methods, metabolism engineering and gene engineering. These methods can functionalize a series of biomembranes derived from red blood cells, white blood cells, tumor cells, platelets, exosomes and so on. Biomembrane engineering could markedly facilitate the targeted drug delivery, treatment and diagnosis of cancer, inflammation, immunological diseases, bone diseases and Alzheimer's disease. It is anticipated that these membrane modification techniques will advance biomembrane-derived NPs into broader applications in the future.

Keywords: biomembrane-derived nanoparticles, biomimetic, biomembrane engineering, targeted drug delivery, nanoscale theranostics


Citation styles

APA
Wu, Z., Zhang, H., Yan, J., Wei, Y., Su, J. (2023). Engineered biomembrane-derived nanoparticles for nanoscale theranostics. Theranostics, 13(1), 20-39. https://doi.org/10.7150/thno.76894.

ACS
Wu, Z.; Zhang, H.; Yan, J.; Wei, Y.; Su, J. Engineered biomembrane-derived nanoparticles for nanoscale theranostics. Theranostics 2023, 13 (1), 20-39. DOI: 10.7150/thno.76894.

NLM
Wu Z, Zhang H, Yan J, Wei Y, Su J. Engineered biomembrane-derived nanoparticles for nanoscale theranostics. Theranostics 2023; 13(1):20-39. doi:10.7150/thno.76894. https://www.thno.org/v13p0020.htm

CSE
Wu Z, Zhang H, Yan J, Wei Y, Su J. 2023. Engineered biomembrane-derived nanoparticles for nanoscale theranostics. Theranostics. 13(1):20-39.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.